Histology and Immunohistochemistry of Adipose Tissue: A Scoping Review on Staining Methods and Their Informative Value by Tom Schimanski, Rafael Loucas, Marios Loucas, Oliver Felthaus, Vanessa Brébant, Silvan Klein, Alexandra Anker, Konstantin Frank, Andreas Siegmund, Andrea Pagani, Sebastian Geis, Sophia Theresa Diesch, Andreas Eigenberger, Lukas Prantl

“…Background: Histological and immunohistochemical analyses of adipose tissue are essential for evaluating the quality and functionality of lipoaspirates in regenerative medicine and fat grafting procedures. …”
Get full text

Genome-wide association study reveals the genetic basis of vitamin C content in rapeseed (Brassica napus L.) seedlings by Chao Wang, Lieqiong Kuang, Ze Tian, Xinfa Wang, Xinfa Wang, Hanzhong Wang, Hanzhong Wang, Xiaoling Dun

“…Genome-wide association studies (GWAS) identified 31 significant single nucleotide polymorphisms (SNPs) across various chromosomes, which explained 5.68% to 12.78% of the phenotypic variation, integrated into 16 quantitative trait loci (QTLs). Kyoto Encyclopedia of Genes and Genomes (KEGG) and Gene Ontology (GO) enrichment analyses of the 2365 annotated genes near associated SNPs revealed significant involvement in diverse metabolic pathways including peroxisome, ascorbate, secondary metabolites, and terpenoid biosynthesis, as well as biological processes such as hydrogen peroxide/lactate metabolism and ROS biosynthesis, along with associations with specific cellular components and molecular functions. …”
Get full text

Diabetes is causally associated with increased breast cancer mortality by inducing FIBCD1 to activate MCM5-mediated cell cycle arrest via modulating H3K27ac by Binbin Tan, Yang Liu, Qianqian Chen, Weijie Yang, Wenhan Yang, Kaiping Gao, Li Fu, Tiantian Zhang, Penglong Chen, Yongyi Huang, Yuting Wang, Guoqiang Zhang, Juan Xiong, Rihong Zhai

“…Further transcriptomic and qPCR analyses identified that FIBCD1 was highly expressed in BC-DM tumor tissues and in BC cells under hyperglycemia conditions. Functionally, upregulation of FIBCD1 promoted proliferation, migration, and invasion capacities of BC cells in a glucose level-dependent manner. …”
Get full text

Single-Cell RNA Transcriptomics and Multi-omics Analyses Reveal the Clinical Effects of Acupuncture on Methadone Reduction by Yiming Chen, Baochao Fan, Jingchun Zeng, Yutian Zou, Chenyang Tao, Chen Chen, Peiming Zhang, Jian Liang, Fangfang Qi, Hailin Tang, Liming Lu

“…Our findings revealed that acupuncture may activate the defense response to viruses, with altered immune cell functions in classical monocytes correlating with clinical responses to reduced methadone doses. …”
Get full text

Acute cannabis intoxication among the paediatric population by Ginevra Malta, Giuseppe Davide Albano, Gianluca Lavanco, Anna Brancato, Carla Cannizzaro, Antonina Argo, Simona Contorno, Fulvio Plescia, Stefania Zerbo

“…The reliable detection of cannabinoids involves integrating screening methods with confirmatory analytical techniques. …”
Get full text

Nanobodies and their derivatives: pioneering the future of cancer immunotherapy by Haixia Li, Quan Zhou, Nan Cao, Chenghao Hu, Jincheng Wang, Yu He, Shan Jiang, Qi Li, Miao Chen, Li Gong, Ming Luo, Xinzhou Deng, Zhiguo Luo

“…Nonetheless, their short serum half-life and lack of Fc-mediated functions may limit efficacy, which can be addressed by Fc fusion, albumin binding, or multivalent construct design. …”
Get full text

