The immune exhaustion paradox: activated functionality during chronic bacterial infections by María L Ruiz-de la Cruz, Mario César Salinas-Carmona

“…Immune checkpoint molecules function as a “brake” to protect the host from the pathological effects of the immune response during chronic bacterial infections, which contrasts with the concept of exhaustion in the context of cancer. …”
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Interference in melanoma CD248 function reduces vascular mimicry and metastasis by Cheng-Hsiang Kuo, Ya-Fang Wu, Bi-Ing Chang, Chao-Kai Hsu, Chao-Han Lai, Hua-Lin Wu

“…Treatment with rCD248 protein could reduce pulmonary tumor burden, accompanied by a reduction in vascular mimicry in mice with melanoma lung metastasis. Conclusion CD248 expression in melanoma cells promotes malignant transformation by increasing the activity of cell adhesion, migration, and vascular mimicry, whereas rCD248 protein functions as a molecular decoy interfering with tumor-promoting effects of CD248 in melanoma cells.…”
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Regulatory effects of Ishige okamurae extract and Diphlorethohydroxycarmalol on skin barrier function by Seon Gyeong Bak, Hyung Jin Lim, Yeong-Seon Won, Sang-Ik Park, Sun Hee Cheong, Seung Jae Lee

“…Our results suggest that IOE and DPHC could be promising candidates for enhancing skin barrier function.…”
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Genome-wide identification and functional analysis of the longan CONSTANS (CO) family by Jinlin Gou, Xuelian Sang, Liqin Liu, Jiasui Cao, Yao Liu, Ci Ren, Zhixin Zhang, Dengwei Jue, Shengyou Shi

“…DlCOL family genes are differentially expressed in various longan organs, with DlCOL1, DlCOL3, and DlCOL9 expressed in all organs, with the highest expression levels in floral buds. …”
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Characterization of human pseudogene-derived non-coding RNAs for functional potential. by Xingyi Guo, Mingyan Lin, Shira Rockowitz, Herbert M Lachman, Deyou Zheng

“…Cross-tissue comparison revealed that the transcriptional profiles of pseudogenes and their parent genes showed mostly positive correlations, suggesting that pseudogene transcription could have a positive effect on the expression of their parent genes, perhaps by functioning as competing endogenous RNAs (ceRNAs), as previously suggested and demonstrated with the PTEN pseudogene, PTENP1. …”
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Nanoparticles containing intracellular proteins modulate neutrophil functional and phenotypic heterogeneity by Leonore Raudszus, Farbod Bahreini, Susanne Allan, Kai-Uwe Kalies, Charles C. Caldwell, Kathrin Kalies

“…We observed that CDNPs activate BMN transiently with an increase in the expression of CD11b without triggering classical effector functions. …”
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Pre-mRNA Splicing Functions in Plant Sexual Reproduction Development by Dongjie Shao, Xinqi Gao, Yiming Wei

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Research on the functions and potential mechanisms of STAT3 in chronic myelogenous leukemia by Xiaoyun Feng, Yufeng Qin, Yulong Feng, Yingquan Zhuo

“…Methods Through the cancerSEA and CCLE databases, the expression of STAT3 in CML was verified and analyzed. …”
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Functional Characterization of Squalene Epoxidases from <i>Siraitia grosvenorii</i> by Huan Zhao, Ze Song, Xuan Liu, Shukun Gong, Qi Tang, Changli Liu, Yifeng Zhang, Xianan Zhang, Haiyun Gao, Wei Gao, Yating Hu, Luqi Huang

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Function of a novel human gene TOX promoting cell proliferation by DENG Weiwei, LI Jing, GAO Peng, HAO Dongxia, ZHANG Lu, SHI Taiping, WANG Ying

