Modafinil alters the functional connectivity of distinct thalamic nuclei with the neocortex by Stefano Delli Pizzi, Federica Tomaiuolo, Carlo Sestieri, Antonio Maria Chiarelli, Francesco Gambi, Antonio Ferretti, Stefano L Sensi

“…Magnetic Resonance Imaging (MRI) was used to parcel the thalamus into its constituent nuclei, which served as seeds for voxel-wise resting state functional connectivity analyses. Additionally, maps of nuclei-specific functional reorganization were compared to those of receptor/transporter expression to assess their spatial overlaps. …”
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Overlapping functions of argonaute proteins in patterning and morphogenesis of Drosophila embryos. by Wibke J Meyer, Silke Schreiber, Yi Guo, Thorsten Volkmann, Michael A Welte, H Arno J Müller

“…These defects do not appear to result from disruption of siRNA-dependent processes but rather suggest an interference of the mutant Ago2 proteins in an Ago1-dependent pathway. Using loss-of-function alleles, we further demonstrate that Ago1 and Ago2 act in a partially redundant manner to control the expression of the segment-polarity gene wingless in the early embryo. …”
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Circulating MicroRNAs: functional biomarkers for melanoma prognosis and treatment by Su Yin Lim, Suzanah C. Boyd, Russell J. Diefenbach, Helen Rizos

“…The functional complexity of miRNAs—where a single miRNA can regulate multiple messenger RNAs (mRNAs) to fine tune fundamental processes, and a single mRNA can be targeted by multiple miRNAs—underscores their broad significance and impact. …”
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Differential function of Themis CABIT domains during T cell development. by Toshiyuki Okada, Takeshi Nitta, Kentaro Kaji, Akiko Takashima, Hiroyo Oda, Norimasa Tamehiro, Motohito Goto, Tadashi Okamura, Michael S Patrick, Harumi Suzuki

“…Despite the possible involvement of Themis in TCR-mediated signal transduction, its function remains unresolved and controversial. Themis contains two functionally uncharacterized regions called CABIT (cysteine-containing, all-β in Themis) domains, a nuclear localization signal (NLS), and a proline-rich sequence (PRS). …”
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Flow cytometry for evaluating platelet immunophenotyping and function in patients with thrombocytopenia by Chih-Lung Shen, Yi-Feng Wu

“…According to the consensus published by the International Society on Thrombosis and Haemostasis, for inherited and acquired platelet disorders, the two major measures by which flow cytometry determines platelet function are glycoprotein IIb/IIIa/P-selectin (CD62p) expression and percentage of leukocyte–platelet aggregates. …”
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EFFECTS OF MYOCARDIAL CYTOSOLIC FRACTION AND LIPOPOLYSACCHARIDE UPON MONOCYTIC FUNCTIONS by V. G. Matveeva, A. S. Golovkin, M. N. Chernova, I. V. Kudryavtsev, S. V. Ivanov, E. V. Grigoriev

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Nitric Oxide in Plant Cold Stress: Functions, Mechanisms and Challenges by Jing Cui, Mengxiao Huang, Jin Qi, Wenjin Yu, Changxia Li

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Anti-RANKL Inhibits Thymic Function and Causes DRONJ in Mice by Yusuke Nakamura, Takashi Kikuiri, Takahiro Sugiyama, Ayako Maeda, Daisuke Izumiyama, Daigo Yahata, Yoshitaka Yoshimura, Tetsuo Shirakawa, Yoshimasa Kitagawa

“…We examined the development of DRONJ-like lesions and immune function. Results. We showed that administration of anti-mouse RANKL monoclonal antibody and melphalan caused DRONJ-like lesions that recapitulated major clinical manifestations of the human disease, including the characteristic features of an open alveolar socket and exposed necrotic bone. …”
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Structure-function investigation of vsp serotypes of the spirochete Borrelia hermsii. by Rohit Mehra, Diana Londoño, Marie Sondey, Catherine Lawson, Diego Cadavid

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Accounting planning of expenses and revenues in the function of business decision-making by Janaćković Tanja, Pejčić Marina

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Functional Role of RBP in Osteosarcoma: Regulatory Mechanism and Clinical Therapy by Ziyuan Que, Kang Yang, Nan Wang, Shuying Li, Tao Li

“…Moreover, we focus on the attempts to differentiate RBP’s opposite functions in predicting prognosis and collect possible strategies for treatment. …”
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SOX9-dependent fibrosis drives renal function in nephronophthisis by Maulin Mukeshchandra Patel, Vasileios Gerakopoulos, Bryan Lettenmaier, Eleni Petsouki, Kurt A Zimmerman, John A Sayer, Leonidas Tsiokas

“…Here, we show that kidney-specific deletion of Fbxw7, the recognition receptor of the SCFFBW7 E3 ubiquitin ligase, results in a juvenile-adult NPHP-like pathology characterized by slow-progressing corticomedullary cysts, tubular degeneration, severe fibrosis, and gradual loss of kidney function. Expression levels of SOX9, a known substrate of FBW7, and WNT4, a potent pro-fibrotic factor and downstream effector of SOX9, were elevated upon loss of FBW7. …”
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Biological function and application of glucan-water dikinase: a review by Sun Xiao, Bao Jinsong

“…In this review, we summarized the progress made on GWD from the view of its structure, biological functions and its interactions with other enzymes involved in starch metabolism. …”
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Magnetic nanoparticles influence the biological function of mesenchymal stem cells by Xinyue Li, Sheng Qin, Xiaoyun Liao, Yang Li, Aimei Liu

“…However, the potential impact of the MNPs we developed on MSC function remains unclear. In this study, we treated MSC with poly-L-lysine (PLL)-modified MNPs (MSC-MNPs) at a concentration of 0.1 µg/µL to assess their effects on MSC. …”
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Function of the Shaw potassium channel within the Drosophila circadian clock. by James J Hodge, Ralf Stanewsky

“…<h4>Methodology/principal findings</h4>We show that Shaw is endogenously expressed in clock neurons. Differential use of clock gene promoters was employed to express a range of transgenes that either increase or decrease Shaw function in different clusters of clock neurons. …”
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Structural and functional features of endometrium in patients undergoing in - vitro fertilization by Y. A. Kovalenko, L. M. Chuprinenko

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Sensory neuron LKB1 mediates ovarian and reproductive function by Melissa E Lenert, Emily K Debner, Michael D Burton

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Influence of HCN channels on isolated heart functions in adult rats by A.M. Kuptsova, N.I. Ziyatdinova, L.I. Faskhutdinov, R.G. Biktemirova, T.L. Zefirov

“…It is possible that If participates in the formation of the potential action of working cardiomyocytes and, consequently, in the regulation of the inotropic cardiac function. The study was performed in order to investigate the role of hyperpolarization-activated currents on chronotropy, inotropy, and coronary flow of the Langendorff heart in adult rats. …”
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Cortical and Striatal Functional Connectivity in Juvenile-Onset Huntington’s Disease by Amy Barry, Peg C. Nopoulos

“…The observed left-lateralized somatomotor hypoconnectivity aligns with prior volumetric and gene expression research, highlighting the role of excitotoxic glutamatergic input and the selective vulnerability of high-functioning circuits in disease progression.…”
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A Commander-independent function of COMMD3 in endosomal trafficking by Galen T Squiers, Chun Wan, James Gorder, Harrison Puscher, Jingshi Shen

“…Unexpectedly, our findings revealed a Commander-independent function for COMMD3, a subunit of the Commander complex, in endosomal recycling. …”
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