Exploring alternative paramedic roles: a multinational mixed-methods survey by Fintan Feerick, Eoin Coughlan, Shane Knox, Adrian Murphy, Ivan Grady, Conor Deasy

“…Quantitative data were analysed using Microsoft Excel’s statistical functions, with results presented as frequencies, percentages, and numerical summaries. …”
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Proteomic Analysis of the Effects of Shenzhu Tiaopi Granules on Model Rats with Type 2 Diabetes Mellitus by Zhao JD, Fang ZH

“…Jin-Dong Zhao,1– 3 Zhao-Hui Fang1– 3 1Department of Endocrinology Two, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230031, People’s Republic of China; 2Center for Xin’an Medicine and Modernization of Traditional Chinese Medicine of IHM, the First Affiliated Hospital of Anhui University of Chinese Medicine, Hefei, Anhui Province, 230012, People’s Republic of China; 3Diabetes Institute, Anhui Academy Chinese Medicine, Hefei, 230012, People’s Republic of ChinaCorrespondence: Zhao-Hui Fang, Department of Endocrinology Two, the First Affiliated Hospital of Anhui University of Chinese Medicine, 117 Meishan Road, Hefei, Anhui Province, 230031, People’s Republic of China, Email fangzhaohui1111@163.comBackground: Shenzhu Tiaopi granule (STG) has antidiabetic functions. Data-independent acquisition proteomic technology is an integral part of systems biology. …”
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Lipidomic and proteomic insights from extracellular vesicles in the postmortem dorsolateral prefrontal cortex reveal substance use disorder-induced brain changes by Chioma M. Okeoma, Wasifa Naushad, Bryson C. Okeoma, Carlos Gartner, Yulica Santos-Ortega, Calvin Vary, Savio Lima-Bastos, Victor Corasolla Carregari, Martin R. Larsen, Alessio Noghero, Consuelo Walss-Bass, Rodrigo Grassi-Oliveira

“…Gene Ontology (GO) and protein‒protein interactome analyses revealed functions associated with the identified proteins, such as cell motility, focal adhesion, and acute phase response signaling. …”
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Patients’ daily reporting of symptoms via mobile application reveals a significant difference between patients’ perceptions and doctors’ interpretations by Cvetka Grašič Kuhar, Cvetka Grašič Kuhar, Nina Privšek, Nina Privšek, Marjetka Sraka, Marjetka Sraka, Ema Grašič, Ema Grašič, Timotej Kovač, Matjaž Kukar

“…After three months of chemotherapy, QoL assessments revealed worsening of physical, social, cognitive and role functioning, increased fatigue, systemic therapy side effects, and dyspnea but a reduction in arm and shoulder problems. …”
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Neural network prediction model based on Levy flight and natural biomimetic technology for its application in cancer prediction. by Ruiyu Zhan

“…We performed comparative analyses against other methodologies across various functions and public datasets to assess their effectiveness. …”
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Deubiquitinating Enzymes Regulate Skeletal Muscle Mitochondrial Quality Control and Insulin Sensitivity in Patients With Type 2 Diabetes by Wagner S. Dantas, Elizabeth C. Heintz, Elizabeth R. M. Zunica, Jacob T. Mey, Melissa L. Erickson, Kathryn P. Belmont, Analisa L. Taylor, Gangarao Davuluri, Hisashi Fujioka, Ciarán E. Fealy, Charles L. Hoppel, Christopher L. Axelrod, John P. Kirwan

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Trauma-focused dialectical behavior therapy: study protocol for a randomized controlled multi-center trial in online and face-to-face formats by Ruben Vonderlin, Tali Boritz, Carola Claus, Büsra Senyüz, Saskia Mahalingam, Julia Schmelz, Silja Knolle-Ventjeer, Philip S. Santangelo, Ulrich W. Ebner-Priemer, Christian Schmahl, Jürgen Margraf, Tobias Teismann, Stefanie Lis, Nikolaus Kleindienst, Shelley McMain, Martin Bohus

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Identification and characterization of early human photoreceptor states and cell-state-specific retinoblastoma-related features by Dominic WH Shayler, Kevin Stachelek, Linda Cambier, Sunhye Lee, Jinlun Bai, Bhavana Bhat, Mark W Reid, Daniel J Weisenberger, Jennifer G Aparicio, Yeha Kim, Mitali Singh, Maxwell Bay, Matthew E Thornton, Eamon K Doyle, Zachary Fouladian, Stephan G Erberich, Brendan H Grubbs, Michael A Bonaguidi, Cheryl Mae Craft, Hardeep P Singh, David Cobrinik

