Dietary Puerarin Enhances Growth, Immune Function, Antioxidant Capacity, and Disease Resistance in Farmed Largemouth Bass, <i>Micropterus salmoides</i> by Yi Huang, Wenjing Ma, Disen Zhang, Xi Chen, Zhiqiu Huang, Yuhang Hong

“…Recently, its potential as a functional feed additive in aquaculture has garnered increasing attention. …”
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Curcumin derivative C210 induces Epstein–Barr virus lytic cycle and inhibits virion production by disrupting Hsp90 function by Linli Chen, Xiaojing Guo, Wen Lin, Yingying Huang, Suling Zhuang, Qianfeng Li, Jianhua Xu, Shengnan Ye

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Comprehensive analysis of m7G-related genes METTL1 and WDR4 for predicting prognosis and oncogenic functions in prostate cancer by Degeng Kong, Juanyi Shi, Cong Lai, Jintao Hu, Yelisudan Mulati, Jiawen Luo, Junjie Wang, Yunfei Xiao, Cheng Liu, Kewei Xu

“…Functional enrichment analysis indicated their influence on ribosome-related functions. …”
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Diabetes-associated sleep fragmentation impairs liver and heart function via SIRT1-dependent epigenetic modulation of NADPH oxidase 4 by Yuanfang Guo, Jie Wang, Dongmei Zhang, Yufeng Tang, Quanli Cheng, Jiahao Li, Ting Gao, Xiaohui Zhang, Guangping Lu, Mingrui Liu, Xun Guan, Xinyu Tang, Junlian Gu

“…Here, our findings revealed that sleep fragmentation (SF) displayed notable hepatic detrimental phenotypes, including steatosis and oxidative damage, along with significant abnormalities in cardiac structure and function. All these pathological changes persisted even after sleep recovery for 2 consecutive weeks or more, displaying memory properties. …”
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Mutation-Specific Cardiomyocyte Lines from Patients with Fabry Disease: A Sustainable In Vitro Model to Investigate Structure, Function, and Disease Mechanisms by Kathleen Nicholls, Andrea Wise, David Elliot, Menno ter Huurne, Maria Fuller, Sharon Ricardo

“…Phenotypic characteristics, α-Gal A activity, Gb3 accumulation, functional status, and lipid analysis were assessed. …”
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Loss of G-protein coupled receptor 68 in hematopoietic tissues enhances long-term hematopoietic stem cell function upon aging by Xiaofei He, Caleb Hawkins, Lauren Lawley, Tra Mi Phan, Isaac Park, Nicole Joven, Shanshan Shi, Jing Fang

“…Abstract Background G-protein coupled receptor 68 (Gpr68) was enriched in long-term hematopoietic stem cells, indicating a potential role of Gpr68 in the HSC function. However, there is no significant phenotype in the HSC biology of Gpr68 whole-body KO mice, which may be counteracted by compensation. …”
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Identification of functional pathways and hub genes associated with the heterochronic development of sugarcane axillary buds and sett roots through multi-omics analysis by Jiabao Zheng, Xiaoyu Huang, Yanli Wei, Wenyan Li, Baoshan Chen, Baoshan Chen, Wenlan Li, Wenlan Li

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Genome-Wide Identification of the Shaker Potassium Channel Family in Chinese Cabbage and Functional Studies of <i>BrKAT1</i> in Yeast by Jin-Yan Zhou, Ze-Chen Gu, Dong-Li Hao

