Fusion genes in cancers: Biogenesis, functions, and therapeutic implications by Haiqiong Tang, Qiu Peng, Linda Oyang, Shiming Tan, Xianjie Jiang, Zongyao Ren, Xuemeng Xu, Mengzhou Shen, Haofan Li, Mingjing Peng, Longzheng Xia, Wenjuan Yang, Shizhen Li, Jiewen Wang, Yaqian Han, Nayiyuan Wu, Yanyan Tang, Jinguan Lin, Qianjin Liao, Yujuan Zhou

“…The objective of this review is to undertake a comprehensive examination of the discovery and functional mechanisms of fusion genes present in a range of cancers. …”
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Effect of Exercise and Nutrition Intervention for Older Adults with Impaired Physical Function with Preserved Muscle Mass (Functional Sarcopenia): A Randomized Controlled Trial by Ji S, Baek JY, Go J, Lee CK, Yu SS, Lee E, Jung HW, Jang IY

“…The effectiveness of a program combining exercise and nutritional support—known interventions for individuals with low muscle mass—was evaluated for its impact on older adults with functional sarcopenia.Methods: An unblinded, parallel-group randomized controlled trial was conducted in a public medical center in a rural Korean community. …”
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Technology in Suicide Prevention: Fears and Functionality for Crisis Supporters by Danielle Hopkins, Kelly Mazzer, Debra Rickwood

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Organic Milk Versus Conventional Milk As Functional Milk by Zehra Selcuk, Habip Muruz

“…Foods which have specific target functions and preventive impacts on human health as well as their basic nutritional effects are defined as functional foods. …”
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Functional Urban Areas as the Focus of Development Policy in Poland by Tomasz Kaczmarek

“…For the past 10 years, cities, especially large ones, have been increasingly impacting on their surrounding areas defined as functional urban areas. …”
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Mechanisms of glutamate metabolic function and dysfunction in vascular dementia by Jiawen Wang, Yingmei Zhang, Ning Tian, Dongshan Ya, Jiaxin Yang, Yanlin Jiang, Xiaoxia Li, Xiaohui Lin, Bin Yang, Qinghua Li, Rujia Liao

“…Glutamate, the most abundant amino acid in the brain, plays a critical role as an excitatory neurotransmitter, impacting cognitive function, learning, and memory. …”
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Provision of green areas in functional zones of Voronezh city by Kristina A. Plotnikova, Sergey N. Kirillov

“…In the context of intense urbanization, cities face challenges related to the disruption of ecosystem functions within green areas. The main aim of this paper is to conduct a geoecological assessment of the state of urban greenery in the city of Voronezh using modern methods, including the calculation of significance coefficients for dendrological indicators. …”
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Global change in the trophic functioning of marine food webs. by Aurore Maureaud, Didier Gascuel, Mathieu Colléter, Maria L D Palomares, Hubert Du Pontavice, Daniel Pauly, William W L Cheung

“…The development of fisheries in the oceans, and other human drivers such as climate warming, have led to changes in species abundance, assemblages, trophic interactions, and ultimately in the functioning of marine food webs. Here, using a trophodynamic approach and global databases of catches and life history traits of marine species, we tested the hypothesis that anthropogenic ecological impacts may have led to changes in the global parameters defining the transfers of biomass within the food web. …”
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The Functional Assessment of Balance in Concussion (FAB-C) Battery by Thaer Manaseer, Jackie L. Whittaker, Codi Isaac, Kathryn J. Schneider, Douglas P. Gross

“…# Background There is no clinical tool that assesses multiple components of postural control potentially impacted by sport-related concussion (SRC). # Objective To develop and assess the feasibility and construct validity of the Functional Assessment of Balance in Concussion (FAB-C) battery…”
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Compound loss of muscleblind‐like function in myotonic dystrophy by Kuang‐Yung Lee, Moyi Li, Mini Manchanda, Ranjan Batra, Konstantinos Charizanis, Apoorva Mohan, Sonisha A. Warren, Christopher M. Chamberlain, Dustin Finn, Hannah Hong, Hassan Ashraf, Hideko Kasahara, Laura P. W. Ranum, Maurice S. Swanson

“…Abstract Myotonic dystrophy (DM) is a multi‐systemic disease that impacts cardiac and skeletal muscle as well as the central nervous system (CNS). …”
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Multi-functional role of apolipoprotein E in neurodegenerative diseases by Sadequl Islam, Arshad Noorani, Yang Sun, Makoto Michikawa, Kun Zou

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Amygdala subregional functional connectivity in treatment-resistant depression by Sheryl L. Foster, Ramon Landin-Romero, Sarah Lewis, Ana Rita Barreiros, Sophie Matis, Anthony Harris, Mayuresh S. Korgaonkar

