Identification and functional characterization of key biomarkers in diffuse large B-cell lymphoma: emphasis on STYX as a prognostic marker and therapeutic target by Junaid Abid, Mahmood Basil A. Al-Rawi, Ahmad Mahmood, An Li, Tiemin Jiang

“…In this study, we analyzed two publicly available datasets (GSE32018 and GSE56315) from the Gene Expression Omnibus database (GEO) to identify overlapping differentially expressed genes (DEGs). …”
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Genome-Wide Analysis of PAPS1-Dependent Polyadenylation Identifies Novel Roles for Functionally Specialized Poly(A) Polymerases in Arabidopsis thaliana. by Christian Kappel, Gerda Trost, Hjördis Czesnick, Anna Ramming, Benjamin Kolbe, Son Lang Vi, Cláudia Bispo, Jörg D Becker, Cornelia de Moor, Michael Lenhard

“…As shown by their different mutant phenotypes, these three isoforms are functionally specialized, with PAPS1 modifying organ growth and suppressing a constitutive immune response. …”
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Wu-Mei-Wan enhances brown adipose tissue function and white adipose browning in obese mice via upregulation of HSF1 by Shen Chen, Kexin Nie, Hongzhan Wang, Yang Gao, Xinyue Jiang, Hao Su, Zhi Wang, Yueheng Tang, Fuer Lu, Hui Dong, Jingbin Li

“…WMW also reversed structural damage in BAT, enhancing mitochondrial integrity and thermogenic function, particularly at the low dose. Additionally, WMW treatment promoted the browning of WAT, evidenced by increased expression of key thermogenic proteins such as UCP1 and PGC-1α. …”
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Synergistic Effects of Low-Frequency Ultrasound and Therapeutic Agents on Endothelial and Renal Cells: Emphasis on Cell Functionality, Oxidative Stress, and Inflammatory Markers by Ieva Čiapienė, Joris Vėžys, Vaiva Lesauskaitė, Indrė Matulevičiūtė, Ugnė Meškauskaitė, Vilius Skipskis, Arvydas Strazdauskas, Sonata Trumbeckaitė, Algimantas Bubulis, Vytautas Jūrėnas, Vytautas Ostaševičius, Vytenis Tamakauskas, Vacis Tatarūnas

“…Gene expression related to the ACE axis, inflammation, and vascular and renal cell function was analyzed via qPCR. …”
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Effects of Proanthocyanidins on Growth Performance, Intestinal Inflammation and Barrier Function, and Bile Acid Metabolism-Related Genes in Weaned Piglets Challenged with Lipopolys... by Aiying Yu, Zhenjiang Wang, Sutian Wang, Weiguo Zhao, Lian Chen, Dan Wang, Zhiyi Li, Yuan Wang, Zhengfeng Fang, Sen Lin

“…This study aims to investigate the effects of dietary proanthocyanidins (PACs) on growth performance, intestinal inflammation and barrier function, and bile acid metabolism-related genes in weaned piglets challenged with lipopolysaccharide (LPS). …”
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Role of BDNF-TrkB signaling in the improvement of motor function and neuroplasticity after ischemic stroke in rats by transcranial direct current stimulation by Yu Chen, Lin Mao, Qinxiang Zhou, Dingqun Bai, Yuhan Kong

“…Results: After tDCS treatment, the mNSS was improved, and the motor function was restored. Moreover, tDCS decreased cell swelling after MCAO/R and enhanced the number of neurons. tDCS treatment increased: (1) BDNF, Gap-43, Map-2 expression, (2) KCC2, GABA, and (3) PLCγ, CaMK IV, CREB and ERK1/2, RSK. …”
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Hypermethylation of CDKN2A CpG island drives resistance to PRC2 inhibitors in SWI/SNF loss-of-function tumors by Xinghao Wang, Yajun Wang, Min Xie, Shichao Ma, Yilin Zhang, Lele Wang, Yangfeng Ge, Guobin Li, Mengxi Zhao, Sheng Chen, Chenxi Yan, Hailong Zhang, Wei Sun

