Leveraging AI to explore structural contexts of post-translational modifications in drug binding by Kirill E. Medvedev, R. Dustin Schaeffer, Nick V. Grishin

“…Abstract Post-translational modifications (PTMs) play a crucial role in allowing cells to expand the functionality of their proteins and adaptively regulate their signaling pathways. …”
Get full text

Shared transcriptional regulators and network rewiring identify therapeutic targets linking type 2 diabetes mellitus and hypertension by Claudia Desireé Norzagaray-Valenzuela, Claudia Desireé Norzagaray-Valenzuela, Marco Antonio Valdez-Flores, Josue Camberos-Barraza, Josue Camberos-Barraza, Alberto Kousuke De la Herrán-Arita, Juan Fidel Osuna-Ramos, Javier Magaña-Gómez, Carla Angulo-Rojo, Alma Marlene Guadrón-Llanos, Katia Aviña-Padilla, Loranda Calderón-Zamora

“…Functional enrichment analyses were conducted to elucidate biological processes associated with disease-specific modules.ResultsWe identified distinct regulatory modules: ME3 in T2DM, enriched in metabolic stress response, intracellular trafficking, and inflammation, and ME7 in HTN, enriched in immune response and vascular remodeling. …”
Get full text

Standardized low-resolution brain electromagnetic tomography does not improve EEG Alzheimer's disease assessment by Wolfgang Frühwirt, Martin Mairhofer, Andreas Hahn, Heinrich Garn, Markus Waser, Reinhold Schmidt, Thomas Benke, Peter Dal-Bianco, Gerhard Ransmayr, Dieter Grossegger, Stephen Roberts, Georg Dorffner

“…However, none have investigated whether this complex mapping into 3D space actually adds value over standard surface derivation. …”
Get full text

Differential methylation patterns in cord blood associated with prenatal exposure to neighborhood crime: an epigenome-wide association study and regional analysis by Chantel L. Martin, Jiawen Chen, Alena S. D’Alessio, Cavin K. Ward-Caviness, Ai Ye, Evans K. Lodge, Lea Ghastine, Radhika Dhingra, Dereje D. Jima, Susan K. Murphy, Cathrine Hoyo

“…Genetic influence and gene expression enrichment were assessed using methylation quantitative trait loci (mQTLs) and expression quantitative trait methylation (eQTMs) analyses. Functional enrichment was determined using Gene Ontology and KEGG databases. …”
Get full text

Detailed Investigation of Cobalt-Rich Crusts in Complex Seamount Terrains Using the Haima ROV: Integrating Optical Imaging, Sampling, and Acoustic Methods by Yonghang Li, Huiqiang Yao, Zongheng Chen, Lixing Wang, Haoyi Zhou, Shi Zhang, Bin Zhao

“…To enhance surveys of cobalt-rich crusts (CRCs) on complex seamount terrains, the 4500-m-class Haima ROV integrates advanced payloads, such as underwater positioning systems, multi-angle cameras, multi-functional manipulators, subsea shallow drilling systems, sediment samplers, and acoustic crust thickness gauges. …”
Get full text

Assessing the Compaction Quality of Dolomitic Asphalt Pavements Using Ground Penetrating Radar by Enas Abdelsamei, Diaa Sheishah, Zalán Tobak, Ahmed M. Ali, Károly Barta, Abdelouahed Fannakh, Gergő Magyar, Viktória Blanka-Végi, György Sipos

“…Consequently, a robust function was developed, which can be applied to other asphalts with similar compositions.…”
Get full text

Bibliometric analysis of the S24-7 family and its association with health by Fangmei Gao, Fangmei Gao, Fangmei Gao, Fenfen Wang, Dandan Wang, Guankui Du, Guankui Du, Guankui Du, Fangfang Gao, Fangfang Gao

“…The top three academic journals for S24-7 family research are Food and Function, Frontiers in Microbiology, and Nutrition. …”
Get full text

Dynamic synthetic-scanning photoacoustic tracking monitors hepatic and renal clearance pathway of exogeneous probes in vivo by Jing Lv, Hengrong Lan, Aoji Qin, Tong Sun, Dan Shao, Fei Gao, Junjie Yao, Kamran Avanaki, Liming Nie

“…Inspired by this, we investigated the clearance pathway of a clinical drug, mitoxantrone, revealing reduced liver clearance when hepatic function is impaired. Furthermore, immunoglobulin G clearance analysis revealed significant differences among mice with varying renal injury degrees. …”
Get full text

Identification of a novel linear B-cell epitope recognized by a monoclonal antibody against the capsid protein of goose astrovirus genotypes 2 by Haiqin Li, Haoyu Huang, Cui Lin, Fanfan Zhang, Jia Tan, Na Li, Chengcheng Wu, Jiangnan Huang, Qipeng Wei, Siyi Wang, Yujun Zhu, Yanbing Zeng

“…Conclusions These findings will be useful for the development of diagnostic kits for GoAstV-2 and will aid further research on the structure and function of the capsid protein.…”
Get full text

Multi-Scale Long- and Short-Range Structure Aggregation Learning for Low-Illumination Remote Sensing Imagery Enhancement by Yu Cao, Yuyuan Tian, Xiuqin Su, Meilin Xie, Wei Hao, Haitao Wang, Fan Wang

