Multi-omics dissection of MAPK-driven senescence unveils therapeutic vulnerabilities in KIAA1549::BRAF-fusion pediatric low-grade glioma models by Romain Sigaud, Anja Stefanski, Florian Selt, Daniela Kocher, Diren Usta, Daniel Picard, Isabel Büdenbender, Marc Remke, Stefan M. Pfister, David T. W. Jones, Tilman Brummer, Olaf Witt, Till Milde

“…Trametinib treatment inhibited MAPK activity, OIS and SASP signatures across all omics levels, functionally underscored by reduced sensitivity towards senolytic drugs. …”
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Genome Wide Association Study (GWAS) Identifies Novel Genetic Loci for Second‐Generation Antipsychotics (SGA)‐Induced Metabolic Syndrome (MetS) by Nihal El Rouby, Aniwaa Owusu‐Obeng, Michael H. Preuss, Simon Lee, Mingjian Shi, Rajiv Nadukuru, Sara L. Van Driest, Jonathan D. Mosley, Melissa DelBello

“…The meta‐analysis of the African Ancestry patients of BioVU and BioMe (N = 2018) identified multiple genome‐wide signals that were functionally mapped to NPPC‐DIS3L2 in chromosome 2. Finally, the inverse‐variance weighted average MR (BMI: OR = 1.2, 95% CI: 1.1–1.4, p = 0.002) showed that genetically predicted, higher BMI was associated with an increased risk of SGA‐MetS. …”
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Cost-Efficient RSSI-Based Indoor Proximity Positioning, for Large/Complex Museum Exhibition Spaces by Panos I. Philippopoulos, Kostas N. Koutrakis, Efstathios D. Tsafaras, Evangelia G. Papadopoulou, Dimitrios Sigalas, Nikolaos D. Tselikas, Stefanos Ougiaroglou, Costas Vassilakis

“…Wearable visitor BLE beacons provided cell-level location determined by a prototype tool (VTT), integrating in its architecture different functionalities: raw RSSI data smoothing with Kalman filters, hybrid positioning provision, temporal methods for visitor cell prediction, spatial filtering, and prediction based on popular machine learning classifiers. …”
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6G RIS in Indoor Environments: Assessment of Exposure Variability in Human Users and Non-Users by Silvia Gallucci, Martina Benini, Serena Fiocchi, Gabriella Tognola, Marta Parazzini

“…<inline-formula> <tex-math notation="LaTeX">${\mathrm { SAR}}_{\mathrm { wb}}$ </tex-math></inline-formula> and <inline-formula> <tex-math notation="LaTeX">${\mathrm { SAR}}_{\mathrm { brain}}$ </tex-math></inline-formula> results, studied in terms of peak values, cumulative distribution functions (CDFs) and spatial maps, showed higher <inline-formula> <tex-math notation="LaTeX">${\mathrm { SAR}}_{\mathrm { wb}}$ </tex-math></inline-formula> values in adults compared to children, while <inline-formula> <tex-math notation="LaTeX">${\mathrm { SAR}}_{\mathrm { brain}}$ </tex-math></inline-formula> peaks were more pronounced in child models. …”
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Earthquake rupture variability along the central seismic gap segment (78°– 82°E) of the Himalayan Frontal Thrust, Western and Central Himalaya by Shreya Arora, Natalie Meenan, Eshaan Srivastava, Drew Cochran, Gurvinder Singh, Alana Williams, Mitthu Dhali, Monika Kumaiya, Ramon Arrowsmith, Javed N. Malik, Hisao Kondo

“…Abstract Mapping the extents and terminations of surface ruptures is essential for a better seismic hazard assessment, as these factors indicate the magnitude and location of future earthquakes. …”
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Critical care services in Bagmati province of Nepal: A cross sectional survey [version 4; peer review: 4 approved, 2 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…Results From 87 hospitals, a total of 123 ICUs were identified in the province, providing 1167 beds and 615 functioning ventilators. The average ICU bed availability per 100,000 population was 19, ranging from 3.6 in Makwanpur to 33.9 in Kathmandu. …”
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Spatial Distribution and Intraspecific and Interspecific Associations of Dominant Tree Species in a Deciduous Broad-Leaved Forest in Shennongjia, China by Jiaxin Wei, Linsen Yang, Zhiguo Jiang, Hui Yao, Huiliang Yu, Fanglin Luo, Xiujuan Qiao, Yaozhan Xu, Mingxi Jiang

“…We analyzed the spatial distribution patterns of 20 dominant species with univariate and bivariate g(r) functions, as well as intraspecific and interspecific associations across different life-history stages. …”
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Critical care services in Bagmati province of Nepal: A cross sectional survey [version 3; peer review: 3 approved, 1 approved with reservations] by Subekshya Luitel, Sushila Paudel, Diptesh Aryal, Janaki Pandey, Hem Raj Paneru, Roshni Shakya, Prashant Acharya, Isha Amatya, Rashan Haniffa, Suman Pant, Abi Beane, Pradip Gyanwali

“…Results From 87 hospitals, a total of 123 ICUs were identified in the province, providing 1167 beds and 615 functioning ventilators. The average ICU bed availability per 100,000 population was 19, ranging from 3.6 in Makwanpur to 33.9 in Kathmandu. …”
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The Online Health Information–Seeking Behaviors of People Who Have Experienced Stroke: Qualitative Interview Study by Brigid Clancy, Billie Bonevski, Coralie English, Ashleigh Guillaumier

