Interleukin-37 Suppresses the Function of Type 2 Follicular Helper T in Allergic Rhinitis by Xi Luo, Yanhui Wen, Xiangqian Qiu, Lifeng Zhou, Qingxiang Zeng, Wenlong Liu

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Fibro-adipogenic progenitor cells in skeletal muscle unloading: metabolic and functional impairments by Margarita Sorokina, Danila Bobkov, Natalia Khromova, Natalia Vilchinskaya, Boris Shenkman, Anna Kostareva, Renata Dmitrieva

“…FAPs were purified from m. soleus functioning muscle (Contr) and after functional unloading for 7 and 14 days (HS7 and HS14). …”
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Irradiation of muscle precursor cells impairs the proliferative and angiogenic functions of their extracellular vesicles by Umang Sharma, Settimio Pacelli, M. Adam Meledeo, James A. Bynum, Christopher R. Rathbone

“…This study investigated whether EVs from healthy MPCs (NoRad-EVs) could improve cell function in irradiated cells compared to EVs from irradiated MPCs (Rad-EVs). …”
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An in vitro neurobacterial interface reveals direct modulation of neuronal function by gut bacteria by Juan Lombardo-Hernandez, Jesús Mansilla-Guardiola, Riccardo Aucello, Cristian Botta, Maria Teresa García-Esteban, Antonio Murciano-Cespedosa, David Muñoz-Rodríguez, Elisa Quarta, Álvaro Mateos González, Carmen Juan-Llamas, Kalliopi Rantsiou, Stefano Geuna, Luca Cocolin, Celia Herrera-Rincon

“…Neurons exhibited changes in neuroplasticity-related proteins such as Synapsin I and pCREB, indicating functional modulation. Transcriptomic profiling revealed significant gene expression changes affecting networks linked to neurological conditions and bioelectrical signaling. …”
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WBP1 regulates mitochondrial function and ferroptosis to modulate chemoresistance in colorectal cancer by Yang Wang, Dachuan Qi, Guijie Ge, Ning Cao, Xiangdong Liu, Na Zhu, Feng Li, Xiang Huang, Kui Yu, Jinzhou Zheng, Daoheng Wang, Wenyan Yao, Lili Chen, Ziyang Dong

“…Exogenous mitochondria from wild-type cells restored mitochondrial function, cell proliferation, and suppressed ferroptosis in WBP1-deficient cells, indicating that mitochondrial function acts downstream of WBP1. …”
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Initial function of microRNAs as a defence mechanism against invading organisms by Xiaoshuang Liu, Xinyuan Zang, Helian Feng, Quan Zhao, Chenyu Zhang, Jin Wang

“…To obtain an evolution landscape of miRNA function and elucidate the initial function of miRNAs, we investigated the targets of miRNAs in the viral system and among metazoan species. …”
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The Functional Components and Hepatic Protective Mechanism of Wolfberry Vinegar by Mixed-Culture Fermentation by Xiao Qiang, Man Zhao, Ting Xia, Qi Wang, Junwei Yu, Yunru Song, Huimin Zhang, Changsheng Qiao, Min Wang

“…Moreover, MFV improved histopathological changes and reduced liver biochemical indicators in alcohol-treated mice, indicating the improvement of liver function. In addition, MFV effectively alleviated alcohol-induced liver injury by increasing the expression of alcohol metabolizing enzymes and inhibiting CYP2E1 activity. …”
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Genomic and functional analysis of isochorismate synthase genes in sugarcane and their roles in disease resistance by Zhen Zeng, Xinyu Zhu, Jiaoyun Chen, Shilong Zhang, Sisi Zhou, Kailin Li, Wankuan Shen

“…This study establishes the groundwork for functional studies of sugarcane ICS genes and enhances our understanding of the mechanisms of disease resistance in sugarcane.…”
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Unlocking the role of ClDYAD in initiating meiosis: A functional analysis in watermelon by Xixi Wu, Yangyuqi Zhang, Wenxin Li, Chunhui Tian, Qin Feng, Jiafa Wang, Yanfeng Zhang, Shujuan Tian, Li Yuan

“…In this study, we utilized CRISPR/Cas9 technology to target ClDYAD, a homolog of the meiosis-related genes AtDYAD and OsAM1, and conducted functional analysis to explore the initiation of meiosis in watermelon. …”
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The Multifaceted Roles of BACH1 in Disease: Implications for Biological Functions and Therapeutic Applications by Xiangxiang Wei, Yunquan He, Yueyang Yu, Sichong Tang, Ruiwen Liu, Jieyu Guo, Qingjun Jiang, Xiuling Zhi, Xinhong Wang, Dan Meng