“…., local continuity) structures distributed across different scales of each input LI image to build an appropriate deep mapping function from the LI images to their corresponding high-quality counterparts. …”
Get full text

Identification of genetic locus with resistance to take-all in the wheat-Psathyrostachys huashanica Keng introgression line H148 by Sheng-sheng BAI, Han-bing ZHANG, Jing HAN, Jian-hui WU, Jia-chuang LI, Xing-xia GENG, Bo-ya LÜ, Song-feng XIE, De-jun HAN, Ji-xin ZHAO, Qun-hui YANG, Jun WU, Xin-hong CHEN

“…Genotyping of the F2 population using the KASP marker mapped a major QTL in an interval of 68.8–70.1 Mb on 2AS. …”
Get full text

A generative whole-brain segmentation model for positron emission tomography images by Wenbo Li, Zhenxing Huang, Hongyan Tang, Yaping Wu, Yunlong Gao, Jing Qin, Jianmin Yuan, Yang Yang, Yan Zhang, Na Zhang, Hairong Zheng, Dong Liang, Meiyun Wang, Zhanli Hu

“…A 3D multi-object segmentation model was subsequently proposed to apply whole-brain segmentation to MR images generated from integrated latent mapping models. Moreover, a custom cross-attention module based on a cross-attention mechanism was constructed to effectively fuse the functional information and structural information. …”
Get full text

Genomic Survey of Genes Encoding Major Intrinsic Proteins (MIPs) and Their Response to Arsenite Stress in Pepper (<i>Capsicum annum</i>) by Syed Muhammad Azam, Kaixuan Huang, Jiaxin Yuan, Yanqing Bai, Qiaolin Chen, Panpan Dang, Hend Alwathnani, Hajar Fahad Bin Zayid, Renwei Feng, Christopher Rensing

“…Our study provides important insights into the arsenite uptake and detoxification, offering a foundation for further functional and stress-tolerance studies.…”
Get full text

Identification and characterization of Sr59-mediated stem rust resistance in a novel wheat-rye translocation T2BL·2BS-2RL by Mahboobeh Yazdani, Matthew N. Rouse, Prabin Bajgain, Tatiana V. Danilova, Ivan Motsnyi, Brian J. Steffenson, Mehran Patpour, Mahbubjon Rahmatov

“…This study aimed physical mapping of Sr59 in the 2RL introgression segment and develop a robust molecular marker for marker-assisted selection. …”
Get full text

Evaluating Factors Affecting Interior Architectural Space Quality to Enhance Spatial Resilience and Human Productivity: An Application of Maslow’s Hierarchy of Needs by Moharam Ghahremani Drvish, Farhang Mozafar, Ceyed bagher Hoseini, Fateme Mahdizadeye seraj

“…The results were then mapped onto Abraham Maslow's Hierarchy of Needs. In the current research, the central role of employee productivity has been considered as an influential variable in connecting all components. …”
Get full text

Feature extraction and classification of digital rock images via pre-trained convolutional neural network and unsupervised machine learning by Masashige Shiga, Masao Sorai, Tetsuya Morishita, Masaatsu Aichi, Naoki Nishiyama, Takashi Fujii

Get full text

A Label Correction Learning Framework for Gully Erosion Extraction Using High-Resolution Remote Sensing Images and Noisy Labels by Chunhui Zhao, Yi Shen, Nan Su, Yiming Yan, Shou Feng, Wei Xiang, Yong Liu, Tianhao Zhao

“…To achieve this, we introduce three key components in the framework, including an adaptive correction loss function, a multitree refinement module, and a noise correction module. …”
Get full text

A small RNA from Streptococcus suis epidemic ST7 strain promotes bacterial survival in host blood and brain by enhancing oxidative stress resistance by Zijing Liang, Shuoyue Wang, Xinchi Zhu, Jiale Ma, Huochun Yao, Zongfu Wu

“…In this study, we found that a small RNA rss03 is predominantly present in S. suis, Streptococcus parasuis, and Streptococcus ruminantium, implying a conserved biological function. rss03 with a size of 303 nt mainly exists in S. suis sequence type (ST) 1 and epidemic ST7 strains that are responsible for human infections in China. …”
Get full text

Characterizing myocardial edema and fibrosis in hypertensive crisis with cardiovascular magnetic resonance imaging by Mohammed A. Talle, Pieter-Paul S. Robbertse, Anton F. Doubell, Sa’ad Lahri, Philip G. Herbst

“…Although altered cardiac structure, function, and myocardial architecture on cardiovascular magnetic resonance (CMR) have been associated with increased adverse events in hypertensive patients, the studies did not include patients with hypertensive crisis. …”
Get full text

Untrained perceptual loss for image denoising of line-like structures in MR images. by Elisabeth Pfaehler, Daniel Pflugfelder, Hanno Scharr

“…In particular, we investigate if the special characteristics of these datasets (connectivity, sparsity) benefit from the use of special loss functions for network training. We hereby translate the Perceptual Loss to 3D data by comparing feature maps of untrained networks in the loss function. …”
Get full text