479 Effects of extracellular matrix on pacemaking cardiomyocyte function by Brian Howard, Regan Smithers, Kaitlin Van Brusselen, Hillary K.J. Kao, Deborah K. Lieu

“…Discussion/Significance of Impact: Effects of the microenvironment on hiPSC-PCMs via costamere mechanotransduction may provide insights for engineering biopacemakers with a suitable ECM, to potentially preserve automaticity in hiPSC-PCMs and sustain long-term pacemaking function, making biopacemakers a step closer to reality.…”
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Novel functional drainage density for Blue Carbon Ecotones by Jiaqi Zhang, Matteo Convertino

“…Hydrological networks, as terraformers, play a pivotal role in shaping Blue Carbon Ecotones (BCEs) by influencing ecosystem functions such as ecological dispersal and distribution, water biogeochemistry, and tide-runoff balance, which impact ecohydrological feedback and climate. …”
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A framework for exhaustively mapping functional missense variants by Jochen Weile, Song Sun, Atina G Cote, Jennifer Knapp, Marta Verby, Joseph C Mellor, Yingzhou Wu, Carles Pons, Cassandra Wong, Natascha van Lieshout, Fan Yang, Murat Tasan, Guihong Tan, Shan Yang, Douglas M Fowler, Robert Nussbaum, Jesse D Bloom, Marc Vidal, David E Hill, Patrick Aloy, Frederick P Roth

“…Abstract Although we now routinely sequence human genomes, we can confidently identify only a fraction of the sequence variants that have a functional impact. Here, we developed a deep mutational scanning framework that produces exhaustive maps for human missense variants by combining random codon mutagenesis and multiplexed functional variation assays with computational imputation and refinement. …”
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AFM‐Based Functional Tomography – To Mill or Not to Mill, that is the Question! by Niyorjyoti Sharma, Kristina M. Holsgrove, James Dalzell, Conor J. McCluskey, Jilai He, Dennis Meier, Dharmalingam Prabhakaran, Brian J. Rodriguez, Raymond G.P. McQuaid, J. Marty Gregg, Amit Kumar

“…Tomographic imaging in these material systems has therefore become increasingly important for its ability to correlate the surface‐level functional response with subsurface domain microstructure. …”
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Quality of Life and Functional Performance in Patients with Multiple Sclerosis by Marzena A. Humańska, Paweł Śnieg, Leokadia Rezmerska, Beata Haor, Mariola Głowacka, Mirosława Felsmann, Danuta Ponczek, Krystyna Kurowska, Agnieszka Pluta, Damian Czarnecki

“…The aim of the study was to evaluate functional capacity in patients with multiple sclerosis and its impact on quality of life. …”
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A modified method for assessing sexual function in men by M. I. Yagubov, I. Yu. Kan, N. V. Dobaeva, I. R. Ayriyants

“…Sexual disharmony is a significant factor in the destabilization of family relations, having a negative impact on the demographic situation. Disorders of sexual function often have comorbid associations with various somatic and mental illnesses, which determines the need for a comprehensive interdisciplinary approach to their diagnosis. …”
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Characterization and functional analysis of chicken hnRNP protein by Ke Wang, Manzi Huang, Qinghua Zeng, Huansheng Wu

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Structural and functional analysis of a homotrimeric collagen peptide by Xinling Zhang, Xinling Zhang, Kexin Li, Kexin Li, Nan Lu, Takafumi Takebayashi, Boyu Zhou, Hongbin Xie, Yufan Li, Xingyun Long, Xingjiong Qin, Hongyi Zhao, Hongyi Zhao, Jiying Dong

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Distribution of hand function by age in individuals with Rett syndrome by Jeffrey L. Neul, Tim A. Benke, Eric D. Marsh, Jane B. Lane, David N. Lieberman, Steven A. Skinner, Daniel G. Glaze, Bernhard Suter, Peter T. Heydemann, Arthur A. Beisang, Shannon M. Standridge, Robin C. C. Ryther, Richard H. Haas, Lloyd J. Edwards, Amitha Ananth, Alan K. Percy

“…Conclusions These temporal variations in hand use represent specific considerations that could influence the design of clinical trials that test therapies aiming to ameliorate specific functional limitations in individuals with RTT. Furthermore, the distinct impact of specific MECP2 variants on clinical severity, especially related to hand use, should be considered in such interventional trials.…”
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Reduction of Glucocorticoid Receptor Function in Chronic Fatigue Syndrome by Megan Lynn, Laura Maclachlan, Andreas Finkelmeyer, James Clark, James Locke, Stephen Todryk, Wan-Fai Ng, Julia L. Newton, Stuart Watson