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Dexamethasone-Functionalized PLLA Membranes: Effects of Layer-by-Layer Coating and Electrospinning on Osteogenesis by Flavia Gonçalves, Roberta Molisani Letomai, Marjory Muraro Gomes, Maria dos Remédios Aguiar Araújo, Yasmin Silva Muniz, Maria Stella Moreira, Leticia Cidreira Boaro

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The Lysine Demethylase KDM5B Regulates Islet Function and Glucose Homeostasis by Marie Balslev Backe, Chunyu Jin, Luz Andreone, Aditya Sankar, Karl Agger, Kristian Helin, Andreas Nygaard Madsen, Steen Seier Poulsen, Madhusudhan Bysani, Karl Bacos, Charlotte Ling, Marcelo Javier Perone, Birgitte Holst, Thomas Mandrup-Poulsen

“…We have recently shown that preserving H3K27 and H3K4 methylation using the lysine demethylase inhibitor GSK-J4 reduces cytokine-induced destruction of beta-cells and improves beta-cell function. Here, we investigate the therapeutic potential of GSK-J4 to prevent diabetes development and examine the importance of H3K4 methylation for islet function. …”
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PATHOGENESIS-RELATED PROTEINS: identification, evolution and functional analysis in pear (Pyrus bretschneideri) by Chenyang Han, Qi Wang, Zhiyuan Su, Chaohui Li, Baodian Guo, Fanhang Zhang, Bao Tang, Yancun Zhao, Fengquan Liu, Shaoling Zhang

“…These findings offer valuable insights for future functional analyses and breeding strategies to enhance pear resistance to pathogens.…”
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Function of protein ubiquitination and SUMOylation in regulating flowering time of plants: A review by Zhang Xiaolian, Zhang Jishun, Zou Jie, Zhao Jiehong, Ren Xueliang

“…The function of DELLA proteins was discussed in the third part. …”
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IMMUNOREGULATORY IMBALANCE AND FUNCTIONAL STATE OF THE HEART IN THE PATIENTS WITH DIABETES MELLITUS TYPE 2 by I. V. Kologrivova, T. E. Suslova, I. V. Vinnitskaya, O. A. Koshelskaya, A. A. Boshchenko, O. A. Trubacheva

“…Changes in left ventricular myocardial diastolic function are observed in diabetic patients independently from other comorbidities. …”
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Identification of microRNA in Houttuynia cordata Thunb and prediction of cross kingdom functions by Jiajian He, Ting Chen, Qingyun Xi, Jiajie Sun, Junyi Luo, Meng Li, Haojie Zhang, Bin Zeng, Jiahan Wu, Yongliang Zhang

“…It had been reported to have potential functions such as anti-bacterial, anti-cancer, and anti-inflammatory in human. …”
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Endoplasmic reticulum protein 29 negatively regulates platelet functions and thrombosis in mice by Xiaofeng Yan, Yishan Lu, Keyu Lv, Miao Jiang, Chao Fang, Yi Wu, Aizhen Yang

“…ERp29-deficient platelets had enhanced response in aggregation, ATP release, spreading, clot retraction, αIIbβ3 activation, fibrinogen binding and P-selectin expression. As detected by MPB labeling, the free thiol content of integrin αIIbβ3 in ERp29-deficient platelets were increased compared with WT platelets, suggesting that the role of ERp29 is associated with oxidation of the functional disulfides of integrin αIIb and/or β3 subunits. …”
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Analysis of epilepsy‐associated variants in HCN3 – Functional implications and clinical observations by Peiwei Zhao, Hongbo Xiong, Gunagtao Kuang, Chen Sun, Xiankai Zhang, Yufeng Huang, Sukun Luo, Lei Zhang, Jun Jiang, Xuelian He

“…In vitro functional analyses demonstrated that these variants affected the expression level of HCN3 protein without altering its membrane localization. …”
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Selective EPAC1 activators enhance endothelial function in models of vascular inflammation by Neil MacRitchie, Danila Gurgone, Jolanta Wiejak, Graeme Barker, Paul Burgoyne, Frank Lezoualc’h, Pasquale Maffia, Stephen J. Yarwood

“…Vascular inflammation drives the progression of atherosclerosis and related cardiovascular disorders by impairing endothelial function. Here, we examine the role of EPAC1 - a cAMP-responsive sensor protein - in modulating vascular inflammation and injury using both in vitro and ex vivo models. …”
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The world population development according to a dynamic extension of the Wicksellian production function by Robert W. Grubbström

“…Based on UN figures for the World Population Development combined with the Wicksellian production function, we develop expressions for how the population development depends on capital (saved income) and the maximisation of future discounted per capita consumption.We prefer to adopt the term Wicksellian function, rather than the widely used name Cobb-Douglas function, since it was first published by Knut Wicksell (1851 - 1926) and two years after his death, the same function was published by Charles W. …”
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