The small molecule ML233 is a direct inhibitor of tyrosinase function by Romain Menard, Aissette Baanannou, Caroline Halluin, Dexter Morse, Sadie Kuhn, Joel H. Graber, James Strickland, Romain Madelaine

“…Tyrosinase is the rate-limiting enzyme controlling melanogenesis, and hence tremendous efforts have been made to identify potent and safe inhibitors of tyrosinase function. However, despite decades of research, currently there is no effective treatment that inhibits melanogenesis or tyrosinase activity with no adverse side effects. …”
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An Assessment of Spatial Organization, Architectural Materials, and Structural Functions at Kurul Fortress by Atakan Akçay, Ahmet Emirhan Bulut

“…Despite fortress as a term specifically bringing to mind military functions at first, this settlement was also a cultic place where various gods had been worshipped starting in earlier periods. …”
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Relationship between ear appearance and psychological function among congenital unilateral microtia after autologous cartilage ear reconstruction: a chain mediation model by Xinyu Li, Chenlong Li, Tianyu Zhang, Jing Xu, Yaoyao Fu

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Multi-omics analysis and experiments uncover the function of cancer stemness in ovarian cancer and establish a machine learning-based model for predicting immunotherapy responses by Zhibing Liu, Zhibing Liu, Lei Han, Xiaoyu Ji, Xiaole Wang, Jinbo Jian, Yujie Zhai, Yingjiang Xu, Feng Wang, Xiuwen Wang, Fangling Ning

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Peer Review of “Advancing Early Detection of Major Depressive Disorder Using Multisite Functional Magnetic Resonance Imaging Data: Comparative Analysis of AI Models” by Anonymous

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WCN24-2224 ASSOCIATION OF STEM CELLS AND RENAL ARTERY REVASCULARIZATION PREVENTS LONG TERM DETERIORATION OF RENAL FUNCTION IN RENOVASCULAR HYPERTENSION MODEL IN RATS by Nikolas Waack, Tatiana Guirao, Edgar Maquigussa, Erika Nishi, Milene Ormanji, Olinda Ykuta, Vitória Gusmão, Mirian Boim

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Influence of a laser pulse on thermoelasticity with temperature dependence under the dual-phase-lag model using improved modified extended tanh function method by Wafaa B. Rabie, Hamdy M. Ahmed, Abdallah A. Syied, Assmaa Abd-Elmonem, Nagat A.A. Suoliman, Mohamed F. Ismail

Subjects: “…Dual-phase-lag model (DPL)…”
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Lacticaseibacillus casei IDCC 3451 alleviates cognitive and behavioral functions by reshaping the gut microbiome and regulating intestinal barrier integrity in chronic stress animal models by Anna Kang, Ju Young Eor, Junbeom Lee, Min-Jin Kwak, Daniel Junpyo Lee, Eunsol Seo, Woong Ji Lee, Seon-hui Son, Minho Song, Jun-Mo Kim, Hyung Wook Kim, Jungwoo Yang, Sangnam Oh, Younghoon Kim

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Corrigendum: Pharmacological potential of Withania somnifera (L.) Dunal and Tinospora cordifolia (Willd.) Miers on the experimental models of COVID-19, T cell differentiation, and neutrophil functions by Zaigham Abbas Rizvi, Zaigham Abbas Rizvi, Prabhakar Babele, Upasna Madan, Upasna Madan, Srikanth Sadhu, Srikanth Sadhu, Manas Ranjan Tripathy, Manas Ranjan Tripathy, Sandeep Goswami, Sandeep Goswami, Shailendra Mani, Madhu Dikshit, Madhu Dikshit, Amit Awasthi, Amit Awasthi

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Regulation of Intestinal Barrier Function and Gut Microbiota by Hot Melt Extrusion-Drug Delivery System-Prepared Mulberry Anthocyanin in an Inflammatory Bowel Disease Model by Eun-Ji Go, Byeong Ryeol Ryu, Gyeong Ju Gim, Ye Rim Shin, Min Ji Kang, Min Jun Kim, Jong-Suep Baek, Jung Dae Lim

