Drosophila Smad2 opposes Mad signaling during wing vein development. by Veronika Sander, Edward Eivers, Renee H Choi, Edward M De Robertis

“…RNAi-mediated knockdown of dSmad2 caused formation of extra vein tissue, with phenotypes similar to those seen in Dpp/Mad gain-of-function. Clonal analyses revealed that the normal function of dSmad2 is to inhibit the response of wing intervein cells to the extracellular Dpp morphogen gradient that specifies vein formation, as measured by expression of the activated phospho-Mad protein. …”
Get full text

Properties of Zr – 12.5 % Nb and Zr – 25 % Nb Alloys with hcp and bcc Lattices: ab-initio Modeling by V.O. Kharchenko, D.O. Kharchenko, A.V. Dvornichenko

“…Ab-initio calculations of the electronic structure for Zr – 12.5 % Nb and Zr – 25 % Nb alloys are done using density functional theory, method of linearized augmented plane-wave approximation and generalized gradient approximation. …”
Get full text

Combined simulation and ex vivo assessment of free-edge length in bicuspidization repair for congenital aortic valve diseaseCentral MessagePerspective by Perry S. Choi, MD, Amit Sharir, BS, Yoshikazu Ono, MD, Masafumi Shibata, MD, Alexander D. Kaiser, PhD, Yellappa Palagani, PhD, Alison L. Marsden, PhD, Michael R. Ma, MD

“…Outcomes included transvalvular gradient, regurgitation fraction, and orifice area. …”
Get full text

Smoothing Estimation of Parameters in Censored Quantile Linear Regression Model by Mingquan Wang, Xiaohua Ma, Xinrui Wang, Jun Wang, Xiuqing Zhou, Qibing Gao

“…The method associates the convolutional smoothing estimation with the loss function, which is quadratically derivable and globally convex by using a non-negative kernel function. …”
Get full text

Genetic algorithm-based active noise control systems - simulations using Internet by G. Makarewicz

“…The software for simulation of ANC systems based on gradient and genetic algorithms is described. …”
Get full text

End-systolic wall stress in aortic stenosis: comparing symptomatic and asymptomatic patients by Redi Pecini, Jacob Eifer Moller, Rasmus Carter-Storch, Nicolaj Lyhne Christensen, Lars Melholt Rasmussen, Eva Søndergård, Lars Melgaard Videbæk, Jordi Sanchez Dahl

“…Aims In aortic stenosis (AS), there is poor association between symptoms and conventional markers of AS severity or left ventricular (LV) systolic function. This may reflect that symptoms arise from LV diastolic dysfunction or that aortic valve area (AVA) and transvalvular gradient do not reflect afterload. …”
Get full text

INFLUENCE UNDER-CLOUDY CONVECTIONS ON DEVELOPMENT OF A CLOUDY CONVECTION by Nina Evgenevna Danilova, Yulia Alexandrovna Semyonova, Yulia Leontevna Smerek, Robert Gurgenovich Zakinyan

“…Discussion and conclusion: Analytical expressions are obtained for the dew point deficiencies in the surface layer, which determine the values of the overheating function and the ascending flow rate at the condensation level. …”
Get full text

Numerical solution of KdV-mKdV equation based on PINN and its improved method(基于PINN及其改进算法求解KdV-mKdV方程) by 栗雪娟(LI Xuejuan), 刘瑜欣(LIU Yuxin)

“…Although it has a high solution accuracy compared with the traditional methods, PINN's accuracy was overly dependent on the number of configuration points and weakness of large gradients. To overcome these defects, an improved PINN algorithm is proposed based on the idea of gradient enhancement, namely gradient-enhanced physics-informed neural network (gPINN) for solving the problem. gPINN algorithm makes up the defect of gradient attenuation by embedding the gradient information of partial differential equation residuals into the loss function. …”
Get full text

Fronto-occipital dyscommunication associates with brain hierarchy in schizophrenia by Haonan Pei, Hechun Li, Changyue Hou, Yayun Liu, Jiashuo Liu, Mingjun Duan, Dezhong Yao, Sisi Jiang, Cheng Luo

“…We measured the brain’s functional separation and quantified bidirectional information transfer changes between the frontal and occipital regions. …”
Get full text

Isostatic Crustal Thickness Under The Tibetan Plateau And Himalayas From Satellite Gravity Gradiometry Data by Robert Tenzer, Mohammad Bagherbandi, Lars E Sjöberg, Pavel Novák

“…For this purpose, we solve the Vening Meinesz-Moritz’s (VMM) inverse problem of isostasy de ned in terms of the isostatic gravity gradient. The functional relation between the Moho depth and the second-order radial derivative of the VMM isostatic potential is formulated by means of the (linearized) Fredholm integral equation of the rst kind. …”
Get full text