“…GR function can be estimated ex vivo by measuring dexamethasone (dex) modulation of cytokine response to lipopolysaccharide (LPS), and in vivo using the impact of dex on cortisol levels. …”
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Benefits of Patisiran on Functional Capacity in ATTR Cardiac Amyloidosis by John L. Berk, MD, Olivier Lairez, MD, PhD, Pedro Schwartzmann, MD, PhD, Shaun Bender, PhD, Matthew T. White, PhD, Patrick Y. Jay, MD, PhD, David Danese, MBA, Ronald Witteles, MD

“…The meaningful preservation of functional capacity and quality of life are important priorities. …”
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Validation of the biological function and prognostic significance of AURKA in neuroblastoma. by Jing Chu

“…The aim of this study was to validate the biological function and prognostic significance of AURKA in NB using basic experiments and bioinformatics.…”
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Exofection by exosomes: A transient functional cargo transfer by Ramkumar Menon, Madhuri Tatiparthy, Jessica Selim, Isidore Mushimiyimana, Brinley Harrington, Awanit Kumar, Lauren Richardson, Emmanuel Amabebe, Ananth Kumar Kammala

“…Upon receiving the exosomal cargo, recipient cells transiently express and exhibit the functional activity of the delivered molecules. The functional enhancement mediated by exofection is transient, gradually diminishing once the delivery from the donor cells declines, and the recipient cell no longer needs specific function. …”
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Cardiopulmonary function in adolescent patients with pectus excavatum or carinatum by Anne Tabard-Fougère, Maurice Beghetti, Salim Ramadan, Jim Wilde, Seema Toso, Jean-Paul Vallée, Regula Corbelli, Constance Barazzone-Argiroffo, Pierre Lascombes, Isabelle Ruchonnet-Métrailler

“…There were no significant correlations between pulmonary and cardiac functions or between low CPF and thoracic measurements.Interpretation Our results confirm the modest impact of pectus malformations on CPF at rest, without correlation with anamnestic dyspnoea on exertion, nor with chest pain or anatomical measurements. …”
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Clinical, functional and neuropsychological status of joint replacement patients by Akhsarbek H. Dzhigkaev, Anastasia M. Tynterova, Ivan I. Kozenkov, Eldar V. Khaibulin, Elena V. Trofimova, Konstantin Y. Popadin, Konstantin V. Gunbin, Andrey G. Goncharov

“…The objective was to assess the clinical, functional and neuropsychological status of patients undergoing total knee or hip replacement. …”

Predictors of functional communication in people with aphasia after stroke by Adriana Fernandes, Helena Fraga-Maia, Iara Maso, Isabela Guimarães Matos, Lene Gomes, Matheus Matos, Andressa Santana, Jamary Oliveira-Filho, Pedro Antônio de Jesus, Elen Beatriz Pinto

“…Aphasia can negatively impact functional communication skills, including social networks, social activities, relationships with other people and social support. …”
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The Impact of Noise on Learning in Children and Adolescents: A Meta-Analysis by Gabriela Fretes, Ramon Palau

Subjects: “…noise impact…”
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The effect of cannabis-derived terpenes on alveolar macrophage function by Patrick M. Greiss, Patrick M. Greiss, Patrick M. Greiss, Jacquelyn D. Rich, Jacquelyn D. Rich, Jacquelyn D. Rich, Geoffrey A. McKay, Dao Nguyen, Dao Nguyen, Dao Nguyen, Dao Nguyen, Mark G. Lefsrud, David H. Eidelman, David H. Eidelman, David H. Eidelman, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole, Carolyn J. Baglole

“…These results suggest that terpenes from cannabis have minimal impact on the function of alveolar macrophages.…”
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Cation disordering in ankerite as a function of Fe content by A. Zucchini, M. Masotta, M. Nazzari, M. Fastelli, P. Comodi

“…This has the potential to significantly impact the mineral physics of ankerite under non-ambient conditions, particularly with regard to compressibility, phase stability, thermal and electric conductivity, and its role in the Earth's mantle geophysical modeling.…”
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The impact of supercritical carbon dioxide processing on the aroma and physicochemical properties of soybean flour by Sumanjot Kaur, Ali Ubeyitogullari

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