“…Abstract Polycomb repressive complex 2 (PRC2) catalyzes the writing of the tri-methylated histone H3 at Lys27 (H3K27me3) epigenetic marker and suppresses the expression of genes, including tumor suppressors. The function of the complex can be partially antagonized by the SWI/SNF chromatin-remodeling complex. …”
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Peripubertal DEHP exposure impairs reproductive function in adult male mice by inducing damage to Sertoli cells and disrupting the blood-testis barrier by XU Guiyong, XU Guiyong, ZHANG Lu, ZHANG Lu, SUN Fengqiong, SUN Fengqiong

“…Objective‍　‍To investigate the mechanism by which peripubertal exposure to di-2-ethylhexyl phthalate (DEHP) induces reproductive injury in adult male mice through impairment of Sertoli cell function and the blood-testis barrier. Methods‍　‍A total of 180 male C57BL/6J mice (3 weeks old) were randomly divided into corn oil group (control group), and 5, 25, 125, 250 and 500 mg/kg DEHP exposure groups. …”
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Identification and functional characterization of JrbZIP40 in walnut reveals its role in salt and drought stress tolerance in transgenic Arabidopsis seedlings by Jinyu Wei, Chang Jiao, Xi-Yu Li, Xuemin Li, Xin-Yi Zhang, Yongxu Wang, Yang Song, Kaiyu Yang, Yushi Liu, Jingran Zhang, Mengyao Liu, Yi-Lin Liang, Xinyue Wang, Han Li, Peng Jia, Xuemei Zhang, Guohui Qi, Qinglong Dong

“…DAP-seq and Dual-luciferase results indicated that JrbZIP40 may bind to the JrHB7 and JrATG8G promoters and activate their expression, contributing to stress resistance. Conclusions Overall, this study elucidates the regulatory network and biological functions of JrbZIP40 in drought and salt tolerance, providing a theoretical foundation and candidate gene resources for the future use of genetic engineering to improve walnut stress resistance.…”
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Spade Leaf Extract Phytosome Modulates Krox-20, Neuregulinـ1, Phospholipids, and Cognitive Function of Traumatic Brain Injury Model in Rats by Alif Fariz Jazmi, Putri Fitri Alfiantya, Sitti Ayu Hemas Nurarifah, Erlin Aditia Purmitasari, Lilin Andreas Vitania, Wibi Riawan

“…Krox-20, NRG-1, and phospholipids expression were measured by immunohistochemical assay, while cognitive function were assessed with the Morris Water Maze test. …”
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The downregulation of hormone-sensitive lipase and dysregulation of cholesterol receptors/transporter affect testicular lipid homeostasis and function in HFD-induced oligoasthenosp... by Min Pan, Jingya Li, Yujia Wang, Ziao Liu, Li Li, Tongsheng Wang

“…Conclusion The down-regulation of HSL and dysregulation of cholesterol receptors/transporter may affect lipid homeostasis, thereby damaging testicular function.…”
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HacA-independent functions of the ER stress sensor IreA synergize with the canonical UPR to influence virulence traits in Aspergillus fumigatus. by Xizhi Feng, Karthik Krishnan, Daryl L Richie, Vishukumar Aimanianda, Lukas Hartl, Nora Grahl, Margaret V Powers-Fletcher, Minlu Zhang, Kevin K Fuller, William C Nierman, Long Jason Lu, Jean-Paul Latgé, Laura Woollett, Simon L Newman, Robert A Cramer, Judith C Rhodes, David S Askew

“…Together, these findings demonstrate that IreA has both HacA-dependent and HacA-independent functions that contribute to the expression of traits that are essential for virulence in A. fumigatus.…”
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Genome-wide identification of ARID-HMG related genes in citrus and functional analysis of FhARID1 in apomixis and axillary bud development by Xietian Song, Yin Zhou, Zhen Cao, Nan Wang, Xiaoyu Tian, Lijun Chai, Zongzhou Xie, Junli Ye, Xiuxin Deng