Construction of artificial lung tissue structure with 3D-inkjet bioprinting core for pulmonary disease evaluation by Weimin Wan, Xi Wang, Rongtao Zhang, Yixuan Li, Haonan Wu, Yiman Liu, Fan Zhang, Jia Liu, Guiquan Liu, Lin Zhou, Zhenhua Wu, Hongju Mao, Jian Yang

“…It can also be used to study the role of relevant cells in the disease by adjusting the cell type and adapted to study the bio-functions of immune cells during the cell-cell interactions. …”
Get full text

Climate, soil and management factors drive the quantitative relationships between soil fertility and spring maize water productivity in northern China by Jiao Shi, Minggang Xu, Xinhua He, Huaiping Zhou, Jianhua Li

“…The potential QRs determined by boundary functions were reached up to 6.2, 5.26 and 6.12 kg m−3 in NW, at dry years and under NPK, respectively. …”
Get full text

Enhanced glucose metabolism mediated by CD147 is associated with 18F‐FDG PET/CT imaging in lung adenocarcinoma by Yufan Zhang, Jianjing Liu, Yunchuan Sun, Xiaozhou Yu, Jian Wang, Dong Dai, Yanjia Zhu, Xiuyu Song, Lei Zhu, Xiaofeng Li, Wengui Xu

Get full text

Unraveling edaphic, environmental, and management drivers of soil microbial communities via ester-linked fatty acid methyl esters using a multilocation agroecosystem study by Wayne R. Roper, Verónica Acosta-Martínez, Kristen S. Veum, Christopher J. Burgess, Jennifer M. Moore, Daniel K. Manter, Catherine E. Stewart, Bryan D. Emmett, Mark A. Liebig, Matthew H.H. Fischel, R.Michael Lehman, José G. Franco, Jane M.F. Johnson, Sharon Weyers, Maysoon M. Mikha, Kristin M. Trippe, Jude E. Maul, Robert S. Dungan, Hero T. Gollany, Thomas F. Ducey, Lauren Hale, Virginia L. Jin, Jason S. Cavadini, Catherine L. Reardon

Get full text

Immune-related gene risk model establishment and role of key gene FUCA1 in malignant pleural mesothelioma by Lin Shi, Lin Shi, Lin Shi, Lin Shi, Dongqi Yuan, Dongqi Yuan, Dongqi Yuan, Fuyi Zhu, Yuchao He, Yuchao He, Ran Zuo, Ran Zuo, Liwei Chen, Liwei Chen, Yi Luo, Yi Luo, Yu Wang, Yu Wang, Dingzhi Huang, Dingzhi Huang, Peng Chen, Peng Chen, Hua Guo, Hua Guo

“…Finally, the biological functions of the key gene were examined by in vitro and in vivo experiments.ResultsThe score model was used to divide patients with MPM into low- and high-risk groups. …”
Get full text

Advanced DFE, MLD, and RDE Equalization Techniques for Enhanced 5G mm-Wave A-RoF Performance at 60 GHz by Umar Farooq, Amalia Miliou

“…Furthermore, DFE and MLD are particularly suitable for higher-order modulation formats like 64-QAM and 128-QAM, where accurate equalization and error detection are of utmost importance. The enhanced functionalities of DFE, RDE, and MLD in managing greater modulation orders and expanding transmission range highlight their efficacy in improving the performance and dependability of our system.…”
Get full text

Effectiveness of a Virtual Reality Serious Video Game (The Secret Trail of Moon) for Emotional Regulation in Children With Attention-Deficit/Hyperactivity Disorder: Randomized Clin... by Marina Martin-Moratinos, Marcos Bella-Fernández, María Rodrigo-Yanguas, Carlos González-Tardón, Chao Li, Ping Wang, Ana Royuela, Pilar Lopez-Garcia, Hilario Blasco-Fontecilla

“…ConclusionsSerious video games, when integrated into a multimodal treatment plan, can enhance outcomes for symptoms associated with ADHD. …”
Get full text

