MiRNAs function in the development of resistance against doxorubicin in cancer cells: targeting ABC transporters by Xin-Yan Lu, Hongxu Jin

Get full text

Two novel human cytomegalovirus NK cell evasion functions target MICA for lysosomal degradation. by Ceri A Fielding, Rebecca Aicheler, Richard J Stanton, Eddie C Y Wang, Song Han, Sepehr Seirafian, James Davies, Brian P McSharry, Michael P Weekes, P Robin Antrobus, Virginie Prod'homme, Fabien P Blanchet, Daniel Sugrue, Simone Cuff, Dawn Roberts, Andrew J Davison, Paul J Lehner, Gavin W G Wilkinson, Peter Tomasec

“…Despite activation by IE functions, HCMV effectively suppressed cell surface expression of NKGDLs through both the early and late phases of infection. …”
Get full text

Effect of Wendan decoction granules on preventing endolymphatic hydrops and protecting vestibular function in Guinea pigs by Jingjing Xia, Tiancheng Xie, Jinli Liu, Weikang Cheng, Longyan Liao, Ming Chen, Haibing Hua, Xiaobing Hou

“…The effects of Wendan decoction granules on neurological function, cochlear hydrops, the ultrastructure of the cochlear Corti organ area, inflammatory response, and the expression of AQP2 and P38MAPK in guinea pigs were examined using behavioral experiments, hematoxylin and eosin staining, scanning electron microscopy, ELISA, qRT-PCR, and immunohistochemistry staining. …”
Get full text

Astrocytes from lamina cribrosa are involved in the autoregulatory function of optic nerve head vessels in vitro by Xiaoxiao Feng, Xiaoxiao Feng, Wenjia Zhang, Wenjia Zhang, Tingting Wan, Tingting Wan, Kangwei Jiao, Kangwei Jiao, Liwei Zhang, Liwei Zhang, Changhui Li, Changhui Li, Libo Xiao, Libo Xiao

“…PurposeTo investigate the role of the lamina cribrosa (LC) astrocytes in the autoregulatory capacity of optic nerve head (ONH) vessels and to explore the underlying molecular mechanisms.MethodsThe Oxygen-glucose deprivation/reperfusion model (OGD/R) in vitro was constructed to examine the changes in cell morphology and protein expression in LC astrocytes. LC astrocytes were co-cultured with vascular smooth muscle cells (VSMCs) to detect the role of LC astrocytes in the autoregulatory function of vessels.ResultsThe partial pressure of oxygen (PO2) in the supernatant of LC astrocytes was significantly lower following OGD, and this reduction was more pronounced with longer OGD durations. …”
Get full text

Identification and immune function of the teleost-specific chemokine CCL39 in black rockfish (Sebastes schlegelii) by Fengjun Lin, Pei Zhang, Xuan Xu, Chonghui Chen, Xiaoxu Zhang, Yiying Liu, Chao Li, Qiang Fu

“…In this study, we systematically characterized CCL39, a teleost-specific chemokine, in black rockfish, Sebastes schlegelii (SsCCL39), explored its expression patterns following Aeromonas salmonicida infection, and revealed their immune function and antibacterial mechanism. …”
Get full text

Coacting enhancers can have complementary functions within gene regulatory networks and promote canalization. by Leslie Dunipace, Zsuzsa Ákos, Angelike Stathopoulos

“…Developmental genes are often regulated by multiple enhancers exhibiting similar spatiotemporal outputs, which are generally considered redundantly acting though few have been studied functionally. Using CRISPR-Cas9, we created deletions of two enhancers, brk5' and brk3', that drive similar but not identical expression of the gene brinker (brk) in early Drosophila embryos. …”
Get full text

Excitation-inhibition balance abnormally shapes structure–function coupling of gray matter in Parkinson’s disease by Zhengye Cao, Na Wang, Hongjie Hu, Hongying Zhang, Jingtao Wu, Song’an Shang

“…Abstract How neurobiological underpinnings regulate the heterogeneous expression of structural-functional connectivity coupling (SFC) in Parkinson’s disease (PD) remains largely unknown. …”
Get full text

Rational development of FMN-based orthogonal riboswitch that functions in response to specific non-cognate ligand by Divya Ojha, Ambadas B. Rode

“…Abstract Re-engineering natural riboswitches into orthogonal RNA switches by making them functional in response to exogenous ligands but unresponsive to endogenous cognate ligands is a promising yet less explored strategy for developing gene regulatory tools. …”
Get full text

