Back pain exercise therapy remodels human epigenetic profiles in buccal and human peripheral blood mononuclear cells: an exploratory study in young male participants by Claire Burny, Mia Potočnjak, Mia Potočnjak, Annika Hestermann, Sophie Gartemann, Michael Hollmann, Frank Schifferdecker-Hoch, Nina Markanovic, Simone Di Sanzo, Simone Di Sanzo, Michael Günsel, Victor Solis-Mezarino, Moritz Voelker-Albert, Moritz Voelker-Albert

“…Monitored exercise therapy is a commonly prescribed treatment to relieve pain and functional limitations. However, the benefits of exercise are often gradual, subtle, and evaluated by subjective self-reported scores. …”
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Use of Indocyanine Green (ICG) to Assess Myocardial Perfusion and Territorial Distribution of Vein Grafts Implanted on Coronary Arteries in an Ex-vivo Porcine Model. A Potential Ad... by Cristiano Spadaccio, Antonio Nenna, Diletta Corrado, Carter Glenn, Antonio Panza, Russell Vester, Grzegorz Laskawski, David Rose, Louis Louis

“…The heart was divided into functional regions: anterior wall, lateral wall, inferior wall and right ventricle. …”
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Exploring the Extremes: Characterizing a New Population of Old and Cold Brown Dwarfs by Aaron M. Meisner, S. K. Leggett, Sarah E. Logsdon, Adam C. Schneider, Pascal Tremblin, Mark Phillips

“…Mapping out the populations of thick disk and halo brown dwarfs is important for understanding the metallicity dependence of low-temperature atmospheres and the substellar mass function. …”
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Integrative in silico and Petra/Osiris/Molinspiration (POM) analysis of baicalein: identification of therapeutically relevant pharmacophores against keloid pathology by Abhay Mishra, Anothai Tangsumranjit, Manisha Nigam, Harish Chandra, Faisal A. Almalki, Taibi Hadda, Neti Waranuch

“…Such ligands are crucial for forming bimetallic complexes that can function as efficient biocatalysts against various biological targets. …”
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Dynamics of cerebral blood flow following sertraline treatment in adolescent depression by Wenyu Ren, Wenyu Ren, Xiao Liu, Zhiwei Zhang, Xiaoqin Zhang, Wei Wu, Xingyu Wang, Zhihui Yu, Chuan Liu, Renqiang Yu

“…Among the depressed cohort, 25 participants adhered to the treatment protocol and completed MRI scans. Resting-state functional MRI (rs-fMRI) scans were conducted for all participants, with a subsequent scan for the depression group after 8 weeks of sertraline therapy. …”
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Genetic polymorphism of renin-angiotensin-aldosterone system in type 2 diabetes and in combination with arterial hypertension among Dagestan inhabitants by Marat Z. Saidov, Suleiman N. Mammaev, Halina M. Magadova, Rita Maratovna Balamirzoeva, Zulfia Sh. Magomedova, Zarema S. Magomedova, Aishat U. Gamzaeva

“…BACKGROUND: Type 2 diabetes and arterial hypertension are frequent comorbidities under which activation the renin-angiotensin-aldosterone system is important pathogenetic link. The functional state of the RAAS is genetically determined. …”
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Single-cell transcriptome and multi-omics integration reveal ferroptosis-driven immune microenvironment remodeling in knee osteoarthritis by Yushun Wu, Jing Liu, Wenying Yu, Xiaoding Wang, Jian Li, Weiquan Zeng

“…Functional enrichment (GSEA/GSVA) and immunometabolic profiling were performed.ResultsTwelve chondrocyte clusters were identified, including ferroptosis-active homeostasis chondrocytes (HomC) (p < 0.01), which exhibited 491 DEGs linked to lipid peroxidation. …”
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Evaluation of internal fixation stability of distal humerus C-type fractures based on musculoskeletal dynamics: finite element analysis under dynamic loading by Zhengfeng Jia, Cheng Xu, Weilu Gao, Changsen Yang, Peifu Tang, Jiantao Li

“…Results In this study, we systematically evaluated the biomechanical pattern of internal fixation of distal humerus fracture as well as the postoperative safe activity window and elucidated the enhancement path of functional recovery of distal humerus fracture utilizing AnyBody musculoskeletal dynamics analysis. …”
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Integrative profiling of lung cancer biomarkers EGFR, ALK, KRAS, and PD-1 with emphasis on nanomaterials-assisted immunomodulation and targeted therapy by Li Peng, Hongmei Li, Wencai Yan, Yingjie Liu, Haihao Zhu, Yingcai Hong

“…Protein–protein interaction (PPI) networks were constructed via STRING to explore functional associations and signaling networks. Molecular docking using SwissDock evaluated the binding affinities of established inhibitors. …”
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Drawing as an experience. Knowledge, simulation and participation by Giuseppe Amoruso

“…</p><p>In this renewed social context, the role of the designer who designs or transforms interiors requires a visionary and imaginative force that must translate the cultural dimension of the project into formal expression but also ensure a functional and environmental character that is nowadays integrated by digital technologies. …”
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Koopman-based linearization of preparatory EEG dynamics in Parkinson’s disease during galvanic vestibular stimulation by Maryam Kia, Maryam Kia, Maryam S. Mirian, Saeed Soori, Saeed Saedi, Emad Arasteh, Mohamad Hosein Faramarzi, Abhijit Chinchani, Soojin Lee, Artur Luczak, Martin J. McKeown