“…Yeast two-hybrid and MS/MS spectra further indicated that FhARID1 function requires casein kinase II-mediated post-transcriptional phosphorylation. …”
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Fermented defatted rice bran-derived gut Clostridium butyricum improved the gut barrier function by regulating HIF-1 signaling pathway by Weifa Su, Zipeng Jiang, Tao Gong, Man Du, Fengqin Wang, Zeqing Lu, Mingliang Jin, Yizhen Wang

“…Emerging evidence of the beneficial effects of defatted rice bran (DFRB) on gut health has advanced the development of fermented defatted rice bran as a potential functional food. However, less is known about its effects and underlying mechanisms on gut health. …”
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Berberine alleviates enterotoxigenic Escherichia coli-induced intestinal mucosal barrier function damage in a piglet model by modulation of the intestinal microbiome by Min Du, Xinran Liu, Xu Ji, Yue Wang, Xiaodan Liu, Chunfang Zhao, Chunfang Zhao, Erhui Jin, Erhui Jin, Youfang Gu, Youfang Gu, Hongyu Wang, Feng Zhang, Feng Zhang

“…This is associated with enhancement of the physical, chemical, and immune barrier functions of piglets by enhancing intestinal microbiota homeostasis.…”
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Genome-wide identification of glyoxalase (PbrGLY) gene family and functional analysis of PbrGLYI-28 in response to Botryosphaeria dothidea in pear by Fei Wang, Fengpei Sun, Zhaoyi Yu, Yue Zhang, Yuting Liu, Xiaolei Sun, Dan Li, Shaoling Zhang, Xun Sun

“…Conclusion This study speculates that the PbrGLY family may functionally differentiate and coordinately regulate pear resistance to ring rot disease, with the expression changes of PbrGLYI-28 potentially associated with B. dothidea infection and pear resistance.…”
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Comprehensive prognostic gene identification and functional characterization of GRAMD1A in Wilms tumor: development of risk prediction models and therapeutic implications by Qiang Zeng, Junfeng Tao, Lilu Qin, Yong Zeng, Zhong Liu, Mingxian Xu, Linshan Zeng

“…Identified differentially expressed genes (DEGs) underwent Gene Ontology (GO) and KEGG pathway enrichment analysis to explore biological functions and pathways associated with WT progression. …”
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A functional polymorphism in the promoter region of microRNA-146a is associated with the risk of Alzheimer disease and the rate of cognitive decline in patients. by Lili Cui, You Li, Guoda Ma, Yan Wang, Yujie Cai, Shengyuan Liu, Yanyan Chen, Jia Li, Yuliu Xie, Gen Liu, Bin Zhao, Keshen Li

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Phenylacetylglutamine produced from injury lung alveolar epithelial cells promotes the function of BMSCs by regulating NONRATT006276.2/Mapt pathway by Tianyun Yang, Juan Peng, Rongrong Ren, Lin Song

“…Phenotypic assays indicated that phenylacetylglutamine (PAG) significantly promoted the migration and mitochondrial function of bone marrow MSCs (BMSCs). Whole-transcriptome sequencing (WT-seq) was used to analyze the long noncoding RNA (lncRNA) and mRNA expression profiles of BMSCs treated with PAG. …”
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Functional Analysis of Mouse G6pc1 Mutations Using a Novel In Situ Assay for Glucose-6-Phosphatase Activity and the Effect of Mutations in Conserved Human G6PC1/G6PC2 Amino Acids on G6PC2 Protein Expression. by Kayla A Boortz, Kristen E Syring, Lynley D Pound, Yingda Wang, James K Oeser, Richard M O'Brien

“…This study describes a functional analysis of 22 non-synonymous G6PC2 SNPs, that alter amino acids that are conserved in human G6PC1, mouse G6pc1 and mouse G6pc2, with the goal of identifying variants that potentially affect G6PC2 activity/expression. …”
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