Proteogenomic reprogramming to a functional human blastomere-like stem cell state via a PARP-DUX4 regulatory axis by Ludovic Zimmerlin, Ariana Angarita, Tea Soon Park, Rebecca Evans-Moses, Justin Thomas, Sirui Yan, Isabel Uribe, Isabella Vegas, Clara Kochendoerfer, Willem Buys, Anthony K.L. Leung, Elias T. Zambidis

“…Summary: Here, we show that conventional human pluripotent stem cells cultured with non-specific tankyrase-PARP1-inhibited conditions underwent proteogenomic reprogramming to functional blastomere-like tankyrase/PARP inhibitor-regulated naive stem cells (TIRN-SC). …”
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Identification of WRKY transcription factors in Ipomoea pes-caprae and functional role of IpWRKY16 in sweet potato salt stress response by Jiaying Wu, Yiren Su, Zhiyuan Pan, Yiming Wang, Yongjing Zhang, Ludan Li, Jihong Jiang, Xiaoying Cao

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Identification, Cloning, and Functional Characterization of Carotenoid Cleavage Dioxygenase (CCD) from <i>Olea europaea</i> and <i>Ipomoea nil</i> by Kaixuan Ke, Yufeng Zhang, Xinyi Wang, Zhaoyan Luo, Yangyang Chen, Xianying Fang, Linguo Zhao

“…The optimization of expression parameters, as well as the systematic evaluation of temperature, pH, solvent, and metal ion effects, provided further insights into the stability and functional diversity within the plant CCD1 family. …”
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Functional Analysis of CPSF30 in <i>Nilaparvata lugens</i> Using RNA Interference Reveals Its Essential Role in Development and Survival by Shengli Jing, Jing Yang, Yali Liu, Feifei Wang, Fang Zheng, Aobo Ren, Bingbing Yu, Yue Zhao, Bing Jia, Ruixian Chen, Bin Yu, Qingsong Liu, Jingang Xu

“…Cleavage and Polyadenylation Specificity Factor 30 (CPSF30) is a key protein involved in mRNA 3′ end processing, yet its function in <i>N. lugens</i> remains poorly understood. …”
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Long non-coding RNA ANRIL/p65 negative feedback loop protects intestinal barrier function in inflammatory bowel disease by Keqi Yu, Hong Peng, Zhechuan Zhang, Lu Ye, Ke Zhan, Chuanfei Li, Li Gan, Yuru Lin, Yanhui Wang, Ya Song, Zhechuan Mei, Shengtao Liao, Jinjun Guo, Lin Lv

“…Patients with inflammatory bowel disease (IBD) demonstrate varying expression levels of long non-coding RNAs (lncRNAs) in their intestinal mucosa, which can potentially impact the function of the intestinal barrier. …”
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Dietary functional palatability enhancer improved growth and appetite in largemouth bass (Micropterus salmoides) fed a reduced fish meal diet by Xinyan Zhi, Yixin Gu, Wenli Zhao, Shichao Xie, Yangguang Bao, Sofia Morais, Dong Li, Maolong He, Min Jin, Qicun Zhou

“…This study aimed to investigate the feasibility of using a functional palatability enhancer (PE) to promote healthy growth of largemouth bass (Micropterus salmoides). …”
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ASO-mediated knock-down of GPNMB in mutant-GRN and in Grn-deficient peripheral myeloid cells disrupts lysosomal function and immune responses by Rebecca L. Wallings, Drew A. Gillett, Hannah A. Staley, Savanna Mahn, Julian Mark, Noelle Neighbarger, Holly Kordasiewicz, Warren D. Hirst, Malú Gámez Tansey

“…Grn-deficiency is known to alter peripheral immune cell function, including impaired autophagy and altered cytokine secretion. …”
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Growth Arrest-Specific 6 Enhances the Suppressive Function of CD4+CD25+ Regulatory T Cells Mainly through Axl Receptor by Guang-ju Zhao, Jia-yi Zheng, Jia-lan Bian, Long-wang Chen, Ning Dong, Yan Yu, Guang-liang Hong, Arvine Chandoo, Yong-Ming Yao, Zhong-qiu Lu

“…Results. Tregs express both Axl and Mertk receptors. Gas6 increases the suppressive function of Tregs in vitro and in mice. …”
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TMEM206 Contributes to Cancer Hallmark Functions in Colorectal Cancer Cells and Is Regulated by p53 in a p21-Dependent Manner by Korollus Melek, Barbara Hauert, Sven Kappel

“…Our results show that in colorectal cancer cells, TMEM206 expression is elevated, contributes to cancer hallmark functions, and its regulation is dependent on p53 through a p21-dependent mechanism.…”
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Genome-Wide Identification and Functional Analysis of <i>AP2/ERF</i> Gene Family in <i>Passiflora edulis</i> Sims by Lanjun Luo, Liping Zhang, Ronghao Gu, Shihao Ni, Jingyao Yu, Yachao Gao, Chuanying Fang

“…These findings provide valuable insights into the functional roles of <i>PeAP2</i>/<i>ERF</i> genes in passion fruit, highlighting their significance in postharvest management and flavor quality enhancement strategies.…”
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Imidacloprid Exposure Induced Impaired Intestinal Immune Function in <i>Procambarus clarkii</i>: Involvement of Oxidative Stress, Inflammatory Response, and Autophagy by Zhaolin Li, Yong Shi, Kai Xie, Lei Zhong, Yi Hu, Kaijian Chen

