Cardiac function and architecture are maintained in a model of cardiorestricted overexpression of the prorenin-renin receptor. by Hasan Mahmud, Wellington Mardoqueu Candido, Linda van Genne, Inge Vreeswijk-Baudoin, Hongjuan Yu, Bart van de Sluis, Jan van Deursen, Wiek H van Gilst, Herman H W Silljé, Rudolf A de Boer

“…The (pro)renin-renin receptor, (P)RR has been claimed to be a novel element of the renin-angiotensin system (RAS). The function of (P)RR has been widely studied in renal and vascular pathology but the cardio-specific function of (P)RR has not been studied in detail. …”
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Characterizing Duodenal Immune Microenvironment in Functional Dyspepsia: An AutoML-Driven Diagnostic Framework by Zhang X, Fan X, Hu X, Qian Z, Li J, Wu W, Chen L, Wu S, Ma L, Yang C, Zhang T, Su X, Wei W

“…Expression data from 40 FD patients and 24 healthy controls were analyzed for differentially expressed genes (DEGs) using the Gene Expression Omnibus (GEO) database. …”
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ARL8B regulates lysosomal function and predicts poor prognosis in hepatocellular carcinoma by Liyan Wu, Zelin Weng, Xia Yang, Yuhua Huang, Yansong Lin, Shuo Li, Lingyi Fu, Jingping Yun

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Inhibiting immune escape in lung adenocarcinoma: the role of SPARC in suppressing CD276 function by Yang Zhao, Haimei Li, Yuan Zhang, Zhichang Yang, Xiaoming Chen, Yang Yang

“…SPARC inhibits immune evasion in LUAD by suppressing CD276 functionality. We downloaded RNA-sequencing data from patients with LUAD in The Cancer Genome Atlas and identified a set of genes showing SMC-specific expression in these samples. …”
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DNA G-quadruplex structures act as functional elements in α- and β-globin enhancers by Colm Doyle, Krzysztof Herka, Sean M. Flynn, Larry Melidis, Somdutta Dhir, Stefan Schoenfelder, David Tannahill, Shankar Balasubramanian

“…G-quadruplex DNA secondary structures (G4s) have recently been shown to co-occur with 3D chromatin interactions; however, the functional importance of G4s within enhancers remains unclear. …”
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Identification and functional analysis of novel precursor genes in cyclic peptide biosynthesis in Pseudostellaria heterophylla by Jiao Xu, Wei Zheng, Xiaohong Ou, Hua He, Changgui Yang, Lanping Guo, Chenghong Xiao, Weike Jiang, Guoping Shu, Tao Zhou

“…Abstract Background Pseudostellaria heterophylla, a member of the Caryophyllaceae family, is widely used in traditional Chinese medicine due to its bioactive cyclic peptides (CPs) with immunomodulatory functions. Caryophyllaceae- like CPs, one of the largest types plant-derived CPs, typically consist of 5–12 amino acids and are derived from ribosomally synthesized peptide precursors. …”
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Sepsid even-skipped enhancers are functionally conserved in Drosophila despite lack of sequence conservation. by Emily E Hare, Brant K Peterson, Venky N Iyer, Rudolf Meier, Michael B Eisen

“…Together, these observations suggest that the local arrangement of binding sites relative to each other is more important than their overall arrangement into larger units of cis-regulatory function.…”
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Functional study of laminin subunit α5 in high-grade serous ovarian cancer by Wang Tianli, Shaojing Li, Rong Zhang

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Integrated analysis of gene networks and cellular functions identifies novel heart failure biomarkers by Jiang Juncheng, Chen Lei, Lin Hao, Liang Fei

“…Abstract Introduction Heart failure (HF) is a complex clinical condition characterized by impaired cardiac function and progressive structural remodeling. To elucidate the molecular mechanisms driving HF, this study aimed to identify key regulatory hub genes, explore their functional relevance, and assess their diagnostic and therapeutic potential. …”
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The Function of Ophiocordyceps sinensis in Airway Epithelial Cell Senescence in a Rat COPD Model by Xiaohui Ma, Xingai Jiao, Jinxiang Wu, Jiping Zhao, Yurong Xu, Tian Liu, Jiawei Xu, Lei Yang, Liang Dong