THE RESEARCH RESULTS OF TENDER PROCUREMENTS OF THE DRUGS FOR CANCER PATIENTS IN UKRAINE by G. L. Panfilova, O. V. Tsurikova

“…The most important condition for the effective implementation of this program in the functioning of the social model is the introduction of OMI of evidence-based model provide pharmaceutical oncohematological patients according to their actual needs in the various denominations of drugs, as well as the financial capacity of the national health system.…”
Get full text

Protecting Industrial Control Systems From Shodan Exploitation Through Advanced Traffic Analysis by Sayed Reza Ghazinour Naeini, Alireza Shameli-Sendi, Masoume Jabbarifar

“…Unfortunately, this functionality has been exploited by hackers to pinpoint potential attack targets and their associated weaknesses. …”
Get full text

Problems of optimizing the energy consumption of households in the tasks of improving the energy efficiency of the housing sector by G. G. Grebenuk, S. M. Nikishov, A. A. Krygin, L. A. Sereda

“…In the second part, a mathematical model of their  functioning is proposed using examples of specific household  electrical appliances. …”
Get full text

THE MORAL AND ETHICAL POTENTIAL OF A FUTURE TEACHER’S PERSONALITY – THE FOUNDATION FOR THE PRODUCTIVITY OF THEIR PROFESSIONAL TRAINING by Krasiuk Iryna

“…Based on the research results, it is concluded that moral and ethical potential serves as an effective means of performing professional functions, demonstrating moral and ethical positions, humanity, ethical actions and deeds, pedagogical tact, and professional pedagogical ethics of a teacher. …”
Get full text

Bibliometric and Visualization Analysis of DprE1 Inhibitors to Combat Tuberculosis by Wang Q, Fu H, Zhang Y, Zhang M, Xu J, Fu J

“…Qingqing Wang,1 Huixiao Fu,2 Yining Zhang,3 Man Zhang,1 Jian Xu,1 Jian Fu1,4 1College of Pharmacy, Guizhou University of Traditional Chinese Medicine/National Engineering Technology Research Center for Miao Medicine/Guizhou Engineering Technology Research Center for Processing and Preparation of Traditional Chinese Medicine and Ethnic Medicine, Guiyang, People’s Republic of China; 2Department of Science and Education, The First People’s Hospital of Guiyang, Guiyang, People’s Republic of China; 3College of Traditional Chinese Medicine, Tianjin University of Traditional Chinese Medicine, Tianjin, People’s Republic of China; 4State Key Laboratory of Functions and Applications of Medicinal Plants, Guizhou Medical University, Guiyang, People’s Republic of ChinaCorrespondence: Huixiao Fu, Email fuhuixiao@126.com Jian Fu, Email fu_jian2008@163.comBackground: Tuberculosis (TB) poses a serious threat to public health, particularly owing to the increase in multidrug-resistant tuberculosis (MDR-TB) and extremely drug-resistant tuberculosis (XDR-TB); thus, there is an imperative need for novel treatments to tackle this issue. …”
Get full text

Genome-wide DNA methylation analysis of Astragalus on the intervention of ID2 promoter via PI3K/Akt signaling pathway in peritoneal fibrosis by Manshu Yu, Junyi Zhao, Yun Shan, Huibo Dai, Lei Tang, Li Sheng, Lu Zhang, Meixiao Sheng

“…Chromatin immunoprecipitation and luciferase assays were used to identify the prediction of DNA methyltransferase (Dnmts) binding with methylated target gene. The functions of the validated pathways were further investigated using the knockdown or overexpression strategy. …”
Get full text

DETERMINANTS OF INTEREST RATES ON CORPORATE DEBT by O. Tereshchenko, M. Stetsko, N. Tkachenko, N. Babiak

“…The objective of this article is theoretical and methodological justifying of determining algorithm of the cost of debt capital for enterprises functioning in emerging markets (EM). The methods of research: analysis and synthesis, system analysis, comparative analysis, empirical and statistical methods, factor analysis.  …”
Get full text