Effects of Dendrobium officinale Kimura & Migo flower flavonoids on cognitive function by regulating gut microbiota by Nanzhi Hu, Nanzhi Hu, Kaiyue Wang, Xing Ge, Xin Zhang, Xiaojie Zheng, Shifang Sun

“…The Y-maze experiment was used to test the cognitive ability of mice, the expression of related synaptic protein was detected by WB, and Iba-1 was labeled by immunofluorescence to study the effects of DOFF on inflammatory response and cognitive function by regulating intestinal microbiota.ResultsThe results showed that DOFF intervention could regulate the relative abundance of intestinal flora in D-gal mice, including the relative abundance of Akkermansia, down-regulate the ratio of Firmicutes/Bacteroidetes, up-regulate the expression of ZO-1, and improve the colonic tissue injury. …”
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Human stem cell-derived neurons: a system to study human tau function and dysfunction. by Mariangela Iovino, Rickie Patani, Colin Watts, Siddharthan Chandran, Maria Grazia Spillantini

“…In this study, we have investigated whether human embryonic stem cell-derived neurons could be a good model to study human tau distribution, function and dysfunction.<h4>Methodology/principal findings</h4>Using RT-PCR, immunohistochemistry, western blotting and cell transfections we have investigated whether all 6 adult human brain tau isoforms are expressed in neurons derived from human embryonic and fetal stem cells and whether 4 repeat tau over-expression alone, or with the F3 tau repeat fragment, (amino acid 258-380 of the 2N4R tau isoform with the ΔK280 mutation) affects tau distribution. …”
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Small open reading frame-encoded microproteins in cancer: identification, biological functions and clinical significance by Tingting Zhang, Zhang Li, Jiao Li, Yong Peng

“…In this review, we introduce the translational mechanisms and identification methods of microproteins, summarize their dysregulation in cancer and their biological functions in regulating gene expression, and emphasize their roles in driving hallmark events of cancer. …”
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Transcriptional analysis of murine biliary atresia identifies macrophage heterogeneity and subset-specific macrophage functions by Kyle D. Gromer, Shang-Yang Chen, Gaurav Gadhvi, Liang Feng, Colin Shearn, Swati Antala, Swati Antala, Joshua B. Wechsler, Carla M. Cuda, Cara L. Mack, Ronald J. Sokol, William J. Janssen, Richard M. Green, Harris Perlman, Deborah R. Winter, Sarah A. Taylor, Sarah A. Taylor

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Digoxin reveals a functional connection between HIV-1 integration preference and T-cell activation. by Alexander Zhyvoloup, Anat Melamed, Ian Anderson, Delphine Planas, Chen-Hsuin Lee, Janos Kriston-Vizi, Robin Ketteler, Andy Merritt, Jean-Pierre Routy, Petronela Ancuta, Charles R M Bangham, Ariberto Fassati

“…The drug unmasked a functional connection between HIV-1 integration and T-cell activation. …”
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TRIM21 functions as an oncogene in glioblastoma by transactivating FOSL1 and promoting the ubiquitination of p27 by Vanajothi Ramar, Rajveer Singh Sidhu, Osei Pako, Cheyenne R. Cisse, Alyssa A. Guo, Jason Li, Kelcey Stapleton, Shanchun Guo, Guangdi Wang, Mingli Liu

“…Functional assays demonstrated that TRIM21 enhances glioma cell proliferation and invasion. …”
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Preconditioning with an enriched environment enhances neuroplasticity and functional recovery following cerebral ischemia-reperfusion injury by Yi Zhang, Wen Liu, Lingling Liu, Yang Liu, Youqing Yang, Zhijie Yang, Xiuping Chen

“…Additionally, EE preconditioning resulted in increased expression of NGF and bFGF. These molecular changes were positively correlated with functional recovery in the MCAO model. …”
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Light-regulated voltage-gated potassium channels for acute interrogation of channel function in neurons and behavior. by Henry H Jerng, Jay M Patel, Tamor A Khan, Benjamin R Arenkiel, Paul J Pfaffinger

“…Even though Kv channels have been intensely studied for over 70 year, surprisingly little is known about how specific channels expressed in various neurons and their functional properties impact neuronal network activity and behavior in vivo. …”
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Mis-splicing drives loss of function of p53E224D point mutation. by Ian C Lock, Nathan H Leisenring, Warren Floyd, Eric S Xu, Lixia Luo, Yan Ma, Erin C Mansell, Diana M Cardona, Chang-Lung Lee, David G Kirsch

“…<h4>Results</h4>Expression of human p53E224D from cDNA translated to a fully functional p53 protein. …”
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Differential changes in anatomical, molecular and functional determinants of intestinal glucose absorption during murine pregnancy by T. Sebastian Overduin, Georgia S. Clarke, Hui Li, Richard L. Young, Kathryn L. Gatford, Amanda J. Page