Discovering the interactome, functions, and clinical relevance of enhancer RNAs in kidney renal clear cell carcinoma by Zhaohui Sun, Haojie Du, Xudong Zheng, Hepeng Zhang, Huajie Hu

Get full text

Effects of Mulberry Leaf Extract on the Liver Function of Juvenile Spotted Sea Bass (Lateolabrax maculatus) by Sishun Zhou, Hao Lin, Lumin Kong, Jianrong Ma, Zhongying Long, Huihui Qin, Zhangfan Huang, Yi Lin, Longhui Liu, Zhongbao Li

“…In order to explore the effect of mulberry leaf extract (ELM) on the liver function of spotted sea bass, 360 fish with healthy constitution (average body weight 9.00 ± 0.02 g) were selected and randomly divided into six groups with three repetitions, and six groups of fish were randomly placed into 18 test tanks (200 L) with 20 fish per tank for the 52-day feeding test. …”
Get full text

The developmental regulator Pax6 is essential for maintenance of islet cell function in the adult mouse pancreas. by Alan W Hart, Sebastien Mella, Jacek Mendrychowski, Veronica van Heyningen, Dirk A Kleinjan

“…Immunohistochemical analysis of the pancreata revealed almost complete loss of Pax6 and much reduced expression of insulin, glucagon, and somatostatin. Several other markers of islet cell function were also affected. …”
Get full text

Unravelling the temporal dynamics of community functions in protists induced by treated wastewater exposure using metatranscriptomics by Manan Shah, Guido Sieber, Aman Deep, Daniela Beisser, Jens Boenigk

“…While the ecological effects of TWW on microbial diversity have been studied, understanding the functional responses of protist communities remains limited. …”
Get full text

PRELP functions via multiple interactions with intrinsically weak affinity relying on ECM anchoring and remodeling by Hirofumi Kosuge, Makoto Nakakido, Susana de Vega, Shin-ichi Ohnuma, Kouhei Tsumoto

“…Results of this study suggest that PRELP modulates multiple interactions with intrinsically weak binding affinities through the anchoring to ECM proteins and also promotes the ECM protein expression to maintain the preferred environment to exert the molecular functions.…”
Get full text

Fuzzy Computation Tree Temporal Logic with Quality Constraints and Its Model Checking by Xianfeng Yu, Yongming Li, Shengling Geng, Huirong Li

“…The encapsulation of particular quality functions and predicates within temporal logic formulas markedly enhances the representation of detailed temporal characteristics within a system. …”
Get full text

MicroRNAs in Liver Fibrosis: Unraveling Intercellular Crosstalk and the Regulatory Functions of MicroRNA-223 by Chinnatam Phetkong, Chaiyaboot Ariyachet

Get full text

Metaphor Functioning in Military Discourse and Ways of Its Translation into Russian (on Material of English-language Periodicals) by K. A. Degtyarenko, E. V. Kuritskaya

Get full text

Integrative analysis of SEPN1 in glioma: Prognostic roles, functional implications, and potential therapeutic interventions. by Zisong Wang, Danwen Wang, Xuanyu Wang, Yihang Xu, Yunhe Yuan, Yuxin Chen, Zhiqiang Li, Xiaoping Liu

“…<h4>Results</h4>We found that SEPN1 was significantly upregulated in glioma, associated with poor prognosis, functioned as an independent risk factor, and predominantly expressed in malignant glioma cells. …”
Get full text

Quercetin alleviates acute pancreatitis by modulating glycolysis and mitochondrial function via PFKFB3 inhibition by Hai Jiang, Jia Liu, Zhipeng Xu, Qi Song, Junjie Tao, Heng Zhu, Qiliang Li, Lei Li

“…Results Quercetin significantly reduced PFKFB3 expression, inhibited glycolysis, and improved mitochondrial function in inflammatory pancreatic cells. …”
Get full text

Genetic Diversity in the <i>Suppressyn</i> Gene Sequence: From Polymorphisms to Loss-of-Function Mutations by Jun Sugimoto, Danny J. Schust, Takeshi Nagamatsu, Yoshihiro Jinno, Yoshiki Kudo

“…In the present study, we aimed to elucidate the potential contribution of genomic variation to the loss of suppressyn function, extending previous analyses of expression abnormalities in perinatal disorders. …”
Get full text

A Modified NK Cell Degranulation Assay Applicable for Routine Evaluation of NK Cell Function by Snehal Shabrish, Maya Gupta, Manisha Madkaikar

Get full text