Repertoire Development and the Control of Cytotoxic/Effector Function in Human γδ T Cells by Elizabeth M. Urban, Andrei I. Chapoval, C. David Pauza

“…We are interested in the dominant Vγ2Vδ2+ T cell subset in human peripheral blood and the control of effector function in this population. We review the literature on γδ T cell generation and repertoire selection, along with recent work on CD56 expression and defining a cytotoxic/effector lineage within the phosphoantigen-reactive Vγ2Vδ2 cells. …”
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Improved transcriptome assembly and functional annotation of Pleurodeles waltl for regeneration research. by Mhd Yousuf Yassouf, Akira Kinoshita, Md Mahmudul Hasan, Tao-Sheng Li

“…Furthermore, we significantly improved the functional annotation by using the Trinotate pipeline, which includes the identification of complete ORFs, Pfam motifs, gene names, GO terms, and KEGG Orthology, facilitating more robust transcriptomic analyses. …”
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CGRP Receptor Family and Accessory Protein Localization: Implications for Predicted Function by K.R. Oliver

“…Calcitonin gene-related peptide (CGRP), adrenomedullin, amylin, and calcitonin are functionally related neuropeptides. Certain of these peptides mediate their action through receptors which have common components, such as the receptor activity modifying proteins (RAMPs) and CGRP-receptor component protein, as well as possibly through other distinct receptors. …”
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Is the Antiproteinuric Effect of Cyclosporine A Independent of Its Immunosuppressive Function in T Cells? by Bin Zhang, Wei Shi

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Multiple functions for ORF75c in murid herpesvirus-4 infection. by Miguel Gaspar, Michael B Gill, Jens-Bernhard Lösing, Janet S May, Philip G Stevenson

“…The original host enzyme has therefore evolved into a set of distinct and multi-functional viral tegument proteins. One important function is moving incoming capsids to the nuclear margin for viral genome delivery.…”
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Circular RNAs: Biogenesis, Function, and a Role as Possible Cancer Biomarkers by Luka Bolha, Metka Ravnik-Glavač, Damjan Glavač

“…Generally, circRNAs function as microRNA (miRNA) sponges and have a regulatory role in transcription and translation. …”
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Dynamic duo: Kir6 and SUR in KATP channel structure and function by Bruce L. Patton, Phillip Zhu, Assmaa ElSheikh, Camden M. Driggers, Show-Ling Shyng

“…SUR is an ATP binding cassette (ABC) protein family homolog that lacks membrane transport activity but is essential for KATP expression and function. For more than four decades, understanding the structure-function relationship of Kir6 and SUR has remained a central objective of clinical significance. …”
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Large-scale turnover of functional transcription factor binding sites in Drosophila. by Alan M Moses, Daniel A Pollard, David A Nix, Venky N Iyer, Xiao-Yong Li, Mark D Biggin, Michael B Eisen

“…The gain and loss of functional transcription factor binding sites has been proposed as a major source of evolutionary change in cis-regulatory DNA and gene expression. …”
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Intertextual Inclusions in Russian Spiritual Epistolary Communication: Typology, Functions, Context by A. N. Smolina

“…The following features were revealed: (1) formation of meanings with the help of quotations, reminiscences and allusions, connected with the spiritual education of the addressee, his moral perfection, the creation of an inner man in himself, strengthening in faith, the study of the foundations of Christianity, the knowledge of church Orthodox life; (2) focus on Christian values: the gospel commandments, the doctrine of salvation, Christian virtues, and others; (3) prescribing perfection in acquiring mercy, humility, patience, obedience, sobriety, non-possession, repentance and other virtues, fighting sins, reading the Gospel and the writings of the holy fathers; an expression of evaluation of sweat in relation to sins and virtues, issues related to spiritual education and development, the fulfillment of church rules and Christian commandments, the achievement of soul salvation, following the instructions of confessors; (4) creation and strengthening of a common spiritual and religious space through the implementation of the iconic function of intertextual inclusions.…”
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Evaluation of Hypoglycemic Polyphenolic Compounds in Blueberry Extract: Functional Effects and Mechanisms by Yue Qin, Jielong Guo, Yuchen Lin, Yilin You, Weidong Huang, Jicheng Zhan

