Identification of critical residues at the C-terminal tip of ACKR4 regulating chemokine internalization and βarrestin involvement by Oliver J. Gerken, Nicola Catone, Daniel F. Legler

“…Abstract Background Atypical chemokine receptors (ACKRs) play an important role in regulating the availability of chemokines and are responsible for the formation of chemokine gradients required for the directed migration of immune cells in health and disease. …”
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Thermal analysis for convective transport of nanoparticles with effective phenomenon of damped shear-thermal flux: A fractional model by Qasim Ali, Sami Ullah Khan, Adnan, Hakim AL Garalleh, M. Waqas, Nurnadiah Zamri, Dilsora Abduvalieva, Manish Gupta

“…Moreover, these solutions are described in respect of the Lorenzo-Hartley G-function together with the Mittag-Leffler function. …”
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Increasing Vegetation Cover Enhances Ecosystem Services in the Rare Earth Mining Area of China: Threshold Effects and Implications by Yuqing Liu, Zhubin Zheng, Jianzhong Li, Ge Liu, Shaohua Lei, Jie Xu, Wei Luo, Chao Du, Wei Huang, Chao Huang, Jingli Ren

“…It also underscores the need for the public and managers to recognize the impact of vegetation restoration on ecosystem functions in rare Earth mining areas.…”
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Species Diversity and Community Composition of Macrofungi in the Dongling Mountains, Western Beijing, China by Jia-Mao Huang, Tai-Min Xu, Wen Zhao, Reyila Mumin, Long Zeng, Yi-Fei Sun, Bao-Kai Cui

“…Macrofungi are a group of fungi with important ecological functions and economic value in forest ecosystems. …”
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Differential Ca2+ handling by isolated synaptic and non-synaptic mitochondria: roles of Ca2+ buffering and efflux by Jyotsna Mishra, Kyle Bevers, Keguo Li, Armaan Zare, James S. Heisner, Ailing Tong, Wai-Meng Kwok, Wai-Meng Kwok, Wai-Meng Kwok, Wai-Meng Kwok, David F. Stowe, David F. Stowe, David F. Stowe, David F. Stowe, Amadou K. S. Camara, Amadou K. S. Camara, Amadou K. S. Camara, Amadou K. S. Camara

“…Synaptic mitochondria appear to rely mainly on mCa2+ efflux via mNCE, while non-synaptic mitochondria rely mainly on Pi-dependent mCa2+ sequestration. The functional implications of differential mCa2+ handling at neuronal synapses may be adaptations to cope with the higher metabolic activity and larger mCa2+ transients at synaptosomes, reflecting a distinct role they play in brain function.…”
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Identification and attribution analysis of integrated ecological zones based on the XGBoost-SHAP model: A case study of Chengdu, China by Xiaobin Huang, Xiaosheng Liu, Yuanhang Jin, Xue Gao, Youliang Chen

“…Taking Chengdu, China, as a case study, this study develops an ecological zoning framework based on the eXtreme Gradient Boosting-SHapley Additive exPlanations (XGBoost-SHAP) model. …”
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A novel peptide targeting CCR7 inhibits tumor cell lymph node metastasis by Yixuan Sun, Yuzhen Qian, Lu Qiu, Xueqin Zhu, Haoming Ning, Liwei Pang, Xiaoshuang Niu, Yi Liu, Xiuman Zhou, Guanyu Chen, Wenjie Zhai, Yanfeng Gao

“…It has been reported that cancer cells can upregulate CC Chemokine Receptor 7 (CCR7) expression and hijack its normal functions, enabling them to migrate along the gradient of CCL19 and CCL21 toward the lymph nodes and colonies as the initial stage of distant metastasis. …”
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A Preliminary Study on the Qualitative and Quantitative Changes of Amino Acids in Whole Apple, Apple Peel, and Flesh Samples Grown in Lithuania by Aurita Bračiulienė, Vaidotas Žvikas, Mindaugas Liaudanskas, Valdimaras Janulis

“…Amino acids are vital gradient compounds involved in protein synthesis and the regulation of physiological functions. …”
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Accelerometer-Measured Physical Activity and Neuroimaging-Driven Brain Age by Han Chen, Zhi Cao, Jing Zhang, Dun Li, Yaogang Wang, Chenjie Xu

“…Brain age was estimated using an ensemble learning approach called Light Gradient-Boosting Machine (LightGBM). Over 1,400 image-derived phenotypes (IDPs) were initially chosen to undergo data-driven feature selection for brain age prediction. …”
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An ensemble strategy for piRNA identification through hybrid moment-based feature modeling by Mansoor Ahmed Rasheed, Tamim Alkhalifah, Fahad Alturise, Yaser Daanial Khan

“…By integrating multiple deep learning networks, the objective is to create a robust tool for forecasting transposon-derived piRNAs, thereby contributing to a deeper understanding of their biological functions and regulatory mechanisms. Piwi-interacting RNAs (piRNAs) are currently considered the most diverse and abundant class of small, non-coding RNA molecules. …”
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Exploring potential methylation markers for ovarian cancer from cervical scraping samples by Ju-Yin Lien, Lu Ann Hii, Po-Hsuan Su, Lin-Yu Chen, Kuo-Chang Wen, Hung-Cheng Lai, Yu-Chao Wang

