Regulation of stem cell fate and function by using bioactive materials with nanoarchitectonics for regenerative medicine by Wei Hu, Jiaming Shi, Wenyan Lv, Xiaofang Jia, Katsuhiko Ariga

“…The different cytoskeletal forces lead to substantial transcription and protein expression, which affect stem cell fate and function. …”
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Androgen Modulates Functions of Endothelial Progenitor Cells through Activated Egr1 Signaling by Yizhou Ye, Xizhe Li, You Zhang, Zhenya Shen, Junjie Yang

“…The relationship between androgen and the functions of EPCs has animated much interest and controversy. …”
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Enhancing Effects of Lactobacillus brevis CQPC12 on Motor Function in Mice Damaged by Antibiotics by Jiyou Wu, Xiaoguang Yang, Yuhua Yang

“…Finally, LBCQPC12 demonstrated potential utility in the creation of functional probiotics by reducing oxidative inflammation, skeletal muscle damage, and motor function in the central nervous system brought on by antibiotics.…”
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Functional Characterization of the Osteoarthritis Susceptibility Mapping to CHST11-A Bioinformatics and Molecular Study. by Louise N Reynard, Madhushika Ratnayake, Mauro Santibanez-Koref, John Loughlin

“…Using bioinformatics and experimental analyses, our aims were to characterise the rs835487 association signal and to identify the causal functional variant/s. Database searches revealed that rs835487 resides within a linkage disequilibrium (LD) block of only 2.7 kb and is in LD (r2 ≥ 0.8) with six other SNPs. …”
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Complement Receptor Type 1 Suppresses Human B Cell Functions in SLE Patients by Mariann Kremlitzka, Bernadett Mácsik-Valent, Anna Polgár, Emese Kiss, Gyula Poór, Anna Erdei

“…Furthermore, our data give evidence that although B lymphocytes of active systemic lupus erythematosus (SLE) patients express lower level of CR1, the inhibitory capacity of this complement receptor is still maintained and its ligand-induced clustering results in significant inhibition of the main B cell functions, similar to that found in the case of healthy individuals. …”
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Unlocking the life code: a review of SnoRNA functional diversity and disease relevance by Yinghui Li, Xinzhe Chen, Shudan Xiao, Haoxuan Wang, Bo Li, MeiHua Zhang, Kun Wang

“…They are widely involved in post-transcriptional modifications of ribosomal RNAs, including methylation and pseudouridylation, precisely regulating the process of ribosome biogenesis, ensuring the integrity of ribosome structure and function, and thereby guaranteeing the accuracy and efficiency of protein synthesis. snoRNAs not only maintain cell growth, proliferation, and differentiation under normal physiological conditions but also have abnormal expression closely associated with various diseases, such as cancer, cardiovascular diseases and neurodegenerative diseases. …”
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Endothelial function vessel wall measures in patients with gout associated with coronary heart disease by E S Feofanova, L A Knyaseva

“…Objective. To study function of endothelium in pts with gout associated with coronary heart disease (CHD) depending on hyperuricemia (HU) expression. …”
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Functional assembly of surface microbiota of Ulva fasciata improves nutrient absorption efficiency and growth by Han Wang, De-hua Li, Jing-ru Wang, Rong Wang, Chang-li Liang, Zhong Hu, Jun-he Liu

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Induction of flowering in Arabidopsis through functional peptide-mediated FT mRNA delivery by Masaki Odahara, Maai Mori, Shougo Ishio, Satoshi Kogawara, Keiji Numata

“…We developed a non-transgenic flowering induction system in the model plant Arabidopsis, employing the exogenous introduction of FT mRNA through a functional peptide-mediated delivery. Utilizing the functional peptide BP100-KH9 as a nanocarrier for nucleic acid delivery into plant cells, we confirmed the production of FT protein from the introduced FT mRNA, which was fused with a reporter gene Citrine. …”
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Functional improvement of natural Saccharomyces cerevisiae yeast strains by cell surface molecular engineering by Sara Granuzzo, Monica Rossetto, Lucio Zennaro, Francesca Righetto, Paolo Antoniali, Raffaele Lopreiato

“…Abstract Background Cellular boundaries of microorganisms can be modified by the expression in the cell wall of specific proteins endowed with relevant properties, improving their functional performance. …”
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Impact of Physical Activity Level on Whole-Body and Muscle-Cell Function in Older Adults by Hyo-Seong Yeo, Jae-Young Lim