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Identification and functional characterization of ent-kaurene synthase gene in Ilex latifolia by Mei Yang, Guanhua Liu, Yoshimi Yamamura, Jianyu Fu

“…This study would help us to determine diterpenoid metabolism and GAs biosynthesis in I. latifolia, to better understand the regulation function of GAs in growth and development.…”
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Ubinuclein 2 is essential for mouse development and functions in X chromosome inactivation. by Asun Monfort, Giulio Di Minin, Sarah Sting, Charles Etienne Dumeau, Peter Scambler, Anton Wutz

“…The HIRA complex mediates deposition of histone H3.3 independent of replication. Its functions in gene regulation in mice remain to be fully understood. …”
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New views on physiological functions and regulation of butyrylcholinesterase and potential therapeutic interventions by Samaneh Hajimohammadi, Samaneh Hajimohammadi, Oksana Lockridge, Patrick Masson

“…This review explores current insights into BChE functions and regulatory physiological mechanisms, with particular emphasis on its interaction with microRNAs (miRNAs) and defense against toxicants. …”
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Metaboloepigenetics: Role in the Regulation of Flow-Mediated Endothelial (Dys)Function and Atherosclerosis by Francisco Santos, Hashum Sum, Denise Cheuk Lee Yan, Alison C. Brewer

“…Through mechanotransduction, shear stress regulates endothelial cell function in both homeostatic and diseased states. Accumulating evidence reveals that epigenetic changes play critical roles in the etiology of cardiovascular diseases, including atherosclerosis. …”
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Unbiased functional clustering of gene variants with a phenotypic-linkage network. by Frantisek Honti, Stephen Meader, Caleb Webber

“…Groupwise functional analysis of gene variants is becoming standard in next-generation sequencing studies. …”
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Immunoglobulin superfamily 3 (Igsf3) function is dispensable for brain development by Carolina Cocito, Chaomei Xiang, Meng Huang, Tatyana Gongora, Pallavi Surana, Ramana Davuluri, Nadia Dahmane, Jeffrey P. Greenfield

“…We generated an Igsf3 knockout (KO) mouse using a CRISPR/Cas9-based approach and explored the function of Igsf3 in regulating cortical development. …”
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Construction organoid model of ovarian endometriosis and the function of estrogen and progesterone in the model by Ruiqi Zhang, Yu’e Yang, Ruyue Li, Yuan Ma, Shaohan Ma, Xiuxin Chen, Bowei Li, Bei Li, XinYi Qi, Chunfang Ha

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Lactate-induced protein lactylation in cancer: functions, biomarkers and immunotherapy strategies by Wenjuan Wang, Hong Wang, Qi Wang, Xiaojing Yu, Liangliang Ouyang

“…Contemporary research reveals that lactate functions not merely as the terminal product of glycolysis but also as a nexus for initiating physiological and pathological responses within the body. …”
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Proteomic characterization and bioinformatic insights into MUC18 function in gastric cancer by Sung-Jin Kim, Su-Min Lee, Yun-Jeong Seo, Jae-Young Kim

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Macrophage origin limits functional plasticity in helminth-bacterial co-infection. by Dominik Rückerl, Sharon M Campbell, Sheelagh Duncan, Tara E Sutherland, Stephen J Jenkins, James P Hewitson, Tom A Barr, Lucy H Jackson-Jones, Rick M Maizels, Judith E Allen

“…However, in the setting of persistent, chronic infection the functional importance of macrophage-intrinsic adaptation to changing environments vs. recruitment of new macrophages remains unclear. …”
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