“…Galvanic Vestibular Stimulation (GVS), a non-invasive neuromodulation technique, shows promise in enhancing motor function in PD, but its underlying neural mechanisms are poorly understood. …”
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Eco-friendly approach to corrosion inhibition of aluminum by Congo red dye in alkaline media: Experimental assessment, QSAR modeling, diffusion studies, and DFT/MC/MD simulations by Ayoub Chahid, Said Meftah, Mohamed Essahli, Mohammed Chafi, Rachid Kellal, Driss Benmessaoud Left, Mustapha Zertoubi

“…DFT and DFTB+ calculations identified key adsorption centers through Mulliken charges, MEP maps, and Fukui functions. COSMO-RS and sigma profile analysis revealed favorable solvation and hydrogen-bonding behavior. …”
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Diagnostic capabilities of cardiac computed tomography in the preoperative diagnosis of hypertrophic cardiomyopathy by Olga Y. Dariy, Liudmila A. Yurpolskaya, Inna E. Rychina, Aleksey V. Dorofeev, Elena Z. Golukhova

“…Moreover, to assess myocardial structure remodeling, iodine dual-energy computed tomography maps obtained with delayed contrast enhancement were analyzed. …”
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Quantitative SISCOM assessment for epileptogenic zone localization: insights from a multicenter study comparing two software platforms in temporal lobe epilepsy by Carla Oliveira Young, Brunno Machado de Campos, Edna Marina de Souza, Sergio Querino Brunetto, Maria Julia de Oliveira Santos Gualberto, Leonardo Alexandre-Santos, Marcos Geraldo Merichelo de Oliveira, Marina Koutsodontis Machado Alvim, Fernando Cendes, Elba Etchebehere, Lauro Wichert-Ana, Bárbara Juarez Amorim

“…IntroductionPharmacoresistant epilepsy affects around one-third of individuals with epilepsy, requiring precise diagnosis, particularly in cases where surgical resection of the epileptogenic zone (EZ) is an option. Functional imaging techniques, such as ictal-interictal subtraction SPECT coregistered to MRI (SISCOM), have proven useful in pre-surgical evaluation by improving EZ localization accuracy. …”
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Hybrid Graph Representation and Learning Framework for High-Level Synthesis Design Space Exploration by Pouya Taghipour, Eric Granger, Yves Blaquiere

“…Learning-based methods, particularly graph neural networks (GNNs), have shown considerable potential in addressing HLS QoR/DSE problems by modeling the mapping function from control data flow graphs (CDFGs) of HLS designs to their logic, enabling early estimation of QoR during the compilation phase of the hardware design flow. …”
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Genome-wide characterization and expression analysis of the ADF gene family in response to salt and drought stress in alfalfa (Medicago sativa) by Mengmeng Shi, Yike Wang, Peng Lv, Yujie Gong, Qi Sha, Xinyan Zhao, Wen Zhou, Lingtao Meng, Zegang Han, Lingxiao Zhang, Lingxiao Zhang, Yongwang Sun, Yongwang Sun

“…These results provide comprehensive information on the MsADF gene family in alfalfa and lay a solid foundation for elucidating their biological function.…”
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Identification of DNA Methylation Differences in Pituitary Tissues of Sichuan White Geese Using Whole-Genome Bisulfite Sequencing (WGBS) by Lin Ma, Xianzhi Zhao, Guoda A, Tongtong Song, Meng Wu, Zhihao Yan, Min Xiao, Wenbo Jiang, Yixiao Gao, Haiwei Wang, Zhuping Chen, Keshan Zhang, Jiajia Xue, Yi Luo, Chao Wang, Youhui Xie, Ying Chen, Guangliang Gao, Qigui Wang

“…We achieved high-quality sequencing data (mean 19.09 Gb raw reads, 15.49 Gb clean reads, 79.1% unique mapping rate) with a bisulfite conversion efficiency of 99.88%. …”
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Dynamic Cap‐Mediated Substrate Access and Potent Inhibitor Design of Monkeypox Virus I7L Protease by Haixia Su, Guoqing Wu, Muya Xiong, Yuhang Wang, Junyuan Cao, Mengyuan You, Yingchun Xiang, Tianqing Nie, Minjun Li, Gengfu Xiao, Leike Zhang, Qiang Shao, Yechun Xu

“…Therefore, this work provides a comprehensive understanding of the MPXV I7L protease's structure, dynamics, and function, and presents an example of successful rational design of covalent peptidomimetic inhibitors, serving as a good starting point for drug development against MPXV.…”
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The effect of different water types commonly applied during laser diffraction measurement on the particle size distribution of soils by Viktória Labancz, Hilda Hernádi, Gyöngyi Barna, Zsófia Bakacsi, Tamás Szegi, Mihály Kocsis, András Makó

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Examining inter‐regional and intra‐seasonal differences in wintering waterfowl landscape associations among Pacific and Atlantic flyways by Matthew J. Hardy, Christopher K. Williams, Brian S. Ladman, Maurice E. Pitesky, Cory T. Overton, Michael L. Casazza, Elliott L. Matchett, Diann J. Prosser, Jeffrey J. Buler

“…We used 9 years (2014–2023) of data from the US NEXRAD network to model winter waterfowl relative abundance in the CVC and MA as a function of weather, temporal period, environmental conditions, and landcover characteristics using boosted regression tree modelling. …”
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