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eVIP2: Expression-based variant impact phenotyping to predict the function of gene variants.
Published 2021-07-01“…While advancements in genome sequencing have identified millions of somatic mutations in cancer, their functional impact is poorly understood. We previously developed the expression-based variant impact phenotyping (eVIP) method to use gene expression data to characterize the function of gene variants. …”
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Cellular expression, trafficking, and function of two isoforms of human ULBP5/RAET1G.
Published 2009-01-01“…<h4>Methodology/principal findings</h4>We pursue a number of approaches to characterise the expression, trafficking, and function of the two isoforms of ULBP5/RAET1G. …”
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Cross-sex hormone therapy in rats induces sex-specific adaptations of renal function and sodium transporters expression
Published 2025-08-01“…After 2 months of treatment, BP and renal function [inulin clearance (GFR), ions, and acid excretions] were evaluated. …”
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Characterization analyses of MADS-box genes highlighting their functions with seed development in Ricinus communis
Published 2025-05-01“…Despite its well-established importance in many species, the function and evolution of MADS-box genes in Ricinus communis (castor) remain unexplored. …”
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Versatile physiological functions of the Nudix hydrolase family in berry development and stress response in grapevine
Published 2022-01-01“…Although Nudix hydrolases are involved in plant detoxification processes in response to abiotic and biotic stresses, the biological functions of Nudix hydrolases remain largely unclear in grapevine. …”
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A Closed-form Expression for the Variance of Truncated Distribution and its Uses
Published 2025-08-01“…While many previous studies have proposed inequalities or relationships that depend on the shape of the population distribution, the approach here is built on a family of bounded probability distributions based on skewing functions. We offer closed-form expressions for its moments and the asymptotic behavior as the support's semi-range tends to zero and infinite. …”
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Functional deletion of α7 nicotinic acetylcholine receptor impairs Ca2+-dependent glutamatergic synaptic transmission by affecting both presynaptic and postsynaptic protein expression and function
Published 2025-08-01“…We thus studied molecular and functional properties of glutamatergic transmission in 4–6-months-old α7-KO mice, representing a prodromal phase of the AD-like neuropathology. …”
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Transcriptional Regulation and Function of Malic Enzyme 1 in Human Macrophage Activation
Published 2024-09-01Get full text
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Insights into the functional mechanisms of three terpene synthases from Lavandula angustifolia (Lavender)
Published 2024-12-01“…The terpene synthases in lavender, such as Lavandula angustifolia linalool synthase (LaLINS), limonene synthase (LaLIMS), and bergamotene synthase (LaBERS), are key enzymes in terpene biosynthesis. However, the functional mechanisms underlying these enzymes remain poorly understood. …”
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Genetic Improvement and Functional Characterization of AAP1 Gene for Enhancing Nitrogen Use Efficiency in Maize
Published 2025-07-01“…This study elucidates the functional mechanisms of the amino acid transporter <i>ZmAAP1</i> in nitrogen absorption and stress resilience. …”
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Functional study of ZmHDZ4 in maize (Zea mays) seedlings under drought stress
Published 2024-12-01“…Identification and functional analysis of drought tolerance genes have potential practical importance in understanding the molecular mechanisms of drought stress. …”
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Cloning vectors for gene delivery, integration and expression in Campylobacter jejuni
Published 2022-06-01Subjects: Get full text
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Decoding Acute Myeloid Leukemia: A Clinician’s Guide to Functional Profiling
Published 2024-11-01Subjects: Get full text
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Density-functional theory formulated in terms of functional integrals
Published 2025-01-01“…In this short paper, we derive the common expression of the grand potential in the framework of the density functional theory by starting from the expression given in this previous work. …”
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