Galectin-3 secreted by triple-negative breast cancer cells regulates T cell function by Annat Raiter, Yael Barhum, Julia Lipovetsky, Chen Menachem, Sharona Elgavish, Shmuel Ruppo, Yehudit Birger, Shai Izraeli, Orna Steinberg-Shemer, Rinat Yerushalmi

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Epigenetic Alterations in Ovarian Function and Their Impact on Assisted Reproductive Technologies: A Systematic Review by Charalampos Voros, Antonia Varthaliti, Despoina Mavrogianni, Diamantis Athanasiou, Antonia Athanasiou, Aikaterini Athanasiou, Anthi-Maria Papahliou, Constantinos G. Zografos, Vasileios Topalis, Panagiota Kondili, Menelaos Darlas, Sophia Sina, Maria Anastasia Daskalaki, Marianna Theodora, Panos Antsaklis, Georgios Daskalakis

“…<b>Results</b>: A total of 15 studies satisfied the inclusion criteria, with substantial relationships found between distinct epigenetic markers and ovarian function. Changes in miRNA expression patterns in follicular fluid and granulosa cells were associated with oocyte maturation, ovarian reserve, and implantation potential. …”
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Sex Disparities in P53 Regulation and Functions: Novel Insights for Personalized Cancer Therapies by Miriana Cardano, Giacomo Buscemi, Laura Zannini

“…Epidemiological studies have revealed significant sex differences in the incidence of tumors unrelated to reproductive functions, with females demonstrating a lesser risk and a better response to therapy than males. …”
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Early growth response 1 transcription factor and its context-dependent functions in glioblastoma by Saleh Rasras, Esma’il Akade, Seyed Ehsan Mohammadianinejad, Maedeh Barahman, Mohammad Bahadoram

“…Early growth response 1 expression is prevalent in glioblastoma, affecting over 80% of cases. …”
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Modelling Functional Thyroid Follicular Structures Using P19 Embryonal Carcinoma Cells by Fatimah Najjar, Liming Milbauer, Chin-Wen Wei, Thomas Lerdall, Li-Na Wei

“…Thyrocyte differentiation-maturation process is monitored by the expression of essential transcriptional factors and thyrocyte-specific functional genes. …”
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Aggressive Periodontitis: A case report with exome sequencing and functional characterization of identified variant by Waheed Awotoye, Patricia Ayanbadejo, Steven Eliason, Kehinde Umeizudike, Ayodele Ogundana, Dan Su, Tadkamol Krongbaramee, Emmanuel Aladenika, Azeez Alade, Abimbola Oladayo, Abdul-Warith Akinshipo, Tamara Busch, Wasiu Adeyemo, Brad Amendt, Azeez Butali

“…Sequencing analysis of the coding regions of NOD2 was conducted using individuals of African ancestry, to identify the pathogenic protein-altering variants in individuals with AgP using: 1) In Silico tools and clinical variant classification system; 2) IF staining to understand the expression pattern, and 3) In vitro cell based assay to understand the variant protein function. …”
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Nodal Injection of <i>Agrobacterium tumefaciens</i> for Gene Functional Analysis in Peanut: An Appraisal by Malizukiswe Vincent Vacu, Chunjiao Jiang, Haojie Sun, Guangdi Yuan, Jing Yu, Jun Zhang, Chuantang Wang

“…Peanut is a key cash crop worldwide, yet the limited availability of functional genes and markers for breeding hinders further progress, largely due to the lack of an efficient and user-friendly transformation system. …”
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Design and screening of novel endosomal escape compounds that enhance functional delivery of oligonucleotides in vitro by H. Yesid Estupiñán, Tom Baladi, Samantha Roudi, Michael J. Munson, Jeremy Bost, Oskar Gustafsson, Daniel Velásquez-Ramírez, Deepak Kumar Bhatt, Daniel Hagey, Dennis Hekman, Shalini Andersson, Samir EL Andaloussi, Anders Dahlén

“…., gapmers), while SSOs alter transcript splicing to restore or inhibit protein function. RNA interference (RNAi) is another approach to down-regulate gene expression via the RISC complex. …”
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Unveiling immune mechanisms and potential biomarkers in intervertebral disc degeneration through integrated analysis by Xuehu Xie, Guoqiang Zhang, Ning Liu

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From laboratory to clinic: opportunities and challenges of functional food active ingredients in cancer therapy by Nie Zhang, Nie Zhang, Yanzhi Ren, Yahui Xu, Yahui Xu

