A Sequence-to-Sequence Transformer Model for Satellite Retrieval of Aerosol Optical and Microphysical Parameters from Space by Luo Zhang, Haoran Gu, Zhengqiang Li, Zhenhai Liu, Ying Zhang, Yisong Xie, Zihan Zhang, Zhe Ji, Zhiyu Li, Chaoyu Yan

“…Unlike conventional end-to-end single-parameter retrieval methods, this algorithm leverages the encoding–decoding capabilities of the transformer model, coupling multi-source data such as polarized satellite, meteorological, model, and surface characteristics, and incorporates a physically coherent consistency loss function. This approach transforms traditional single-parameter numerical regression into a sequence-to-sequence relationship mapping. …”
Get full text

RAG recombinase expression discriminates the development of natural killer cells by Jasmin Sprissler, Jasmin Sprissler, Ulrich Pannicke, Eva-Maria Rump, Hubert Schrezenmeier, Hubert Schrezenmeier, Hubert Schrezenmeier, Nicolas Casadei, Nicolas Casadei, Michaela Pogoda, Michaela Pogoda, Laurence Kuhlburger, Morgana Barroso Oquendo, Stefan Czemmel, Klaus-Michael Debatin, Klaus-Michael Debatin, Miriam Erlacher, Klaus Schwarz, Klaus Schwarz, Klaus Schwarz, Kerstin Felgentreff, Kerstin Felgentreff

“…Despite their strong effector function, DNA damage response and survival to ionizing radiation were compromised.DiscussionThese findings suggest a role of RAG expression in NK cell ontogeny supporting the development of a terminally differentiated effector population.…”
Get full text

Infrared Satellite Detection Limits for Monitoring Atmospheric Ammonia by Mark W. Shephard, Shailesh K. Kharol, Enrico Dammers, Christopher E. Sioris, Andrew Bell, Rik Jansen, Jerome Caron, Ralph Snel, Emanuela Palombo, Karen E. Cady-Pereira, Chris A. McLinden, Erik Lutsch, Robert O. Knuteson

“…Information on the frequency of a given detection limit, and the cumulative probability of detection, are provided as a function of instrument spectral resolution and noise. …”
Get full text

Two Novel Single-Chain Variable Fragments, EB211 and EB279, Exert Antibacterial Activity Against Acinetobacter baumannii by Destabilizing the Outer Membrane by Eilnaz Basardeh1, Farzaneh Nazari1, Abolfazl Fateh1, Seyed Davar Siadat1, Akbar Oghalaie2, Masoumeh Azizi3, Fatemeh Rahimi-Jamnani1*

“…Their unique ability to function independently of the host immune system makes scFvs a highly promising option for effective treatment. …”
Get full text

Structure and Fragmentation Scale of a Massive Star-forming Filament in NGC 6334: High-resolution Mid-infrared Absorption Imaging with JWST by Philippe André, Michael Mattern, Doris Arzoumanian, Yoshito Shimajiri, Annie Zavagno, Daisei Abe, Delphine Russeil

“…This characteristic scale  ∼0.1 pc has important implications for the origin of the star formation efficiency in dense gas and the initial mass function.…”
Get full text

Method for the use of polymer beads as dosimeters for low-energy electron irradiation by Joana Kira Besecke, Joana Kira Besecke, Joana Kira Besecke, Lysann Kenner, André Poremba, Jessy Schönfelder, Jessy Schönfelder, Tobias Teichmann, Martin Thoma, Martin Thoma, Thomas Grunwald, Thomas Grunwald, Elizabeth von Hauff, Elizabeth von Hauff, Ulla König, Björn Poppe, Simone Schopf, Simone Schopf

“…Thus, flow cytometric fluorescence measurements allow dose mapping: the signal of each bead could be assigned to a corresponding dose. …”
Get full text

Comparison of pilot tone-triggered and electrocardiogram-triggered cardiac magnetic resonance imaging: a prospective clinical feasibility study by Xianling Qian, Yali Wu, Peter Speier, Caixia Fu, Yunzhu Wu, Lude Cheng, Yinyin Chen, Shiyu Wang, Caizhong Chen, Kai Liu, Ling Chen, Hang Jin, Mengsu Zeng

“…Image quality and quantitative measurements were evaluated, including T2WI signal intensity, native T1-mapping, T2-mapping, and extracellular volume fraction (ECV) values, and comparative signal-to-noise ratio (compSNR) and comparative contrast-to-noise ratio (compCNR) of cine and LGE images, left/right ventricular function. …”
Get full text

