Potential role of N6-methyladenosine modification in circular RNA biogenesis and function in the inflammatory responses by Heedoo Lee, Heedoo Lee, Leo Chen, Yang Jin

“…This mini-review elaborates on recent advances in m6A modification on circRNA biogenesis and function, focusing on the role of circRNA m6A modification in the development of inflammatory responses.…”
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E nterocloster clostridioformis protects against Salmonella pathogenesis and modulates epithelial and mucosal immune function by Benjamin S. Beresford-Jones, Satoshi Suyama, Simon Clare, Amelia Soderholm, Wangmingyu Xia, Puspendu Sardar, Junhee Lee, Katherine Harcourt, Trevor D. Lawley, Virginia A. Pedicord

“…Abstract Background Promoting resistance to enteric pathogen infection is a core function of the gut microbiota; however, many of the specific host–commensal interactions that mediate this protection remain uncharacterised. …”
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Pharmacological Blocking of Adiponectin Receptors Induces Alzheimer’s Disease-like Neuropathology and Impairs Hippocampal Function by Hui-Hui Guo, Hai-Ning Ou, Jia-Sui Yu, Suk-Yu Yau, Hector Wing-Hong Tsang

“…<b>Conclusions</b>: These findings highlight the critical role of peripheral manipulation of adiponectin receptors in modulating cognitive function and adult neurogenesis, offering insights into potential therapeutic strategies for AD and related cognitive disorders.…”
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Loss-function-of a UMP kinase leads to impaired chloroplast development and photosynthesis efficiency in cucumber by Ming Pan, Cancan Xia, Shenao Gu, Huanle He, Gang Wang, Yiqun Weng, Jian Pan, Junsong Pan

“…The tnyl2 mutant, characterized by stunted growth and a photo-bleached phenotype, reveals a compromised chloroplast structure and function. Through genetic analysis, CsUMPK (Csa6G483490) emerged as the pivotal gene associated with these abnormalities, playing a vital role in chlorophyll synthesis and chloroplast integrity. …”
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Individuals co-exposed to sand fly saliva and filarial parasites exhibit altered monocyte function. by Moussa Sangare, Yaya Ibrahim Coulibaly, Naureen Huda, Silvia Vidal, Sameha Tariq, Michel Emmanuel Coulibaly, Siaka Yamoussa Coulibaly, Lamine Soumaoro, Ilo Dicko, Bourama Traore, Ibrahim Moussa Sissoko, Sekou Fantamady Traore, Ousmane Faye, Thomas B Nutman, Jesus G Valenzuela, Fabiano Oliveira, Seydou Doumbia, Shaden Kamhawi, Roshanak Tolouei Semnani

“…<h4>Conclusions/significance</h4>Together, our data suggest that SG or recombinant salivary proteins from Pd alter human monocyte function by upregulating selective inflammatory cytokines.…”
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Evaluation of clopidogrel impact on canine platelet function using flow cytometry and thromboelastography platelet mapping by Eunchae Yoon, Chaewon Shin, Hyeona Bae, Kyu-Woan Cho, Dong-In Jung, Jinho Park, Dongbin Lee, DoHyeon Yu

“…BackgroundClopidogrel is frequently used in veterinary medicine to therapeutically decrease platelet function, although some different dosages have been published. …”
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Conserved functional features of natural killer cell subsets in chicken, human, and murine immune systems by Seung Je Woo, Jaeryeong Kim, Hong Jo Lee, Kyung Youn Lee, Kyung Je Park, Jin-Kyoo Kim, Jin Lee Kim, Byung Chul Park, Minseok Seo, Jae Yong Han

“…Cross-species analysis revealed that most genes exhibited distinct expression patterns within NK subsets, reflecting evolutionary divergence, though functional genes were conserved across chicken, humans, and mice. …”
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Functional roles of folic acid in alleviating dexamethasone‐induced fatty liver syndrome in laying hens by Xi Sun, Junjie Ma, Chaohui Wang, Zhouzheng Ren, Xin Yang, Xiaojun Yang, Yanli Liu

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GDNF overexpression in astrocytes enhances branching and partially preserves hippocampal function in an Alzheimer’s rat model by Ana Abril Vidal Escobedo, Facundo Peralta, Gustavo Ramón Morel, Martino Avallone, Tomas Björklund, Paula Cecilia Reggiani, Joaquín Pardo

“…These findings demonstrate the capacity of the AAV-GFAP-GDNF-TdTom construct to induce astrocytic branching and partially preserve memory function. They also underscore its partial therapeutic potential in a neuroinflammatory, metabolically compromised and neurodegenerative context.…”
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In silico identification and functional annotation of universal stress protein (USP) gene family in Chenopodium quinoa by Hajira Imran, Alvina Gul, Rehan Zafar Paracha, Rabia Amir, Faiza Munir, Muhammad Faraz Bhatti

“…Analysis of cis-elements, protein–protein interactions, and micro-RNAs that target CqUSPs revealed important insights into the regulatory mechanisms, functional associations and post-transcriptional control of these genes. …”
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Cloning, structural and function analysis of MiMYB44L gene in kernels of Macadamia integrifolia by XU Peng, TAN Qiujin, SONG Haiyun, ZHENG Shufang, YANG Xiaozhou, HUAN Xiuju, ZHANG Tao, ZHOU Chunheng, WEI Yuanrong, WANG Wenlin*

