Effects of Vitamin B6 Deficiency on the Composition and Functional Potential of T Cell Populations by Bingjun Qian, Shanqi Shen, Jianhua Zhang, Pu Jing

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Nonredundant, Highly Connected MicroRNAs Control Functionality in Breast Cancer Networks by Guillermo de Anda-Jáuregui, Jesús Espinal-Enríquez, Diana Drago-García, Enrique Hernández-Lemus

“…We hypothesize that highly influential, nonredundant miRs, which we call Commodore miRs (Cdre-miRs), have an important role on the control of biological functions through transcriptional networks. In this work, we analyze the regulation of gene expression by miRs in healthy and cancerous breast tissue using bipartite miR-gene networks inferred from the Cancer Genome Atlas (TCGA) expression data. …”
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Role of GM-CSF in normalizing the effect of Uremic Toxins on Neutrophil Apoptosis and Function by Nariman Zahran, Ola Mahmoud Mahmoud, Manal Zahran, Azza Sayed, Manar Rafaat

“…The retention of many uremic compounds, interact negatively with biologic functions. It is the interest of this study to evaluate the influences of uremic plasma from chronic kidney disease (CKD) patients, with and without urinary tract infection (UTI) on neutrophil apoptosis and activation. …”
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He's frequency–amplitude formulation for nonlinear oscillators using Jacobi elliptic functions by Alex Elías-Zúñiga, Luis Manuel Palacios-Pineda, Isaac H Jiménez-Cedeño, Oscar Martínez-Romero, Daniel Olvera Trejo

“…In this work, the Duffing’s type analytical frequency–amplitude relationship for nonlinear oscillators is derived by using Hés formulation and Jacobi elliptic functions. Comparison of the numerical results obtained from the derived analytical expression using Jacobi elliptic functions with respect to the exact ones is performed by considering weak and strong Duffing’s nonlinear oscillators.…”
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Splenic macrophage functional profile and its role in the immunopathogenesis of canine visceral leishmaniasis by Tainã Luís de Souza, Tainã Luís de Souza, Marta de Almeida Santiago, Francini Neves Ribeiro, Francini Neves Ribeiro, Fabiano Borges Figueiredo, Artur Augusto Velho Mendes Junior, Rodrigo Caldas Menezes, Renato Porrozzi, Fernanda Nazaré Morgado

“…Flow cytometry analysis identified co-expression of arginase-1 and PD-L1, as well as Arginase-1high+ cells. …”
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Treatment of Hippophae rhamnoides Polysaccharides on Alcoholic Hepatitis and Intestinal Barrier Function in Mice by Qing LI, Guangli MA, Yiheng ZHAI, Tao MENG

“…Conclusion: HRP has a protective effect on alcoholic hepatitis, improving liver damage and intestinal barrier function in mice, and reducing liver lipid accumulation and inflammatory response.…”
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Human Amniotic Fluid Cells Form Functional Gap Junctions with Cortical Cells by Anna Jezierski, Kerry Rennie, Roger Tremblay, Bogdan Zurakowski, Andreé Gruslin, Marianna Sikorska, Mahmud Bani-Yaghoub

“…In this study, we show that AF cells express high levels of CX43 (GJA1) and are able to establish functional gap junctions with cortical cultures. …”
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Nuclear receptors in health and disease: signaling pathways, biological functions and pharmaceutical interventions by Ping Jin, Xirui Duan, Zhao Huang, Yuan Dong, Jianmei Zhu, Huiming Guo, Hui Tian, Cheng-Gang Zou, Ke Xie

“…Therefore, understanding the molecular mechanisms underlying nuclear receptor functions is essential for the development of novel therapeutic strategies. …”
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Molecular cloning and functional characterization of the shikimate kinase gene from Baphicacanthus cusia by Yuxiang Huang, Yuxiang Huang, Yuxiang Huang, Hexin Tan, Qing Li, Xunxun Wu, Zhiying Guo, Zhiying Guo, Junfeng Chen, Lei Zhang, Yong Diao

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PABPN1 functions as a downstream gene of CREB to inhibit the proliferation of preadipocytes by Xiao-Han Zhang, Jia-Xin Li, Xiao-Xu Wu, Qian Zhang, Ming Tian, Si-Qi Yang, Di Liu, Xiu-Qin Yang

