Functional and structural analysis of missense variants in the human PDCD1 Gene by Hanâ Baba, Meryem Bouqdayr, Anass Abbad, Asmae Saih, Benson R. Kidenya, Mohamed A. Sesay, Simpson Addo, Lahcen Wakrim, Anass Kettani

“…Background: Programmed death-1 (PD-1) is an immune checkpoint receptor that regulates T-cell function by modulating and terminating immune responses. …”
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T-bet overexpression enhances CAR T cell effector functions and antigen sensitivity by M. Eric Kohler, Kole R DeGolier, Terry J Fry, Amalia M Rivera-Reyes, Jennifer M Cimons, Samuel D Burciaga, Michael C Yarnell, Amanda J Novak

“…T-bet overexpression enhanced some effector functions in vitro but did not improve CAR T cell-mediated control of leukemia expressing high levels of antigen in vivo. …”
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Phylogenetic and functional diversity among Drosophila-associated metagenome-assembled genomes by Aaron A. Comeault, Alberto H. Orta, David B. Fidler, Tobias Nunn, Amy R. Ellison, Tayte A. Anspach, Daniel R. Matute

“…Our results provide evidence that wild drosophilid flies harbor phylogenetically and functionally diverse microbial communities. These findings highlight a need to quantify the abundance and function of insect-associated bacteria from the genera Gilliamella, Orbus, Entomomonas, and others on the performance of their insect hosts across diverse environments.IMPORTANCEWhile much attention has been given to catalogue the taxonomic diversity intrinsic to host-associated microbiomes, much less is known about the functional consequences of this variation, especially in wild, non-model host species. …”
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Development of Functional Antibodies Directed to Human Dialyzable Leukocyte Extract (Transferon®) by Gabriela Mellado-Sánchez, Juan José Lázaro-Rodríguez, Sandra Avila, Luis Vallejo-Castillo, Said Vázquez-Leyva, Gregorio Carballo-Uicab, Marco Velasco-Velázquez, Emilio Medina-Rivero, Lenin Pavón, Rommel Chacón-Salinas, Sonia Mayra Pérez-Tapia

“…In conclusion, it is feasible to elicit specific and functional antibodies anti-hDLE with different potential uses during the life cycle of the product.…”
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Association of plasma metabolites and cardiac mitochondrial function with heart failure progression by Vandana Revathi Venkateswaran, Ruicong She, Stephen J. Gardell, Jasmine A. Luzum, Ramesh Gupta, Kefei Zhang, L. Keoki Williams, Hani N. Sabbah, David E. Lanfear

“…We investigated these mechanisms in a canine chronic HFrEF model. We tested associations between changes in plasma metabolites, left ventricular (LV) end‐diastolic volume and cardiomyocyte mitochondrial function. …”
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Atrophy related neuroimaging biomarkers for neurological and cognitive function in Wilson disease by Ann Carolin Hausmann, Christian Rubbert, Silja K. Querbach, Vivien Lorena Ivan, Alfons Schnitzler, Christian Johannes Hartmann, Julian Caspers

“…Results Patients with neuro-WD demonstrated increased third ventricle width and bicaudate index, along with significant striatal-thalamic atrophy patterns that correlated with global cognitive function, mental processing speed, and verbal memory. …”
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SH3 interactome conserves general function over specific form by Xiaofeng Xin, David Gfeller, Jackie Cheng, Raffi Tonikian, Lin Sun, Ailan Guo, Lianet Lopez, Alevtina Pavlenco, Adenrele Akintobi, Yingnan Zhang, Jean‐François Rual, Bridget Currell, Somasekar Seshagiri, Tong Hao, Xinping Yang, Yun A Shen, Kourosh Salehi‐Ashtiani, Jingjing Li, Aaron T Cheng, Dryden Bouamalay, Adrien Lugari, David E Hill, Mark L Grimes, David G Drubin, Barth D Grant, Marc Vidal, Charles Boone, Sachdev S Sidhu, Gary D Bader

“…Our results suggest a model of network evolution where general function of the SH3 domain network is conserved over its specific form.…”
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The Prognostic Value of Left Atrial Function in Patients with Acute Myocardial Infarction by Jorun Tangen, Thuy Mi Nguyen, Daniela Melichova, Lars Gunnar Klaeboe, Marianne Forsa, Kristoffer Andresen, Adrien Al Wazzan, Oyvind Lie, Kristina Haugaa, Helge Skulstad, Harald Brunvand, Thor Edvardsen

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Prognostic value of right atrial function in patients with significant tricuspid regurgitation by Takahiro Nishihara, Yoichi Takaya, Rie Nakayama, Yu Yoshida, Norihisa Toh, Toru Miyoshi, Kazufumi Nakamura, Shinsuke Yuasa

