Genome-wide association study of post COVID-19 syndrome in a population-based cohort in Germany by Anne-Kathrin Ruß, Stefan Schreiber, Wolfgang Lieb, J. Janne Vehreschild, Peter U. Heuschmann, Thomas Illig, Katharina S. Appel, Maria J. G. T. Vehreschild, Dagmar Krefting, Lennart Reinke, Alin Viebke, Susanne Poick, Stefan Störk, Jens-Peter Reese, Thomas Zoller, Lilian Krist, David Ellinghaus, Bärbel U. Foesel, Christian Gieger, Bettina Lorenz-Depiereux, Martin Witzenrath, Gabriele Anton, Michael Krawczak, Jan Heyckendorf, Thomas Bahmer

“…The SNP is located in a region including the NEK6, PSMB7 and ADGRD2 genes which, however, does not immediately suggest an etiological connection to PCS. As regards functional plausibility, variants of a possible effect mapped to the olfactory receptor gene region (lead SNP rs10893121 at position chr11:123,854,744; p = 2.5 × 10− 6). …”
Get full text

Serum proteomics of adults with acute liver failure provides mechanistic insights and attractive prognostic biomarkers by Katharina Remih, Franziska-Maria Hufnagel, Anna Sophie Karl, Valerie Durkalski-Mauldin, William Martens Lee, Constantine J. Karvellas, Zemin Su, Jody A. Rule, Petra Tomanová, Laura Krieg, Isabel Karkossa, Kristin Schubert, Martin von Bergen, Frank Tacke, Sonja Luckhardt, Nicole Ziegler, Aimo Kannt, Bastian Engel, Richard Taubert, Robert John Fontana, Pavel Strnad

“…Single-cell RNAseq data mapped biomarkers to cells of origin; functional enrichment analysis provided mechanistic insights. …”
Get full text

Microplastic and Copper Exposure Effects on Intestinal Gene Expression in Eriocheir sinensis: A Transcriptomics-Based Investigation by Jian XU, Guangpeng FENG, Yunzhi YAN, Jinhui CHEN, Jianhui WU, Zuchang YANG

“…MPs and Cu2+ may affect the expression of cyp450 and related genes (ugt), potentially compromising the immune function of E. sinensis. Notably, ugt was significantly upregulated in Groups M vs D and downregulated in Groups MC vs D. …”
Get full text

Similar Instances Reuse Based Numerical Control Process Decision Method for Prismatic Parts by Changhong XU, Shusheng ZHANG, Jiachen LIANG, Rui HUANG, Rong BIAN

“…Then, the framework of the proposed approach is illustrated, which explains four significant steps: similar subpart instances retrieval, optimal target function construction, PSD establishment, and NC process scheme optimization. …”
Get full text

Measure selection for an electronic patient-reported outcome (ePRO) system for CAR T-cell therapy patients: a modified Delphi consensus studyResearch in context by Sarah E. Hughes, Foram Khatsuria, Christel McMullan, Karen L. Shaw, Anita Walker, Francesca Kinsella, David Burns, Olalekan L. Aiyegbusi, Elin Haf Davies, John Ansell, Evelyn Chakera, Charles Craddock, Alastair Denniston, Rebecca Lloyd, Paul Ferguson, Ronjon Chakraverty, Melanie Calvert

“…These measures, EQ5D-5L, measuring HRQoL, and Functional Assessment of Chronic Illness Therapy–Item GP5 (FACT-GP5), single-item global indicator of cancer treatment tolerability, will be included in the ePRO system. …”
Get full text

A Comprehensive Analysis of Spitzer 4.5 μm Phase Curves of Hot Jupiters by Lisa Dang, Taylor J. Bell, Ying (Zoe) Shu, Nicolas B. Cowan, Jacob L. Bean, Drake Deming, Eliza M.-R. Kempton, Megan Weiner Mansfield, Emily Rauscher, Vivien Parmentier, Alexandra Rochon, Kevin B. Stevenson, Mark Swain, Laura Kreidberg, Tiffany Kataria, Jean-Michel Désert, Robert Zellem, Jonathan J. Fortney, Nikole K. Lewis, Michael Line, Caroline Morley, Adam Showman

