ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions by Lu Xia, Yiwen Pan, Xianbin Wang, Rong Hu, Jie Gao, Wei Chen, Keke He, Dongbin Cui, Youbo Zhao, Lu Liu, Laijun Lai, Min Su

“…Conclusions In summary, our results suggest that administration of ERMAP can protect DSS-induced colitis in mice by regulating T cell and macrophage functions. This study adds to the evidence for various mechanistic pathways associated to the pathogenesis of IBD, which could subsequently be translated to novel therapeutics.…”
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Tribochemical synthesis of functionalized covalent organic frameworks for anti-wear and friction reduction by Xiaozhi Zhang, Qi Lu, Yaojie Yan, Tingting Zhang, Shujuan Liu, Meirong Cai, Qian Ye, Feng Zhou, Weimin Liu

“…The prime focus of our research was on the preparation and functionalization of COF materials via tribochemical reactions, unraveling a new avenue for the rational design and preparation of functional materials.…”
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Supportive functions of soil organic carbon for ecosystem services in karst desertification areas by Wang Xingfu, Liu Yi, Xiong Kangning, Huang Xianfei, Zhang Zhenming

“…In this study, we explored the supportive functions of soil organic carbon (SOC) for ecosystem services in karst rocky desertification areas. …”
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Fibro-adipogenic progenitor cells in skeletal muscle unloading: metabolic and functional impairments by Margarita Sorokina, Danila Bobkov, Natalia Khromova, Natalia Vilchinskaya, Boris Shenkman, Anna Kostareva, Renata Dmitrieva

“…This work is aimed to investigate how skeletal muscle disuse affects the functionality and metabolism of FAPs. Methods Hindlimb suspension (HS) rat model employed to investigate muscle response to decreased usage. …”
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NEK2 regulates B cell function and the severity of experimental autoimmune encephalomyelitis by Si-Ting Wu, Tian-Xiang Zhang, Zhirui Liu, Xueting An, Xiaoshan Du, Shu Yang, Ti Wu, Guanju Di, Jingshi Song, Bin Feng, Chunyang Wang, Chao Zhang

“…Administration of the NEK2 inhibitor INH1 in a murine model of experimental autoimmune encephalomyelitis (EAE) led to notable improvements in neurological function, amelioration of demyelination, and a decrease in the infiltration of inflammatory cells in the central nervous system (CNS) compared to vehicle-treated EAE mice. …”
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Nodal and cripto-1: distinct functions regulate trophoblast specification in mouse pregnancy by Laura Girardet, Laura Girardet, Neha Kamath, Neha Kamath, Daniel Dufort, Daniel Dufort

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An in vitro neurobacterial interface reveals direct modulation of neuronal function by gut bacteria by Juan Lombardo-Hernandez, Jesús Mansilla-Guardiola, Riccardo Aucello, Cristian Botta, Maria Teresa García-Esteban, Antonio Murciano-Cespedosa, David Muñoz-Rodríguez, Elisa Quarta, Álvaro Mateos González, Carmen Juan-Llamas, Kalliopi Rantsiou, Stefano Geuna, Luca Cocolin, Celia Herrera-Rincon

“…We developed an in vitro model using the foodborne bacterium Lactiplantibacillus plantarum and rat cortical neural cultures to study neuronal responses to bacterial presence through morphological, functional, and transcriptomic analyses. …”
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Biogeography and ecological functions of underestimated CPR and DPANN in acid mine drainage sediments by Sheng-Xuan Peng, Shao-Ming Gao, Zhi-Liang Lin, Zhen-Hao Luo, Si-Yu Zhang, Wen-Sheng Shu, Fangang Meng, Li-Nan Huang

“…Our comprehensive analyses have allowed first insights into the biogeographic patterns and functional differentiation of these major enigmatic prokaryotic groups in the AMD model system.…”
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Bacterial interactions underpin worsening lung function in cystic fibrosis-associated infections by Damian W. Rivett, Lauren R. Hatfield, Helen Gavillet, Michelle Hardman, Christopher van der Gast

“…The literature, however, has traditionally focused on the presence of pathogens in isolation or univariate measures like number of species to predict decline of lung function and ignores large swathes of data. Here, we suggest that looking at the interactions between species identified by 16S rRNA gene sequencing, rather than at species singularly, could elucidate hitherto unknown properties of these complicated infections. …”
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A novel indicator for predicting functional recovery in elderly hip fracture patients by Weicheng Wu, Zhening Guo, Peiyao Zhu, Bo Lv, Yongtao Mao, Chang She, Wei Xu, Jun Gu, Jie Pan, Liubing Li, Liubing Li

