The CaSBP11 gene functions as a negative regulator in pepper drought stress by Huai-Xia Zhang, Yuan Zhang, Bo-Wen Zhang, Fei-Fei Pan

“…Subsequently, we employed virus-induced gene silencing, overexpression, and protein interaction experiments to investigate the function of CaSBP11 under drought stress. Our results revealed that drought conditions significantly upregulated CaSBP11 expression, whereas ABA treatment suppressed it. …”
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Vaginal metatranscriptome meta-analysis reveals functional BV subgroups and novel colonisation strategies by Scott J. Dos Santos, Clara Copeland, Jean M. Macklaim, Gregor Reid, Gregory B. Gloor

“…Compared to amplicon sequencing and shotgun metagenomic approaches focusing on a single or few species, investigating the transcriptome of the vaginal microbiome at a system-wide level can provide insight into the functions which are actively expressed and differential between states of health and disease. …”
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Progranulin sustains STAT3 hyper‐activation and oncogenic function in colorectal cancer cells by Federica Laudisi, Fabio Cherubini, Antonio Di Grazia, Vincenzo Dinallo, Davide Di Fusco, Eleonora Franzè, Angela Ortenzi, Illari Salvatori, Silvia Scaricamazza, Ivan Monteleone, Naoya Sakamoto, Giovanni Monteleone, Carmine Stolfi

“…Although STAT3 is recognized as an attractive therapeutic target in CRC, conventional approaches aimed at inhibiting its functions have met with several limitations. Moreover, the factors that sustain hyper‐activation of STAT3 in CRC are not yet fully understood. …”
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Enriched environment improves memory function by promoting synaptic remodeling in vascular dementia rats by Shuang Lin, Chuan-Jie Wang, Peng-Kun Yang, Bing Li, Yi Wu, Ke-Wei Yu

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Adaptive immune responses against common viruses are sustained and functional in end-of-life patients by Anna Olofsson, Marion Humbert, Rokeya S. Rekha, Maria Helde Frankling, Fridtjof Lund-Johansen, Peter Bergman, Linda Björkhem-Bergman, Annika C. Karlsson

“…Although some virus-specific T cells from patients exhibited elevated expression of costimulatory and coinhibitory molecules, their functional profile remained largely intact compared to controls. …”
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Congenital heart disease-causing Gata4 mutation displays functional deficits in vivo. by Chaitali Misra, Nita Sachan, Caryn Rothrock McNally, Sara N Koenig, Haley A Nichols, Anuradha Guggilam, Pamela A Lucchesi, William T Pu, Deepak Srivastava, Vidu Garg

“…Examination of these mice demonstrated that the Gata4 G295S protein has functional deficits in early myocardial development. …”
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Genome-wide identification and functional analysis of the GRAS gene family in Medicago lupulina L by Li Fan, Ruimiao Wang, Pedro García-Caparrós, Lihua Meng, Xudong Sun

“…To further predict the potential functions of MlPAT1s genes, we performed molecular cloning and transcriptional activation assays on MlGRAS3/31/35/62/65. …”
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Haplotype-resolved genomes provide insights into the origins and functional significance of genome diversity in bivalves by Shikai Liu, Chenyu Shi, Chenguang Chen, Ying Tan, Yuan Tian, Daniel J. Macqueen, Qi Li

“…Summary: Bivalves are famed for exhibiting vast genetic diversity of poorly understood origins and functional significance. Through comparative genomics, we demonstrate that high genetic diversity in these invertebrates is not directly linked to genome size. …”
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Investigation regarding the effects of different monochromatic lights on lipid metabolism and immune function in chickens by Xiaodong Tan, Yuting Jin, Jiahua Li, Jie Dong, Minjie Huang, Deqian Wang

“…Moreover, in the blue light group, upregulated XDH, CRLF2, and IFIH1 expression facilitates the immunity of chickens. This study reveals potential pathways through which light affects lipid metabolism and immune function, providing new insights into how light influences animal development and production.…”
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Functional and aesthetic evaluation of adjacent tissue flap repairing defects of oral commissure area by Xuewei Jia, Xiaomeng Xue, Fayu Liu, Pai Pang, Yang Yue, Menghan Li, Zhongzheng Qi, Changfu Sun