“…We also found that CREB could promote PABPN1 expression by binding to a motif in the promoter. Further analysis confirmed that PABPN1 functions as a downstream gene of CREB to regulate the proliferation of preadipocytes. …”
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ERMAP attenuates DSS-induced colitis in mice by regulating macrophage and T cell functions by Lu Xia, Yiwen Pan, Xianbin Wang, Rong Hu, Jie Gao, Wei Chen, Keke He, Dongbin Cui, Youbo Zhao, Lu Liu, Laijun Lai, Min Su

“…Conclusions In summary, our results suggest that administration of ERMAP can protect DSS-induced colitis in mice by regulating T cell and macrophage functions. This study adds to the evidence for various mechanistic pathways associated to the pathogenesis of IBD, which could subsequently be translated to novel therapeutics.…”
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Binomial convolution sum of divisor functions associated with Dirichlet character modulo 8 by Jin Seokho, Park Ho

“…In this article, we compute binomial convolution sums of divisor functions associated with the Dirichlet character modulo 8, which is the remaining primitive Dirichlet character modulo powers of 2 yet to be considered. …”
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NEK2 regulates B cell function and the severity of experimental autoimmune encephalomyelitis by Si-Ting Wu, Tian-Xiang Zhang, Zhirui Liu, Xueting An, Xiaoshan Du, Shu Yang, Ti Wu, Guanju Di, Jingshi Song, Bin Feng, Chunyang Wang, Chao Zhang

“…Collectively, these findings underscore an immunomodulatory function for NEK2 and highlight its potential as a therapeutic target in the treatment of multiple sclerosis.…”
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USP21-EGFR signaling axis is functionally implicated in metastatic colorectal cancer by Ji Hye Shin, Mi-Jeong Kim, Ji Young Kim, Bongkum Choi, Yeeun Kang, Seo Hyun Kim, Ha-Jeong Lee, Dohee Kwon, Yong Beom Cho, Kyeong Kyu Kim, Eunyoung Chun, Ki-Young Lee

“…Additionally, a reciprocal link between EGFR signaling and Fra-1 activation has been identified, mediated through matrix metalloproteinases (MMPs). However, the functional implications of the USP21-EGFR signaling axis in metastatic CRC (mCRC) are not fully understood. …”
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Insights into the molecular mechanisms underlying the function of lysyl oxidase like 1 in cancers by Xinmeng Wang, Xiaoyi Wang, Yihan Li, Dan Zhao, Jintao He, Lin Wang, Zhengliang Li, Wei Xiong

“…LOXL1 has diverse biological functions, and its dysregulation is the basis of many clinical diseases. …”
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Construction and functional identification of overexpression vector of the peach PpCLH1 gene by LIU Xin, ZHANG Xiaoyu, MENG Junren, LI Ang, DUAN Wenyi, SUN Shihang, PAN Lei, ZENG Wenfang, WANG Zhiqiang, NIU Liang

“…[Conclusion] This study conducted identification and functional studies on the PpCLH1 gene, discovering that PpCLH1 is significantly highly expressed during the fruit color transition period. …”
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Spectral Intensity Variation by the Correlation Function of Refractive Index Fluctuations of the Liquid Medium by Nageshwar Singh

“…It is proposed that a macroscopic theory of propagation and scattering of light through random media can be functional for the dye liquid flowing media in the microscopic levels too, with modest approximations. …”
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A motor function for the DEAD-box RNA helicase, Gemin3, in Drosophila. by Ruben J Cauchi, Kay E Davies, Ji-Long Liu

“…Loss of function of gemin3 results in lethality at larval and/or prepupal stages. …”
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Disrupted mitochondrial morphology and function exacerbate inflammation in elderly-onset ulcerative colitis by Mengmeng Zhang, Hong Lv, Xiaoyin Bai, Gechong Ruan, Qing Li, Kai Lin, Hong Yang, Jiaming Qian

“…Results Thirty mDEGs were identified between adult- and elderly-onset UC, which were related primarily to mitochondrial respiratory function and also had significant correlation with different infiltrates of immune cells. …”
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Remote Assessment of Platelet Function in Patients with Acute Stroke or Transient Ischaemic Attack by Philip M. Bath, Jane May, Katie Flaherty, Lisa J. Woodhouse, Natalia Dovlatova, Sue C. Fox, Timothy J. England, Kailash Krishnan, Thompson G. Robinson, Nikola Sprigg, Stan Heptinstall, TARDIS Investigators

“…The aim of this substudy was to assess the effect of antiplatelet agents taken at baseline on platelet function reactivity and activation. Methods. Platelet function, assessed by remotely measured surface expression of P-selectin, was assessed in patients at their time of randomisation. …”
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