“…We explore phase-curve trends as a function of irradiation temperature, orbital period, planetary radius, mass, and stellar effective temperature. …”
Get full text

Random Finite Element Analysis and Random Factor response Mechanism for Geocell-reinforced Soil Retaining Walls by ZHANG Bingbing, SONG Fei

“…Based on the above method, the random field numerical model of geocell-reinforced soil retaining wall was successfully established, and the probability distribution characteristics of horizontal displacement and vertical settlement of the retaining wall were obtained through large-scale stochastic simulation, and the corresponding cumulative distribution function was constructed. Finally, the global sensitivity analysis method was adopted, focusing on revealing the influence laws of key parameters (<italic>K</italic>, <italic>n</italic>, <italic>φ</italic>₀ and <italic>P</italic>_Mt), their coefficients of variation and spatial fluctuation ranges on the deformation characteristics of the retaining wall, and quantitatively analyzing the mapping relationship between each parameter and the deformation response of the structure.Results and Discussions　Through the in-depth analysis of the random field parameters of foundation soil, backfill soil and geocell-reinforced retaining wall, it is revealed that the soil parameters have significant layering characteristics and the trend of change with depth, which is highly consistent with the layering distribution characteristics of the soil in the actual project, and verifies the reliability of the constructed random field model. …”
Get full text

Identification and expression analysis of ACBPs family members of Hippophae rhamnoides subsp. sinensis Rousi in response to lead stress by CHEN Ke, LI Xinjuan, ZHANG Tian, REN Qiandan, SUN Jing, ZHOU Wu

“…Group 3 contained the most exons, increasing the likelihood of alternative splicing and enhancing functional diversity. The gene family's promoter regions contain various cis-acting elements responsive to plant hormones, meristematic activity, and stress stimuli, suggesting that HrLACBPs have multiple biological functions. …”
Get full text

A multi-omics reciprocal analysis for characterization of bacterial metabolism by Gabriel Santos Arini, Gabriel Santos Arini, Gabriel Santos Arini, Tiago Cabral Borelli, Tiago Cabral Borelli, Tiago Cabral Borelli, Elthon Góis Ferreira, Rafael de Felício, Paula Rezende-Teixeira, Matheus Pedrino, Matheus Pedrino, Franciene Rabiço, Franciene Rabiço, Guilherme Marcelino Viana de Siqueira, Guilherme Marcelino Viana de Siqueira, Luiz Gabriel Mencucini, Luiz Gabriel Mencucini, Henrique Tsuji, Henrique Tsuji, Lucas Sousa Neves Andrade, Leandro Maza Garrido, Gabriel Padilla, Alberto Gil-de-la-Fuente, Alberto Gil-de-la-Fuente, Mingxun Wang, Norberto Peporine Lopes, Daniela Barretto Barbosa Trivella, Letícia Veras Costa-Lotufo, María-Eugenia Guazzaroni, Ricardo Roberto da Silva, Ricardo Roberto da Silva, Ricardo Roberto da Silva

“…Starting from LC-ESI(+)-HRMS/MS data, and mapping the annotated enzymes and metabolites belonging to the same pathways, our integrative analysis allowed us to correlate the compound Brevianamide F to a new BGC, previously assigned to other function.…”
Get full text

Identification of plum PsNAC gene family and its expression patterns in development of fruit hollowness and browning by DENG Honghong, PENG Chao, LIANG Xi, ZHANG Ziyang, LIU Junwei, LI Binqi, WEI Mingkang, WANG Xueying, LI Liumin, CHEN Faxing