“…Truncation of the N-terminal 63 amino acids of <i>BrKAT1.2</i> resulted in the loss of potassium absorption capability, suggesting that the N-terminus is essential for maintaining the potassium absorption function of <i>BrKAT1.2</i>. Furthermore, the expression of the two <i>BrKAT1</i> genes in the salt-sensitive yeast G19 enhances yeast tolerance to salt stress. …”
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New insights into radioresistance in breast cancer identify a dual function of miR‐122 as a tumor suppressor and oncomiR by Isidro X. Perez‐Añorve, Claudia H. Gonzalez‐De la Rosa, Ernesto Soto‐Reyes, Fredy O. Beltran‐Anaya, Oscar Del Moral‐Hernandez, Marisol Salgado‐Albarran, Oscar Angeles‐Zaragoza, Juan A. Gonzalez‐Barrios, Daniel A. Landero‐Huerta, Margarita Chavez‐Saldaña, Alejandro Garcia‐Carranca, Nicolas Villegas‐Sepulveda, Elena Arechaga‐Ocampo

“…Functional analysis revealed that miR‐122 has a role as a tumor suppressor in parental cells by decreasing survival and promoting radiosensitivity. …”
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Klf5-adjacent super-enhancer functions as a 3D genome structure-dependent transcriptional driver to safeguard ESC identity by Guangsong Su, Bohan Chen, Yingjie Song, Qingqing Yin, Wenbin Wang, Xueyuan Zhao, Sibo Fan, Jie Lian, Dongqing Li, Jinfang Bi, Peng Li, Zhongfang Zhao, Lei Zhang, Jiandang Shi, Wange Lu

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Histidine triad nucleotide‐binding protein 2 attenuates doxorubicin‐induced cardiotoxicity through restoring lysosomal function and promoting autophagy in mice by Hao Jiang, Jinyan Zhang, Daile Jia, Liwei Liu, Jinfeng Gao, Beijian Zhang, Zhen Dong, Xiaolei Sun, Wenlong Yang, Tiantong Ou, Suling Ding, Luna He, Yiqin Shi, Kai Hu, Aijun Sun, Junbo Ge

“…These findings highlight HINT2 as a key cardioprotective factor that mitigates DIC by restoring the NAD+/NADH ratio, lysosomal function, and autophagy. Therapeutic strategies enhancing HINT2 expression or supplementing NMN may reduce cardiac damage and heart failure caused by DOX.…”
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Sex biased expression and co-expression networks in development, using the hymenopteran Nasonia vitripennis. by Alfredo Rago, John H Werren, John K Colbourne

“…The effect of expressing a gene is also influenced by which other genes are simultaneously expressed (functional interactions). …”
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Possibility of alleviating dextran sulfate sodium-induced colitis in mice by modulate intestinal barrier function and gut microbiota with laminarin acetyl esters by Kit-Leong Cheong, Amanullah Sabir, Suresh Veeraperumal, Franck Quero, Rui Li, Qiaoli Zhao, Karsoon Tan, Saiyi Zhong, Udayakumar Veerabagu

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Toll-like receptor 8 agonists improve NK-cell function primarily targeting CD56brightCD16− subset by Enrico Maggi, Giovanni Scambia, Anna Fagotti, Lorenzo Moretta, Andrea Pelosi, Irene Veneziani, Valentina D'Oria, Claudia Alicata, Nadine Landolina, Biancamaria Ricci

“…This study was addressed to establish which endosomal TLR could directly mediate NK activation and function after proper stimuli. It was also important to establish the most suitable TLR agonist to be used as adjuvant in tumor vaccines or in combined cancer immunotherapies.Methods We assessed endosomal TLR expression in total NK cells by using RT-qPCR and western blotting technique. …”
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In vitro phenotypic re-orientation of functionally important neutrophil subpopulations and their microbicidal activity in the children with purulent inflammatory diseases influence... by I. V. Nesterova, G. A. Chudilova, M. N. Mitropanova, V. N. Pavlenko, L. V. Lomtatidze, S. V. Kovaleva, V. A. Tarakanov, N. K. Barova