“…Background: Treatment resistance impacts almost 50 % of depression patients, with amygdala dysfunction being widely implicated. fMRI studies have typically focussed on identifying whole rather than individual subregional amygdala functional connectivity but this approach, together with cohort heterogeneity, is likely contributing to inconsistent results. …”
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Intranasal insulin for improving cognitive function in multiple sclerosis by Scott D. Newsome, Kathryn C. Fitzgerald, Abbey Hughes, Meghan Beier, Jacqueline Koshorek, Yujie Wang, Daniela Pimentel Maldonado, Thomas Shoemaker, Taimur Malik, Tarik Bayu, Pablo E. Ravenna, Ama Avornu, Elias S. Sotirchos, Meghan Romba, John Muschelli, Todd T. Brown, Peter A. Calabresi, Ellen M. Mowry

“…There is an urgent need to identify/develop novel therapies that can help cognitive function in MS. Insulin is critical for helping with regulation of multiple CNS functions, including learning and memory. …”
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Exposure to microplastics during pregnancy and fetal liver function by Chuanzhuo Wang, Hua Chang, Huan Wang, Hui Li, Silu Ding, Fang Ren

“…Our findings provide novel evidence that placental MP exposure is associated with altered fetal liver enzyme levels, particularly ALP, AST, and GGT, indicating potential impacts on hepatic function. These results underscore the need for further investigation into the underlying mechanisms and long-term health implications of prenatal MP exposure.…”
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Impact of Low-Energy and High-Energy Early Enteral Nutrition Strategies on Patient Outcomes in Acute Kidney Injury by Hou A, Zhao C

“…Ajuan Hou, Caiping Zhao Department of Nephrology, Xianyang Central Hospital, Xianyang, 712000, People’s Republic of ChinaCorrespondence: Caiping Zhao, Email hhjjss33@163.comObjective: To investigate the impact of different early enteral nutrition (EEN) strategies on nutritional indicators and immune function in patients with acute kidney injury (AKI) undergoing continuous renal replacement therapy (CRRT).Methods: A retrospective analysis was conducted on 60 CRRT-treated AKI patients from January 2020 to March 2024, divided into a control group (high-energy EEN) and an observation group (low-energy EEN). …”
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The status on achieving Kt/V target and the analysis of impact factors of Kt/V in maintenance peritoneal dialysis patients by ZHANG Suo-jian, ZHANG Xu, CAO Juan, LI Hai-tao, CAI Xiao-qin, ZHAO Ye, XU Yu

“…Objective To explore the present status on achieving Kt/V target and the impact factors of Kt/V in maintenance peritoneal dialysis（MPD） patients.Methods This was a cross-sectional study carried out in Peritoneal Dialysis Center of Taixing People’s Hospital.A total of 77 clinical stable peritoneal dialysis patients with duration ≥3 months who completed dialysis adequacy and biochemical assessment from November 2014 to May 2015 were enrolled in this study.All the patients used either continuous ambulatory peritoneal dialysis（CAPD） or daytime ambulatory peritoneal dialysis（DAPD）.The status on achieving Kt/V target was investigated.The demographic data and clinical characteristics were compared according to varied Kt/V.Results The total Kt/V was 1.75 ± 0.57 and creatinine clearance rate（Ccr） was（57.44 ± 19.58） L.week^-1.（1.73 m²）^-1 for the whole patients and there was 54.54%subjects achieving the Kt/V target.The patients with Kt/V≥1.7 had higher proportion of female,lower proportion of diabetic nephropathy patients,smaller height,weight and body mass index（BMI）,higher urine volume and higher residual renal function（RRF） than in those with Kt/V<l.7（P<0.05）.There was no significant difference between age,the way of peritoneal dialysis,months of peritoneal dialysis duration and dialysate volume.Kt/V was correlated inversely with height（r=-0.444,P = 0.001）,weight（r=-0.457,P = 0.001） and BMI（r=-0.240,P=0.035）.Kt/V was correlated positively with 24-h urine volume（r= 0.357,P = 0.001）,and RRF（r= 0.330,P = 0.003）.There was no association of Kt/V with age and dialysate volume.Binary Logistic regression analysis showed that female,smaller size,and high RRF were the protection factors.Conclusions About 67.4%of peritoneal dialysis patients can reach the Kt/V target recommended by K/DOQI.Gender,body size and RRF were the impact factors of Kt/V in MPD patients.…”
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Obesity and Mechanisms of its Negative Impact on the Cardiovascular System by S. V. Miklishanskaya, L. V. Solomasova, M. A. Mazur

“…Our review is devoted to the description of the mechanisms of influence of obesity on the structural and functional parameters of the heart, which create prerequisites for the development of cardiovascular diseases, as well as the existing contradictions. …”
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The impact of ion beams and thermal annealing on the structure and electrophysical properties of individual multi-walled carbon nanotubes and their ensembles by E. V. Knyazev, K. E. Ivlev, V. E. Kan

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The Impact of Case Management on Elderly Patients with Chronic Obstructive Pulmonary Disease by Li N, Wang W, Lv Y, Li C, Mu X

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Impacts of local environment and land use/cover on spatial-temporal patterns of α and β fish diversity in the Anning River, China by Ruihang Zhou, Pengcheng Lin, Zhijun Xia, Tao Chang, Huijun Ru, Yunfeng Li, Baoshan Ma

“…Variance partitioning analysis showed that two types of environmental factors had a greater influence on α diversity compared to β diversity, and a stronger impact on species diversity than on functional diversity. …”
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