The Role and Function of Non-Coding RNAs in Cholangiocarcinoma Invasiveness by Yu Meng, Fang Wei, Ye Zhang, Wenting He, Haijiao Yan, Jun Wu

“…This review comprehensively synthesizes the expression, biogenesis, interactions, signaling pathways, and functional mechanisms of ncRNAs in the invasiveness of CCA. …”
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Heterologous Caseins: The Role of Phosphorylation in Their Functionality and How to Achieve It by Soledad Mora Vásquez, Santiago García-Jacobo, Guy A. Cardineau, Silverio García-Lara

“…While some endogenous kinases may partially compensate, they are typically insufficient to replicate the phosphorylation pattern required for functionality. We evaluate potential strategies to address these limitations, analyze the role of phosphorylation in casein functionality, provide insights into existing patents and experimental approaches, and highlight ongoing research efforts. …”
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Identification and functional characterization of cardiac pacemaker cells in zebrafish. by Federico Tessadori, Jan Hendrik van Weerd, Silja B Burkhard, Arie O Verkerk, Emma de Pater, Bastiaan J Boukens, Aryan Vink, Vincent M Christoffels, Jeroen Bakkers

“…In conclusion we demonstrate that Isl1-expressing cells, organized as a ring-shaped structure around the venous pole, hold the pacemaker function in the adult zebrafish heart. …”
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Identifying sex-based disparities in porcine mitochondrial function by Hao Liu, Wenshu Shi, Xing Zhang, Xinmiao He, Xingbo Zhao

“…The results highlight the effect of sex on mitochondrial function and gene expression, and provide important data for a comprehensive understanding of the mechanisms underlying sex regulation of energy metabolism-related traits in pigs.…”
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The role of vesicle trafficking genes in osteoblast differentiation and function by Hui Zhu, Yingying Su, Jamie Wang, Joy Y. Wu

“…We selected 22 trafficking genes that have not been well characterized in bone for functional validation in MC3T3-E1 pre-osteoblasts. Transient siRNA knockdown of trafficking genes including Sec24d, Gosr2, Rab2a, Stx5a, Bet1, Preb, Arf4, Ramp1, Cog6 and Pacs1 significantly increased mineralized nodule formation and expression of osteoblast markers. …”
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The Double-Edged Sword of Vitamin A: Function and Toxicity by Paulina Grzeszczuk, Magdalena Jabłonowska

“…After intestinal absorption, it is primarily stored in the liver and converted into active compounds such as retinoic acid, which regulate gene expression and support epithelial health and immune function. …”
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Study of the functional product’s protein compounds digestion features by E. R. Vasilevskaya, A. G. Akhremko, E. K. Polishchuk, L. V. Fedulova

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An Integrated Optogenetic and Bioelectronic Platform for Regulating Cardiomyocyte Function by Olurotimi A. Bolonduro, Zijing Chen, Corey P. Fucetola, Yan‐Ru Lai, Megan Cote, Rofiat O. Kajola, Akshita A. Rao, Haitao Liu, Emmanuel S. Tzanakakis, Brian P. Timko

“…Here we report an integrated optogenetic and bioelectronic platform for stable and long‐term stimulation and monitoring of cardiomyocyte function in vitro. Optical inputs are achieved through the expression of a photoactivatable adenylyl cyclase, that when irradiated with blue light causes a dose‐dependent and time‐limited increase in the secondary messenger cyclic adenosine monophosphate with subsequent rise in autonomous cardiomyocyte beating rate. …”
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DCAF13 is essential for mouse uterine function and fertility by Qianhui Zhou, Xiaohui Li, Ningjing Wang, Liang Zhang, Enhui Jiang, Kaixuan Wang, Xingyu Yan, Cong Zhang

“…DCAF13 has been implicated in oocyte and embryo development, but its role in the uterus remains elusive. To investigate its function, we generated Dcaf13 conditional knockout (cKO) mice and discovered that the uteri of cKO mice became smaller and thinner as they mature, and the embryos were unable to implant, leading to infertility. …”
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The Functions and Implications of MicroRNAs in Premature Ovarian Insufficiency by Hui Gao, Xi‐Xia Cao, Hua Hua, Hui Zhu

“…ABSTRACT Background Premature ovarian insufficiency (POI) is a condition in women characterized by the premature decline of ovarian function before age 40, evident through menstrual irregularities such as amenorrhea or oligomenorrhea, elevated FSH levels exceeding 25 U/L, and a progressive decrease in estrogen levels. …”
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Research Progress on the Functional Regulation Mechanisms of ZKSCAN3 by Jianxiong Xu, Xinzhe Li, Jingjing Xia, Wenfang Li, Zhengding Su

