The modern view of the idea of gamma-aminobutyric acid and its metabolite use to restore the motor function by А. G. Rodinskij, Т. V. Dемchenko, A. V. Моzgunov, К. V. Pysarevska

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Unveiling the immunomodulatory dance: endothelial cells’ function and their role in non-small cell lung cancer by Sophia Daum, Lilith Decristoforo, Mira Mousa, Stefan Salcher, Christina Plattner, Baharak Hosseinkhani, Zlatko Trajanoski, Dominik Wolf, Peter Carmeliet, Andreas Pircher

“…In general, endothelial cells exhibit diverse immunomodulatory properties, influencing immune cell recruitment, antigen presentation, and regulation of immune checkpoint expression. Understanding the multifaceted roles of TECs as well as assigning specific functional hallmarks to various TEC phenotypes offer new avenues for targeted development of therapeutic interventions, particularly in the context of advanced immunotherapy and anti-angiogenic treatments. …”
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Atypical function of a centrosomal module in WNT signalling drives contextual cancer cell motility by Yi Luo, Miriam Barrios-Rodiles, Gagan D. Gupta, Ying Y. Zhang, Abiodun A. Ogunjimi, Mikhail Bashkurov, Johnny M. Tkach, Ainsley Q. Underhill, Liang Zhang, Mohamed Bourmoum, Jeffrey L. Wrana, Laurence Pelletier

“…Thus, a centrosomal module plays an atypical function in WNT signalling and actin nucleation that is critical for cancer cell motility and is associated with more aggressive cancers. …”
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Apelin-13 exerts protective effects against acute kidney injury by lysosomal function regulation by Hao Pan, Shuangshuang Li, Yong Ning, Zhizhi Hu

“…Additionally, apelin-13 was found to reduce the expression of the (pro)renin receptor, restore lysosomal membrane permeability, augment lysosomal biogenesis, and enhance autophagic flux in the kidney following AKI.Conclusions Our study elucidates novel mechanisms underlying the protective effects of apelin in AKI through modulating lysosomal function and autophagy.…”
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Dopamine Treatment and Cognitive Functioning in Individuals with Parkinson’s Disease: The “Cognitive Flexibility” Hypothesis Seems to Work by Alberto Costa, Antonella Peppe, Ilenia Mazzù, Mariachiara Longarzo, Carlo Caltagirone, Giovanni A. Carlesimo

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Yeast-based assays for the functional characterization of cancer-associated variants of human DNA repair genes by Tiziana Cervelli, Samuele Lodovichi, Francesca Bellè, Alvaro Galli

“…DNA repair gene mutations are associated with many types of cancers, therefore the evaluation of the functional impact of these mutations is crucial for risk assessment and for determining therapeutic strategies. …”
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Multi-functional mechanisms of immune evasion by the streptococcal complement inhibitor C5a peptidase. by Nicola N Lynskey, Mark Reglinski, Damien Calay, Matthew K Siggins, Justin C Mason, Marina Botto, Shiranee Sriskandan

“…Taken together, these data show that ScpA is a multi-functional virulence factor with both complement-dependent and independent roles in streptococcal pathogenesis.…”
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Enhancing NADPH to restore redox homeostasis and lysosomal function in G6PD-deficient microglia by Abir Mondal, Soumyadeep Mukherjee, Prince Upadhyay, Isha Saxena, Soumya Pati, Shailja Singh

“…Supplementing metabolites such as citric and malic acid improved NADPH levels, while small molecules like dieckol and resveratrol enhanced IDH1 and ME1 expression. The combination of these approaches restored redox homeostasis and lysosomal function, offering potential therapeutic strategies for G6PD deficiency.…”
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Replication Protein A Presents Canonical Functions and Is Also Involved in the Differentiation Capacity of Trypanosoma cruzi. by Raphael Souza Pavani, Marcelo Santos da Silva, Carlos Alexandre Henrique Fernandes, Flavia Souza Morini, Christiane Bezerra Araujo, Marcos Roberto de Mattos Fontes, Osvaldo Augusto Sant'Anna, Carlos Renato Machado, Maria Isabel Cano, Stenio Perdigão Fragoso, Maria Carolina Elias

“…Here, we demonstrate experimentally that the T. cruzi RPA complex interacts with DNA via RPA-1 and is directly related to canonical functions, such as DNA replication and DNA damage response. …”
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Targeting SMOX Preserves Optic Nerve Myelin, Axonal Integrity, and Visual Function in Multiple Sclerosis by Harry O. Henry-Ojo, Fang Liu, S. Priya Narayanan

“…Immunofluorescence studies confirmed these findings, showing increased preservation of myelin and axonal proteins in MDL72527-treated EAE mice compared to the vehicle-treated group. Functional assessment studies (Electroretinography) demonstrated significant improvement in RGC function and axonal conduction in EAE mice treated with MDL72527. …”
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RNA Polymerase III Output Is Functionally Linked to tRNA Dimethyl-G26 Modification. by Aneeshkumar G Arimbasseri, Nathan H Blewett, James R Iben, Tek N Lamichhane, Vera Cherkasova, Markus Hafner, Richard J Maraia

