Enhancer RNA transcription pinpoints functional genetic variants linked to asthma by Sarah K. Sasse, Amber Dahlin, Lynn Sanford, Margaret A. Gruca, Arnav Gupta, Fabienne Gally, Ann Chen Wu, Carlos Iribarren, Robin D. Dowell, Scott T. Weiss, Anthony N. Gerber

“…Our findings establish eRNA signatures as a tool for discovery of functional genetic variants and define a novel association between air pollution, glucocorticoid signaling and asthma.…”
Get full text

Double-spiral as a bio-inspired functional element in engineering design by Mohsen Jafarpour, Mohammad Aryayi, Stanislav N. Gorb, Hamed Rajabi

“…Abstract Spiral, one of the most well-known functional patterns in nature that can be observed in structures such as the proboscis of lepidoptera and snail shells or as vortices forming in flowing fluids, has long served as a source of inspiration for humans in the creation of numerous spiral-based designs. …”
Get full text

Multi-Function Evaluation and Internal Land Use Optimization of Rural Settlements by Nan Wang, Lei Zhang, Jinmin Hao, Jinyi Zhang

“…Rural settlement is the main vehicle for the existence and development of the countryside. The functions of rural settlements vary across different regions, influencing land use patterns. …”
Get full text

Internal audit functions and sustainability audits: Insights from manufacturing firms by Gilbert K. Amoako, Jonas Bawuah, Emmanuel Asafo-Adjei, Catherine Ayimbire

“…We examined the nexus between four internal audit functions (IAF) and sustainability audits (SA) of manufacturing firms. …”
Get full text

ACTIVITY OF HOST DEFENSE FUNCTIONS IN STRESS CONDITIONS AND THEIR CORRECTION BY THE DERINAT DRUG by E. G. Rybakina, S. N. Shanin, E. E. Fomicheva, I. A. Kozinec, E. A. Korneva

“…Moreover, a corrective effect of Derinat drug upon the mentioned indices of host defense functions was evaluated. The changes in functional activity of immunocompetent cells were found to be dependent on intensity of stress application, whereas alterations in blood hormone level did not depend on these conditions, i.e., application of both stress models revealed increased corticosterone concentrations and reduced testosterone levels in rat blood. …”
Get full text

Trajectories of human brain functional connectome maturation across the birth transition. by Lanxin Ji, Iris Menu, Amyn Majbri, Tanya Bhatia, Christopher J Trentacosta, Moriah E Thomason

“…Yet, we presently lack rigorous examination of the longitudinal emergence of human brain functional networks over the birth transition. Leveraging a large, longitudinal perinatal functional magnetic resonance imaging (fMRI) data set, this study models developmental trajectories of brain functional networks spanning 25 to 55 weeks of post-conceptual gestational age (GA). …”
Get full text

SplitAx: A novel method to assess the function of engineered nucleases. by Richard A Axton, Sharmin S Haideri, Martha Lopez-Yrigoyen, Helen A Taylor, Lesley M Forrester

“…We demonstrate successful use of the SplitAx assay to assess the function of zinc finger nucleases, CRISPR hCAS9 and TALENS. …”
Get full text

Beneficial Effects of Resveratrol on Testicular Functions: Focus on Its Antioxidant Properties by Adele Chimento, Arianna De Luca, Massimo Venditti, Francesca De Amicis, Vincenzo Pezzi

“…Interestingly, resveratrol (RSV), a natural polyphenol with proven health-promoting actions, has been found to be an effective free radical scavenger in several in vitro and in vivo models, providing protection against OS. In this review, we discussed mechanisms related to the modulation of redox homeostasis in the testis and how the alteration of these processes can determine a damage in testicular function; particularly, we focused on the antioxidant properties of RSV that could give beneficial effects in preserving male fertility.…”
Get full text

Extracellular Matrix Signaling Cues: Biological Functions, Diseases, and Therapeutic Targets by Tian Zhao, Ye Huang, Jingfei Zhu, Yujie Qin, Hao Wu, Jiaxuan Yu, Qianwen Zhai, Shun Li, Xiang Qin, Dengfeng Wang, Tingting Li, Yiyao Liu

Get full text

Vitamin D and Male Sexual Function: A Transversal and Longitudinal Study by Giacomo Tirabassi, Maurizio Sudano, Gianmaria Salvio, Melissa Cutini, Giovanna Muscogiuri, Giovanni Corona, Giancarlo Balercia

