SLC26A4 targeted to the endolymphatic sac rescues hearing and balance in Slc26a4 mutant mice. by Xiangming Li, Joel D Sanneman, Donald G Harbidge, Fei Zhou, Fei Zhou, Taku Ito, Raoul Nelson, Nicolas Picard, Régine Chambrey, Dominique Eladari, Tracy Miesner, Andrew J Griffith, Daniel C Marcus, Philine Wangemann

“…The transgene prevented abnormal enlargement of the membranous labyrinth, restored a normal endocochlear potential, normal pH gradients between endolymph and perilymph in the cochlea, normal otoconia formation in the vestibular labyrinth and normal sensory functions of hearing and balance. …”
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Viral inactivation in von Willebrand factor preparations via UVC irradiation: an experimental approach by ZHANG Yalu, MA Jie, ZHANG Rong, YANG Chunhui

“…[Methods] An ultraviolet inactivator (254 nm primary wavelength) was employed to optimize UV exposure dosages for the samples, and the initial test groups were set at five irradiation gradients: 100, 200, 400, 1 000, and 1 500 J/m2 gradients. …”
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Fluidic-manipulation-enabled multiplexed dose delivery of RONS by a CAP chip for dose optimization enhancement by Fang Wang, Liangyu Zhou, Wei Guo, Haisong Lin, Ruotong Zhang, Shaolong Kuang, Yuan Liu, Xiaoxue Fan, Yau Kei Chan, Hui Deng, Ho Cheung Shum

“…This approach disentangles the roles of short-lived and long-lived RONS in therapeutic applications, offering critical insights into their bio-functional mechanisms. The concept of multiplexed dose treatment with fluidic manipulation promises to catalyze the development of high-efficiency CAP devices and advance research in CAP-based therapies.…”
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Features of the anatomical structure of leaves depending on the high-altitude growth of apricot in Dagestan by D. M. Anatov, Z. M. Asadulaev, Z. R. Ramazanova, R. M. Osmanov

“…The adaptive changes during the distribution of Prunus armeniaca L. in Dagestan are important for understanding microevolution, structural and functional differentiation processes of populations along environmental gradients based on the organism’s reaction norm. …”
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Mechanisms and modelling of diffusion in solids: a multiscale framework with industrial case studies and AI enhancements by Barah, Obinna Onyebuchi, Natukunda, Faith, Bori, Ige, Ukagwu, Kelechi John

“…Diffusion in solids is a fundamental mechanism governing mass transport, phase transformations, and microstructural evolution in metals, alloys, and functional materials. This review presents a comprehensive overview of key atomic-scale diffusion mechanisms, including substitutional, interstitial, grain boundary, and surface/pipe pathways, within the classical framework of Fick’s steady-state and non-steady-state laws. …”
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Endothelial Plasticity: Shifting Phenotypes through Force Feedback by Guido Krenning, Valerio G. Barauna, José E. Krieger, Martin C. Harmsen, Jan-Renier A. J. Moonen

“…Hemodynamic forces such as fluid shear stress and cyclic strain are strong modulators of the endothelial phenotype and function. Although endothelial plasticity is essential during development and adult physiology, proatherogenic stimuli can induce adverse plasticity which contributes to disease. …”
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Drivers of methane-cycling archaeal abundances, community structure, and catabolic pathways in continental margin sediments by Longhui Deng, Longhui Deng, Damian Bölsterli, Clemens Glombitza, Bo Barker Jørgensen, Hans Røy, Mark Alexander Lever, Mark Alexander Lever

“…Focusing on four continental margin sites of the North Sea-Baltic Sea transition, we here investigate the in situ drivers of methane-cycling archaeal community structure and metabolism based on geochemical and stable carbon-isotopic gradients, functional gene (mcrA) copy numbers and phylogenetic compositions, and thermodynamic calculations. …”
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Atomic-scale understanding of oxide growth and dissolution kinetics of Ni-Cr alloys by Penghao Xiao, Christine A. Orme, S. Roger Qiu, Tuan Anh Pham, Seongkoo Cho, Michael Bagge-Hansen, Brandon C. Wood

“…To this end, we combine experiments with a first-principles-derived, multiscale computational framework that transcends thermodynamic descriptions to explicitly simulate the kinetic evolution of surface oxides of Ni-Cr alloys as a function of composition, temperature, pH, and applied voltage. …”
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ACCDW-YOLO: an effective detection method for small-sized pests and diseases in navel oranges by Kai Wang, Youliang Chen, Hanzheng Sun

“…The Wise Intersection over Union version 3 (WIoUv3) loss function was used to reduce the competitiveness of high-quality anchor boxes, reduce the harmful gradients generated by low-quality samples, and improve the overall performance of the model. …”
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Detection of failures in HV surge arrester using chaos pattern with deep learning neural network by Chun‐Chun Hung, Meng‐Hui Wang, Shiue‐Der Lu, Cheng‐Chien Kuo