“…Abstract Aims Although right ventricular (RV) dysfunction is associated with adverse outcomes in tricuspid regurgitation (TR), the potential role of right atrial (RA) function is unknown. We aimed to investigate the relationship between RA function and clinical outcomes in patients with significant TR. …”
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Risk prediction of kidney function in long-term kidney transplant recipients by Krzysztof Batko, Krzysztof Batko, Anna Sączek, Małgorzata Banaszkiewicz, Jolanta Małyszko, Ewa Koc-Żórawska, Marcin Żórawski, Marcin Żórawski, Karolina Niezabitowska, Katarzyna Siek, Alina Bętkowska-Prokop, Andrzej Kraśniak, Marcin Krzanowski, Katarzyna Krzanowska

“…BackgroundLimited tools exist for predicting kidney function in long-term kidney transplant recipients (KTRs). …”
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Dual inflammation in schizophrenia infected with COVID-19: Impact on cognitive function by Qi Zhou, Jiayi Li, Jiahui Zhu, Mingqia Wang, Zhuokai Zhang, Jiamin Shao, Peng Wang, Xuan Dong, Gangming Cheng, Yuan Liu, Chuan Shi

“…General linear model was used to compare the immune-inflammatory markers, and correlation analysis was used to explore the relationship of inflammatory levels and cognitive function. …”
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Research Progress and Prospect of Green Infrastructure with Public Health Promotion Function by Tongyu LI, Junyi LIXU, Binxia XUE, Yan (USA) SONG

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The association of dementia risk symptoms and functional activity in adults with Down syndrome by Selena E. Washington, Amy E. Bodde, Brian C. Helsel, Rebecca M. Bollinger, Nora Smith, Lauren T. Ptomey, Beau Ances, Susan L. Stark

“…Abstract INTRODUCTION Adults with Down syndrome (DS) have an increased risk of Alzheimer's disease (AD) dementia, often showing neuropathological indicators by age 40. Physical function and activities of daily living (ADLs) are understudied areas of function that may inform dementia risk. …”
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LISTENING IN L2 ROMANIAN: WHY FUNCTION WORDS GO UNNOTICED by Ioana-Silvia SONEA

“…By integrating insights from John Field’s research on input processing and Baddeley’s working memory model, we explore how L2 learners prioritize content words over function words in real-time listening. …”
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Shank3 mutation manifests in abnormal gastrointestinal morphology and function in mice by Gari L. Eberly, Gari L. Eberly, Marie Manthey, Marie Manthey, Marie Manthey, Karen K. L. Pang, Karen K. L. Pang, Karen K. L. Pang, Heba Hussein, Emmanuel Vargas Paniagua, Emmanuel Vargas Paniagua, Scott Machen, Scott Machen, Sara Maeve Klingensmith, Polina Anikeeva, Polina Anikeeva, Polina Anikeeva, Polina Anikeeva, Polina Anikeeva

“…This study aimed to characterize gastrointestinal morphology and function in Shank3B mutant mice, a common genetic model of ASD, to identify potential alterations to the GI tract that could underlie ASD-associated GI comorbidities.MethodsGI and enteric nervous system morphology was characterized using Hematoxylin and Eosin staining and immunohistochemistry. …”
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The Second Wave of the COVID-19 Pandemic in Poland - Characterised Using FDA Methods by Patrycja Hęćka

“…For this purpose, firstly the author convert data of sixteen voivodeships to smooth functions, and then used the principal component analysis and multiple function-on-function linear regression model to predict the number of hospitalised and intensive care patients due to the COVID-19 infection during the second wave of the pandemic. …”
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Brain Function Characteristics of Children with Attention-Deficit/Hyperactivity Disorder Aged 4-9 Years During a GO/NOGO Task: An Functional Near-Infrared Spectroscopy Study by Cui Z, Liang A, Huang H, Ni X

“…Limitations include the cross-sectional design and relatively small sample size, which should be addressed in future longitudinal studies.Keywords: attention deficit hyperactivity disorder, fNIRS, execution function, brain network…”
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Prefrontal cortex activity during binocular color fusion and rivalry: an fNIRS study by Xiang Liu, Xiang Liu, Xiang Liu, Xuesong Jin, Xuesong Jin, Lijun Yun, Lijun Yun, Zaiqing Chen, Zaiqing Chen, Zaiqing Chen, Zaiqing Chen

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A New Class of Bivariate Distributions: Properties, Estimation, and Modeling by Jumanah Ahmed Darwish, Saman Hanif Shahbaz, Muhammad Qaiser Shahbaz

“…The new bivariate power function distribution is used to model some real data.…”
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Application of Genetic Algorithm to Estimation of Function Parameters in Lightning Currents Approximations by V. Javor, K. Lundengård, M. Rančić, S. Silvestrov

“…Genetic algorithm (GA) is applied for the estimation of two-peaked analytically extended function (2P-AEF) parameters in this paper. 2P-AEF is used for approximation of measured and typical lightning discharge currents. …”
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