Effect of Storage Temperature on Key Functions of Cultured Retinal Pigment Epithelial Cells by Lara Pasovic, Jon Roger Eidet, Berit S. Brusletto, Torstein Lyberg, Tor P. Utheim

“…RPE cultures stored at 4°C and 16°C for one week are capable of maintaining the expression levels of genes important for key RPE functions close to control levels.…”
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XB130—A Novel Adaptor Protein: Gene, Function, and Roles in Tumorigenesis by Xiao-Hui Bai, Hae-Ra Cho, Serisha Moodley, Mingyao Liu

“…XB130 (AFAP1L2) is an adaptor protein involved in many cellular functions, such as cell survival, cell proliferation, migration, and gene and miRNA expression. …”
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The Role of microRNA in the Regulation of Differentiation and the Functionality of Osteoblasts, Osteoclasts, and Their Precursors in Osteoporosis by Bulat I. Yalaev, Elena I. Kaletnik, Yulia S. Karpova, Zhanna E. Belaya, Ildar R. Minniakhmetov, Natalia G. Mokrysheva, Rita I. Khusainova

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Function of vasohibin-2 and the mechanism of alternative splicing in triple-negative breast cancer by WANG Wei, WANG Hongli, ALIBIYATI·i Ain, YILIYAER· Rousu, NUER AYI, YANG Liang

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Zfp423 Regulates Sonic Hedgehog Signaling via Primary Cilium Function. by Chen-Jei Hong, Bruce A Hamilton

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The impact of KLF2 modulation on the transcriptional program and function of CD8 T cells. by Gavin C Preston, Carmen Feijoo-Carnero, Nick Schurch, Victoria H Cowling, Doreen A Cantrell

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Genetic and sex-specific regulation of mitochondrial function in gonadal and inguinal adipose tissue by Dorota Kaminska, Calvin Pan, Laurent Vergnes, Ashlyn Ro, Gurugowtham Ulaganathan, Aldons J. Lusis

“…We previously identified a female-specific chr17 trans-eQTL hotspot regulating mitochondrial gene expression in gonadal white adipose tissue (gWAT). Here, we tested whether iWAT contributes comparably to sex differences in mitochondrial function and futile cycling. …”
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Renin-Angiotensin System Induced Secondary Hypertension: The Alteration of Kidney Function and Structure by Zahra Pezeshki, Mehdi Nematbakhsh

“…Based on a variety of sources including PubMed, Google Scholar, Scopus, and Science-Direct, in the current review, we will discuss the role of RAS-induced secondary hypertension on the alteration of renal function.…”
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Identification and functional analysis of energy metabolism and pyroptosis-related genes in diabetic nephropathy by Shan He, Jian Ye, Yu Wang, Lu yang Xie, Si Yi Liu, Qin kai Chen

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Impact of POU3F4 mutation on cochlear development and auditory function by Jiong Dang, Panpan Bian, Chao Chen, Chi Chen, Wenqi Shan, Luhang Cai, Yong Li, Huan Tan, Baicheng Xu, Minxin Guan, Yufen Guo

“…RNA sequencing, qPCR and Western blot were conducted to evaluate gene expression and mitochondrial function. Results The transcription of POU3F4 was abnormal and the expression was normal in lymphoblastoid cell lines. …”
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Pleiotropic regulatory function of the RNA chaperone Hfq in the Pseudomonas protegens FD6 by Deyu Wen, Jieyu Hu, Ziying Gao, Chenglin Xing, Yao Xiao, Tao Wu, Xiaogang Wu, Qingxia Zhang

“…However, Hfq positively regulated the production of 2,4-DAPG and activated the phlD expression. Additionally, mutation of hfq abolished the function of the type VI secretion system (T6SS) due to a decrease in the expression of T6SS-related genes. …”
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Increased PRP19 in Hepatocyte Impedes B Cell Function to Promote Hepatocarcinogenesis by Zhiyong Liu, Xiahui Lin, Danying Zhang, Dezhen Guo, Wenqing Tang, Xiangnan Yu, Feng Zhang, Si Zhang, Ruyi Xue, Xizhong Shen, Ling Dong