“…The findings of this study will serve as a crucial foundation for further exploration into the biological functions of PsNAC gene family and the molecular mechanism by which PsNAC gene family members regulate fruit HB in Huangguan plum.…”
Get full text

Worlds Next Door: A Candidate Giant Planet Imaged in the Habitable Zone of α Centauri A. II. Binary Star Modeling, Planet and Exozodi Search, and Sensitivity Analysis by Aniket Sanghi, Charles Beichman, Dimitri Mawet, William O. Balmer, Nicolas Godoy, Laurent Pueyo, Anthony Boccaletti, Max Sommer, Alexis Bidot, Elodie Choquet, Pierre Kervella, Pierre-Olivier Lagage, Jarron Leisenring, Jorge Llop-Sayson, Michael Ressler, Kevin Wagner, Mark Wyatt

“…For the first time with JWST, we demonstrate the application of reference star differential imaging to simultaneously subtract the coronagraphic image of a primary star ( α Cen A) and the point-spread function (PSF) of its binary companion ( α Cen B) to conduct a deep search for exoplanets and exozodiacal dust emission. …”
Get full text

The TESS–Keck Survey. XXIV. Outer Giants May Be More Prevalent in the Presence of Inner Small Planets by Judah Van Zandt, Erik A. Petigura, Jack Lubin, Lauren M. Weiss, Emma V. Turtelboom, Tara Fetherolf, Joseph M. Akana Murphy, Ian J. M. Crossfield, Gregory J. Gilbert, Teo Močnik, Natalie M. Batalha, Courtney Dressing, Benjamin Fulton, Andrew W. Howard, Daniel Huber, Howard Isaacson, Stephen R. Kane, Paul Robertson, Arpita Roy, Isabel Angelo, Aida Behmard, Corey Beard, Ashley Chontos, Fei Dai, Steven Giacalone, Michelle L. Hill, Rae Holcomb, Steve B. Howell, Andrew W. Mayo, Daria Pidhorodetska, Alex S. Polanski, James Rogers, Lee J. Rosenthal, Ryan A. Rubenzahl, Nicholas Scarsdale, Dakotah Tyler, Samuel W. Yee, Jon Zink

“…We assembled our sample of 47 stars using a single selection function and observed each star at monthly intervals to obtain ≈30 RV observations per target. …”
Get full text

Пізній протестантизм в Україні в процесі пострадянських внутрішньо-інституційних суспільних трансформацій... by Ольга СПИС

“…It is concluded that presence of evolution in Late Protestant Ukrainian communities in the first fifteen years of functioning in religious liberty environment determines their sequential institutionalization and de-sectanization. …”
Get full text

卒中关联基因驱动不同族裔与卒中亚型的药物重定位研究Research on Drug Repositioning across Different Ethnic Groups and Stroke Subtypes Driven by Stroke-Associated Genes... by 张杰，勾岚，李兰欣，许喆，石延枫，姜明慧，李昊，程丝(ZHANG Jie, GOU Lan, LI Lanxin, XU Zhe, SHI Yanfeng, JIANG Minghui, LI Hao, CHENG Si )

“…Abstract: Objective Given the challenges of drug transformation for stroke-associated genes and the genetic heterogeneity across different ethnic groups and stroke subtypes, this study aims to perform drug repositioning analysis targeting these genes based on improved functional annotation of stroke-associated genes, to identify potential cross-indication drug candidates for stroke treatment. …”
Get full text

DUALZ—Deep UNCOVER-ALMA Legacy High-Z Survey by Seiji Fujimoto, Rachel Bezanson, Ivo Labbe, Gabriel Brammer, Sedona H. Price, Bingjie Wang, John R. Weaver, Yoshinobu Fudamoto, Pascal A. Oesch, Christina C. Williams, Pratika Dayal, Robert Feldmann, Jenny E. Greene, Joel Leja, Katherine E. Whitaker, Adi Zitrin, Sam E. Cutler, Lukas J. Furtak, Richard Pan, Iryna Chemerynska, Vasily Kokorev, Tim B. Miller, Hakim Atek, Pieter van Dokkum, Stéphanie Juneau, Susan Kassin, Gourav Khullar, Danilo Marchesini, Michael Maseda, Erica J. Nelson, David J. Setton, Renske Smit