“…Background The aim of this study was to examine the effects of different levels of physical activity on functional capacity, muscle strength, and the contractile properties of single muscle fibers in older adults. …”
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Isolation and Functional Determination of SKOR Potassium Channel in Purple Osier Willow, Salix purpurea by Yahui Chen, Xuefeng Peng, Jijie Cui, Hongxia Zhang, Jiang Jiang, Zhizhong Song

“…In this study, we determined a Shaker-type K+ channel gene in purple osier (Salix purpurea), designated as SpuSKOR, and determined its function using a patch clamp electrophysiological system. …”
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Gastric juice MicroRNAs as biomarkers for functional dyspepsia: an observational case-control study by Radu A. Farcas, Teodora Surdea-Blaga, Ştefan Popa, Flaviu Rusu, Alexandra Chira, Cristina Sabo, Vlad-Ionuţ Nechita, Liviuţa Budişan, Oana Zanoaga, Ioana Berindan-Neagoe, Ioana Berindan-Neagoe, Ioana Berindan-Neagoe, Ştefan Strilciuc, Dan L. Dumitrascu

“…Background and aimsMicroRNAs (miRNAs, miRs) are stable RNA molecules that regulate gene expression and hold promise as biomarkers. Functional dyspepsia (FD), a complex gastrointestinal disorder, is characterized by motility dysfunction, visceral hypersensitivity, and gut microbiome alterations. …”
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Outage Performance and Novel Loss Function for an ML-Assisted Resource Allocation: An Exact Analytical Framework by Nidhi Simmons, David E. Simmons, Michel Daoud Yacoub

“…Specifically, we introduce a novel loss function to minimize the outage probability of an ML-based resource allocation system. …”
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α7 Nicotinic Receptor Promotes the Neuroprotective Functions of Astrocytes against Oxaliplatin Neurotoxicity by Lorenzo Di Cesare Mannelli, Barbara Tenci, Matteo Zanardelli, Paola Failli, Carla Ghelardini

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Zebrafish model for functional screening of flow-responsive genes controlling endothelial cell proliferation by George Bowley, Sophie Irving, Imo Hoefer, Robert Wilkinson, Gerard Pasterkamp, Hazem M. S. Darwish, Stephen White, Sheila E. Francis, Tim Chico, Emily Noel, Jovana Serbanovic-Canic, Paul C. Evans

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Lactate Regulates Metabolic and Pro-inflammatory Circuits in Control of T Cell Migration and Effector Functions. by Robert Haas, Joanne Smith, Vidalba Rocher-Ros, Suchita Nadkarni, Trinidad Montero-Melendez, Fulvio D'Acquisto, Elliot J Bland, Michele Bombardieri, Costantino Pitzalis, Mauro Perretti, Federica M Marelli-Berg, Claudio Mauro

“…In CD4+ T helper cells, sodium lactate also induces a switch towards the Th17 subset that produces large amounts of the proinflammatory cytokine IL-17, whereas in CD8+ T cells, lactic acid causes the loss of their cytolytic function. We further show that the expression of lactate transporters correlates with the clinical T cell score in the synovia of rheumatoid arthritis patients. …”
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Function of eEF-1γ in the nucleus in response to insulin in hepatocellular carcinoma cells by Abu Jubayer Hossain, Amir Hamza, Rokibul Islam, Oyungerel Dogsom, Jae-Bong Park

“…Functionally, si-eEF-1γ reduced cell proliferation and deceased c-Myc and cyclin D1 protein levels. …”
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Evolutionary Dynamics and Functional Bifurcation of the C2H2 Gene Family in Basidiomycota by Chao Duan, Jie Yang

“…This study performed a phylogenomic analysis of the C2H2 gene family across 30 Basidiomycota species, identifying 1032 genes distributed across six evolutionary clades (Groups I–VI). Functional diversification and lineage-specific expansions were observed: Group II (37.1%) formed a conserved core, while wood decayers (e.g., <i>Schizophyllum commune</i>) and edible fungi (e.g., <i>Pleurotus ostreatus</i>) exhibited clade-specific expansions in Groups III and V, respectively. …”
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Multi-omics analysis reveals the evolution, function, and regulatory mechanisms of SPF pheromones in Anurans by Puyang Zheng, Yunyun Lv, Yuzhou Gong, Gang Wang, Bin Wang, Xiuqin Lin, Xun Liao, Jianghong Ran, JiaTang Li, Feng Xie

“…Overall, these findings not only highlight the underestimated diversity and function of pheromones in anurans, but also provide important insights into the evolution of protein-based pheromones in vertebrates.…”
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