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A high-saturated, long-chain fatty acid ketogenic diet negatively impacts visual and motor-sensory function in a pre-clinical model of multiple sclerosis
Published 2025-05-01“…The purpose of our study was to use functional and structural biomarkers to determine the neuroprotective effects of a KD composed of long-chain, saturated fatty acids and how the timing of its implementation impacts these biomarkers in an experimental autoimmune encephalomyelitis (EAE) model.MethodsEAE was induced in 80 female C57BL/6J mice by immunization with MOG35-55 and randomly assigned to stay on the standard diet or to start the KD at one of three time points (preconditioned, prophylactic, or late). …”
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Responses in growth performance, antioxidant capacity, hepatopancreas morphology, and non-specific immune function after functional protein peptide replace fishmeal in the Pacific...
Published 2025-10-01“…The Pacific white shrimp (Litopenaeus vannamei), an economically significant species in aquaculture, has garnered considerable attention in current research regarding the substitution of fishmeal (FM) in its feed. Functional protein peptides (FPP) comprised primarily of enzymolysis chicken chondropeptide and wall-breaking yeast were utilized in an eight-week experiment to investigate the impact of replacing FM with FPP on growth performance, antioxidant capability, non-specific immunity, and hepatopancreas morphology in L. vannamei. …”
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Estimating Romania’s potential GDP: a production function and multivariate approach
Published 2025-03-01“…This research assesses Romania’s potential GDP and its variances employing the production function methodology and a multivariate approach. The Cobb-Douglas function measures potential production by integrating labor, capital, and total factor productivity (TFP), utilizing Kalman filtering for labor and the perpetual inventory approach for capital. …”
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Functional diversity of soil microbiomes in forest ecosystems and the spread of ESKAPE pathogens
Published 2025-02-01“…The article presents original research results focused on the long-term investigation of the soil microbiome in forest ecosystems, particularly examining microbial community structure, the abundance of major ecological-functional groups, and the spread of ESKAPE pathogens (Enterococcus faecium, Staphylococcus aureus, Klebsiella pneumoniae, Acinetobacter baumannii, Pseudomonas aeruginosa, Enterobacter species). …”
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A time for sex: circadian regulation of mammalian sexual and reproductive function
Published 2025-01-01“…Evidence supporting the importance of proper clock function on fertility comes from several lines of work demonstrating that misalignment of biological rhythms or disrupted function of the body’s master clock, such as occurs from repeated shift work or chronic jet lag, negatively impacts reproduction by interfering with both male and female fertility. …”
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Effective Microbial Strategies to Remediate Contaminated Agricultural Soils and Conserve Functions
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Exosomes in oral squamous cell carcinoma: functions, challenges, and potential applications
Published 2025-01-01“…Oral squamous cell carcinoma (OSCC) accounts for approximately 90% of all oral cancers, significantly impacting the survival and quality of life of patients. …”
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Gradient formulae for probability functions depending on a heterogenous family of constraints
Published 2021-08-01“…Probability functions measure the degree of satisfaction of certain constraints that are impacted by decisions and uncertainty. …”
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Dietary microbes and functional dyspepsia: modulating the gut microecology for therapeutic benefit
Published 2025-08-01“…The pathogenesis of functional dyspepsia (FD) is closely associated with intestinal microecological alterations. …”
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Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies
Published 2025-01-01“…Contemporary research reveals that lactate functions not merely as the terminal product of glycolysis but also as a nexus for initiating physiological and pathological responses within the body. …”
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Biomechanics in the tumor microenvironment: from biological functions to potential clinical applications
Published 2025-01-01“…This comprehensive review of biomechanics will enhance the understanding of the functional role of biomechanical forces and provide basic knowledge for the discovery of novel therapeutic targets.…”
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Chemical genomics informs antibiotic and essential gene function in Acinetobacter baumannii.
Published 2025-03-01“…Here, we systematically probe the function of essential genes by screening a CRISPR interference knockdown library against a diverse panel of chemical inhibitors, including antibiotics. …”
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Modulation of Monocyte Effector Functions and Gene Expression by Human Cytomegalovirus Infection
Published 2024-11-01“…The human cytomegalovirus (CMV) infection has significant impacts on monocyte effector functions and gene expression. …”
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A Three-Parameter S-Shaped Function of Flood Return Period and Damage
Published 2016-01-01“…To demonstrate and assess the new features and trends of flood risk in urbanized areas, a novel S-shaped function of return period and damage (R-D) is proposed. …”
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Long-Term Effects of Musical Training and Functional Plasticity in Salience System
Published 2014-01-01“…The structural and functional impacts of the human brain have been observed in musicians. …”
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ISG-15, beyond its functions in the cell: a mini review
Published 2025-07-01“…Viral proteins and de-ISGylating enzymes are known to influence ISG15 secretion levels, thereby impacting its immunomodulatory potential. This mini-review summarizes the existing studies aimed at understanding the mechanisms behind the secretion and functions of extracellular ISG15, with a particular focus on its immunomodulatory effects during infection. …”
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