Novel laser model of optic nerve transection provides valuable insights about the dynamics of optic nerve regeneration by Chloe Moulin, Galina Dvoriantchikova, Niloufar Bineshfar, Ben Swingle, Gaby Martinez, Daniel Groso, Michelle Zhang, Dmitry Ivanov, Daniel Pelaez

“…Through microscopy of axon dynamics, functional testing to assess visual pathway recovery, TUNEL cell death and EdU cell proliferation assays, and RNA-seq of the retina and optic nerve, we characterized the optic nerve injury response and subsequent recovery. …”
Get full text

Midterm Experience with the Self-Expandable Venus P-Valve™ for Percutaneous Pulmonary Valve Replacement in Large Right Ventricular Outflow Tracts by Peter Kramer, Anastasia Schleiger, Phuoc Duong, Felix Berger

“…Flow was unobstructed with a mean gradient estimated by echocardiography of 12 ± 4 mmHg. …”
Get full text

Ferromagnetic double Sr2PrSnO6 perovskite: DFT analysis of physical, optoelectronic, and transport properties for advanced opto-spintronics by Rifat Sarker Apu, Nazmul Hasan, Rubaiyet I. Haque, Alamgir Kabir, Md Harunur Rashid

“…The physical, magneto-electronic, optical, and transport characteristics of the noble inorganic f-electron-based double perovskite Sr2PrSnO6 are analyzed, with first-principles density functional theory (DFT) computation for advanced spintronics, optoelectronic, and magneto-RAM applications. …”
Get full text

Research on the Effectiveness of Temperature Control with MPCM Grouting for Cracks in the Earthen Ruins of Gaochang Ancient City by Jiahua Zou, Xiaofei Mao, Dongbo Li

“…Facing the challenges of temperature gradient-induced soil cracking and delamination in earthen ruins like Gaochang Ancient City, this study develops a novel phase change microcapsule (MPCM) grouting material designed for dual functionality: structural reinforcement and thermal regulation. …”
Get full text

Infrared Small Target Detection via Multidirectional Local Gravitational Force and Level-Line Connectivity by Xuying Hao, Xianyuan Liu, Yujia Liu, Yijuan Qiu, Yunjing Zhang, Yi Cui, Tao Lei

“…The LGF model integrates information from each pixel within the local region and introduces a new sigmoid function to reduce noise, enabling fine-grained gradient detection. …”
Get full text

Valve-in-valve transcatheter aortic valve replacement on a self-expandable nitinol frame due to degeneration of primary bioprosthetic valve cusps. Clinical case of a high-risk surg... by L. S. Kokov, V. V. Sokolov, M. V. Parkhomenko, R. Sh. Muslimov, M. V. Bulanova, N. M. Bikbova

“…Echo data showed that the bioprosthetic AV peak systolic pressure gradient decreased from 90 to 29 mmHg, average gradient – from 42 to 19 mmHg. …”
Get full text

Prediction of Voice Therapy Outcomes Using Machine Learning Approaches and SHAP Analysis: A K-VRQOL-Based Analysis by Ji Hye Park, Ah Ra Jung, Ji-Na Lee, Ji-Yeoun Lee

“…Multiple regression analysis and four machine learning algorithms—random forest (RF), gradient boosting (GB), light gradient boosting machine (LightGBM), and extreme gradient boosting (XGBoost)—are applied to predict changes in K-VRQOL scores across the total, physical, and emotional domains. …”
Get full text

Dual Antiplatelet Regimens for Transcatheter Aortic Valve Replacement and Corresponding Cardiac CT Evaluation of the Leaflets: Single-center Experience by Mirvat Alasnag, Waqar Ahmed, Ibrahim Al-Nasser, Khaled Al-Shaibi

“…Signs and symptoms of ischemic stroke, valve function, gradient, and cardiac CT findings of hypo-attenuated leaflet thickening and reduced leaflet mobility were recorded for all those who completed 6 months of follow-up. …”
Get full text

Thermal mechanical response analysis of the first wall in laser initial confinement fusion reactors by Xinze Li, Bingqian Zhang, Chengcheng Tong, Ronghua Chen, Dalin Zhang, Wenxi Tian, Suizheng Qiu

“…The results indicate that W/Cu functional gradient materials can effectively alleviate thermal stresses on the first wall, especially in addressing the stress concentration at the interface. …”
Get full text

Metabolic reprogramming signature predicts prognosis and immune landscape in small cell lung cancer: MOCS2 validation and implications for personalized therapy by Junyan Wang, Panpan Sun, Fan Zhang, Yu Xu, Shenghu Guo

“…Bulk RNA sequencing from GSE60052 and cBioportal cohorts was used to identify metabolism-related gene modules through WGCNA and develop a Gradient Boosting Machine prognostic model. Functional validation of MOCS2, the top-ranked gene in our model, was conducted through siRNA knockdown experiments in SCLC cell lines.ResultsSingle-cell analysis revealed distinct metabolic reprogramming patterns between chemotherapy-resistant and sensitive samples. …”
Get full text