“…<b>Results:</b> HME-MUL-F2 significantly improved gut barrier function by upregulating tight junction proteins and reducing inflammatory cytokine levels in the colitis model. …”
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Interleukin‐6 receptor alpha and CD27 discriminate intratumoral T helper 17 subpopulations with distinct functional properties in a mouse lung cancer model by Chong Liu, Fei Xiong, Lingying Wang, Kang Chen, Pingshang Wu, Li Hua, Zhuo Zhang

“…Flow cytometry was used to analyze the phenotypes, signaling status, and functions of Th17 subpopulations either in vivo or in vitro. …”
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Melt analysis of mismatch amplification mutation assays (Melt-MAMA): a functional study of a cost-effective SNP genotyping assay in bacterial models. by Dawn N Birdsell, Talima Pearson, Erin P Price, Heidie M Hornstra, Roxanne D Nera, Nathan Stone, Jeffrey Gruendike, Emily L Kaufman, Amanda H Pettus, Audriana N Hurbon, Jordan L Buchhagen, N Jane Harms, Gvantsa Chanturia, Miklos Gyuranecz, David M Wagner, Paul S Keim

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A four gene risk score model for prognosis and immune microenvironment insights in small cell lung cancer based on CAF functional-related genes by Yunfei Chen, Yunfeng Tong, Xinyuan Ye, Yehao Yang, Hui Li, Haicheng Wu, Wanchen Zhai, Yuwei Li, Qian Zhang, Linjing Zhou, Jing Sun, Yun Fan

“…In this study, we introduce an innovative risk scoring model rooted in cancer-associated fibroblast (CAF)-related functional genes, designed to predict patient prognosis and illuminate the microenvironment of SCLC. …”
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Retraction Note: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD by Michiyo Iba, Ross A. McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Masliah

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A multi-domain collaborative denoising bearing fault diagnosis model based on dynamic inter-domain attention mechanism and noise-aware loss function. by Weilin Cao, Liqiang Zhang

“…To address this problem, this paper proposes a multi-domain collaborative denoising diagnostic model based on dynamic inter-domain attention mechanism and noise-aware loss function. …”
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A human forebrain organoid model reveals the essential function of GTF2IRD1-TTR-ERK axis for the neurodevelopmental deficits of Williams syndrome by Xingsen Zhao, Qihang Sun, Yikai Shou, Weijun Chen, Mengxuan Wang, Wenzheng Qu, Xiaoli Huang, Ying Li, Chao Wang, Yan Gu, Chai Ji, Qiang Shu, Xuekun Li

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Noninvasive grading of renal interstitial fibrosis and prediction of annual renal function loss in chronic kidney disease: the optimal solution of seven MR diffusion models by Guanjie Yuan, Zhouyan Liao, Ping Liang, Lingli Cai, Kailun Zhou, Ting Yin, Wei Chen, Omar Darwish, Chuou Xu, Min Han, Zhen Li

“…Objectives To explore the optimal choice of seven diffusion models (DWI, IVIM, DKI, CTRW, FROC, SEM, and sADC) to assess renal interstitial fibrosis (IF) and annual renal function loss in chronic kidney disease (CKD).Methods One hundred thirty-three CKD patients and 30 controls underwent multi-b diffusion sequence scans. …”
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Functional Characterization of LTR12C as Regulators of Germ-Cell-Associated TA-p63 in U87-MG and T98-G In Vitro Models by Lucia Meola, Sohum Rajesh Shetty, Angelo Peschiaroli, Claudio Sette, Camilla Bernardini

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Early-Life Energy Overconsumption and Vitamin A Deficiency Alters Growth, Metabolic Health, and Motor Functions: A Mouse Model of Double-Burden Malnutrition by Joseph R Arballo, Maggie Pena, Simran Sran, Lona Bhardwaj, Marjorie Haskell, Reina Engle-Stone, Peng Ji

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RETRACTED ARTICLE: Aging exacerbates the brain inflammatory micro-environment contributing to α-synuclein pathology and functional deficits in a mouse model of DLB/PD by Michiyo Iba, Ross A. McDevitt, Changyoun Kim, Roshni Roy, Dimitra Sarantopoulou, Ella Tommer, Byron Siegars, Michelle Sallin, Somin Kwon, Jyoti Misra Sen, Ranjan Sen, Eliezer Masliah

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