Targeting PD-1 and CD85j can restore intratumoral CD4+ GzmB+ T-cell functions to combat MHC-II-expressing tumors by Xue Wang, Xu Wang, WenBin Zou, Zhiwei Yuan, Hui Xiong, Xiangning Fu, Lequn Li, Yu Xi, Boyu Wang, Tianlai Wang, Kelin Meng, Taiyan Yu, Shaojie Hu, Rirong Qu, Chenxi Zeng, Yitao Tian, Yixin Cai, Shengling Fu

“…Dual blockade of PD-1 and CD85j alongside IL-15 restores the effector function of CD4+GzmB+ T cells and drives CD4+GzmB+ T-cell transformation in the tumor microenvironment to combat MHC-II-expressing tumors.…”
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Cyanobacteria Desertifilum tharense NIOF17/006 as a novel aquafeed additive: effect on the growth, immunity, digestive function, and gene expression of whiteleg shrimp postlarvae by Mohamed Ashour, Ahmed Said Al-Souti, Ahmed Mamoon, Fawzia S. Ali, Mostafa E. Elshobary, Mohamed M. Mabrouk, Ahmed I. A. Mansour, Abdallah Tageldein Mansour, Ehab El-Haroun, Ahmed F. Abdelhamid

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Learning a Foreign Language in Older Adults Shapes the Functional Connectivity of Distinct Cerebellar Sub‐Regions With Cortical Areas Rich in CB1 Receptor Expression by Giovanna Bubbico, Federica Tomaiuolo, Carlo Sestieri, Golnoush Akhlaghipour, Alberto Granzotto, Antonio Ferretti, Mauro Gianni Perrucci, Stefano L. Sensi, Stefano Delli Pizzi

“…While previous studies have investigated the impact of FLL on the cortical connectome, its effects on subcortical‐cortical resting‐state functional connectivity (rs‐FC) remain unexplored. The present study focuses on the connectivity of the cerebellum, based on its involvement in learning and aging. …”
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The Spatiotemporal Pattern of Glis3 Expression Indicates a Regulatory Function in Bipotent and Endocrine Progenitors during Early Pancreatic Development and in Beta, PP and Ductal Cells. by Hong Soon Kang, Yukimasa Takeda, Kilsoo Jeon, Anton M Jetten

“…To obtain greater insights into the functions of Glis3 in pancreas development, we examined the spatiotemporal expression of Glis3 protein in a knockin mouse strain expressing a Glis3-EGFP fusion protein. …”
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Simultaneous effect of naringenin and beta-catenin signaling inhibitor C-82 on modulating gene expression and functional pattern of mesenchymal stem cells from endometriosis patients by Hoda Fazaeli, Faezeh Davoodi Asl, Azar Sheikholeslami, Mohsen Sheykhhasan, Naser Kalhor, Leila Naserpour, Rahil Jannatifar, Seyedeh Saeideh Sahraei

“…E-MenSCs showed increased early apoptosis and decreased levels of ROS, IL-6 and IL-8, ER, α-SMA, and Ki-67 protein expression. Results: Our results shed light on the function of C-82 and naringenin in modulating E-MenSCs. …”
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Inhibiting Pyk2/Src expression by miR-23b-3p suppressed liver cancer stem cell function and hepatic carcinoma progression by Meng Sha, Jiang Zhang, Jin-kai Liu, Xiao-ye Qu, Chuan Shen, Ying Tong, Jie Cao

“…Conclusions Inhibiting Pyk2/Src expression by miR-23b-3p suppressed LCSCs function and aggravated HCC progression. …”
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Pentosan polysulfate decreases myocardial expression of the extracellular matrix enzyme ADAMTS4 and improves cardiac function in vivo in rats subjected to pressure overload by aortic banding. by Maria Vistnes, Jan Magnus Aronsen, Ida G Lunde, Ivar Sjaastad, Cathrine R Carlson, Geir Christensen

“…Furthermore, PPS-treatment improved systolic function, demonstrated by an improved fractional shortening (vehicle 48±3% versus PPS 60±1%, p<0.01) after AB. …”
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IDENTIFICATION AND ASSESSMENT OF THE AIRCRAFT FUNCTIONAL SYSTEMS IN THE FLIGHT SAFETY MANAGEMENT SYSTEMS by I. D. Dashkov, B. V. Zubkov

“…The article discusses issues related to determining the technical states of aircraft functional systems (FS). Mathematical formulas are given for expressing the relationship between the main parameters characterizing the model.…”
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Pharmacological and resting state fMRI reveal Osteocalcin’s effects on mouse brain regions with high Gpr37 and Gpr158 expression by Natalia K. Freus, Isabel Wank, Maximilian Häfele, Liubov S. Kalinichenko, Christian P. Müller, Sandra Strobelt, Andreas Ludwig, Andreas Hess, Silke Kreitz

“…We used multiparametric magnetic resonance imaging (MRI) including pharmacological MRI and resting state functional MRI, along with gene expression data for Gpr37 and Gpr158 to investigate the physiological effects of intravenously administered OCN on the wild type mouse brain. …”
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A new predictive factor VGF based on IHC experiments, gene pathways and molecular functional groups for tumor immune microenvironment and prognosis of adrenocortical carcinoma by Junpeng Chi, Keyuan Lou, Jiankun Zhang, Jiankun Zhang, Jiankun Zhang, Jitao Wu, Yuanshan Cui, Yuanshan Cui