“…Furthermore, an over-representation analysis was conducted to explore the functions associated with genes mapped from differentially methylated positions (DMPs) in comparisons between normal and tumor samples, as well as between benign and malignant samples. …”
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Formation control method for multiple flight vehicles based on adaptive dynamic programming by Jie XIAO, Qingpu TANG, Jiale LI, Guofei LI

“…For complex nonlinear multivehicle systems, even with incomplete basis functions, the method’s efficacy is also demonstrated.…”
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Valve-in-valve transcatheter aortic valve replacement: state of art by Marco Fabio Costantino, Gianpaolo D’Addeo, Francesca Cortese, Luisiana Stolfi

“…Post-procedural evaluation involves assessing clinical and hemodynamic outcomes, with long-term studies indicating favorable results but highlighting the importance of careful evaluation of transprosthetic gradients and valve function. ViV TAVR offers promising outcomes but requires meticulous patient selection, procedural planning, and post-procedural management to ensure optimal results.…”
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Evaluation of Morphometric Factors on the Distribution of Debris: A Case Study on the Attica Ripples on the South of Paveh- Kermanshah Province, Iran by Mohammad Ahmadi

“…The slope parameters, aspect slopes, curvature, hypsometry and solar radiation were extracted using digital elevation model and ArcMap functions. The gradient factor were classified in five classes (treatment), the aspect slopes in eight treatments, and solar radiation in five treatments. …”
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Azimuthally-variant perfect vector beams for the control of arbitrary phase and polarization ring patterns by Andrea Vogliardi, Gianluca Ruffato, Daniele Bonaldo, Simone Dal Zilio, Filippo Romanato

“…Using dual-functional silicon metaoptics, we achieve the compact generation of a novel class of perfect vortices, termed azimuthally-variant perfect vector beams. …”
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Modification of surface layers by high energy treatment by M. N. Vereschagin, S. N. Tselueva, M. Yu. Tseluev

“…The nature of heating, which is determined by the rate of change of temperature, temperature gradients, the time to reach the temperatures of structural and phase transitions, is different depending on the properties of the material being processed and the processing conditions.When modifying the surface layers by high-energy processing by changing the power and time of exposure to laser radiation, you can get a wide range of structural states of the treated surface areas of the material.It is shown that the shape of TVP diagrams and cooling curves of precision alloys on the surface of a two-layer metal system after heating them with laser radiation are determined by the competition of two processes acting in opposite directions: an increase in the driving force of the crystallization process with an increase in supercooling and a decrease in the surface of atoms.The method of surface modification by moving laser radiation allows to obtain amorphous functional layers of precision alloys on the surface of metal products.…”
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Conditions for the emergence of circumnutations in plant roots. by Ilya Loshchilov, Emanuela Del Dottore, Barbara Mazzolai, Dario Floreano

“…Here we describe a model capable of replicating root growth behaviors, which we used to analyze the role of circumnuntations, revealing their emergence I) under gravitropic stress, as a combination of signal propagation and sensitivity to the signal carriers; II) as a result of the interplay between gravitropic and thigmotropic responses; and III) as a behavioral strategy to detect and react to resource gradients. The latter function requires the presence of a hypothetical internal oscillator whose parameters are regulated by the perception of environmental resources.…”
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Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry by Hansotto Reiber

“…With the popular description of the CSF flow dependent barrier function, the dynamics and concentration gradients of blood-derived, brain-derived and leptomeningeal proteins in CSF or the specificity-independent functions of B-lymphocytes in brain also the neurologist, psychiatrist, neurosurgeon as well as the neuropharmacologist may find essentials for diagnosis, research or development of therapies. …”
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Knowledge-base for interpretation of cerebrospinal fluid data patterns. Essentials in neurology and psychiatry by Hansotto Reiber

“…With the popular description of the CSF flow dependent barrier function, the dynamics and concentration gradients of blood-derived, brain-derived and leptomeningeal proteins in CSF or the specificity-independent functions of B-lymphocytes in brain also the neurologist, psychiatrist, neurosurgeon as well as the neuropharmacologist may find essentials for diagnosis, research or development of therapies. …”
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Epithelial GREMLIN1 disrupts intestinal epithelial-mesenchymal crosstalk to induce a wnt-dependent ectopic stem cell niche through stromal remodelling by Eoghan J. Mulholland, Hayley L. Belnoue-Davis, Gabriel N. Valbuena, Nuray Gunduz, Amelia Ligeza, Muyang Lin, Sujata Biswas, Ester Gil Vasquez, Sulochana Omwenga, Nadia Nasreddin, Michael C. Hodder, Lai Mun Wang, Aik Seng Ng, Elizabeth Jennings, Kim S. Midwood, Neesha Dedi, Shazia Irshad, Rachel A. Ridgway, Toby J. Phesse, James East, Ian PM Tomlinson, Gareth CG Davies, Owen J. Sansom, Simon J. Leedham

“…Abstract In homeostasis, counterbalanced morphogen signalling gradients along the vertical axis of the intestinal mucosa regulate the fate and function of epithelial and stromal cell compartments. …”
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