“…In the whole sample, after performing logistic regression models, higher levels of 25(OH) vitamin D were significantly associated with high values of total testosterone and of all the International Index of Erectile Function (IIEF) questionnaire parameters. …”
Get full text

Contralesional hippocampal spreading depolarization promotes functional recovery after stroke by Andrew K. J. Boyce, Yannick Fouad, Renaud C. Gom, Donovan M. Ashby, Cristina Martins-Silva, Leonardo Molina, Tamas Füzesi, Carina Ens, Wilten Nicola, Alexander McGirr, G. Campbell Teskey, Roger J. Thompson

Get full text

The effects of an individual music intervention on executive functions in adults with intellectual disabilities by Gerianne J.J. Smeets, Maaike M. Van Rest, Karin M. Volkers, Xavier M.H. Moonen, Erik J.A. Scherder

“…Background: People with intellectual disabilities (ID) often demonstrate impairments in executive functioning (EF). In other clinical populations, music interventions have demonstrated positive effects on EF. …”
Get full text

Stability and functional consequences of disulfide bond engineering in Aspergillus flavus uricase by Mohammad Reza Rahbar, Navid Nezafat, Mohammad Hossein Morowvat, Amir Savardashtaki, Mohammad Bagher Ghoshoon, Mohammad Soroosh Hajizade, Younes Ghasemi

“…Abstract Disulfide bond engineering is a promising strategy for enhancing the stability and functional lifespan of enzymes in therapeutic and industrial applications. …”
Get full text

Sex differences in the association between lipids and cognitive function in older adults by Jiahao Chen, Yinming Wang, Wenyan Guo, Muyuan Jiang, Zixuan Gai, Huinan Zhang, Mulei Chen, Yifan Fan

“…Background: It is well known that cognitive function is associated with gender differences. However, the effect of sex differences on the relationship between lipids fractions and cognitive function in older adults has been contentious. …”
Get full text

Transcriptomic and functional analysis of triphenyl phosphate exposure in prostate cancer progression by Li Cai, Guizhi Du

“…Functional assays were carried out to assess TPP-induced phenotypic changes. …”
Get full text

Formation of the Guillotine Cutting Card of a Sheet by the Guillotine Layout Functions by A.A. Andrianova, T.M. Mukhtarova, V.R. Fazylov

“…An extension of the concept of the guillotine layout function has been suggested in the paper for solving the problem of rectangular orthogonal packing, which is a function that assigns a triple of values to the width of the sheet. …”
Get full text

Prognosis of Functional Results of Arising or Immature Cataract Phacoemulsification High Myopia by A. A. Pilyagina, O. A. Fabrikantov, S. V. Shutova

“…The true prognosis of visual functions in these patients will allow solving the problem of cataract phacoemulsification expediency, decreasing the risks of complications.Purpose. …”
Get full text

CXCR1/2 antagonism inhibits neutrophil function and not recruitment in cancer by Jeff W. Kwak, Helena Q. Nguyen, Alex Camai, Grace M. Huffman, Surapat Mekvanich, Naia N. Kenney, Xiaodong Zhu, Timothy W. Randolph, A. McGarry Houghton

“…Instead, CXCR1/2 inhibition alters neutrophil function by blocking the polarization of transcriptional programs toward immune suppressive phenotypes and rendering neutrophils incapable of suppressing lymphocyte proliferation. …”
Get full text

Functional tradeoffs underpin salinity-driven divergence in microbial community composition. by Chris L Dupont, John Larsson, Shibu Yooseph, Karolina Ininbergs, Johannes Goll, Johannes Asplund-Samuelsson, John P McCrow, Narin Celepli, Lisa Zeigler Allen, Martin Ekman, Andrew J Lucas, Åke Hagström, Mathangi Thiagarajan, Björn Brindefalk, Alexander R Richter, Anders F Andersson, Aaron Tenney, Daniel Lundin, Andrey Tovchigrechko, Johan A A Nylander, Daniel Brami, Jonathan H Badger, Andrew E Allen, Douglas B Rusch, Jeff Hoffman, Erling Norrby, Robert Friedman, Jarone Pinhassi, J Craig Venter, Birgitta Bergman

“…Bacterial community composition and functional potential change subtly across gradients in the surface ocean. …”
Get full text

The impact of structured motor learning intervention on preschool children’s executive functions by Yanli Hao, Lingsong Kong, Xiaozan Wang, Xin Yu

“…Pre- and post-intervention executive functions were assessed using the EF-TOUCH. Multiple linear regression models were used to evaluate the effect of the intervention on executive functions. …”
Get full text