“…An opportunity of reorienting a deficient NG subpopulational phenotype in purulent inflammatory diseases due to the rearrangement of the receptor set induced by various immunotropic substances may serve as a key to recovery of normal NG functioning.Our aim was to study the effect of glucosaminylmuramyldipeptide (GMDP) under in vitro conditions upon the phenotypic profile of four functionally significant subpopulations, i.e., CD62L+CD63-NG, CD62L+CD63+NG and CD64-CD32+CD16+CD11b+NG, CD64+CD32+CD16+CD11b+NG, along with assessment of expression density of appropriate membrane molecules and NG microbicidal activity in the children with purulent inflammatory diseases. 90 samples of peripheral blood (PC) were taken from children 2 to 4 years old, including 12 children with minor purulent infection (MPI), and 7 children were studied as conditionally healthy controls. …”
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IL-2 and IL-15 augment HBV therapeutic vaccination and PD1 blockade for functional cure in the AAV-HBV mouse model by Gavin Lewis, Kirsten Malo, Thomas Rowland, Jenaya Hooks, Hao Yuan Liu, Sonam Popli, George Kukolj, Craig S. Pace

“…Research into a cure has focused on finite combinatorial interventions that aim to reduce HBV surface antigen (HBsAg), suppress virus specific immune tolerance, and induce an adaptive response that functionally controls the virus.MethodsIn C57BL/6 mice transduced with adeno-associated virus encoding the HBV genome, which replicate HBV and persistently express HBsAg at 104 IU/mL or higher, a combination of small interfering RNA (siRNA) knockdown of HBsAg expression followed by immunization with a self amplifying RNA therapeutic HBV vaccine failed to establish HBV control. …”
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Structural and functional alterations of neurons derived from sporadic Alzheimer’s disease hiPSCs are associated with downregulation of the LIMK1-cofilin axis by Raimondo Sollazzo, Domenica Donatella Li Puma, Giuseppe Aceto, Fabiola Paciello, Claudia Colussi, Maria Gabriella Vita, Guido Maria Giuffrè, Francesco Pastore, Alessia Casamassa, Jessica Rosati, Agnese Novelli, Sabrina Maietta, Francesco Danilo Tiziano, Camillo Marra, Cristian Ripoli, Claudio Grassi

“…We then focused on PAK1-LIMK1-Cofilin signaling, which plays a key role in regulating synaptic structure and function, both of which are disrupted in neurodegenerative diseases such as AD. …”
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Dietary supplementation with Chinese herb ultrafine powder improves intestinal morphology and physical barrier function by altering jejunal microbiota in laying hens by Jue Gui, Jue Gui, Md Abul Kalam Azad, Wenchao Lin, Wenchao Lin, Chengwen Meng, Chengwen Meng, Xin Hu, Yadong Cui, Wei Lan, Jianhua He, Xiangfeng Kong, Xiangfeng Kong, Xiangfeng Kong

“…Moreover, Spearman’s correlation analysis revealed the potential correlation between the abundance of the jejunal microbiota and jejunal morphology and the physical barrier function of laying hens.DiscussionCollectively, these findings suggest that dietary CHUP supplementation could enhance the beneficial bacteria abundance, physical barrier function, and metabolic function associated with short-chain fatty acids and bacteriocins production. …”
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Staphylococcal enterotoxin-like X (SElX) is a unique superantigen with functional features of two major families of staphylococcal virulence factors. by Ries J Langley, Yi Tian Ting, Fiona Clow, Paul G Young, Fiona J Radcliff, Jeong Min Choi, Richard P Sequeira, Silva Holtfreter, Heather Baker, John D Fraser

“…We now reveal that SElX also possesses functional characteristics of the SSLs. A region of SElX displays high homology to the sialyl-lactosamine (sLacNac)-specific binding site present in a sub-family of SSLs. …”
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Novel function of ribosomal protein RPL14B: regulation of CdSe quantum dots biosynthesis in living Saccharomyces cerevisiae cells by Jiye Liu, Yong Li, Jiawei Tu, Daiwen Pang, Lipeng Zhong, Zhixiong Xie

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