“…Post-translational modifications, such as phosphorylation and ubiquitination, dynamically modulate its subcellular localization and activity, enabling context-dependent functional plasticity. Functionally, ZKSCAN3 acts as a master switch in autophagy by repressing the transcription of autophagy-related genes under nutrient-replete conditions, while its nuclear-cytoplasmic shuttling under stress conditions links metabolic reprogramming to cellular survival. …”
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Types and Functions of Repetition in the Works of Howard Phillips Lovecraft by N. S. Tatarincev

“…The subject of the paper is repetition, which plays a special role in a literary text as a means of artistic expression. Conducting research is relevant for several reasons, like interest in the consideration of the functional aspects of the literary text as a whole, or to H. …”
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The role of the 5’ sensing function of ribonuclease E in cyanobacteria by Ute A. Hoffmann, Elisabeth Lichtenberg, Said N. Rogh, Raphael Bilger, Viktoria Reimann, Florian Heyl, Rolf Backofen, Claudia Steglich, Wolfgang R. Hess, Annegret Wilde

“…RNA degradation is critical for synchronising gene expression with changing conditions in prokaryotic and eukaryotic organisms. …”
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The biogenesis, regulation and functions of transitive siRNA in plants by Tan Huijun, Liu Yuelin, Guo Hongwei

“…Members of this class of siRNAs function in various biological processes ranging from development to stress adaptation. …”
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Neural function of Netrin-1 in precancerous lesions of the pancreas by Hiba Haidar, Anaïs Bellon, Karen Sleiman, Mélanie Hocine, Nicolas Rama, Nicolas Gadot, Darren R. Carpizo, Patrick Mehlen, Fanny Mann

“…However, the molecular signals driving this early neuroplasticity and its functional consequences remain poorly understood. Here, we identify the axon guidance molecule Netrin-1 as a key factor secreted by pancreatic cells within precursor lesions of pancreatic cancer. …”
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Spline approximation of multivalued functions in linear structures routing by D. A. Karpov, V. I. Struchenkov

“…In this case, it is possible to analytically calculate the derivatives of the objective function with respect to the spline parameters in the absence of its analytical expression through these parameters.Results. …”
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FUNCTIONS OF VANDALISM IN YOUTH BEHAVIOUR: FROM PERSONALITY TO SOCIETY by O. V. Kruzhkova, I. V. Vorobyeva, R. Yu. Porozov, B. Zarbova

“…At the second (individual-subjective) level, the demonstrative-and-protest function, functions of reactions, compensation and self-expression are allocated. …”
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Brain Functional Reserve in the Context of Neuroplasticity after Stroke by Jan Dąbrowski, Anna Czajka, Justyna Zielińska-Turek, Janusz Jaroszyński, Marzena Furtak-Niczyporuk, Aneta Mela, Łukasz A. Poniatowski, Bartłomiej Drop, Małgorzata Dorobek, Maria Barcikowska-Kotowicz, Andrzej Ziemba

“…So far, studies have proven that regeneration after stroke and recovery of lost functions may be assigned to neuronal plasticity understood as ability of brain to reorganize and rebuild as an effect of changed environmental conditions. …”
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Nicotinamide Inhibits CD4+ T-Cell Activation and Function by Lotte Nijhuis, Alejandra Bodelόn, Rianne C. Scholman, Isabelle Houtzager, Lyanne J. P. M. Sijbers, Enric Mocholi, Lucas W. Picavet, Jorg J. A. Calis, Michal Mokry, Sebastiaan J. Vastert, Jorg van Loosdregt

“…Here, we address this gap by investigating how NAM influences CD4+ T-cell activation and function. We also describe that NAM treatment significantly suppresses CD4+ T-cell activation in vitro, as evidenced by impaired proliferation and reduced expression of surface activation markers. …”
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Compound loss of muscleblind‐like function in myotonic dystrophy by Kuang‐Yung Lee, Moyi Li, Mini Manchanda, Ranjan Batra, Konstantinos Charizanis, Apoorva Mohan, Sonisha A. Warren, Christopher M. Chamberlain, Dustin Finn, Hannah Hong, Hassan Ashraf, Hideko Kasahara, Laura P. W. Ranum, Maurice S. Swanson

“…These findings support the hypothesis that compound loss of MBNL function is a critical event in DM pathogenesis and provide novel mouse models to investigate additional pathways disrupted in this RNA‐mediated disease.…”
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