“…So, the identification and function study of human functional genes involved in regulation of cell proliferation will provide new directions for mechanism research of cell proliferation and therapy strategy of various related diseases.By searching the human RefSeq and expressed sequence tag (EST) databases in GenBank, human function gene TOX (thymocyte selection-associated high mobility group box) (NCBI RefSeq No: NM _014729) was cloned from human multi-tissue cDNA library by using PCR (polymerase chain reaction) assay. …”
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Diesel exhaust particle exposure in vitro alters monocyte differentiation and function. by Nazia Chaudhuri, Hannah Jary, Simon Lea, Naimat Khan, Katie C Piddock, David H Dockrell, Ken Donaldson, Rodger Duffin, Dave Singh, Lisa C Parker, Ian Sabroe

“…Chronic exposure to lower concentrations of diesel exhaust particles impaired CXCL8 cytokine responses to lipopolysaccharide and heat killed E. coli, and this phenotype was associated with a reduction in CD14 and CD11b expression. Chronic diesel exhaust particle exposure may therefore alter both numbers and function of lung macrophages differentiating from locally recruited monocytes in the lungs of healthy people and patients with chronic obstructive pulmonary disease.…”
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Mechanism of pentoxifylline mediated down-regulation of killer lineage cell functions by R. S. Parhar, P. Ernst, K. Sheth, M. Einspenner, S. Al-Sedairy

“…Pentoxifylline (PTX) is known to modulate neutrophil functions. In the present study the effects of PTX on lipopolysaccharide (LPS) and cytokine induced T-cell and macrophage (ΦM) activation, and on natural killer (NK) cell and lymphokine activated killer (LAK) cell mediated cytotoxicity were examined. …”
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Cellular senescence-associated genes in rheumatoid arthritis: Identification and functional analysis. by You Ao, Qing Lan, Tianhua Yu, Zhichao Wang, Jing Zhang

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Transcriptomic and functional analysis of triphenyl phosphate exposure in prostate cancer progression by Li Cai, Guizhi Du

“…TCGA-based survival modeling was used to evaluate the prognostic relevance of selected genes. Functional assays were carried out to assess TPP-induced phenotypic changes. …”
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Research progress on the tsRNA biogenesis, function, and application in lung cancer by Yu Chen, Zhuowei Shao, Shibo Wu

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Bioinformatics prediction of function of T-cell exhaustion related genes in ischemic stroke by Yajun Gao, Ruyu Bai, Bo Gao, Ma Li

“…Functional enrichment analysis revealed that these genes were involved in immune response and cellular processes, which were closely related to the level of immune cell infiltration. …”
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Slowpoke functions in circadian output cells to regulate rest:activity rhythms. by Daniela Ruiz, Saffia T Bajwa, Naisarg Vanani, Tanvir A Bajwa, Daniel J Cavanaugh

“…Interestingly, slo mutants have previously been shown to have aberrant rest:activity rhythms, in part due to a necessary function of slo within central clock cells. However, rescue of slo in all clock cells does not fully reestablish behavioral rhythms, indicating that expression in non-clock neurons is also necessary. …”
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A functional portrait of Med7 and the mediator complex in Candida albicans. by Faiza Tebbji, Yaolin Chen, Julien Richard Albert, Kearney T W Gunsalus, Carol A Kumamoto, André Nantel, Adnane Sellam, Malcolm Whiteway

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Functional characteristics of bone marrow stromal cells in patients with acute leukemia by I. M. Barhatov, N. Y. Tsvetkov, A. I. Shakirova, D. S. Romanyuk, O. G. Smykova, L. S. Zubarovskaya, B. V. Afanasyev

“…In this paper we evaluated the major functional characteristics of stromal cells: proliferative activity, hematopoiesis supportive and differentiation ability, as well as analysis of the expression of adhesion molecules. …”
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Innate epithelial and functional differences in airway epithelium of children with acute wheeze by Kevin Looi, Kevin Looi, Kevin Looi, Thomas Iosifidis, Thomas Iosifidis, Thomas Iosifidis, Thomas Iosifidis, Saraya Harrison, Saraya Harrison, Stephen M. Stick, Peter LeSouef, Peter LeSouef, Peter LeSouef, Ingrid A. Laing, Ingrid A. Laing, Anthony Kicic, Anthony Kicic, Anthony Kicic, Anthony Kicic

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