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Intervenções baseadas em métodos de relaxação em contexto escolar na perspetiva de promoção de saúde e bem-estar: uma revisão sistemática (Relaxation methods based interventions i... by Sara Sarroeira, Beatriz Oliveira Pereira, Graça S. Carvalho, Eugenio Rodríguez Fernandéz

“…The results suggest that the concept of relaxation can be used from different perspectives and that relaxation for children promotes the reduction of visible symptoms of anxiety, the improvement of autonomous functions, the child's autonomy and initiative, the interactions with others, the socio-emotional development and short-term memory development. …”
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Phase 1 trial of durvalumab (anti–PD-L1) combined with lenalidomide in relapsed/refractory cutaneous T-cell lymphoma by Christiane Querfeld, Joycelynne Palmer, Zhen Han, Xiwei Wu, Yate-Ching Yuan, Min-Hsuan Chen, Chingyu Su, Ni-Chun Tsai, D. Lynne Smith, Samantha N. Hammond, Liliana Crisan, Joo Y. Song, Raju Pillai, Steven T. Rosen, Jasmine Zain

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Hippo/YAP signaling pathway in colorectal cancer: regulatory mechanisms and potential drug exploration by Lingqiu Zhang, Lingqiu Zhang, Lingqiu Zhang, Lingqiu Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Fan Zhang, Haimei Liang, Haimei Liang, Haimei Liang, Haimei Liang, Xiangling Qin, Xiangling Qin, Xiangling Qin, Xiangling Qin, Yuemi Mo, Yuemi Mo, Yuemi Mo, Yuemi Mo, Shiyi Chen, Shiyi Chen, Shiyi Chen, Shiyi Chen, Jinling Xie, Jinling Xie, Jinling Xie, Jinling Xie, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Xiaotao Hou, Jiagang Deng, Jiagang Deng, Jiagang Deng, Jiagang Deng, Jiagang Deng, Erwei Hao, Erwei Hao, Erwei Hao, Erwei Hao, Zhengcai Du, Zhengcai Du, Zhengcai Du, Zhengcai Du

“…Notably, emerging evidence reveals context-dependent tumor-suppressive functions of YAP/TAZ in specific CRC subtypes, such as via suppression of Wnt signaling. …”
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Polygoni Multiflori Radix Praeparata polysaccharides enhance gut health and mitigate ischemic stroke by regulating SCFA and amino acid metabolism in gut microbiota by Lingyu Ruan, Zhennan Wang, Mengyun Zheng, Qi Zheng, Qing Qing, Hongyan Lin, Yuheng Tao, Liqun Wang, Junsong Wang, Wenhao Ge, Wenhao Ge

“…Further, 1H NMR based metabolomics and 16S rRNA gene sequencing examined gut microbiota metabolites and profiles, respectively, in order to elucidate the underlying mechanisms from the perspective of the gut-brain axis.ResultsPMP significantly improved the neurologic functions and reduced the cerebral infarction volume in MCAO/R rats. …”
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Finite element model-based evaluation of the effectiveness of the incisional skinbridge procedure for posterior horseshoe perianal abscess by Shi Rong, Wang Jing, Ke Minhui, Chen Zuqing, Huang Juan, Chen Riqi, Wang Zhaochu

“…Tailoring the skin-bridge design might be crucial in preserving postoperative anal integrity and functionality following perianal abscess surgery.…”
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Comprehensive N-glycosylation profiling of recombinant spike S1 protein from the wild-type SARS-CoV-2 and its variants by Yao Peng, Yao Peng, Yao Peng, Tian-Tian Tong, Qiu-Yu Deng, Lee-Fong Yau, Jia-Qi Qiu, Qing Zhao, Jia-Qi Wu, Zhi-Qiang Xin, Man-Ci Guan, Yue Li, Zhi-Hong Jiang, Hu-Dan Pan, Hu-Dan Pan, Liang Liu, Liang Liu, Liang Liu, Jing-Rong Wang, Jing-Rong Wang

“…UHPLC-TOF MS analysis revealed unoccupied N-glycosylation sites in S1-Gamma (N657), S1-Delta (N61), and S1-Lambda (N17, N61, N657), with N17 and N61 showing low glycan occupancy (0%-3.4%), suggesting these sites may lack glycan shield protection.DiscussionThis study provides a comprehensive N-glycosylation profile of the S1 protein across different variants, offering an essential structural basis for future vaccine development and research on viral functions.…”
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Efficiency evaluation of product oil pipeline under transportation market by Hao ZHANG, Renfu TU, Xu ZHANG, Xinyi YANG, Yiwei SU, Yuheng XIA, Jun YAN, Rui QIU