“…The timing and regional specificity of adaptations in small intestinal (SI) anatomy and transport, and their functional consequences, remain unclear. We therefore assessed anatomy and expression of macronutrient transporters in the duodenum, jejunum, and ileum collected from time‐mated pregnant C57BL/6 mice at gestational day (GD) 6.5, 12.5, or 17.5 and age‐matched nonpregnant females. …”
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Genetic factors regulating lung vasculature and immune cell functions associate with resistance to pneumococcal infection. by Magda S Jonczyk, Michelle Simon, Saumya Kumar, Vitor E Fernandes, Nicolas Sylvius, Ann-Marie Mallon, Paul Denny, Peter W Andrew

“…These candidate genes are known to regulate TGFβ signalling, smooth muscle and immune cells functions. Interestingly, our pulmonary histopathology and gene expression data demonstrated, lung vasculature plays an important role in resistance to pneumococcal infection. …”
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A cytoplasmic new catalytic subunit of calcineurin in Trypanosoma cruzi and its molecular and functional characterization. by Patricio R Orrego, Héctor Olivares, Esteban M Cordero, Albert Bressan, Mauro Cortez, Hernán Sagua, Ivan Neira, Jorge González, José Franco da Silveira, Nobuko Yoshida, Jorge E Araya

“…In this study, we cloned a new isoform of the gene coding for CL strain catalytic subunit CaNA (TcCaNA2) and characterized it molecularly and functionally. There is one copy of the TcCaNA2 gene per haploid genome. …”
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Rare variants in the endocytic pathway are associated with Alzheimer's disease, its related phenotypes, and functional consequences. by Lingyu Zhan, Jiajin Li, Brandon Jew, Jae Hoon Sul

“…Careful examination using NFTs revealed one significantly associated gene, ANKRD13D. To identify functional associations, we integrated bulk RNA-Seq data from over 600 brain tissues and found two endocytic expression genes (eGenes), HLA-A and SLC26A7, that displayed significant influences on their gene expressions. …”
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Kiperin Postbiotic Supplement-Enhanced Bacterial Supernatants Promote Fibroblast Function: Implications for Regenerative Medicine by Lutfiye Karcioglu Batur, Cuneyd Yavas, Yağmur Ekenoğlu Merdan, Ashabil Aygan

“…This study aimed to evaluate the effects of a postbiotic supplement (PS)—composed of inactivated strains of <i>Escherichia coli</i>, <i>Lacticaseibacillus rhamnosus</i>, and <i>Lactiplantibacillus plantarum</i>—on fibroblast function, particularly in the context of bacterial secretomes from common pathogenic strains. …”
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A study on the functional role of the DHCR24 gene in gonadal differentiation and development of Macrobrachium nipponense by Pengfei Cai, Wenyi Zhang, Sufei Jiang, Yiwei Xiong, Hui Qiao, Shubo Jin, Hongtuo Fu

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Functional Verification and Prognostic Value of Neutrophil Extracellular Trap-Related Genes in Pancreatic Cancer Progression by Jiaxin Xu, Liying Tu, Lijing Ma, Qisheng Tang, Yu Cao, Lihong Jiang

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Functional feed ingredients modulate the immune response of RTgutGC cells to LPS-induced inflammation by Malene Malchus Fosse, Laura Rivera Méndez, Tania Rodríguez-Ramos, Brian Dixon, Henrik Sundh, Rolf Erik Olsen

“…Functional feed ingredients can enhance the fish gut integrity and immune resilience during challenging situations in the aquaculture industry. …”
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An Efficient Universal Generating Function-Based Analyzing Approach for Multistate System with Imperfect Coverage Failure by Zheng Li, Jinlei Qin

“…Using the technique of the universal generating function (UGF), a component’s UGF expression with ICF can be incorporated in two steps. …”
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Functional Role of PPARs in Ruminants: Potential Targets for Fine-Tuning Metabolism during Growth and Lactation by Massimo Bionaz, Shuowen Chen, Muhammad J. Khan, Juan J. Loor

“…However, a wealth of information has accumulated in little more than a decade on ruminant PPARs including isotype tissue distribution, response to synthetic and natural agonists, gene targets, and factors affecting their expression. Functional characterization demonstrated that, as in monogastrics, the PPAR isotypes control expression of genes involved in lipid metabolism, anti-inflammatory response, development, and growth. …”
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A partial structural and functional rescue of a retinitis pigmentosa model with compacted DNA nanoparticles. by Xue Cai, Zack Nash, Shannon M Conley, Steven J Fliesler, Mark J Cooper, Muna I Naash

“…The nanoparticles were taken up into virtually all photoreceptors and mediated significant structural and biochemical rescue of the disease without histological or functional evidence of toxicity. Electroretinogram recordings showed that nanoparticle-mediated gene transfer restored cone function to a near-normal level in contrast to transfer of naked plasmid DNA. …”
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