“…However, the immune function and regulatory mechanisms of B cells in HCC remain unclear. …”
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HTT loss-of-function contributes to RNA deregulation in developing Huntington’s disease neurons by Emilia Kozłowska, Agata Ciołak, Grażyna Adamek, Julia Szcześniak, Agnieszka Fiszer

“…Moreover, we identified miRNAs that were consistently deregulated in HD and HTT-KO cells, including miR-214, miR-199, and miR-9. These miRNAs may function in the network that regulates TWIST1 and HTT expression via a regulatory feed-forward loop in HD. …”
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Effects of Vitamin D Deficiency on the Function of the Cardiac Autonomic Nervous System in Rats by Xuemei Luo, Jie Xiong, Hong Cai, Runmei Zou, Fang Li, Yuwen Wang, Cheng Wang

“…The purpose of this study was to evaluate the mechanism of VDdef on the function of cardiac ANS in rats. Methods. After 10 weeks of VD deficiency feeding, we successfully established a VD-deficient rat model. …”
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<i>Prg4</i> and Osteoarthritis: Functions, Regulatory Factors, and Treatment Strategies by Peng-Jie Fu, Sheng-Yuan Zheng, Yan Luo, Zhuo-Qun Ren, Zi-Han Li, Ya-Ping Wang, Bang-Bao Lu

“…Therapeutic strategies targeting <i>PRG4</i> in OA have shown promising results, including recombinant PRG4 protein injections, gene therapies, and small molecules that enhance endogenous <i>Prg4</i> expression or mimic its function. Further research into the molecular mechanisms regulating <i>Prg4</i> expression will be essential in developing more effective OA treatments. …”
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An integrative pan-cancer analysis of USP37 and functional validation in pancreatic cancer by Jiafei Chen, Jiafei Chen, Liang Lin, Dongxing Chen, Jingui Wang, Wuhan Zhou

“…BackgroundUSP37, a versatile deubiquitinase, plays a pivotal role in numerous cellular functions. Although its involvement in cancer development is well-established, the comprehensive pan-cancer analysis of USP37 remains relatively uncharted.MethodsRNA sequencing data from both normal and cancerous tissues were retrieved from The Cancer Genome Atlas (TCGA) and Genotype-Tissue Expression (GTEx) databases. …”
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Transdifferentiation of Integrin Beta 1 High+ Skin Progenitor Cells Into Functional Hepatocytes by Jung Hwa Lim, Dae Hun Kim, Junhee Lee, Cho-Rok Jung, Hyun Mi Kang

“…Furthermore, when exposed to high concentrations of activin A, along with Wnt3a and BMP4, these cells efficiently differentiated into definitive endoderm, exhibiting high FOXA2 expression. Under our culture conditions, they further differentiated into functional hepatocytes. …”
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The Immune Regulatory Functions of CD226 and Its Implications in Immune-Mediated Diseases by Keyan Liu, Yuanzhen Liu, Huabao Xiong, Zhaochen Ning

“…CD226, a member of the immunoglobulin superfamily, serves as a critical regulator in various immunological processes. CD226 is expressed across immune and non-immune cells, with predominant expression being observed in natural killer (NK) cells and T cells. …”
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Enhancing thymic function improves T-cell reconstitution and immune responses in aged mice. by Abigail Morales-Sánchez, Marieke Lavaert, Melanie S Vacchio, Gustavo Ulises Martinez-Ruiz, Daniel Egbase, Yongge Zhao, Ross Lake, Masaki Ishikawa, Fatima Zohra Braikia, Dragana Jankovic, Ranjan Sen, Rémy Bosselut, Avinash Bhandoola, Jennifer E Cowan

“…We developed two mouse models that allow us to experimentally prevent or reverse thymic involution. Constitutive Myc expression in thymic epithelial cells (TEC) of middle-aged mice enhanced thymic function, and increased numbers of peripheral naïve CD4 and CD8 T-cells. …”
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The changes of immune function after neuroblastoma chemotherapy and the prediction of potential immune targets by Yunfei Ma, Yan Su, Jing Huang, Wen Zhao, Cheng Huang, Jing Qin, Shengjie You, Yan Hu, Xin Ni

“…The immune-related differential proteins before and after chemotherapy were obtained through differential expression analysis and dynamic expression model analysis. …”
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