“…ResultsA sample of 15 relatively independent, high-functioning people who had experienced stroke from 4 Australian states, aged between 29 and 80 years, completed the interview. …”
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Autosomal dominant hypercalciuria in a mouse model due to a mutation of the epithelial calcium channel, TRPV5. by Nellie Y Loh, Liz Bentley, Henrik Dimke, Sjoerd Verkaart, Paolo Tammaro, Caroline M Gorvin, Michael J Stechman, Bushra N Ahmad, Fadil M Hannan, Sian E Piret, Holly Evans, Ilaria Bellantuono, Tertius A Hough, William D Fraser, Joost G J Hoenderop, Frances M Ashcroft, Steve D M Brown, René J M Bindels, Roger D Cox, Rajesh V Thakker

“…Thus, our findings indicate that the TRPV5 S682P mutant is functionally significant and study of HCALC1, a novel model for autosomal dominant hypercalciuria, may help further our understanding of renal calcium reabsorption and hypercalciuria.…”
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Defining Public Health Transformation: A Scoping Review by Violet Phooko, Kuhlula Maluleke, Sebueng Ramatsokotla, Thato Serite, Kabelo Kgarosi, Funeka Sokudela, Tivani Mashamba‐Thompson

“…Such transformation requires a fundamental change in public health systems' structure, functioning and interactions, supported by continuous quality improvement, innovation, partnerships, community‐driven efforts and systems change. …”
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Dissecting PTPN7‐driven aggressiveness in IDH‐wildtype astrocytomas: multi‐omics, clinical validation, and spatial transcriptomics for prognostic insights by Tung Liu, Yu-Chieh Lin, Pei-Chi Chang, Dueng-Yuan Hueng, Yao-Feng Li

“…This study examines the prognostic significance, spatial distribution, and immune‐related functions of PTPN7, aiming to elucidate its potential as a prognostic role and therapeutic target in glioma treatment. …”
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Distribution of macrozoobenthic taxa - potential indicators of vulnerable marine ecosystems in the western part of Bering Sea. 1. Anadyr Bay area by Victor A. Nadtochy, Nickolay V. Kolpakov, Ilya A. Korneichuk

“…This by-effect of fishing could affect negatively on functioning of bottom biocenoses, reproduction of exploited species, and decrease generally productivity of vulnerable marine ecosystems (VME). …”
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Optimal Vibration Fields in Problems of Modeling Dynamic States of Technical Objects by A. V. Eliseev, N. K. Kuznetsov

“…Lagrange formalism, elements of operational calculus based on Laplace integral transformations, sections of vibration theories, algebraic methods, and the theory of spline functions were used for structural mathematical modeling.Results. …”
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Exploring potential methylation markers for ovarian cancer from cervical scraping samples by Ju-Yin Lien, Lu Ann Hii, Po-Hsuan Su, Lin-Yu Chen, Kuo-Chang Wen, Hung-Cheng Lai, Yu-Chao Wang

“…Furthermore, an over-representation analysis was conducted to explore the functions associated with genes mapped from differentially methylated positions (DMPs) in comparisons between normal and tumor samples, as well as between benign and malignant samples. …”
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Variabilidad espacial y diaria del contenido de humedad en el suelo en tres sistemas agroforestales Spatial and daily variability of soil moisture content in three agroforestry sys... by Mariela Rivera Peña, Edgar Amézquita Collazos, Idupulapati Rao, Juan Carlos Menjivar Flores

“…The geo-statistical analysis showed that the random component of the spatial dependence was predominant over the nugget effect. The functions of semivariograms, structured for each variable were used to generate maps of interpolated contours at a fine scale. …”
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The role of autophagy in periodontal diseases: a bibliometric analysis from 2006 to 2023 by Bitong Zhang, Bitong Zhang, Yahui Wang, Yahui Wang, Yahui Wang, Haoxiang Chang, Haoxiang Chang, Chong Wang, Chong Wang, Hong Fan, Hong Fan, Xiuyun Ren, Xiuyun Ren

“…Bibliometric and knowledge mapping analyses were performed using CiteSpace [6.3. …”
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Development and clinical application of an automated machine learning-based delirium risk prediction model for emergency polytrauma patients by Zhenyi Liu, Yihao Huang, Long Li, Yisha Xu, Peng Wu, Zhigang Zhang, Tingyong Han, Liangjie Zhang, Ming Zhang

“…To address high-dimensional clinical heterogeneity, an Improved Flood Algorithm (IFLA)—enhanced with sine mapping initialization and Cauchy mutation perturbations—was integrated into an automated machine learning (AutoML) framework for simultaneous feature selection and hyperparameter optimization. …”
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Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension by Francesco Paolo Lo Muzio, Alessia Caputo, Rosario Statello, Mirko Hu, Roberta Maestri, Giovanna Pelà, Aderville Cabassi, Margherita Burattini, Giacomo Rozzi, Silvia Berrettoni, Barbara Montanini, Stefano Rossi, Lorenzo Fassina, Giovanni Battista Luciani, Gianluigi Condorelli, Michele Miragoli

“…Methods In this study, we investigate the late-stage effects of PAH on both electrical and mechanical functions, as well as their coupling, in each ventricle using the monocrotaline-treated rat model. …”
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Mass cytometry analysis reveals a cross-tissue immune landscape in Actinobacillus pleuropneumoniae-induced pneumonia by Yanyan Tian, Xuan Jiang, Chuntong Bao, Tamin Abdelaal, Dexi Chen, Wenjing Wang, Fengyang Li, Liancheng Lei, Na Li

“…Meanwhile, the specific functions of APP infection-related immune subsets were explored. …”
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