Genetic evidence of serum phosphate-independent functions of FGF-23 on bone. by Despina Sitara, Somi Kim, Mohammed S Razzaque, Clemens Bergwitz, Takashi Taguchi, Christiane Schüler, Reinhold G Erben, Beate Lanske

“…To elucidate the pathophysiological role of augmented renal proximal tubular expression of NaPi2a in Fgf-23-/- mice and to examine serum phosphate-independent functions of Fgf23 in bone, we generated a new mouse line deficient in both Fgf-23 and NaPi2a genes, and determined the effect of genomic ablation of NaPi2a from Fgf-23-/- mice on phosphate homeostasis and skeletal mineralization. …”
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Signalling pathways and cellular functions of KDEL receptors: implications in cancer biology by Beatrice Dufrusine, Ilaria Cela, Chiara Gramegna Tota, Marta Palumbo, Michele Sallese

“…In conclusion, endomembrane-initiated signalling through KDELR plays a pivotal role in regulating fundamental cellular processes, maintaining physiological functions, and modulating key aspects of cancer biology.…”
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Research Progress on the Effect of Exercise Rehabilitation on Functional Level and Physical Fitness by YIN Lianhua, ZHENG Yan, WU Lijuan, NI Xuling, CHEN Lidian

“…The essence of rehabilitation is the recovery and reconstruction of body function,and cardiopulmonary function is not only the core of body function, but also the core element of physical fitness. …”
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Novel function of TREK-1 in regulating adipocyte differentiation and lipid accumulation by Ajung Kim, Seoyeong Jung, Yongeun Kim, Jonghoon Jung, Soomin Lee, Hojin Lee, Min Jung Kim, Jae-Yong Park, Eun Mi Hwang, Jaekwang Lee

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Dicer deficiency affects microglial function during demyelination and impairs remyelination by Ajai Tripathi, Nagendra Kumar Rai, Aaron Perles, Haley Courtney, Claire Jones, Adya Sapra, Jason Plemel, Ranjan Dutta

“…Here, we investigate the role of Dicer1, a critical enzyme in microRNA biogenesis, in affecting microglial function, demyelination, and remyelination. Loss of Dicer1 in microglia resulted in amplified inflammatory responses, defective myelin debris clearance, and disruption of metabolic homeostasis, leading to exacerbated demyelination and delayed remyelination. …”
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Functional flexibility of a type III polyketide synthase in Mycobacterium marinum by Umesh Prasad Sah Hathi, Samir Giri, Sonali Srivastava, Gorkha Raj Giri, Eira Choudhary, Nisheeth Agarwal, Priti Saxena

“…Summary: Type III polyketide synthases (T3PKSs) exhibit remarkable potential to biosynthesize a wide array of architecturally distinct and functionally important metabolites. Genes for T3PKSs widely occur in pathogenic mycobacterial genomes, with no information about their physiological significance in pathogenesis. …”
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High-Density Lipoprotein Function in Exudative Age-Related Macular Degeneration. by Laura Pertl, Sabine Kern, Martin Weger, Silke Hausberger, Markus Trieb, Vanessa Gasser-Steiner, Anton Haas, Hubert Scharnagl, Akos Heinemann, Gunther Marsche

“…The present study is the first to assess HDL composition and metrics of HDL function in patients with exudative AMD and control patients.…”
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Hexokinase2-engineered T cells display increased anti-tumor function by Raphaëlle Toledano Zur, Shiran Didi Zurinam, Maria Radman, Elia Funaro Balouka, Tatiana Borodianskiy-Shteinberg, Dieter Saur, Cyrille J. Cohen

“…This metabolic competition supports tumor growth while impairing T-cell anti-tumor responses, partly by reducing glycolytic function. Hexokinase 2 (HK2), a key enzyme in glycolysis, plays a pivotal role in maintaining T-cell functionality.MethodsTo enhance T-cell function, primary human T cells were genetically engineered to overexpress HK2 alongside a tumor-specific receptor. …”
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Neural stem cells traffic functional mitochondria via extracellular vesicles. by Luca Peruzzotti-Jametti, Joshua D Bernstock, Cory M Willis, Giulia Manferrari, Rebecca Rogall, Erika Fernandez-Vizarra, James C Williamson, Alice Braga, Aletta van den Bosch, Tommaso Leonardi, Grzegorz Krzak, Ágnes Kittel, Cristiane Benincá, Nunzio Vicario, Sisareuth Tan, Carlos Bastos, Iacopo Bicci, Nunzio Iraci, Jayden A Smith, Ben Peacock, Karin H Muller, Paul J Lehner, Edit Iren Buzas, Nuno Faria, Massimo Zeviani, Christian Frezza, Alain Brisson, Nicholas J Matheson, Carlo Viscomi, Stefano Pluchino

“…We found that the transfer of these mitochondria from EVs to mtDNA-deficient L929 Rho0 cells rescued mitochondrial function and increased Rho0 cell survival. Furthermore, the incorporation of mitochondria from EVs into inflammatory mononuclear phagocytes restored normal mitochondrial dynamics and cellular metabolism and reduced the expression of pro-inflammatory markers in target cells. …”
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Functional analysis of the Escherichia coli mrdA gene in melittin resistance by Chong-Yi Zhao, Xiao Li, Ting Zhao, Ying Liu, Xue-Shan Xia, Xiao-Mei Wu