“…This method was devised based on the engineering practices of pipelines, integrating operational requirements at refineries, oil storage facilities, and transportation channels. …”
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Determinants of divergent Salmonella and Shigella epithelial colonization strategies resolved in human enteroids and colonoids by Petra Geiser, Maria Letizia Di Martino, Ana C. C. Lopes, Alexandra Bergholtz, Magnus Sundbom, Martin Skogar, Wilhelm Graf, Kajsa Björner, Johan Vessby, Dominic-Luc Webb, Per M. Hellström, Jens Eriksson, Mikael E. Sellin

“…Taken together, the study reveals how a small set of virulence factors shapes divergent epithelial colonization strategies by related enterobacteria.IMPORTANCEPathogenic bacteria employ partially overlapping sets of virulence factor functions to colonize host epithelia but can differ markedly in their pathogenesis and disease kinetics. …”
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Genome-Wide Analyses and Expression Profiling of <i>PME</i>/<i>PMEI</i> Gene Families Reveal Their Relevance to Chilling Stress Response and Grafted Healing Efficiency in Cucumber/... by Huangfang Lin, Huilan Ye, Qingqing Shao, Saichuan Cheng, Ge Bi, Biying Lin, Honghui Lin, Lei He, Baoying Shen, Haisheng Zhu, Qingfang Wen, Shuang Liu, Qingqing Chen

“…Pectin methylesterases (PMEs) and their inhibitors (PMEIs) serve as pivotal enzymes in pectin methylation modifications, playing crucial roles in plant morphogenesis, cell adhesion, and maintenance of the cell wall integrity. However, there have been limited studies exploring the functions of the <i>PME</i>/<i>PMEI</i> gene families in the healing process of grafted-cucumber seedlings and their responses to stress conditions. …”
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Biventricular electromechanical dysfunction and molecular remodeling in a rat model of advanced pulmonary arterial hypertension by Francesco Paolo Lo Muzio, Alessia Caputo, Rosario Statello, Mirko Hu, Roberta Maestri, Giovanna Pelà, Aderville Cabassi, Margherita Burattini, Giacomo Rozzi, Silvia Berrettoni, Barbara Montanini, Stefano Rossi, Lorenzo Fassina, Giovanni Battista Luciani, Gianluigi Condorelli, Michele Miragoli

“…Methods In this study, we investigate the late-stage effects of PAH on both electrical and mechanical functions, as well as their coupling, in each ventricle using the monocrotaline-treated rat model. …”
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The prevalence, patterns, and antifungal drug resistance of bloodstream infection-causing fungi in Sichuan Province, China (2019–2023): a retrospective observational study using na... by Jin Deng, Jin Deng, Jin Deng, Ya Liu, Ya Liu, Ya Liu, Ling Shu, Ling Shu, Ling Shu, Dan Zhou, Dan Zhou, Dan Zhou, Yi Xie, Yi Xie, Yi Xie, Ying Ma, Ying Ma, Ying Ma, Mei Kang, Mei Kang, Mei Kang

“…Our objective was to gain insights into regional differences in the distribution and resistance patterns of fungal pathogens.MethodsWe performed a retrospective analysis of fungal bloodstream infections (BSIs) from 31 hospitals (2019–2023). Integrated clinical and laboratory data were analyzed using WHONET 5.6 to assess resistance patterns, and Microsoft Excel (with PivotTable functionality) was used to analyze epidemiological trends.ResultsAnnual fungal isolations increased steadily over the study period. …”
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Reassembly of a tropical rainforest: A new chronosequence in the Chocó tested with the recovery of tree attributes by Sebastián Escobar, Felicity L. Newell, María‐José Endara, Juan E. Guevara‐Andino, Anna R. Landim, Eike Lena Neuschulz, Ronja Hausmann, Jörg Müller, Karen M. Pedersen, Matthias Schleuning, Constance J. Tremlett, Edith Villa‐Galaviz, H. Martin Schaefer, David A. Donoso, Nico Blüthgen

“…Hence, our chronosequence can be used to determine the time for recovery and stability (resistance and resilience) of different taxa and ecosystem functions, including species interaction networks. …”
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