Structural and Functional Analysis of the Lectin-like Protein Llp1 Secreted by <i>Ustilago maydis</i> upon Infection of Maize by Marvin Christ, Itzel Rubio Elizalde, Paul Weiland, Antonia Kern, Thomas Iwen, Christopher-Nils Mais, Jan Pané-Farré, Stephan Kiontke, Florian Altegoer, Johannes Freitag, Gert Bange

“…Some of them, termed effectors, help to evade plant defenses and manipulate cellular processes within the host. The function of many proteins specifically secreted during infection remains elusive. …”
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A Gain-Of-Function Mutation in the Plcg2 Gene Protects Mice from Helicobacter felis-Induced Gastric MALT Lymphoma. by Jennifer Gossmann, Manfred Stolte, Michael Lohoff, Philipp Yu, Roland Moll, Florian Finkernagel, Holger Garn, Cornelia Brendel, Alwina Bittner, Andreas Neubauer, Minh Q Huynh

“…We used BALB/c mice with a gain-of-function mutation in the Plcg2 gene (Ali5) to analyze its role in the development of gastric MALT lymphoma. …”
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Morpho-functional state of the liver and changes of blood biochemical parameters in rats exposed to lead sulfide nanoparticles in the remote terms of research by Omelchuk S.T., Aleksiychuk V.D.

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Heterologous Overexpression and Functional Analysis of the <i>Isodon suzhouensis IsKS1</i> Gene in <i>Arabidopsis thaliana</i> by Fawang Liu, Kefeng Zhai, Dongmei Xie

“…<i>Isodon suzhouensis,</i> also known as “Wangzaozi”, is an edible and medicinal plant belonging to the Lamiaceae family. Its main functional constituents are the tetracyclic diterpenoids known as wangzaozins. …”
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Interleukin-35 impairs human NK cell effector functions and induces their ILC1-like conversion with tissue residency features by Valentin Picant, Lara Revol-Bauz, Laurie Tonon, Timothée Casini, Aurélien Voissière, Dominique Poujol, Emilie Picard, Céline Rodriguez, Cyril Degletagne, Emily Sible, Uzma Hasan, Anthony Ferrari, Christophe Caux, Nathalie Bendriss-Vermare

“…Abstract Natural Killer (NK) cells play pivotal immunological roles including direct cytotoxic effector function and secretion of inflammatory and immunomodulating cytokines. …”
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Structure and functional analysis of the Legionella pneumophila chitinase ChiA reveals a novel mechanism of metal-dependent mucin degradation. by Saima Rehman, Lubov S Grigoryeva, Katherine H Richardson, Paula Corsini, Richard C White, Rosie Shaw, Theo J Portlock, Benjamin Dorgan, Zeinab S Zanjani, Arianna Fornili, Nicholas P Cianciotto, James A Garnett

“…However, it is unclear how these enzymes are able to carry out this dual function. Legionella pneumophila is the causative agent of Legionnaires' disease, an often-fatal pneumonia and its chitinase ChiA is essential for the survival of L. pneumophila in the lung. …”
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4‐1BB and cytokines trigger human NK, γδ T, and CD8+ T cell proliferation and activation, but are not required for their effector functions by Laurent Vidard

“…When freshly purified, none had effector functions, except the NK cells, which could be activated by CD16 engagement. …”
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The multi-functional reovirus σ3 protein is a virulence factor that suppresses stress granule formation and is associated with myocardial injury. by Yingying Guo, Meleana M Hinchman, Mercedes Lewandrowski, Shaun T Cross, Danica M Sutherland, Olivia L Welsh, Terence S Dermody, John S L Parker

“…Overall, our results indicate that σ3 functions to suppress PKR activation and subsequent SG formation during viral infection and that these functions correlate with virulence in mice.…”
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Task-Related Controllability of Functional Connectome During a Working Memory Task in Schizophrenia, Bipolar Disorder, and Major Depressive Disorder by Jun Yang, Zhening Liu, Feiwen Wang, Wenjian Tan, Danqing Huang, Xuan Ouyang, Haojuan Tao, Guowei Wu, Yunzhi Pan, Jie Yang, Lena Palaniyappan

“…We investigate whether shared and illness-specific alterations in controllability underlie WM deficits in MPDs. We examined functional magnetic resonance imaging data during an n-back WM task from 105 patients with schizophrenia (SZ), 67 with bipolar disorder (BD), 51 with major depressive disorder (MDD), and 80 healthy controls (HCs). …”
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Functional Characterization of <i>MaSPL8</i> Reveals Its Different Roles in Biotic and Abiotic Stress Responses in Mulberry by Longyan Zheng, Wenhao Zhang, Liuqing Wei, Mengqi Li, Li Liu

“…In this study, we functionally characterized <i>MaSPL8</i> in mulberry (<i>Morus alba</i>) and investigated its regulatory roles in biotic and abiotic stress responses. …”
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A Causal Inference Approach to Mediation Analysis in Vitreomacular Traction: How Much Does Traction Resolution Mediate Functional Outcomes? by Benedicte Lescrauwaet, Stijn Vansteelandt, Timothy L. Jackson, SriniVas R. Sadda, Luc Duchateau