“…Conclusion Taking into account the differences between each reconstruction method, the Estlander flap is the preferred method for small and medium-sized defects, the McGregor and Colmenero flap can better restore motor function.The methods of repairing defects of the oral commissure area described in our study do not differ significantly in speech expression, flap tactile sensitivity, or aesthetic outcomes. …”
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Molecular mechanisms explaining sex-specific functional connectivity changes in chronic insomnia disorder by Liyong Yu, Zhifu Shen, Wei Wei, Zeyang Dou, Yucai Luo, Daijie Hu, Wenting Lin, Guangli Zhao, Xiaojuan Hong, Siyi Yu

“…Abstract Background This study investigates the hypothesis that chronic insomnia disorder (CID) is characterized by sex-specific changes in resting-state functional connectivity (rsFC), with certain molecular mechanisms potentially influencing CID's pathophysiology by altering rsFC in relevant networks. …”
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Levo-Stepholidine as a Potential Cognitive Enhancer: Insights into Executive Function and Memory Improvements by Zhengwei Hu, Xueqing Zhu, Yirui Liang, Yuqiu Zhang, Ping Zheng, Xuehan Zhang

“…Molecular mechanism investigations reveal that <i>l</i>-SPD upregulates the expression of prefrontal glutamate receptors. These results demonstrate that <i>l</i>-SPD improves executive function and memory. …”
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Unraveling the cohesin-chromatin interface: identifying protein interactions that modulate chromosome structure and function by Natalie L. Rittenhouse, Riya Gohil, June E. Arricastres, Jill M. Dowen

“…Abstract Background The evolutionarily conserved cohesin complex is a pleiotropic regulator of chromosome structure and function, participating in sister chromatid cohesion, transcriptional regulation of genes, DNA replication, and DNA repair. …”
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Exploring the potential effect of electroacupuncture on cardiovascular function and lipid profiles in spontaneously hypertensive rats by Hye-Yoom Kim, Sarah Shin, Jung-Joo Yoon, You-Mee Ahn, Ji-Hye Song, Da-Som Lee, Ji-Yeun Park, Ho-Sub Lee, Jeeyoun Jung

“…These changes in aortic lipid profiles correlated significantly with systolic blood pressure and cardiac function indicators. Furthermore, EA treatment significantly altered the expression of Cers2 and GNPAT. …”
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Guilingji capsules enhances erectile function by promoting testosterone-dependent angiogenesis in the corpus cavernosum by Xujun Yu, Jingyi Zhang, Suyun Xu, Jing Zhou, Chenglin Zhuang, Junjun Li, Baojun Zhuang

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Vitamin C enhances the in vitro development of early porcine embryos by improving mitochondrial function by Lei Wang, Liu She, Peng Qiu, Meiyun Lv, Yunchuan Zhang, Yunjia Qi, Qin Han, Deshun Shi, Chan Luo

“…Comparative analysis of in vitro and in vivo gene expression profiles of morula found that most of the differentially expressed genes were enriched in pathways related to mitochondrial function. …”
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Identification and Functional Validation of the <i>PeDHN</i> Gene Family in Moso Bamboo by Yaqin Ye, Yanting Chang, Wenbo Zhang, Tiankui Chu, Hanchen Tian, Yayun Deng, Zehui Jiang, Yanjun Ma, Tao Hu

“…Subcellular localization experiments showed that YK₂S-type dehydrins (PeDHN2/5/6) localized to both the nucleus and the plasma membrane, while K₂S-type dehydrins (<i>PeDHN4</i>/8) were exclusively localized to the plasma membrane, indicating functional differentiation. qRT-PCR analysis revealed that the expression of <i>PeDHN2/4/5/6/8</i> was significantly responsive to stress treatments with ABA, NaCl, and PEG. …”
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Auto-aggregation Properties of Probiotic Lactobacillus delbrueckii str. IAHAHI: From Genes to Function by Astghik PEPOYAN, Liana GRIGORYAN, Natalya HARUTYUNYAN, Susanna MIRZABEKYAN, Marine BALAYAN, Artak GALSTYAN, Vardan TSATURYAN, Anahit MANVELYAN

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Thiazolopyridines Improve Adipocyte Function by Inhibiting 11 Beta-HSD1 Oxoreductase Activity by Thirumurugan Rathinasabapathy, Kimberly Marie Palatini Jackson, Yiwen Thor, Ayuba Sunday Buru, Debora Esposito, Xu Li, Mallikarjuna Rao Pichika, Ahmad Sazali Hamzah, Slavko Komarnytsky

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Impact of PEGylation and hyaluronan functionalization on lipoplex-mediated mRNA delivery to the canine retina by Tatyana Appelbaum, David A. Smith, Kei Takahashi, Jennifer C. Kwok, Hannah Sorenson, William A. Beltran

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