Resolving mechanisms of immune‐mediated disease in primary CD4 T cells by Christophe Bourges, Abigail F Groff, Oliver S Burren, Chiara Gerhardinger, Kaia Mattioli, Anna Hutchinson, Theodore Hu, Tanmay Anand, Madeline W Epping, Chris Wallace, Kenneth GC Smith, John L Rinn, James C Lee

“…To determine whether causal variants could be identified from their functional effects, we adapted a massively parallel reporter assay for use in primary CD4 T cells, the cell type whose regulatory DNA is most enriched for immune‐mediated disease SNPs. …”
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WCMU-net: An Effective Method for Reducing the Impact of Speckle Noise in SAR Image Change Detection by Yu Duan, Kaimin Sun, Wangbin Li, Jinjiang Wei, Song Gao, Yingjiao Tan, Wanghui Zhou, Jun Liu, Junyi Liu

“…In this study, we introduce a focal loss function to enhance the robustness of the network, allowing for high-precision change detection of SAR images with different noise levels through parameter adjustment. …”
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Research trends and hotspots of central sleep apnea: a bibliometric analysis by Yin-Chao Hao, Yin-Chao Hao, Meng-Chu Zhu, Meng-Chu Zhu, Wei-Xuan Li, Jing-Jing Sha, Xue-Tong Dong, Song-Jun Wang, Chao-Long Lu, Chao-Long Lu

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Comparison of short-term clinical outcomes of intra-articular injection of micro-fragmented adipose tissue and stromal vascular fraction cells for knee osteoarthritis treatment: A... by Takuma Maeda, Satoshi Sobajima, Tomoyuki Matsumoto, Masanori Tsubosaka, Takehiko Matsushita, Hideki Iwaguro, Ryosuke Kuroda

“…Patients with KL grades I–IV varus knee OA, significant pain (VAS ≥40), and functional impairment despite conservative treatments were included. …”
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History and prospects of flax genetic markers by Daiana A. Zhernova, Elena N. Pushkova, Tatiana A. Rozhmina, Elena V. Borkhert, Alexander A. Arkhipov, Alexander A. Arkhipov, Elizaveta A. Sigova, Elizaveta A. Sigova, Ekaterina M. Dvorianinova, Ekaterina M. Dvorianinova, Alexey A. Dmitriev, Alexey A. Dmitriev, Nataliya V. Melnikova

“…A major challenge remains the lack of knowledge on functional polymorphisms. To date, only a few are known, mainly mutations in the FAD3 genes responsible for reduced linolenic acid content in linseed oil. …”
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New State Identification Method for Rotating Machinery under Variable Load Conditions Based on Hybrid Entropy Features and Joint Distribution Adaptation by Xiaoming Xue, Nan Zhang, Suqun Cao, Wei Jiang, Jianzhong Zhou, Liyan Liu

“…Then, hybrid entropy features that can characterize the dynamic and complexity of time series in the local space, global space, and frequency domain were extracted from each intrinsic mode function. As for the training and testing set under different load conditions, all data was mapped into a reproducing space by joint distribution adaptation to reduce the distribution discrepancies between datasets, where the pseudolabels of the testing set and the final diagnostic results were obtained by the k-nearest neighbor algorithm. …”
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Harnessing the diversity of a lettuce wild relative to identify anthocyanin-related genes transcriptionally responsive to drought stress by Inés Medina-Lozano, Inés Medina-Lozano, Jérôme Grimplet, Jérôme Grimplet, Aurora Díaz, Aurora Díaz

“…Some wild variants had high or moderate predicted impacts on the respective protein function: a transcription factor that responds to abiotic stresses, a heat shock protein involved in stomatal closure, and a phospholipase participating in anthocyanin accumulation under abiotic stress. …”
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Optical Full Adder Based on Integrated Diffractive Neural Network by Chenchen Deng, Yilong Wang, Guangpu Li, Jiyuan Zheng, Yu Liu, Chao Wang, Yuyan Wang, Yuchen Guo, Jingtao Fan, Qingyang Du, Shaoliang Yu

“…To enable precise logical operations, we propose an on-chip nonlinear solution leveraging the similarity between the hyperbolic tangent (tanh) function and reverse saturable absorption characteristics of quantum dots. …”
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Get ready for short tandem repeats analysis using long reads-the challenges and the state of the art by Marija Chaushevska, Marija Chaushevska, Karmele Alapont-Celaya, Anne Kristine Schack, Anne Kristine Schack, Lukasz Krych, M. Carmen Garrido Navas, M. Carmen Garrido Navas, M. Carmen Garrido Navas, Anastasia Krithara, Gjorgji Madjarov, Gjorgji Madjarov

“…Certain repeat expansions can significantly impact cellular function by altering protein synthesis, impairing DNA repair, and leading to neurodegenerative and neuromuscular diseases. …”
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Ydj1 governs fungal morphogenesis and stress response, and facilitates mitochondrial protein import via Mas1 and Mas2 by Jinglin L. Xie, Iryna Bohovych, Erin O.Y. Wong, Jean-Philippe Lambert, Anne-Claude Gingras, Oleh Khalimonchuk, Leah E. Cowen, Michelle D. Leach