“…This study investigates the effects of IMI exposure on the intestinal immune function of red swamp crayfish (<i>Procambarus clarkii</i>, <i>P. clarkii</i>), focusing on oxidative stress, inflammatory response, and autophagy. …”
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Angiotensin (1–7) Improves Pancreatic Islet Function via Upregulating PDX-1 and GCK: A Dose-Dependent Study in Mice by Ziwei Lin, Jiaqi Lin, Anqi Huang, Zixu Zhang, Xinyi Wu, Guoshu Yin, Chiju Wei, Wencan Xu

“…Conclusion: Angiotensin (1–7) could improve glucose and lipid metabolism and islet function by promoting the expression of PDX-1 and GCK genes in the pancreas of db/db mice.…”
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ArfGAP3 Protects Mitochondrial Function and Promotes Autophagy Through Rab5a‐Mediated Signals in Ageing Skeletal Muscle by Mao Chen, Xiaoyu Huang, Bingshu Li, Ya Xiao, Liying Chen, Fangyi Zhu, Shasha Hong, Jianming Tang, Suting Li, Jie Min, Wenyi Jin, Yubiao Zhang, Lian Yang, Yang Li, Shufei Zhang, Li Hong

“…Methods Mouse models of natural ageing and D‐gal (D‐galactose)–induced ageing were subject to analyse the structure, function and pathological alterations of the PFM and the expression of ArfGAP3. …”
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ADRB2 inhibition suppresses cancer immune evasion by regulating tumor SOX10-PD-L1 axis and T cell function by Yang Wang, Wei Zhang, Yu Zhang, Ling Chen, Shiyu Wang, Kun Song, Feng Yu, Jing Ouyang, Shan Cao, Cong Peng, Dongbo Liu, Yingying Dai, Wenwu Pei, Ziyang Hong, Weihua Huang, Yijing He, Panpan Liu, Hanying Yi, Gan Zhou, Howard McLeod

“…Additionally, similar studies in colorectal cancer (CRC) models confirmed the conserved function of the ADRB2-SOX10-PD-L1 axis.Results This study explores the role of ADRB2 in regulating tumor PD-L1 expression and T cell functionality, offering insights for cancer immunotherapy. …”
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Taurine Prevents Impairments in Skin Barrier Function and Dermal Collagen Synthesis Triggered by Sleep Deprivation-Induced Estrogen Circadian Rhythm Disruption by Qi Shao, Zhaoyang Wang, Yifang Li, Xun Tang, Ziyi Li, Huan Xia, Qihong Wu, Ruxue Chang, Chunna Wu, Tao Meng, Yufei Fan, Yadong Huang, Yan Yang

“…These disruptions can impair skin barrier functionality and decrease dermal collagen synthesis. …”
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Bruton’s tyrosine kinase inhibition re-sensitizes multidrug-resistant DLBCL tumors driven by BCL10 gain-of-function mutants to venetoclax by Caroline A. Coughlin, Dhanvantri Chahar, Marianna Lekakis, Abdessamad A. Youssfi, Lingxiao Li, Evan Roberts, Natalia Campos Gallego, Claude-Henry Volmar, Ola Landgren, Shaun Brothers, Anthony J. Griswold, Catalina Amador, Daniel Bilbao, Francesco Maura, Jonathan H. Schatz

“…Here, we build on recent findings implicating gain-of-function mutations in the BCL10 signaling protein as drivers of resistance to Bruton’s tyrosine kinase (BTK) inhibitors. …”
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Disease-Associated Dopamine Receptor D2 Variants Exhibit Functional Consequences Depending on Different Heterotrimeric G-Protein Subunit Combinations by Nele Niebrügge, Olga Trovato, Roman Praschberger, Andreas Lieb

“…<b>Conclusions:</b> Although our results indicate that the interaction of the two variants with the most highly expressed heterotrimeric G-protein complex subunit combinations also results in a gain-of-function phenotype, they also clearly demonstrate that the phenotype can be significantly altered, dependent on heterotrimeric G-protein complex expression.…”
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Clinical and functional characterization of the GABRB3 p.Met80Val variant in early-onset epilepsy with long-term follow-up by Ran Hua, Junhong Jiang, Baotian Wang, Zihao Zhu, Juan Wang, De Wu, Li Yang

“…Structural modeling suggested that the p.Met80Val variant compromises the structural integrity of the protein. Functional assays revealed a 2.6-fold increase in GABRB3 protein expression and enhanced fluorescence intensity, with most of the protein localized in the cytoplasm. …”
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Combined strategy of α 9-integrin transduction and AEIDGIEL peptide-functionalized fibrin gel biomaterials to promote mature DRG neurite growth by Anda Cimpean, Anda Cimpean, Lars Roll, Jacqueline Reinhard, Jessica C. F. Kwok, Jessica C. F. Kwok, Andreas Faissner, Fred de Winter, James W. Fawcett, James W. Fawcett, Pavla Jendelová

“…Previous studies have shown that α9-integrin expression and activation in mature dorsal root ganglion neurons enable the regeneration of injured axons within the spinal cord. …”
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Effects of glucokinase haploinsufficiency on the pancreatic β‐cell mass and function of long‐term high‐fat, high‐sucrose diet‐fed mice by Ikumi Shigesawa, Akinobu Nakamura, Yuki Yamauchi, Shinichiro Kawata, Asuka Miyazaki, Hiroshi Nomoto, Hiraku Kameda, Yasuo Terauchi, Tatsuya Atsumi

“…However, their β‐cell mass and glucose‐stimulated insulin secretion did not decrease between 40 and 60 weeks‐of‐age, but rather, tended to increase, and there was no progressive deterioration in glucose tolerance. The expression of Aldh1a3 in pancreatic islets, which is high in several models of diabetes and is associated with an impairment in β‐cell function, was high in Gck+/+HFHS mice, but not in Gck+/−HFHS mice. …”
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