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Electroacupuncture Modulates Microbial Phenylalanine Metabolism and Enhances the Intestinal Barrier Function to Alleviate Colitis in Mice by Zhu L, Au R, Dai L, Li Y, Xu F, Cui Y, Hu J, Shen H

“…Pro-inflammatory cytokines were detected, and the core molecule of intestinal barrier function were analyzed. The composition of intestinal flora was analyzed using 16S sRNA sequencing, while the changes of metabolites in colon tissue were detected by Ultra-performance liquid chromatography–tandem mass spectrometry (UPLC/MS/MS).Results: Treatment with both high and low frequencies of EA at ST36 significantly ameliorated the symptoms of colitis, while also exerting systemic and local anti-inflammatory effect by downregulating the proinflammatory cytokines, iNOS and MPO. …”
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Identification and Functional Analysis of Cystathionine Beta-Synthase Gene Mutations in Chinese Families with Classical Homocystinuria by Xin Liu, Xinhua Liu, Jinfeng Liu, Junhong Guo, Danyao Nie, Jiantao Wang

“…Bioinformatics and in vitro functional analysis showed that the c.1359-1G>C mutation affects the normal splicing of <i>CBS</i> gene, resulting in the production of two abnormal transcripts and the production of two truncated proteins. …”
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Characteristics and Functions of Different Intestinal Segments in Juvenile Greater Amberjack (<i>Seriola dumerili</i>) by Kunfeng Zhu, Mouyan Jiang, Mengyao Yan, Yang Huang, Tonglin Yang, Chunhua Zhu

“…The greater amberjack (<i>Seriola dumerili</i>), a key species in marine aquaculture, relies heavily on its intestine for nutrient absorption and immune function. However, the structural and functional specialization of its intestinal segments remains poorly understood. …”
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Diversity and functional specialization of oyster immune cells uncovered by integrative single-cell level investigations by Sebastien De La Forest Divonne, Juliette Pouzadoux, Oceane Romatif, Caroline Montagnani, Guillaume Mitta, Delphine Destoumieux-Garzón, Benjamin Gourbal, Guillaume M Charriere, Emmanuel Vignal

“…This integrative analysis enabled us to reconcile molecular and cellular data and identify distinct cell types performing specialized immune functions, such as phagocytosis, reactive oxygen species production, copper accumulation, and expression of antimicrobial peptides. …”
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Structural and functional analysis of the accessory gene regulators of Staphylococcus aureus and Staphylococcus epidermidis: an in Silico approach by Subhamoy Dey, Tuhin Manna, Kartik Chandra Guchhait, Monalisha Karmakar, Debarati Jana, Priyanka Raul, Saroj Ballav, Mousumi Manna, Subrata Hazra, Amiya Kumar Panda, Chandradipa Ghosh

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Identification of methionine metabolism related prognostic model and tumor suppressive functions of BHMT in hepatocellular carcinoma by Wenli Liu, Kaiheng Hu, Yaqing Fu, Tianmin Zhou, Qingmei Zhong, Wu Wang, Yang Gui, Ping Zhang, Di Yao, Xiaohong Yang, Weifeng Zhu, Zhuoqi Liu, Daya Luo, Yingqun Xiao

“…In summary, this study innovatively provides first methionine metabolism-related prognostic model and unveils the tumor suppressive function of BHMT in HCC, providing potential mechanism by which BHMT exert its function.…”
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Curcumin as a promising therapeutic agent for diabetic neuropathy: from molecular mechanisms to functional recovery by Shirin Barati, Abdullah Yadegari, Maedeh Shahmohammadi, Fatemeh Azami, Fatemeh Tahmasebi, Mohammad Reza Rouhani, Sahar Kazemi, Elmira Roshani Asl

“…Curcumin is considered a potential treatment for diabetic neuropathy (DN) because it measurably reduces markers of oxidative stress and inflammatory cytokines, while significantly alleviating neuropathic pain and improving nerve function. MicroRNAs (miRNAs or miR), which are small non-coding RNAs consisting of 19–25 nucleotides, are stable in circulation and can regulate multiple target genes. …”
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The Spatial‐Temporal Alternative Splicing Profile Reveals the Functional Diversity of FXR1 Isoforms in Myogenesis by Wei Wang, Xinhao Fan, Weiwei Liu, Yuxin Huang, Shuhong Zhao, Yalan Yang, Zhonglin Tang

“…Notably, this study identifies a muscle‐specific SE (exon 15) within the Fxr1 gene, whose AS generates two dynamically expressed isoforms with distinct functions: the isoform without exon 15 (Fxr1E15−) regulates myoblasts proliferation, while the isoform incorporating exon 15 (Fxr1E15+) promotes myogenic differentiation and fusion. …”
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Adipocyte associated glucocorticoid signaling regulates normal fibroblast function which is lost in inflammatory arthritis by Heather J. Faust, Tan-Yun Cheng, Ilya Korsunsky, Gerald F. M. Watts, Shani T. Gal-Oz, William V. Trim, Suppawat Kongthong, Anna Helena Jonsson, Daimon P. Simmons, Fan Zhang, Robert Padera, Susan Chubinskaya, Accelerating Medicines Partnership: RA/SLE Network, Kevin Wei, Soumya Raychaudhuri, Lydia Lynch, D. Branch Moody, Michael B. Brenner

“…Little is known about what regulates the homeostatic functions of fibroblasts. Here, we perform RNA sequencing and identify a gene expression program in healthy synovial fibroblasts characterized by enhanced fatty acid metabolism and lipid transport. …”
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