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26081
Sleep Disorders and Reproductive Health: Mechanisms, Consequences, and Potential Interventions
Published 2025-02-01“…Chronic stress, obesity, and other factors accompanying sleep disturbances can impair the functioning of hormonal axes, ultimately leading to oxidative stress—a metabolic basis for fertility issues. …”
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26082
Automated protocol templates with efficient schedule of activities table generation for healthy volunteer trials
Published 2025-08-01“…Additionally, a web-based SoA generator (developed with React.js) was created, featuring user-friendly functions for flexible start day adjustments, trial parameter settings, and automatic annotations. …”
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26083
Anti-colorectal cancer effect of total minor ginsenosides produced by lactobacilli transformation of major ginsenosides by inducing apoptosis and regulating gut microbiota
Published 2025-01-01“…Total minor ginsenosides (TMG) were obtained through the fermentation of major ginsenosides with Lactiplantibacillus plantarum, and potential anticancer effects of TMGs on the mouse colon cancer cell line CT26.WT, in vitro and in vivo, were investigated.Materials and MethodsWe employed the Cell Counting Kit-8 (CCK-8), TdT-mediated dUTP nick end labeling (TUNEL), and Western blot analysis in vitro to explore the anti-proliferative and pro-apoptotic functions of TMG in CT26.WT cells. …”
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26084
Optimized non-toxic double absorber perovskite solar cell with efficiency beyond 33%
Published 2025-05-01“…After achieving the optimal configuration, the defect concentration was varied to assess its impact on cell functionality. Device modeling indicates that the proposed design performs effectively at a temperature of 300 K, with the optimal thickness for the La2NiMnO6 absorber estimated to approximately 0.8 µm under AM 1.5G 1 sun illumination. …”
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26085
Advancements in chondrocyte 3-dimensional embedded culture: Implications for tissue engineering and regenerative medicine
Published 2025-04-01“…However, in 2D culture, chondrocytes tend to lose their distinctive phenotypes and functionalities after serial passage, thereby limiting their efficacy for tissue engineering purposes.The mechanism of dedifferentiation in 2D culture can be attributed to various factors, including abnormal nuclear strength, stress-induced mitochondrial impairment, chromatin remodeling, ERK-1/2 and the p38/mitogen-activated protein kinase (MAPK) signaling pathway. …”
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26086
COMPARATIVE ASSESSMENT OF PAIN AND LIFE QUALITY IN THE PATIENTS AFTER OPEN AND VIDEO-ASSISTED LOBECTOMY FOR LUNG CANCER
Published 2018-01-01“…When using the questionnaires of SF-36 (U = 8,742.50; p < 0.05) and EORTC QLQ-C30 (U = 3,759.00; p < 0.05) and the special module of QLQ-LC13 for lung cancer (U = 4,243.00; p < 0.05), the obtained data also indicated the better life quality and functions, reduction of pathologic manifestations versus open surgical access. …”
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26087
Advancing Dye Degradation: Integrating Microbial Metabolism, Photocatalysis, and Nanotechnology for Eco-Friendly Solutions
Published 2025-03-01“…Nanoparticle-mediated approaches benefit from a high surface area and rapid adsorption, with ongoing improvements in synthesis, functionalization, and reusability, particularly through magnetic nanoparticle integration. …”
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26088
Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model
Published 2025-02-01“…We previously prototyped BRFDs using an iron-manganese-nitrogen (FeMnN) alloy and demonstrated their flow diversion functionality, radial strength, bioresorbability, and MRI compatibility in benchtop tests. …”
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26089
Three-Dimensional Printing and Its Impact on the Diagnosis and Treatment of Neurodegenerative Disease
Published 2025-04-01“…Neurodegenerative disorders include Alzheimer’s and Parkinson’s, both of which lead to progressive loss of neurons resulting in the severe loss of cognitive and motor functions. These diseases are among the heavy burdens on global healthcare systems largely because there is no cure, and current treatments apply almost entirely to controlling symptoms rather than disease progression. …”
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26090
Investigation of Fe3O4 nanoparticles synthesized via co-precipitation coated with chitosan, PEG, and folate for targeted paclitaxel delivery in fibrosarcoma treatment
Published 2025-04-01“…Structural characterization via X-ray diffraction (XRD) confirmed the stoichiometric composition and particle dimensions. To enhance functionality, the Fe3O4 NPs were coated with chitosan (Cs), polyethylene glycol (PEG), and folic acid (FA), and loaded with the anticancer drug paclitaxel (PTX), forming nanoencapsulated Fe3O4@Cs-PEG-PTX-FA particles with sizes ranging from 100 to 130 nm. …”
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26091
Identification of three small nucleolar RNAs (snoRNAs) as potential prognostic markers in diffuse large B‐cell lymphoma
Published 2023-02-01“…In addition, SNORD1A co‐expressed genes were inseparably linked to the biological functions of the ribosome and mitochondria. Potential transcriptional regulatory networks have also been identified. …”
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26092
ARTERIAL HYPERTENSION INFLUENCES THE HEALTH-RELATED QUALITY OF LIFE OF 65+ YEAR-OLD PATIENTS
Published 2025-08-01“…This resulted in significantly lower scores in two SF-12 domains: Physical Functioning (p = 0.014) and Bodily Pain (p = 0.010). …”
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26093
Pharmacology complex compound of pro-gly-pro-leu with heparin: hypoglycemic, fibrinolitic and anticoagulant effects in rats with hyperglycemia
Published 2019-12-01“…It is also known that the anticoagulant heparin inhibits blood coagulation and exhibits a hypoglycemic effect in the body.The aim of the study is to obtain a complex of the Pro-Gly-Pro-Leu (PGPL) peptide and the unfractionated heparin, to study its effect on glucose and anticoagulant fibrinolytic properties and show its ability to restore the impaired functions of the insular and coagulating blood systems in experimental hyperglycemia in rats.Materials and Methods. …”
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26094
Statistics on Differences in the Institutional Composition of the National Economy and Issues Related to its Harmonization
Published 2020-09-01“…At the same time, it is obvious that the ratio between the public and other (non-state) sectors refers to the issue of strategic importance, to the issue of the effectiveness of the country's economic system in its integrity, and therefore requires theoretical, methodological and practical resolution.The objectives of the research are: (1) to determine the relative scale and efficiency of the public sector functioning in the national economy, to establish minimum necessary and maximum possible values of its scale; (2) to determine the size and establish a measure of harmonious combination of institutional components of the domestic economy aimed at maximizing its efficiency.Materials and methods. …”
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26095
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26096
Research on underground coal gasification from 2023 to 2024: A systematic review
Published 2025-04-01“…Furthermore, they have demonstrated the inherent advantages and cost benefits of UCG in producing hydrogen-rich gas and have revealed the potential multiple functions of acoustic emission positioning technology for real-time UCG production monitoring. …”
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26097
MiRNA-455-5p regulates the growth and development of adipose tissue by targeting IGF-1R gene
Published 2024-12-01“…These findings may improve our understanding of mechanism of the molecular regulation of miRNA-455-5p and IGF-1R in pigs, and provide a theoretical basis for increasing pork production.TEASER TEXT The miRNA-455-5p was involved in the negative regulation of adipose tissue development by inhibiting the expression of its target gene IGF-1R.ABSTRACT Adipose tissue is an organ with metabolic, endocrine and immune functions, affecting the life span of animals and their susceptibility to diseases. …”
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26098
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26099
A role of pigment epithelium-derived factor in zinc-mediated mechanism of neurodegeneration in glaucoma
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26100