Effects of Methotrexate on Plasma Cytokines and Cardiac Remodeling and Function in Postmyocarditis Rats by Zhengang Zhang, Pei Zhao, Aihua Li, Xiaolei Lv, Yang Gao, Hongguang Sun, Yongling Ding, Jian Liu

“…In this study, we used a rat model of cardiac myosin-induced experimental autoimmune myocarditis to investigate the effects of low-dose methotrexate (0.1 mg/kg/d for 30 d) on the plasma level of cytokines and cardiac remodeling and function. …”
Get full text

Functional multispectral optoacoustic tomography imaging of hepatic steatosis development in mice by Shan Huang, Andreas Blutke, Annette Feuchtinger, Uwe Klemm, Robby Zachariah Tom, Susanna M Hofmann, Andre C Stiel, Vasilis Ntziachristos

“…Lipid visualization in particular can play a critical role in understanding functional relations in lipid metabolism. We investigated the potential of multispectral optoacoustic tomography (MSOT) as a novel modality to non‐invasively visualize lipids in laboratory mice around the 930nm spectral range. …”
Get full text

Functional insights from recombinant production of bacterial proteases in Saccharomyces cerevisiae by Tova Lindh, Mattias Collin, Rolf Lood, Magnus Carlquist

Get full text

The Structural and Functional Responses of Rhizosphere Bacteria to Biodegradable Microplastics in the Presence of Biofertilizers by Xueyu Cheng, Xinyang Li, Zhonghua Cai, Zongkang Wang, Jin Zhou

“…After partial least squares path model (PLS-PM) analysis, we observed that both materials influenced the rhizosphere environment through the bacterial communities and functions. …”
Get full text

Investigating the function of religion and social capital in shaping sustainable social development by Ayesha Akter Sumi, Jaffary Bin Awang, Rasheedul Haque, Sayeeduzzafar Qazi, Nur Farhana Abdul Rahman, Abdul Rahman Bin S. Senathirajah

“…It also investigates whether the function of religion moderates these relationships. …”
Get full text

An approach to measuring language-specific brain function in developmental language disorder by Caroline Larson, Jason C. Crutcher, Hannah R. Thomas, Michael C. Stevens

“…Purpose: Evidence characterizing brain function in developmental language disorder (DLD) is limited because measured brain function may reflect individual variability in task performance and error processing. …”
Get full text

Cross-subject affective analysis based on dynamic brain functional networks by Lifeng You, Tianyu Zhong, Erheng He, Xuejie Liu, Qinghua Zhong

“…However, due to inter-subject variability and non-smoothness of EEG signals, the generalization performance of models across subjects remains a challenge.MethodsIn this study, we proposed a novel approach that combines time-frequency analysis and brain functional networks to construct dynamic brain functional networks using sliding time windows. …”
Get full text

Hexokinase2-engineered T cells display increased anti-tumor function by Raphaëlle Toledano Zur, Shiran Didi Zurinam, Maria Radman, Elia Funaro Balouka, Tatiana Borodianskiy-Shteinberg, Dieter Saur, Cyrille J. Cohen

“…In vivo studies using a human tumor xenograft model demonstrated the superior therapeutic efficacy of HK2-engineered T cells, including delayed tumor growth and improved survival.ConclusionHK2 overexpression improves T-cell metabolic fitness and functionality in hostile TMEs, offering a promising foundation for the development of next-generation immunotherapies targeting T-cell metabolism.…”
Get full text

The Adverse Effects of Thyrotropin Absence on Pancreatic β Cell Function in Mice by Yu Yang, Yu Chen, Jie Chen, Danyu Zhang, Jianhua Wang, Xiaodong Mao, Xiao Wei, Xingjia Li, Xianghua Ma, Chao Liu, Kun Wang

“…We used thyrotropin receptor (TSHR) knockout mice (Tshr-/-) as a model of TSH deletion to study its function in pancreatic β cells. …”
Get full text

Taxonomic and functional nestedness of bird communities in urban parks of Liuzhou, China by Binqiang Li, Nehafta Bibi, Shanjun Ma, Wenxuan Chen, Miaodan Yang, Na Xiang, Qingjiang Cui, Lifeng Tan

“…However, the nested pattern strongly depended on the choice of the null model. In contrast, as the park area gradually decreases, we observed significant functional nestedness, implying that the trait loss in parks with decreasing area follows an ordered pattern, where smaller parks represent nested subsets of functional traits found in larger parks. …”
Get full text

Chidamide functions as a VISTA/PSGL-1 blocker for cancer immunotherapy by Xiaoshuang Niu, Wenshan Zhao, Xiuman Zhou, Feiyu Luo, Youmei Xiao, Tao Luo, Xinghua Sui, Wanqiong Li, Qingyu Dong, Xin Yang, Zhuoying He, Wenzhi Shang, Yixuan Sun, Yanfeng Gao