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Linguistic and Cultural Aspect of Interpretation of Aphoristic Expressions with Zoocomponents ‘Dog’ and ‘Horse’ (Khanty and Khakass Languages) by A. D. Kaksin

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Dietary Phyllanthus Emblica inclusion regulates growth, serum biochemistry, organ histology, gene expression, and resistance against Aspergillus Flavus in Nile Tilapia (Oreochromis... by Samyah D. Jastaniah, Najah M. Albaqami

“…In terms of body composition, crude lipids decreased, while ash percentages increased after fish were fed with P. emblica (P < 0.05). Liver function decreased significantly, while protein fraction, blood hematology and digestive enzymatic profile (amylase, and lipase) were significantly increased in all treated groups. …”
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Jerusalem artichoke extracts regulate the gene expression of key enzymes involved in fatty acid biosynthesis by Soo Jin Lee, Woo-Cheol Shin, Sangmin Ju, Mi-Ri Gwon, Jae-Hwa Lee, Young-Ran Yoon, Stuart K. Calderwood, Dae Young Lee, Heeyoun Bunch

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Whole-Genome Sequence Analysis of <i>Flammulina filiformis</i> and Functional Validation of <i>Gad</i>, a Key Gene for γ-Aminobutyric Acid Synthesis by Wenyun Li, Junjun Shang, Dapeng Bao, Jianing Wan, Chenli Zhou, Zhan Feng, Hewen Li, Youran Shao, Yingying Wu

“…Molecular docking analysis showed that Ff-GAD2 may have better catalytic activity than Ff-GAD1. To verify the function of <i>Ff-gad2</i>, its heterologous expression in the mycelia of the mononuclear <i>Hypsizigus marmoreus</i> was analyzed. …”
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Effects of <i>Marquandomyces marquandii</i> SGSF043 on the Germination Activity of Chinese Cabbage Seeds: Evidence from Phenotypic Indicators, Stress Resistance Indicators, Hormone... by Xu Zheng, Yuxia Huang, Xinpeng Lin, Yuanlong Chen, Haiyan Fu, Chunguang Liu, Dong Chu, Fengshan Yang

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Investigation of some finite integrals incorporating incomplete Aleph functions by Sachin Kumar, Manvendra Narayan Mishra, Ravi Shanker Dubey, Rahul Sharma

“…Our method is based on the finite integral operator applied to incomplete Aleph functions. This approach makes it easier to derive integral formulas that connect the incomplete Aleph functions using well-known special functions and algebraic expressions. …”
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Morphology and functional organization of subcutaneous adipose tissue: modern concepts of structural and functional heterogeneity and age-related changes (systematic literature rev... by M. A. Shirshakova, S. E. Shemyakov, A. A. Supil'nikov, Yu. E. Mel'nikova

“…Contemporary understanding of structural and functional heterogeneity of adipose tissue has fundamentally changed our perception of its role in metabolic disease pathogenesis and aging processes. …”
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Decoding the synergistic mechanisms of functional microbial agents on the microecology and metabolic function in medium-high temperature Daqu starter for enhancing aromatic flavor by Min Zhu, Zhao Deng, Mingyao Wang, Yu Tie, Wenxue Zhang, Zhengyun Wu, Zhengfu Pan, Guorong Luo, Renfu Wu, Jianliang Qin, Katsuya Gomi

“…Herein, we reveal the mechanisms of functional microbial agents for enhancing aromatic compounds through reducing interspecies interactions and simplifying the ecological network to drive the aggregated distribution of lactic acid bacteria, and inducing a localized microecology comprised of Aspergillus, Pichia, Millerozyma, Pseudomonas, Paenibacillus, and Rhizomucor, effectively boosting the expression of key enzymes for aromatic synthesis. …”
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A Systems Biology Approach to Elucidating Functional and Genomic Signatures in Host-Pathogen Interactions of Triple Infections: Tuberculosis, HIV, and SARS-CoV-2 by Mohd. Imran, Hayat Ali Alzahrani, Ranya Mohammed Elmagzoub, Zia Ur Rehman, Khadiga G. Abd Elaleem, Ahlam S. Mohamed, Aida A. Elsharief, Hayaa M. Alhuthali

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Logopedic rehabilitation of patients after surgical treatment of malignant tumors of the oropharyngeal zone by A. M. Stepanova, T. A. Petrova, G. A. Tkachenko, S. O. Podvyaznikov

“…Logopedic rehabilitation of patients with tumors of the oropharyngeal zone plays an important role in the postoperative period, as it is aimed at restoring of all of the above functions.Restoration of the swallowing function is possible due to the restoration of the motor function of preserved anatomical structures, as well as the mobility of transplanted tissues with adequately performed plastic.To restore the respiratory function, it is recommended to use the following methods: coordination of inhalation and exhalation; inhalation commission which sufficient for expression; search for the optimal position of the body; the pause function and breathing exercises. …”
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