Reliability of multi-site UK Biobank MRI brain phenotypes for the assessment of neuropsychiatric complications of SARS-CoV-2 infection: The COVID-CNS travelling heads study. by Eugene Duff, Fernando Zelaya, Fidel Alfaro Almagro, Karla L Miller, Naomi Martin, Thomas E Nichols, Bernd Taschler, Ludovica Griffanti, Christoph Arthofer, Gwenaëlle Douaud, Chaoyue Wang, Thomas W Okell, Richard A I Bethlehem, Klaus Eickel, Matthias Günther, David K Menon, Guy Williams, Bethany Facer, David J Lythgoe, Flavio Dell'Acqua, Greta K Wood, Steven C R Williams, Gavin Houston, Simon S Keller, Catherine Holden, Monika Hartmann, Lily George, Gerome Breen, Benedict D Michael, Peter Jezzard, Stephen M Smith, Edward T Bullmore, COVID-CNS Consortium

“…A multi-modal brain MRI protocol comprising sequences for T1-weighted MRI, T2-FLAIR, diffusion MRI (dMRI), resting-state functional MRI (fMRI), susceptibility-weighted imaging (swMRI), and arterial spin labelling (ASL), was defined in close approximation to prior UK Biobank (UKB) and C-MORE protocols for Siemens 3T systems. …”
Get full text

Construção e Validação de um Modelo de Competências Digitais para alunos da Educação a Distância no Brasil: MCompDigEAD / Construction and Validation of a Model of Digital Competen... by Ketia Kellen Araújo da Silva, Patricia Alejandra Behar, Teresa Romeu-Fontanillas, Montse Guitert-Catasús

“…As a result, we obtained a model composed of six areas: Introduction to Digital Technologies, Digital Communication, Network Information Management, Digital Health and Safety, Digital Citizenship and Presence, and Digital Content Creation and Development, divided into three digital competencies: functional digital literacy, critical digital literacy and digital fluency, fourteen specific skills detailed through knowledge, skills and attitudes (CHA) and three levels of proficiency, initial, intermediate and advanced with use case examples. …”

Large-scale integration of meta-QTL and genome-wide association study identifies genomic regions and candidate genes for photosynthetic efficiency traits in bread wheat by Ming Chen, Tao Chen, Letong Yun, Zhuo Che, Jingfu Ma, Binxue Kong, Jiangying Long, Chunhua Cheng, Kaiqi Guo, Peipei Zhang, Lijian Guo, Delong Yang

“…For the key CG TaGGR-6A (TraesCS6A02G307700) involved in the porphyrin metabolism pathway, a functional kompetitive allele-specific PCR (KASP) marker was developed at 2464 bp (A/G) position within the 3′ untranslated region, successfully distinguishing two haplotypes: TaGGR-6A-Hap I (type AA) and TaGGR-6A-Hap II (type GG). …”
Get full text

Using Human‐Centred Design to Codesign Patient Engagement Tools With a Patient Advisory Council: Successes and Challenges by Madelyn Knaub, Santiago Leon, Surakshya Pokharel, Veronika Kiryanova, Kim Giroux, Prachi Khanna, Anna Rychtera, D'Arcy Duquette, Pamela Mathura, Nancy Verdin, Anshula Ambasta

“…Human Centred Design (HCD), a problem‐solving methodology focused on creating functional solutions for users, offers a promising approach to co‐building patient engagement tools. …”
Get full text

Evaluation of white matter in patients with multiple sclerosis through diffusion tensor magnetic resonance imaging Avaliação da substância branca em pacientes com esclerose múltipl... by Rachel E. Maia de Andrade, Emerson L. Gasparetto, Luiz Celso Hygino Cruz Jr., Fabiana Brito Ferreira, Roberto Cortês Domingues, Edson Marchiori, Romeu Cortês Domingues

“…METHOD: Forty patients with clinical-laboratorial diagnosis of relapsing-remitting MS and 40 age- and sex-matched controls, who underwent conventional and functional (DTI) MR imaging, were included in the study. …”
Get full text

Serum vitamin D levels in patients with Bell’s palsy: a systematic review and meta-analysis by Elaheh Foroughi, Mehrdad Mozafar, Shayesteh Haghighi, Maryam Moghbel Baerz, Kosar Salehi Torabi, Aref Hafezi Bafti, Fatemeh Asadi, Mani Khorsand Askari, Erfan Shahabinejad