“…BackgroundThe inflammatory response following hip fracture significantly influences postoperative functional recovery in patients. However, to date, no inflammatory index has been identified as a reliable and accurate predictor of functional recovery, especially in elderly patients with hip fractures. …”
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Association of genetic risk of Alzheimer’s disease and cognitive function in two European populations by Biqi Wang, Lori B. Chibnik, Seung Hoan Choi, Deborah Blacker, Anita L. DeStefano, Honghuang Lin

“…Abstract Although there is some evidence of an association between Alzheimer’s disease polygenic risk score (AD PRS) and cognitive function, limited validations have been performed in large populations. …”
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Quantifying the spatial impact of an invasive Acacia on ecosystem functioning using remote sensing by André Große-Stoltenberg, Christiane Werner, Christine Hellmann, Jens Oldeland, Jan Thiele

“…For seven sites, we employed Generalized Linear Mixed Models to model the effects of environmental variables and Acacia-related variables on proxies of ecosystem functions. …”
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Quinoa malt and blueberry functional beverage: effect of malting and consumer sensory evaluation by Eliana Gabriela Contreras, Tatiana Rojas-Ayerve, Elizabeth Fuentes-Campos, Erika Lizet Chaiña Mamani, Alessandra Arosena-Chao, Ana María Muñoz Jauregui

“… Background: Consumers are looking for functional, natural products, valuing minimally processed, additive-free foods that include ancestral crops such as quinoa for their sustainability, nutritional quality and cultural connection.  …”
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Training/detraining-induced gender specific functional adaptations of isolated rat heart by Dragojlović-Ružičić Radica, Radovanović Dragan, Milanović Zvezdan, Petković Anica, Jeremić Jovana, Nikolić-Тurnić Tamara, Milosavljević Isidora, Srejović Ivan, Živković Vladimir, Krivokuća Živko, Jakovljević Vladimir, Đorđević Dušica

“…Conclusion. By using a model of the isolated rat heart, the present study confirmed the existence of training-induced changes in cardiac function. …”
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Optimization of Convolutional Neural Networks With Multi-Objective Function Metaheuristics for Melanoma Detection by Pamela Hermosilla, Ricardo Soto, Eric Monfroy, Emanuel Vega, Lucas Erazo, Valentina Guzman

“…Based on these findings, we propose a novel weighted multi-objective function (MOF) that balances key performance metrics according to clinical needs, with particular emphasis on Accuracy for overall correctness, Recall for reducing false negatives, and AUC for enhancing class discrimination in melanoma detection, thus ensuring both general reliability and high sensitivity in detecting melanoma. …”
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Function and mechanism of cancer-testis antigen CT63 in chronic myeloid leukemia by KONG Ruxin, ZHOU Yaqun, WEI Tingyi, LEI Ming

“…In the subcutaneous xenotransplantation model, down-regulation of CT63 inhibited tumor growth in nude mice. …”
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Effects of acupuncture versus moxibustion on functional dyspepsia: a randomized clinical trial by Yangke Mao, Pan Zhang, Zhaoxuan He, Yuke Teng, Zilei Tian, Sha Yang, Kuan Fang, Wei Zhang, Yuting Wang, Tao Yin, Fang Zeng

“…Abstract Background Functional dyspepsia (FD) is a prevalent gastrointestinal disorder, despite its high prevalence and impact on quality of life, effective treatments are limited. …”
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p-phenoxyphenol impaired male fertility by disrupting the testicular function and local microenvironment by Xiaojuan Han, Danni Jiang, Qianni Li, Pengfei Li, Lan Chao, Yang Yang

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Functional Properties and Safety Considerations of Zinc Oxide Nanoparticles Under Varying Conditions by Ana Rita Mendes, Carlos M. Granadeiro, Andreia Leite, Otmar Geiss, Ivana Bianchi, Jessica Ponti, Dora Mehn, Eulália Pereira, Paula Teixeira, Fátima Poças

“…Zinc oxide nanoparticles (ZnO NPs) exhibit diverse morphologies and sizes, influencing their functional properties. However, the relationship between their morphology and behavior under varying conditions remains poorly understood. …”
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Formalizing Latin American Perspectivism: A Neutrosophic MultiPerspectivism Model by Maikel Y. Leyva Vázquez, Florentin Smarandache

“…This paper addresses the challenge of formally modeling the complex, often contradictory, knowledge systems inherent in Latin American decolonial thought. …”
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