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Single-cell transcriptomics reveals metabolic remodeling and functional specialization in the immune microenvironment of bone tumors by Jun Chen, Na Cui, Shao-Hui He, Chun-Yan Xia, Wei-Qing Li

“…Methods Immune cells were isolated from 13 bone tumor samples and profiled via scRNA-seq to delineate cellular compositions, metabolic adaptations, and intercellular communication networks. Differential gene expression analysis, metabolic pathway enrichment, and pseudotime trajectory inference were employed to characterize functional states and differentiation processes of immune cell subsets. …”
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Expansins in Salt and Drought Stress Adaptation: From Genome-Wide Identification to Functional Characterisation in Crops by Siarhei A. Dabravolski, Stanislav V. Isayenkov

“…This manuscript explores the functions of expansins in salt and drought stress responses across multiple plant species, highlighting their involvement in cell wall loosening, transcriptional regulation, ion and osmotic homeostasis, and phytohormone signalling. …”
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Analyzing longitudinal trait trajectories using GWAS identifies genetic variants for kidney function decline by Simon Wiegrebe, Mathias Gorski, Janina M. Herold, Klaus J. Stark, Barbara Thorand, Christian Gieger, Carsten A. Böger, Johannes Schödel, Florian Hartig, Han Chen, Thomas W. Winkler, Helmut Küchenhoff, Iris M. Heid

“…Abstract Understanding the genetics of kidney function decline, or trait change in general, is hampered by scarce longitudinal data for GWAS (longGWAS) and uncertainty about how to analyze such data. …”
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Inhibiting CFTR through inh-172 in primary neutrophils reveals CFTR-specific functional defects by Ana Lúcia Da Silva Cunha, Marfa Blanter, Janne Renders, Mieke Gouwy, Natalie Lorent, Mieke Boon, Sofie Struyf, Marianne S. Carlon

“…When co-culturing neutrophils with CF sputum supernatant and airway epithelial cells, the extent of phagocytosis was reduced, underscoring the importance of recreating an inflammatory environment as seen in PwCF lungs to model immune responses in vitro. Despite low CFTR expression in blood neutrophils, functional defects were found in inh-172-treated and CF neutrophils. …”
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Chloroplast Functionality at the Interface of Growth, Defense, and Genetic Innovation: A Multi-Omics and Technological Perspective by Chunhua Zhang, Wenting Li, Yahan Wu, Shengli Li, Bao Hua, Haizhou Sun

“…Advancements in chloroplast genomics, transcription, translation, and proteomics have deepened our understanding of their regulatory functions and interactions with nuclear-encoded proteins. …”
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Arabidopsis MEB3 functions as a vacuolar metal transporter to regulate iron accumulation in roots by Kaichiro Endo, Arpan Kumar Basak, Arpan Kumar Basak, Alwine Wilkens, Alwine Wilkens, Mohamadreza Mirzaei, Mohamadreza Mirzaei, Stanislav Kopriva, Kenji Yamada

“…Here, we show that MEMBRANE PROTEIN OF ER BODY 3 (MEB3), a VIT family member, functions as a vacuolar metal transporter for iron distribution in Arabidopsis thaliana. …”
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Real-world goal-directed behavior reveals aberrant functional brain connectivity in children with ADHD. by Liya Merzon, Sofia Tauriainen, Ana Triana, Tarmo Nurmi, Hanna Huhdanpää, Minna Mannerkoski, Eeva T Aronen, Mikhail Kantonistov, Linda Henriksson, Emiliano Macaluso, Juha Salmi

“…Functional connectomics is a popular approach to investigate the neural underpinnings of developmental disorders of which attention deficit hyperactivity disorder (ADHD) is one of the most prevalent. …”
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Fluoride effect on renal and hepatic functions: A comprehensive decade review of In vitro and In vivo studies by Sirigala Lavanya, Kasirajan Hema Shree, MDS, Prathiba Ramani

“…The data extraction process focused on critical aspects such as sample size, methodologies used, key findings, and conclusions regarding fluoride's impact on kidney and liver functions. The review also includes a detailed analysis of gene expression, KEGG pathways, and STRING analysis, further enhancing the reliability of the results. …”
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Activation of the Rat P2X7 Receptor by Functionally Different ATP Activation Sites by Fritz Markwardt, Malte Berthold, Sanaria Hawro Yakoob, Günther Schmalzing

“…The 7-7-7 concatamer exhibited a biphasic ATP⁴⁻ concentration dependence, best fit by the sum of two Hill functions, confirming the existence of functionally distinct ATP⁴⁻ activation sites. …”
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