Identification and expression characterization of apple β-tubulin gene family in apple by HUANG Huiling, WANG Yanxiang, WANG Yue, NING Qinqin, LI Ming, HAO Pengbo, CONG Liu, BAI Tuanhui, SHI Jiangli, JIAO Jian, WANG Miaomiao, LIU Yu, ZHAO Yujie, WAN Ran, SHEN Yawen, ZHANG Hengtao, ZHANG Kunxi, ZHENG Xianbo

“…However, little is known about apple tubulin family genes and their potential functions. Therefore, the present study was to identify the apple β-tubulin family genes and to determine the candidate β-tubulin genes involved in regulating apple dwarfing. …”
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Optimized lipid nanoparticles enable effective CRISPR/Cas9-mediated gene editing in dendritic cells for enhanced immunotherapy by Kuirong Mao, Huizhu Tan, Xiuxiu Cong, Ji Liu, Yanbao Xin, Jialiang Wang, Meng Guan, Jiaxuan Li, Ge Zhu, Xiandi Meng, Guojiao Lin, Haorui Wang, Jing Han, Ming Wang, Yong-Guang Yang, Tianmeng Sun

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Epizootic shell disease induces systemic transcriptomic shifts in Homarus americanus, characterized by increased shell degradation and impaired energy metabolism across tissues by Minseo Kim, Dianjun Cao, Vincent Cavaleri, Kyudong Han, Kyudong Han, Kyudong Han, Seyoung Mun, Seyoung Mun, Seyoung Mun, Soo Jin Jeon

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Lithium Chloride Effect on Mortality and Neurological Deficits in the Model of Ischemic Stroke in Rats by O. A. Grebenchikov, R. A. Cherpakov, A. K. Evseyev, A. V. Ershov, A. N. Kuzovlev, P. A. Lonchinsky, S. S. Petrikov, A. K. Shabanov

“…Also, the dosage of 63 mg/kg contributed to better memory retention during the assessment of cognitive functions.Conclusion. Lithium chloride at a dosage of 63 mg/kg significantly (p=0.037) reduced the mortality and severity of neurological deficits in the simulation of experimental ischemic stroke in rats compared to the control group.…”
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Preliminary study of the mechanism of isolinderalactone inhibiting the malignant behavior of bladder cancer by Qun Wang, Wenkai Xu, Lu Ying, Hongjin Shi, Yuxin Sun, Wei Feng, Haole Xu, Jun Xie, Hairong Wei, Zhao Yang, Haifeng Wang

“…Isolinderalactone (ILL), extracted from the dried tubers of Linderae aggregate, has multiple functions, such as antioxidation, antitumor, and anti-infection effects. …”
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Role of Obstructive Sleep Apnoea in Sensorineural Hearing Loss: A Cross-sectional Study by J Shanmugh, RB Namasivaya Navin, K Gowthame, S Prabakaran, D Balaji, R Muthukumar, S Rajasekaran

“…Aim: To assess hearing functions in patients with OSAS, aiming to elucidate the relationship between the disorder and sensorineural hearing loss. …”
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Evaluating the efficiency of emergency operation centers during pandemics: a cross-sectional study with operational managers in Iran by Majid Sartipi, Majid Sartipi, Asiye Aminafshar, Asiye Aminafshar, Abdolrazzagh Pakzad, Mohammadreza Shafiei, Hojjat Farahmandnia, Asghar Tavan

“…This study examined the preparedness and management functions of the Zahedan University of Medical Sciences incident command system (ICS) in response to incidents and disasters, focusing on its implementation during the pandemic.Materials and methodsThe study employed a cross-sectional design. …”
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Effects of Various Direct-acting Antivirals in the Quality of Life of Patients with Chronic Hepatitis C by Hatun ÖZTÜRK ÇERİK, Şaban ESEN, Betül ALTINTAŞ ÖNER, Merve ÇELİK, Tuğba ÖZDEMİR, İlkay BOZKURT, Esra TANYEL

“…Among SF-36 parameters, a significant improvement was observed in physical functioning, physical role limitations, body pain, and vitality in groups 1 and 3 at the end of the treatment (p<0.001, p<0.001, p=0.001, and p<0.001). …”
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Short-term use of ceftriaxone sodium leads to intestinal barrier disruption and ultrastructural changes of kidney in SD rats by Wenli Zou, Yueming Liu, Wei Zhang, Bo Lin, Wei Shen, Yiwen Li, Qiang He, Juan Jin

“…In addition, KEGG metabolic prediction revealed different metabolic functions in each group. TEM examination of colon revealed that dramatic morphological changes were observed in the ceftriaxone (Cef) group, wherein microvilli were misaligned and shortened significantly and morphologically intact bacteria were seen on the epithelial cell surface. …”
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Normothermic <i>ex vivo</i> lung perfusion using a developed solution followed by orthotopic left lung transplantation (experimental study) by I. V. Pashkov, S. V. Gautier, V. K. Bogdanov, D. O. Oleshkevich, D. M. Bondarenko, N. P. Mozheiko, N. S. Bunenkov, N. V. Grudinin