“…Additional analysis demonstrated that loss of MAS1, MAS2 or YDJ1 perturbs mitochondrial morphology and function. Deletion of YDJ1 impairs import of Su9, a protein that is cleaved to a mature form by Mas1 and Mas2. …”
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Kinematics of Supernova Remnants Using Multiepoch Maximum Likelihood Estimation: Chandra Observation of Cassiopeia A as an Example by Yusuke Sakai, Shinya Yamada, Toshiki Sato, Ryota Hayakawa, Nao Kominato

“…To achieve greater accuracy in capturing the dynamics of SNRs, kinematic features and point-spread function effects were integrated into the MLE framework. …”
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The Significance of Cellular Senescence Hub Genes in the Diagnosis and Subtype Classification of a Comprehensive Database of Gene Expression in Intervertebral Disc Degeneration by Fei Liu, Silong Gao, Ji Yin, Chao Song, Yongliang Mei, Zhaoqiang Wang, Zongchao Liu

“…We further explored the functional and prognostic significance of these genes using support vector machine recursive feature elimination (SVM‐RFE), random forest (RF), and least absolute shrinkage and selection operator (LASSO) algorithms. …”
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Metabolomic profiling of rectal microorganisms in Tibetan sheep across cold and warm seasons by Qi-Tala An, Zhipeng Zhao, Yaxiong Ren, Xia Liu, Liangwei Yao, Siyuan Chen, Zhikuan Yuan, Peijian Feng, Wenhao Li, Xiaohua Du

“…The current study sought to investigate the characteristics of alterations in rectal metabolites and their functional implications during the cold and warm seasons in Tibetan sheep. …”
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Moving beyond post hoc explainable artificial intelligence: a perspective paper on lessons learned from dynamical climate modeling by R. J. O'Loughlin, D. Li, R. Neale, T. A. O'Brien, T. A. O'Brien

“…We propose three types of understanding as a basis to evaluate trust in dynamical and AI models alike: (1) instrumental understanding, which is obtained when a model has passed a functional test; (2) statistical understanding, obtained when researchers can make sense of the modeling results using statistical techniques to identify input–output relationships; and (3) component-level understanding, which refers to modelers' ability to point to specific model components or parts in the model architecture as the culprit for erratic model behaviors or as the crucial reason why the model functions well. …”
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A scoping review of stroke rehabilitation in Africa: interventions, barriers, and research gaps by Nicholas Aderinto, Gbolahan Olatunji, Emmanuel Kokori, Chinonyelum Emmanuel Agbo, Adetola Emmanuel Babalola, Ismaila Ajayi Yusuf, Edun Mariam Tolulope, Anuoluwa Oyeboyin Oyelude, Faith Adedayo Adejumo, Israel Charles Abraham

“…Findings indicate that stroke rehabilitation interventions in Africa, including physical therapy, task-specific training, psychoeducational programs, tele-rehabilitation, mobile phone-supported interventions, and programs targeting activities of daily living (ADLs), are implemented in some settings to enhance functional independence, motor, cognitive, and speech functions, and psychological well-being. …”
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Circulating Plasma Proteins as Biomarkers for Immunotherapy Toxicity: Insights from Proteome-Wide Mendelian Randomization and Bioinformatics Analysis by Liansha Tang, Wenbo He, Handan Hu, Jiyan Liu, Zhike Li

“…Systems biology approaches including tissue-specific expression profiling, pathway enrichment, and protein interaction network analysis revealed spatial and functional drivers of irAE pathogenesis. <b>Results:</b> Proteome-wide MR mapping identified eight plasma proteins (CCL20, CSF1, CXCL9, CD40, TGFβ1, CLSTN2, TNFSF12, TGFα) causally associated with all-grade irAEs, and five (CCL20, CCL25, CXCL10, ADA, TGFα) with high-grade irAEs. …”
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Spatial and seasonal distribution of selected nitrogen cycle genes in deep waters of the Baltic Proper by Michał Grabski, Michał Grabski, Ewa Kotlarska, Aneta Łuczkiewicz, Konrad Hryniewicz, Grzegorz Węgrzyn, Beata Szymczycha

“…As the microbial community structure and functional capacities remain underestimated in terms of temporal and geographical coverage in the Baltic Sea, our understanding of the nitrogen cycle with respect to ecosystem functioning and climate change is limited. …”
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Interventions to improve mental health and well-being in care-experienced children and young people aged less than 25: the CHIMES systematic review by Rhiannon Evans, Sarah MacDonald, Robert Trubey, Jane Noyes, Michael Robling, Simone Willis, Soo Vinnicombe, Maria Boffey, Charlotte Wooders, Asmaa El-Banna, GJ Melendez-Torres

“…Limitations The review was limited by a paucity of theory and economic evaluations, so it is unclear how interventions might function or their potential cost-effectiveness. Interventions were insufficiently described, making it challenging to map the evidence base. …”
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A Patent Infringement Analysis Approach Based on Patent Knowledge Graph Driven Fusion of Graph and Image Similarity by Liting Jing, Chenlong Zhou, Di Feng, Yubo Dou, Xiaoyan Fan, Shaofei Jiang

“…First, an ontology model based on requirement-function-structure-location features (RFSL) is constructed. …”
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New Concepts in Phospholipase D Signaling in Inflammation and Cancer by Julian Gomez-Cambronero

“…Lastly, there is evidence in the upstream direction of cell signaling that mTOR and S6K keep PLD2 gene expression function down-regulated in basal conditions. In summary, the involvement of PLD2 in cell signaling continues to expand geometrically. …”
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