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TIMM23 overexpression drives NSCLC cell growth and survival by enhancing mitochondrial function by Jianhua Zha, Jiaxin Li, Hui Yin, Mingjing Shen, Yingchen Xia

“…TIMM23 (translocase of inner mitochondrial membrane 23) is a core component of the mitochondrial import machinery, facilitating the translocation of proteins across the inner mitochondrial membrane into the matrix. Its expression and potential functions in NSCLC were tested. …”
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Function of Adenosine 2A Receptor in High-Fat Diet-Induced Peripheral Neuropathy by Ji Li, Huan-Qiu Liu, Xin-Bai Li, Wen-Jun Yu, Tao Wang

“…Our results demonstrate that HFD dysregulates the A2AR-mediated Sema3a expression, with functional implications for the type 2 diabetes-induced peripheral neuropathy. …”
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Modified pea apyrase has altered nuclear functions and enhances the growth of yeast and Arabidopsis by Manas K. Tripathy, Huan Wang, Robert D. Slocum, Han-Wei Jiang, Ji-Chul Nam, Tanya Sabharwal, Roopadarshini Veerappa, Katherine A. Brown, Katherine A. Brown, Xingbo Cai, Peter Allen Faull, Greg Clark, Stanley J. Roux

“…Apyrases (NTPDases) regulate growth and development in multiple eukaryotic organisms and function in multiple sub-cellular locales. An earlier report showed that the ectopic expression of psNTP9 (PS), a chromatin-associated pea (Pisum sativum) apyrase, enhanced the uptake of inorganic phosphate (Pi) and increased the growth of yeast and Arabidopsis. …”
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Co-dependence of HTLV-1 p12 and p8 functions in virus persistence. by Cynthia A Pise-Masison, Maria Fernanda de Castro-Amarante, Yoshimi Enose-Akahata, R Cody Buchmann, Claudio Fenizia, Robyn Washington Parks, Dustin Edwards, Martina Fiocchi, Luiz Carlos Alcantara, Izabela Bialuk, Jhanelle Graham, Jean-Claude Walser, Katherine McKinnon, Bernardo Galvão-Castro, Antoine Gessain, David Venzon, Steven Jacobson, Genoveffa Franchini

“…Three groups were identified on the basis of p12 and p8 expression: predominantly p12, predominantly p8 and balanced expression of p12 and p8. …”
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Generalization of the formula of Faa di Bruno for a composite function with a vector argument by Rumen L. Mishkov

“…The paper presents a new explicit formula for the nth total derivative of a composite function with a vector argument. The well-known formula of Faa di Bruno gives an expression for the nth derivative of a composite function with a scalar argument. …”
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Dietary Fatty Acid Saturation Modulates Sphingosine-1-Phosphate-Mediated Vascular Function by Daniel W. Nuno, Kathryn G. Lamping

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Functional and distinct roles of Piezo2-mediated mechanotransduction in dental primary afferent neurons by Pa Reum Lee, Kihwan Lee, Ji Min Park, Shinae Kim, Seog Bae Oh

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Apocynin and Hyperbaric Oxygen Therapy Improve Renal Function and Structure in an Animal Model of CKD by Andrija Vukovic, Danijela Karanovic, Nevena D Mihailovic-Stanojevic, Zoran Miloradovic, Predrag Brkic, Maja Zivotic, Jelena Nesovic Ostojic, Milan Ivanov, Sanjin Kovacevic, Una-Jovana Vajic, Djurdjica Jovovic, Silvio R. De Luka

“…Combined treatment (apocynin and HBOT) normalized blood pressure (BP) values, renal function, and improved kidney structure by modulating FN and HIF-1α, without affecting desmin protein expression. …”
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Osteopontin protects from ovalbumin-induced asthma by preserving the microbiome and the intestinal barrier function by Jinli Huang, Hongyu Qiao, Qiuhong Li, Yi Zhang, Chenyu Zhang, Hui Su, Xin Sun

“…In addition, gut structure was impaired, and expression of tight junction-related proteins was reduced in Spp1−/− mice, which disrupted gut barrier function. …”
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Dual Function of Wnt Signaling during Neuronal Differentiation of Mouse Embryonic Stem Cells by Hanjun Kim, Sewoon Kim, Yonghee Song, Wantae Kim, Qi-Long Ying, Eek-hoon Jho

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