“…The ability to restore suboptimal donor lungs, previously considered unsuitable for transplantation, can improve organ functionality, and thus increase the number of lung transplants. …”
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Placental Mesenchymal Stromal Cells (PMSCs) and PMSC-Derived Extracellular Vesicles (PMSC-EVs) Attenuated Renal Fibrosis in Rats with Unilateral Ureteral Obstruction (UUO) by Regul... by Zhu Zhu, Chaonan Han, Shuli Xian, Feng Zhuang, Feng Ding, Wei Zhang, Yingli Liu

“…PMSCs can convert the inflammatory environment into an anti-inflammatory environment by affecting the polarization of CD4+ T cells and macrophages, inhibiting the inflammatory factors IFN-γ and IL-17, and upregulating the expression of the anti-inflammatory factors TGF-β and IL-10, ultimately leading to renal protection. Such functions may be mediated by the paracrine activity of PMSC-EVs.…”
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Dose-dependent effects of capsaicin on intestinal morphology and microbiota composition in mice: Structural, immunohistochemical, and microbial insights by Kai Li, Jianghai Xu, Siying Chen, Aifei Du, Shaohua Feng, Shibin Yuan, Bangyuan Wu

“…While low-dose administration supports mucosal integrity and promotes beneficial microbial functions, higher doses disrupt epithelial architecture and induce dysbiosis. …”
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Health Workforce related challenges for Emergency Obstetric Care at peripheral health facilities: Providers’ Perspective by Sarika Dakhode, Abhay Gaidhane, Pramita Muntode, Sonali Choudhari, Quazi Syed Zahiruddin, Ajay Dawale

“…Abstract Introduction: Ministry of Health and Family Welfare of India is constantly Functioning to provide optimum health care to achieve Sustainable Development Goals (SDGs) by updating health infrastructure. …”
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Pioneering the IBD specialist nurse role in China: a shared decision-making model for clinical practice innovation by Shuyan Li, Zijun Ni, Yan Ma, Yan Chen, Hongling Sun, Jingfen Jin, Jingfen Jin, Jingfen Jin

“…This initiative defined the organizational structure, selection criteria and processes, role functions, core competencies, and training and assessment standards for the position. …”
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Morphometric Analysis of the Proximal and Distal Ends of Adult Dry Femur Bone: A Cross sectional Study in the Population of North Karnataka, India by Shilpa M Bhimalli, Agamdeep Singh Bedi, Mugdha Malik, Vinod Chandgadkar, Sheetal V Pattanshetti, Daksha Dixit

“…It enhances the understanding of many other factors that influence bone, such as its strength, structural integrity, and functions. Aim: To quantify the morphometric parameters of the proximal and distal ends of the adult femur, including measurements of size, shape, and angular relationships. …”
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TESTING THE INTERACTION OF HEART LEFT VENTRICLE AND CONTINUOUS-FLOW PUMP ON A MOCK CIRCULATION MODEL UNDER NORMAL AND PATHOLOGICAL CONDITIONS by G. P. Itkin, A. A. Drobyshev, O. Yu. Dmitrieva, A. S. Buchnev, A. A. Sysoev

“…Hydrodynamic circulation models that can closely imitate cardio – vascular system are important to defi ne the range of effective functioning of the pumps under normal and heart disease conditions which is of great importance for defi ning the mode of these pumps in real clinical conditions.The aim of study is to create a new hydrodynamic circulation model of the systemic circulation to study the processes of interaction of heart left ventricle and continuous – fl ow pumps.Materials and methods. …”
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Immune status changes in patients with phlegmon in the maxillofacial region relation with purulent process prevalence by N. G. Barannik, S. D. Varzhapetyan, A. V. Sidoryako, Yu. S. Karabinova

“…One manifestation of violation of protective functions in this group of patients are changes in the synthesis of interleukin blood. …”
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Optimization of the defense forces personnel under mobilization conditions: The role of occupational selection as a personnel allocator by V. V. Kalnysh, A. V. Shvets

“…The proposed conceptual model of optimization of the occupational selection system in the defense forces reflects 4 main elements and functions of it. Conclusions. Based on the analysis of existing domestic regulations, it was shown that occupational selection is a key mechanism for improving the personnel arrangement of the Defense Forces of Ukraine. …”
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MORAL AND SPIRITUAL FOUNDATIONS OF YOUTH POLICY IN REAL SECTOR OF ECONOMY by N. V. Popova

“…As a rule, management teams of enterprises expect the generation of young workers to possess initiative and role behaviour which consists in highly skilled independent performance of production functions. At the same time, creative importance of «Person – Person» relations is underestimated. …”
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Knowledge and Awareness about Anesthesia and Perception about Anesthesiologists and their Role during the COVID-19 Pandemic among Patients at a Zonal Hospital: A Cross-sectional Su... by Mayank Rajput, Dewendra J. Gajbhiye, Nagesh Venkata Ivaturi, Shambhavi Rajiva, Vivek Yadav

“…However, even today, in the 21st century, anesthesia functions in relative obscurity, succinctly labelled as a ‘behind the screen’ specialty by the medical fraternity itself. …”
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