“…This review provides a comprehensive analysis of the potential of functional food active ingredients in cancer prevention and therapy. …”
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Self-directed music play to improve executive function in young children using NIRS by Taku Kosokabe, Makoto Mizusaki, Wakako Nagaoka, Miwa Honda, Noriyuki Suzuki, Yusuke Moriguchi

“…Here, we examine how music play influences behavioral performance and prefrontal cortex (PFC) activity in preschoolers using functional near-infrared spectroscopy (fNIRS). In a randomized controlled trial, 57 three-year-olds participated in either an Orff-Schulwerk-based music play program emphasizing creative self-expression (n = 27) or a control program (n = 30). …”
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Protocol for assessing auditory function, cochlear synaptopathy, and afferent terminal morphology in laboratory mice by Indra Pal, Atri Bhattacharyya, Babak V-Ghaffari, Essence Devine Williams, Maolei Xiao, Mark Allen Rutherford, María Eulalia Rubio

“…We detail procedures for assessing hearing function, the expression and localization of α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid (AMPA)-type glutamate receptor subunits, and the ultrastructure of cochlear-ribbon synapses. …”
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Transcriptional landscape of small non-coding RNAs reveals diversity of categories and functions in molluscs by Songqian Huang, Kazutoshi Yoshitake, Shigeharu Kinoshita, Shuichi Asakawa

“…To unravel the small RNA (sRNA) expression patterns and genomic function in molluscs, we generated a comprehensive sRNA dataset by sRNA sequencing (sRNA-seq) of eight mollusc species. …”
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Withaferin a modulation of microglia autophagy mitigates neuroinflammation and enhances cognitive function in POCD by Haijun Hu, Bingbing Cao, Dan Huang, Yue Lin, Bin Zhou, Jun Ying, Lelin Huang, Lieliang Zhang

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Meta-analysis and in-silico functional characterization of the SNCA variant rs356220 in Parkinson’s disease by Shradha Menon, Naushad Rais

“…Subsequently, we characterized the functional impact of this non-coding variant in the pathophysiology of PD. …”
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Systematic characterization of the barrier function of diverse ex vivo models of damaged human skin by Manon Barthe, Manon Barthe, Laure-Alix Clerbaux, Jean-Paul Thénot, Véronique M. Braud, Hanan Osman-Ponchet

“…The skin barrier function was evaluated in terms of permeability, dermal absorption capacity, stratum corneum thickness and gene expression of barrier markers. …”
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Structural and functional state of postinfarction myocardium and vascular endothelial growth factor: is there a connection? by A. M. Vorob'ev, V. I. Ruzov, A. S. Salmin, M. A. Mel'nikova

“…To reveal the relationship between the serum concentration of vascular endothelial growth factor and the structural and functional state of the myocardium in patients in the post-infarction period at the stage of rehabilitation.Materials and methods. …”
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Mammalian display to secretion switchable libraries for antibody preselection and high throughput functional screening by Ramona Gaa, Hannah Melina Mayer, Daniela Noack, Kavita Kumari, Ralf Guenther, Shang-Pu Tsai, Qingyong Ji, Achim Doerner

“…Second, a functional screen for internalization was established and comparison of autocrine versus co-encapsulation setups highlighted the advantages of an autocrine one cell approach. …”
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Claudin 4 in pancreatic β cells is involved in regulating the functional state of adult islets by Hongtu Li, Abraham Neelankal John, Takahiro Nagatake, Yoko Hamazaki, Fang‐Xu Jiang

“…The tight junction family molecule claudin 4 (Cldn4) was the highest enriched amongst over 140 structural genes analysed. Cldn4 expression was ~75‐fold higher in adult islets than in exocrine tissues and was mostly up‐regulated during functional maturation of developing islet cells. …”
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Turtle functions downstream of Cut in differentially regulating class specific dendrite morphogenesis in Drosophila. by Mikolaj J Sulkowski, Srividya Chandramouli Iyer, Mathieu S Kurosawa, Eswar Prasad R Iyer, Daniel N Cox

“…Neurons display a myriad diversity of dendritic geometries which serve as a basis for functional classification. Several types of molecules have recently been identified which regulate dendrite morphology by acting at the levels of transcriptional regulation, direct interactions with the cytoskeleton and organelles, and cell surface interactions. …”
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