Neonatal hypoxia leads to impaired intestinal function and changes in the composition and metabolism of its microbiota by Jun Wen, Yue Wu, Fengfeng Zhang, Yanchu Wang, Aifen Yang, Wenwen Lu, Xiaofeng Zhao, Huaping Tao

“…At the genetic level, hypoxia caused dysregulation of the expression of genes involved in intestinal barrier function, including antimicrobial activity, immune response, intestinal motility, and nutrient absorption. …”
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Characterization and enzymatic function of thioredoxin glutathione reductase in Orientobilharzia turkestanicum isolated from Xizang by Wenqiang Tang, Yongcheng Yue, Bin Shi, Xialing Zhao, Yang Hong

“…This study focuses on the molecular characterization and functional analysis of thioredoxin glutathione reductase (TGR) from O. turkestanicum, a key enzyme involved in the parasite’s antioxidant defense system. …”
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Association Between Irisin Level and Cognitive Function: A Systematic Review and Meta‐Analysis by Chengyan Han, Zining Zhou, Linlin Kong, Jing Lu, Xinyun Li

“…Conclusions This study implied that irisin has a positive effect on cognitive function, and the mechanism may be associated with promoting the expression of BDNF.…”
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DualNetM: an adaptive dual network framework for inferring functional-oriented markers by Bingjie Dai, Hanshuang Li, Peizhuo Wang, Pengwei Hu, Jixiang Xing, Yanan Hu, Qilemuge Xi, Yongchun Zuo

“…Functional-oriented markers are identified from bidirectional co-regulatory networks through the integration of gene co-expression networks. …”
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Angiogenesis-related genes and immune microenvironment in moyamoya disease: a transcriptomic and functional analysis by Zhenyu Zhou, Hongchuan Niu, Shaoqi Xu, Junze Zhang, Yutong Liu, Chengxu Lei, Shihao He, Yuanli Zhao

“…Hub genes were selected by differential analysis and weighted correlation network analysis. Functional enrichment, immune infiltration, and metabolic pathway analyses and drug prediction mapping (Connectivity Map [CMap]) were performed. …”
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Simultaneous impairment of neuronal and metabolic function of mutated gephyrin in a patient with epileptic encephalopathy by Borislav Dejanovic, Tania Djémié, Nora Grünewald, Arvid Suls, Vanessa Kress, Florian Hetsch, Dana Craiu, Matthew Zemel, Padhraig Gormley, Dennis Lal, EuroEPINOMICS Dravet working group, Candace T Myers, Heather C Mefford, Aarno Palotie, Ingo Helbig, Jochen C Meier, Peter De Jonghe, Sarah Weckhuysen, Guenter Schwarz

“…Thus, we describe a missense mutation that affects both functions of gephyrin and suggest that the identified defect at GABAergic synapses is the mechanism underlying the patient's severe phenotype.…”
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The Impact of Hyperbaric Oxygen Therapy on Functional and Structural Plasticity in Rats With Spinal Cord Injury by Xinyi Yang, Zhongyue Wu, Huimin Lai, Lingling Chen, Dairong Cao, Fang Liu

“…ABSTRACT Introduction Spinal cord injury (SCI) can result in sensory and locomotor function loss below the injured segment. Hyperbaric oxygen therapy (HBOT) has been proven to alleviate SCI. …”
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Spatiotemporal regulation by downstream genes of Prok2 in the olfactory system: from development to function by Bo-Ra Kim, Min-Seok Rha, Min-Seok Rha, Hyung-Ju Cho, Hyung-Ju Cho, Joo-Heon Yoon, Joo-Heon Yoon, Chang-Hoon Kim, Chang-Hoon Kim, Chang-Hoon Kim, Chang-Hoon Kim

“…Remarkably, downstream signaling genes of Prok2, including intermediate filament genes and genes expressed in the putative OB, were found to mediate olfactory system organization.DiscussionOverall, these findings reveal the role of Prok2 in olfactory system organization and elucidate how olfactory development defects translate to olfactory function.…”
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A Review of Novel Antioxidant Ergothioneine: Biosynthesis Pathways, Production, Function and Food Applications by Haijing Zhang, Zheng Liu, Zhong Wang, Ziteng Lei, Yan Jia, Wei Chen, Ruoyu Shi, Chengtao Wang

“…Ergothioneine (EGT), a natural thiol compound with potent antioxidant properties, exhibits diverse biological functions, including anti-inflammatory, neuroprotective, and cardioprotective effects. …”
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The impact of active components from on the growth, intestinal barrier function, and immunity of broiler chickens by Luli Zhou, Guanyu Hou, Hanlin Zhou, Khaled Abouelezz, Yuxiu Ye, Dingfa Wang