“…We assess the infrared luminosity function up to z ∼ 10 and find it is consistent with predictions from galaxy formation models. …”
Get full text

Seditious Spaces by Nurul Azreen Azlan

“…Given that public space is shaped by the colonial legacy, how does it facilitate or hinder street protests as a function of democracy, which is also a vestige of colonialism? …”
Get full text

The First Insight-HXMT Localization Catalog of Short-duration Gamma-Ray Bursts: The First Six Years by Shuo Xiao, Yan-Ting Zhang, Yue Wang, Yan-Qiu Zhang, Shao-Lin Xiong, Shuang-Nan Zhang, Shi-Jie Zheng, Jin-Peng Zhang, Peng Zhang, Cheng-Kui Li, Xiao-Bo Li, Shu-Xu Yi, Zhen Zhang, Bing Li, Hua Feng, Cong-Zhan Liu, Ming-Yu Ge, Xu-Fang Li, Zheng-Wei Li, Yu-Peng Xu, Xiang-Yang Wen, Jian-Chao Sun, Lian Tao, Qi-Bin Yi, Ce Cai, Yi Zhao, Wang-Chen Xue, Jia-Cong Liu, Chao Zheng, Chen-Wei Wang, Wen-Jun Tan, You-Li Tuo, Li-Ming Song, Fang-Jun Lu, Ti-Pei Li

“…In this work, we locate these sGRBs by adopting an enhanced time-delay localization method based on the Li modified cross-correlation function (Li-CCF), jointly with Insight-HXMT/HE, Gravitational-wave high-energy Electromagnetic Counterpart All-sky Monitor, Fermi/Gamma-ray Burst Monitor (GBM), INTEGRAL/SPI-ACS, and Konus-Wind. …”
Get full text

EPHA4 signaling dysregulation links abnormal locomotion and the development of idiopathic scoliosis by Lianlei Wang, Xinyu Yang, Sen Zhao, Pengfei Zheng, Wen Wen, Kexin Xu, Xi Cheng, Qing Li, Anas M Khanshour, Yoshinao Koike, Junjun Liu, Xin Fan, Nao Otomo, Zefu Chen, Yaqi Li, Lulu Li, Haibo Xie, Panpan Zhu, Xiaoxin Li, Yuchen Niu, Shengru Wang, Sen Liu, Suomao Yuan, Chikashi Terao, Ziquan Li, Shaoke Chen, Xiuli Zhao, Pengfei Liu, Jennifer E Posey, Zhihong Wu, Guixing Qiu, DISCO study group (Deciphering Disorders Involving Scoliosis & COmorbidities), Shiro Ikegawa, James R Lupski, Jonathan J Rios, Carol A Wise, Jianguo T Zhang, Chengtian Zhao, Nan Wu

“…In this study, we first reanalyzed the loci associated with IS, drawing upon previous studies. Subsequently, we mapped these loci to candidate genes using either location-based or function-based strategies. …”
Get full text

Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…There was also no difference in other lower urinary tract symptoms, sexual function or quality of life. Routine data were received for 98% of men. …”
Get full text

Urodynamics tests for the diagnosis and management of male bladder outlet obstruction: long-term follow-up of the UPSTREAM non-inferiority RCT by Madeleine Clout, Amanda L Lewis, Madeleine Cochrane, Grace J Young, Paul Abrams, Peter S Blair, Christopher Chapple, Gordon T Taylor, Sian Noble, Tom Steuart-Feilding, Jodi Taylor, J Athene Lane, Marcus J Drake

“…There was also no difference in other lower urinary tract symptoms, sexual function or quality of life. Routine data were received for 98% of men. …”
Get full text