“…Here, by screening a library of marketed drugs, we identified Chidamide had a strong binding affinity toward VISTA (K D  = 5 nM) and blocked VISTA/PSGL-1 under acidic conditions, thereby significantly enhancing the function of CD8+ T cells and inhibiting the tumor growth in immunocompetent murine CT26 tumor model. …”
Get full text

Neural stem cells traffic functional mitochondria via extracellular vesicles. by Luca Peruzzotti-Jametti, Joshua D Bernstock, Cory M Willis, Giulia Manferrari, Rebecca Rogall, Erika Fernandez-Vizarra, James C Williamson, Alice Braga, Aletta van den Bosch, Tommaso Leonardi, Grzegorz Krzak, Ágnes Kittel, Cristiane Benincá, Nunzio Vicario, Sisareuth Tan, Carlos Bastos, Iacopo Bicci, Nunzio Iraci, Jayden A Smith, Ben Peacock, Karin H Muller, Paul J Lehner, Edit Iren Buzas, Nuno Faria, Massimo Zeviani, Christian Frezza, Alain Brisson, Nicholas J Matheson, Carlo Viscomi, Stefano Pluchino

“…Herein, we investigated the hypothesis that NSCs release and traffic functional mitochondria via EVs to restore mitochondrial function in target cells. …”
Get full text

A composite measurement concept for monitoring cardiac function in Fabry disease by Pooja Nandi, Robert Ellis, Jennifer Hiros, Paul Howard, Biliana O. Veleva-Rotse

“…The composite measurement concept was developed to capture the signs and symptoms most important to people living with FD, alongside heart-rate variability, electrocardiograms, blood pressure, and quality of life as relevant measures within the cardiac domain that can be staged in a progression model with clear group boundaries. Conclusions Based on work completed to date, developing a composite measurement concept that utilizes digital tools to improve the measurement of cardiac function in FD is conceptually possible and aligns with the evidentiary framework for designing and building a monitoring biomarker. …”
Get full text

The Redshift Evolution of the Luminosity Function of Type II Gamma-Ray Bursts by Yan-Kun Qu, Zhong-Xiao Man, Yu-Peng Yang, Shuang-Xi Yi, Mei Du, Fa-yin Wang

“…We find that the no-evolution model can be excluded, while both the luminosity and density evolution models effectively account for the observations. …”
Get full text

The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods by Zhiwei Zhou, Dan Wang, Wei Liu, Lang He, Pengkuan Liang, Junli Hao, Qun Sun

“…This study was to explore the immunity-promoting activity of porcine placenta as a potential raw material for functional foods. Porcine placenta was subjected to the analysis for its bioactive substances, and their immunity-promoting activity was determined in mice supplemented with porcine placenta extract (PPE) and freeze-dried porcine placenta powder at high (PPH) and low (PPL) dosage. …”
Get full text

A Three-Parameter S-Shaped Function of Flood Return Period and Damage by Chaochao Li, Xiaotao Cheng, Na Li, Zhongmin Liang, Yanyan Wang, Song Han

“…The simulation results were used to construct the flood R-D functions. The study results show that the flood R-D model based on the Gompertz function agrees well with the mutability of flood damage in the highly urbanized basin when the flood scale exceeds the defense capability. …”
Get full text

Association of Statin Therapy with Functional Outcomes and Survival in Intracerebral and Subarachnoid Hemorrhage by Bahadar S. Srichawla, Daksha Gopal, Majaz Moonis

“…We aimed to evaluate the impact of statin therapy on the functional outcomes and survival in patients with ICH and SAH. …”
Get full text

A Linguistic Features-Based Approach for the Functional Analysis of Disinformation in Spanish by Eduardo Puraivan, Fabian Riquelme, Rene Venegas

Get full text

Internet Addiction and Its Relationship with Family Functioning in High School Students by Zahra Harsej, Nasrin Mokhtari Lakeh, Farzaneh Sheikholeslami, Ehsan KazemnezhadLeili

“…There was a significant statistical relationship between Internet addiction and family income (P= 0.003), fatherchr('39')s job (P=0.001), and duartion of internet usage per day (P=0.001). Logistic regression model showed that the family functioning score (OR=1.02, 95% CI;1.01-1.04, P=0.001), duration of Internet usage per day (OR=1.02, 95% CI;1.11-1.20, P=0.0001), and gender (male) (OR=1.02, 95% CI;1.26-2.58, P=0.001) significantly affected Internet addiction. …”
Get full text

Design of internal model controller based on robustness/performance tradeoff tuning for robot arm by Li-ye Liu

Subjects: Get full text