“…Conclusion The present study provides preliminary evidence that VR and PT are two of the main active compounds in PSE, which can cooperatively improve growth performance, intestinal barrier integrity, and immune function in chickens.…”
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FUNCTIONAL ACTIVITY OF ANTI-GD2 CAR-T CELLS WITH DIFFERENT ANTIGEN-RECOGNITION MODULE by Dzmitry Lutskovich, Hanna Klych, Maryia Maryia A. Keraz, Kate Lutskovich, Alexander Meleshko

“…The aim of the present study is to obtain chimeric antigenic receptors of the 2nd generation based on three antibodies, with different lengths of the extracellular domain and to evaluate their functional activity against a number of cell lines to justify further clinical trials.…”
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Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy by Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao

“…Here, we provide a comprehensive overview of the mechanisms by which TET proteins mediate DNA demethylation and detail their biological functions. Additionally, we highlight recent advances in understanding the molecular mechanisms linking TET dysregulation to disease pathogenesis and explore their potential as therapeutic targets. …”
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Bacterial community function increases leaf growth in a pitcher plant experimental system by Jessica R. Bernardin, Erica B. Young, Sarah M. Gray, Leonora S. Bittleston

“…However, the specific effects of leaf-associated bacterial community functions on plant growth are poorly understood. Although microbes can promote plant growth through various biochemical mechanisms, investigating the community’s functional contributions to plant growth remains to be explored. …”
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Evidence for the Functional Relevance of <i>vgll3</i> and <i>six6</i> οn Developmental Stages of Commercially Important Fish Species: Gilthead Seabream (<i>Sparus aurata</i> Linnae... by Aristotelis Moulistanos, Elisavet Kaitetzidou, Styliani Minoudi, Konstantinos Gkagkavouzis, Athanasios Kallimanis, Efthimia Antonopoulou, Alexandros Triantafyllidis, Spiros Papakostas

“…This highlights the potential functional relevance of these genetic variations in shaping expression profiles linked to domestication in the species.…”
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Proinflammatory cytokines, oxidative stress, and organ function as biomarkers of soman (GD) chronic neurotoxicity by Nyzil Massey, Suraj S. Vasanthi, Luis G. Gimenez-Lirola, Harm Tyler, Thimmasettappa Thippeswamy

“…The findings highlight the critical need to monitor systemic and neurological impacts, as well as organ function, to develop effective diagnostic and therapeutic strategies for survivors of nerve agent exposure or OP pesticide poisoning. …”
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Phenotypic profle of monocyte-macrophage lineage cells as a function of respiratory epithelium status by A. A. Fedorov, N. A. Ermak, E. B. Topolnitskiy, N. A. Shefer, E. O. Rodionov, O. V. Pankova, N. V. Cherdyntseva, M. N. Stakheyeva

“…It has been suggested that the relationship between reactive changes in the bronchial mucosa and NSCLC progression may be caused by the functional status of monocytic-macrophage cells as important participants in infammation, which determines both the risk of premalignant changes in the epithelium and malignant progression. …”
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Distal electrical stimulation enhances neuromuscular reinnervation and satellite cell differentiation for functional recovery by Chun-Wei Lin, Szu-Han Chen, Siao Muk Cheng, Tzu-Chun Chung, Wentai Liu, Daw-Yang Hwang, Song Li, Sheng-Che Lin, Yuan-Yu Hsueh

“…Abstract Background Peripheral nerve injuries lead to significant motor deficits, with limited treatment options for full functional recovery. Distal electrical stimulation (E-stim) has shown promise in promoting neuromuscular reinnervation, though its mechanisms are not yet fully understood. …”
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SIRT1 prevents noise-induced hearing loss by enhancing cochlear mitochondrial function by Yuelian Luo, Haoyang Wu, Xin Min, Yi Chen, Wenting Deng, Minjun Chen, Chuxuan Yang, Hao Xiong

“…This study revealed that SIRT1 expression in the cochlea progressively decreases in a mouse model of NIHL. …”
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GPR56 function as a key repressor in hepatocyte pyroptosis and the pathogenesis of liver fibrosis by Zhemin Shi, Qi Liu, Mengxia Zhang, Xiaoxiao Du, Yifan He, Lina Zheng, Wei Hong, Tao Han, Kun Zhang

“…Then, WGCNA combined with GO enrichment analysis were employed to predict the functions of GPR56. Additionally, Gain- and loss-of-function models (in vitro and in vivo) were established to explore GPR56’s function and the signaling pathways involved in liver fibrosis and hepatocyte pyroptosis. …”
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Genome-Wide Identification of the TIFY Family in Longan and Their Potential Functional Analysis in Anthocyanin Synthesis by Haowei Qing, Ziang Wu, Xiao Mo, Jinjv Wei, Yuyu Shi, Huiqin Guo, Jiongzhi Xu, Feng Ding, Shuwei Zhang

“…This study provides valuable insights into the functional characterization of longan <i>DlTIFY</i> genes and lays a foundation for future research on their roles in regulating plant development and secondary metabolism.…”
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