Get full text

Development of 6-amido-4-aminoisoindolyn-1,3-diones as p70S6K1 inhibitors and potential breast cancer therapeutics by Adrian Thornton, Rajesh Komati, Hogyoung Kim, Jamiah Myers, Kymmia Petty, Rion Sam, Elijah Johnson-Henderson, Keshunna Reese, Linh Tran, Vaniyambadi Sridhar, Christopher Williams, Jayalakshmi Sridhar

“…The targeting of p70S6K1 by the compounds was confirmed by studying the phosphorylation status of downstream protein rpS6.ResultsIn this study, we have identified a new class of compounds as p70S6K1 inhibitors that function as growth inhibitors of MCF7 breast cancer cells. …”
Get full text

A Single Electrode Organic Neuromorphic Device for Dopamine Sensing in Vivo by Federico Rondelli, Michele Di Lauro, Gioacchino Calandra Sebastianella, Anna De Salvo, Matteo Genitoni, Mauro Murgia, Pierpaolo Greco, Carolina Giulia Ferroni, Riccardo Viaro, Luciano Fadiga, Fabio Biscarini

“…This work presents the development of a label‐free Single Electrode Neuromorphic Device (SEND) specifically designed for in vivo real‐time mapping of dopamine concentration. The device response is investigated as a function of the driving frequency, resulting in the determination of the optimal operational configuration for minimally invasive neuromorphic devices. …”
Get full text

The feedback driven atomic scale Josephson microscope by Samuel D. Escribano, Víctor Barrena, David Perconte, Jose Antonio Moreno, Marta Fernández Lomana, Miguel Águeda, Edwin Herrera, Beilun Wu, Jose Gabriel Rodrigo, Elsa Prada, Isabel Guillamón, Alfredo Levy Yeyati, Hermann Suderow

“…By tracing the periodic oscillations in the new bistable regime as a function of the position in a Scanning Tunneling Microscope, we obtain atomic scale maps of the critical current in 2H-NbSe2 and find spatial modulations due to a pair density wave. …”
Get full text

Ancillary Voltage Control Design for Adaptive Tracking Performance of Microgrid Coupled With Industrial Loads by Subrata K. Sarker, Shahriar Rahman Fahim, Niloy Sarker, Kazi Zakaria Tayef, Abu Bakar Siddique, Dristi Datta, M. A. Parvez Mahmud, Md. Fatin Ishraque, Sajal K. Das, Md Rabiul Islam Sarker, Sk. A. Shezan, Ziaur Rahman

“…Although the utilizing of renewable energy sources (RESs) in microgrid (MG) offers a recognized solution to meet the increasing demand, it’s performance depend on various meteorological factors of RESs. Again, the functioning of MGs is often affected with certain industrial load dynamics which allowing them to alter the operating region and tracking function of the MGs. …”
Get full text

Discovery of phloridzin as a new antagonist for Di(2-ethylhexyl) phthalate-induced male reproductive toxicity based on the adverse outcome pathway network and drug-target gene set... by Huan Gao, Xue Zhang, Ziqi Liu, Xiaoge Yang, Yajie Li, Mengxing Cui, Han Wang, Xiaoyu Chen, Weiying Zhang, Zhihan Liu, Yongjiang Yu, Liping Chen, Daochuan Li, Yongmei Xiao, Wen Chen, Qing Wang

“…Next, we developed a global adverse outcome pathway (AOP) network based on the existed AOP-wiki. After functional enrichment analyses and mapping to the global AOP network, we found that the increased ROS level, cell cycle arrest, and increased apoptosis are key events (KEs) involved in DEHP-mediated MRT, which was validated in TM3 Leydig cell model. …”
Get full text

Mechanisms underlying the spontaneous reorganization of depression network after stroke by Yirong Fang, Xian Chao, Zeyu Lu, Hongmei Huang, Ran Shi, Dawei Yin, Hao Chen, Yanan Lu, Jinjing Wang, Peng Wang, Xinfeng Liu, Wen Sun

“…Exploring post-stroke brain repair processes post-stroke could bridge this gap.We defined a depression network using the normative connectome and investigated the predictive capacity of lesion-induced network damage on depressive symptoms in discovery cohort of 96 patients, at baseline and six months post-stroke. Stepwise functional connectivity (SFC) was used to examine topological changes in the depression network over time to identify patterns of network reorganization. …”
Get full text

Harnessing metabolomics for enhanced crop drought tolerance by Ali Raza, Muhammad Anas, Savita Bhardwaj, Rakeeb Ahmad Mir, Sidra Charagh, Minhas Elahi, Xinyue Zhang, Reyazul Rouf Mir, Wolfram Weckwerth, Alisdair R. Fernie, Kadambot H.M. Siddique, Zhangli Hu, Rajeev K. Varshney

Get full text