“…Abstract As a protective component of HV equipment, the primary function of a surge arrester is to mitigate the impact of surge voltages. …”
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Evaluation of the impact of ecological factors on the habitat suitability and bioactive components accumulation of the medicinal holoparasitic plant Cynomorium songaricum using mac... by Jiacheng Ji, Jiacheng Ji, Xinxin Wei, Xinxin Wei, Huan Guan, Huan Guan, Zikang Jin, Zikang Jin, Xin Yue, Zhuoran Jiang, Youla Su, Youla Su, Shuying Sun, Shuying Sun, Guilin Chen, Guilin Chen

“…BIO6 served as a key shared positive regulator for catechin and total phenolics, while functioning as a key negative regulator for ursolic acid. …”
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A High-Efficient Modeling Method for Aerodynamic Loads of an Airfoil with Active Leading Edge Based on RFA and CFD by Shengyong Fang, Sheng Zhang, Jinlong Zhou, Weidong Yang

“…For the airfoil in freestream, the pressure difference between the upper and lower surfaces and the variations in pressure gradients are significant at its leading edge area. …”
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The Role of Non-Genomic Information in Maintaining Thermodynamic Stability in Living Systems by Robert A. Gatenby, B. Roy Frieden

“…In fact,information theory demonstrates that any cellular structuredescribed by a nonrandom density distribution function may storeand transmit information. Thus, lipids and polysaccharides, whichare both highly structured and non-randomly distributed increasecellular order and potentially contain abundant information aswell as polynucleotides and polypeptides. …”
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Natural convection in a square Cavity: Effects of Rayleigh and Prandtl numbers on heat transfer and flow patterns by Saleh A. Bawazeer, Mohammad S. Alsoufi

“…Stream function analysis tracks the strength and symmetry shifts of vortices across the parameter space. …”
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Scaling species interactions: implications for community ecology and biological scaling theory by Douglas S. Glazier

“…I argue that these patterns can provide new insights into the structure/function of ecological communities (including latitudinal and trophic-level gradients in biotic interactions) and various biological scaling patterns at the organism, population, community, and ecosystem levels. …”
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Exploring the role of ferroptosis in pemphigus: identification of diagnostic markers and regulatory mechanisms by Jing Mao, Jianping Lan, Zheyu Zhuang, Ying Chen, Ying Chen, Yushan Ou, Xinhong Su, Xueting Zeng, Fuchen Huang, Zequn Tong, Xiaoqing Lv, Xiaoqing Lv, Xiaoqing Lv, Hui Ke, Zhenlan Wu, Ying Zou, Bo Cheng, Bo Cheng, Bo Cheng, Chao Ji, Chao Ji, Chao Ji, Ting Gong

“…This study aims to investigate the expression patterns and potential biological functions of ferroptosis-related genes in pemphigus, as well as their regulatory mechanisms.MethodsTo achieve this, skin samples from five pemphigus patients and five healthy controls were collected from Fujian Medical University Union Hospital. …”
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Diverse Roles of the Multiple Phosphodiesterases in the Regulation of Cyclic Nucleotide Signaling in <i>Dictyostelium</i> by Pundrik Jaiswal, Alan R. Kimmel

“…We further outline the major molecular, cellular, and developmental events regulated by cyclic nucleotide signaling, with emphasis on the input of each PDE and consequence of loss-of-function mutations. Finally, we relate the structures and functions of the <i>Dictyostelium</i> PDEs with those of humans and in the context of potential therapeutic understandings.…”
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Fate and risks of potentially toxic elements associated with lacustrine groundwater discharge: quantification, modeling, and biogeochemistry by Shen Qu, Juliang Wang, Keyi Zhang, Mengyu Fan, Yuanzhen Zhao, Xu Yang, Zhongli Wang, Helena I. Gomes, Rachel L. Gomes, Limin Duan, Shaogang Dong, Ruihong Yu

“…Microbial analysis revealed higher diversity (ace index = 1751 ± 577) in groundwater, while surface water PTE had a more pronounced impact on microbial functionality than groundwater (p < 0.001). Health risk assessment demonstrated elevated hazards in PTE contaminated groundwater, posing higher non-carcinogenic (non-carcinogenic risk-HI: 1.43 vs 1.25) and carcinogenic risks (carcinogenic risk assessment-CR: 0.005 vs 0.003) than surface water, with children being more vulnerable (5, 8 and 7 cases per 1000 children were found at carcinogenic risk). …”
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Pine trees structure plant biodiversity patterns in savannas by Raelene M. Crandall, Yingen M. Chew, Jennifer M. Fill, Jesse K. Kreye, J. Morgan Varner, Leda N. Kobziar

“…Abstract Overstory trees serve multiple functions in grassy savannas. Past research has shown that understory species can vary along gradients of canopy cover and basal area in savannas. …”
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Spatial Heterogeneity of Intratumoral Microbiota: A New Frontier in Cancer Immunotherapy Resistance by Qiwen Tan, Xiongjing Cao, Falong Zou, Hanwenchen Wang, Lijuan Xiong, Shenghe Deng

“…Moreover, certain bacterial metabolites form concentration gradients between the tumor core and margins, thereby regulating immune cell function. …”
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