“…ObjectiveThe aim of this study is to examine the functional role and resistance mechanisms of the Escherichia coli (E. coli) peptidoglycan transpeptidase gene, mrdA, in resistance to melittin.MethodsThe resistance of E. coli strains with either knockout or overexpression of the mrdA gene to melittin was initially assessed. …”
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The immunity-promoting activity of porcine placenta in mice as an immunomodulator for functional foods by Zhiwei Zhou, Dan Wang, Wei Liu, Lang He, Pengkuan Liang, Junli Hao, Qun Sun

“…This study was to explore the immunity-promoting activity of porcine placenta as a potential raw material for functional foods. Porcine placenta was subjected to the analysis for its bioactive substances, and their immunity-promoting activity was determined in mice supplemented with porcine placenta extract (PPE) and freeze-dried porcine placenta powder at high (PPH) and low (PPL) dosage. …”
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New Functional Fermented Mare’s Milk Product: Biological Assessment in vivo by Elena S. Simonenko, Sergey V. Simonenko, Anna V. Begunova, Andrey N. Petrov, Elena S. Semenovа

“…The experimental product caused a statistically significant decrease in granulocytes, i.e., the microbiome had an anti-inflammatory effect on the gut microbiota, which, in its turn, affected the cytokine expression. The new product demonstrated strong biological activity, which rendered it functional properties. …”
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Local versus global sleep organization and the quest to determine sleep function by Hans P.A. Van Dongen

“…The research of JM Krueger and colleagues, focusing on sleep organization as a means to elucidate sleep function, led to critical insights as to why we sleep. …”
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The potential functions of HvDJ genes in regulating salt tolerance in barley by Yunfeng Xu, Haoran Sun, Ling Shen, Boyan Wan, Lijun Liu, Guoping Zhang, Guoping Zhang, Guoping Zhang, Qiufang Shen, Qiufang Shen, Qiufang Shen

“…Taken together, the current study provides valuable information for a deeper understanding of the function of HvDJs in regulating salt stress tolerance in barley.…”
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Effects of Exposure to Bisphenol A during Pregnancy on the Pup Testis Function by Qingtao Yang, Xuxia Sui, Junjun Cao, Caixia Liu, Shukai Zheng, Mian Bao, Yuanni Huang, Kusheng Wu

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Responses in growth performance, antioxidant capacity, hepatopancreas morphology, and non-specific immune function after functional protein peptide replace fishmeal in the Pacific... by Baoyang Chen, Anqi Chen, Jian Zhong, Aihua Dong, Xunyin Chen, Mengdie Chen, Rong Yao, Yongkang Chen, Wei Zhao, Jin Niu

“…The Pacific white shrimp (Litopenaeus vannamei), an economically significant species in aquaculture, has garnered considerable attention in current research regarding the substitution of fishmeal (FM) in its feed. Functional protein peptides (FPP) comprised primarily of enzymolysis chicken chondropeptide and wall-breaking yeast were utilized in an eight-week experiment to investigate the impact of replacing FM with FPP on growth performance, antioxidant capability, non-specific immunity, and hepatopancreas morphology in L. vannamei. …”
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Obesity-Associated Metabolomic and Functional Reprogramming in Neutrophils from Horses with Asthma by Alejandro Albornoz, Beatriz Morales, Valentina Bernal Fernandez, Claudio Henriquez, John Quiroga, Pablo Alarcón, Gabriel Moran, Rafael A. Burgos

“…Equine asthma is a chronic respiratory disease characterised by neutrophilic inflammation, airway hyperresponsiveness, and impaired pulmonary function. Obesity, increasingly prevalent among domestic horses, has been identified as a potential risk factor for exacerbating inflammatory conditions. …”
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The Effect of Quercetin on Ovary Functions in Rats with Cyclophosphamide Induced Ovary Damage by Ceren Yildiz Eren, Hulusi Goktug Gurer, Ozlem Ozgur Gursoy, Oktay Yilmaz, Ece Tunc, Serap Unubol Aypak, Gamze Sevri Ekren Asici

“…Conclusions: Our study may prove that Quercetin can protect ovarian function against Cyclophosphamide-induced ovarian damage.…”
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Clinical and brain functional correlates of instrumental rigidity measurement in Parkinson’s disease by Yoshikazu Nakano, Shigeki Hirano, Mitsuyoshi Tamura, Yume Koizumi, Yoshihisa Kitayama, Michiko Izumi, Masahide Suzuki, Kosuke Yamagishi, Yutaro Suzuki, Shinobu Ikeda, Ayaka Arase, Tatsuya Yamamoto, Yoshitaka Yamanaka, Atsuhiko Sugiyama, Kazumoto Shibuya, Takuro Horikoshi, Takashi Uno, David Eidelberg, Satoshi Kuwabara

“…This study aimed to investigate the association of the instrument-measured rigidity with clinical assessments and brain function. In 30 patients with PD, the muscle tone in both arms was evaluated. …”
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Antimicrobial and antivirulence function of cinnamaldehyde against Streptococcus suis type 2 by Lexin Zhu, Zhishu He, Mengqing Li, Jixin Xu, Wei Ding, Wenzhen Zeng, Xiaowu Jiang

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