“…Outcomes, assessed at month 24, included visual acuity improvement (VA-I): ≥2-line increase in VA; visual function questionnaire improvement (VFQ-I): ≥5-point increase in the 25-item visual function questionnaire composite score (VFQ-25cs); visual function improvement (VF-I): defined as either a VA-I or a clinically meaningful improvement in the VFQ-25cs. …”
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Impact of antibody architecture and paratope valency on effector functions of bispecific NKp30 x EGFR natural killer cell engagers by Ammelie Svea Boje, Lukas Pekar, Katharina Koep, Britta Lipinski, Brian Rabinovich, Andreas Evers, Carina Lynn Gehlert, Steffen Krohn, Yanping Xiao, Simon Krah, Rinat Zaynagetdinov, Lars Toleikis, Sven Poetzsch, Matthias Peipp, Stefan Zielonka, Katja Klausz

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Exploring cognitive function and postoperative neurocognitive recovery after cardiac surgery in older adults (ECPON): a protocol for an observational study by Ulrica Nilsson, Markus Saarijärvi, Lina Bergman, Jeanette Eckerblad, Gabriela Markovic, Ernad Zecevic, Tor Damén, Anna Martinik

“…We will also evaluate postoperative patient-reported cognitive symptoms and signs, delirium, frailty, health-related quality of life, depression, perceived self-efficacy, fatigue and functional capacity. Each patient’s close relative will assess the observed cognitive function and report on caregiver burden. …”
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Agronomic improvement using gamma ray induced mutagenesis is associated with changes in phytochemical and phytohormonal profiles in functional rice variety ‘Gathuwan’ by Anjali Chauhan, Rahul Checker, Parmeshwar K. Sahu, Raviraj Singh Patel, Samrath Baghel, Deepak Sharma, Deepak Sharma, Bikram K. Das

“…These metabolic changes support the functional potential of the mutants and provide insights into the biological mechanisms underlying their traits. …”
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Ablation of the Evolutionarily Acquired Functions of the <i>Atp1b4</i> Gene Increases Metabolic Capacity and Reduces Obesity by Nikolai N. Modyanov, Lucia Russo, Sumona Ghosh Lester, Tamara R. Castañeda, Himangi G. Marathe, Larisa V. Fedorova, Raymond E. Bourey, Sonia M. Najjar, Ivana L. de la Serna

“…In placental mammals, the co-option of vertebrate orthologous <i>ATP1B4</i> genes has profoundly altered the properties of the encoded BetaM proteins, which function as bona fide β-subunits of Na,K-ATPases in lower vertebrates. …”
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Identification and functional characterization of T-cell exhaustion-associated lncRNA AL031775.1 in osteosarcoma: a novel therapeutic target by Yameng Wang, Yameng Wang, Yameng Wang, Yameng Wang, Jinghong Yuan, Jinghong Yuan, Jinghong Yuan, Keying Guo, Keying Guo, Keying Guo, Zhuoer Zhang, Junchao Zhu, Junchao Zhu, Junchao Zhu, Shahrzad Arya, Guowen Huang, Guowen Huang, Guowen Huang, Shengqin Li, Shengqin Li, Shengqin Li, Qi Chen, Xijuan Liu, Jingyu Jia, Jingyu Jia, Jingyu Jia

“…A six-lncRNA prognostic model was established using LASSO regression and validated in separate cohorts. Functional assays evaluated the impact of the lncRNA AL031775.1 on osteosarcoma cell behavior and T-cell function.ResultsTwenty-four key T-cell exhaustion-related genes were identified and significantly enriched in immune-related pathways, indicating their importance in the osteosarcoma immune microenvironment. …”
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Functional humanization of 15-lipoxygenase-1 (Alox15) protects mice from dextran sodium sulfate induced intestinal inflammation by Florian Reisch, Marjann Schäfer, Dominika Labuz, Halina Machelska, Sabine Stehling, Gerhard P. Püschel, Michael Rothe, Dagmar Heydeck, Hartmut Kuhn

“…The human genome involves six functional ALOX genes and each of them encodes for a functionally distinct enzyme. …”
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Clinical and functional evaluation of intramyocardial implantation of autologous bone marrow cells treated with erythropoietinduring the CAD surgery (6-month results) by A. V. Fomichev, A. M. Chernyavskiy, K. K. Gulyaeva, O. V. Poveschenko, A. P. Lykov, J. E. Kareva, S. M. Minin, N. A. Nikitin

“…Aim. Clinical and functional evaluation of the implantation of autologous bone marrow cells treated with erythropoietin in laser channels during coronary bypass grafting in patients with end-stage coronary lesion.Materials and methods. 60 patients with coronary artery disease with diffuse and (or) distal right coronary artery disease were randomized into two groups: patients of group 1 (n = 30) underwent coronary bypass grafting, implantation of autologous bone marrow cells treated with erythropoietin in laser channels, patients of the 2nd group (n = 30) were operated with coronary bypass grafting of the left coronary artery system. …”
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Association of Platelet Indices with Cardiac Enzymes and Left Ventricular Function in Patients with Acute Myocardial Infarction: A Cross-sectional Study by P Kireeti, Rajesh Singh Laishram, Mayanglambam Bijoy, Sunil Kumar Leishangthem, Rajkumar Ajaykumar, Keisham Jaya Chanu, Ningthoukhongjam Reema, Dhanaraj Singh Chongtham

“…However, the association of platelet indices with cardiac enzymes and Left Ventricular (LV) function in patients with Acute Myocardial Infarction (AMI) remains unexplored. …”
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DEREGULATED EXPRESSIONS OF MYC ALTER THE EXPRESSIONS OF tRNAS IN BREAST CANCER CELLS by Pervin Elvan Tokgün, Onur Tokgün

“…Further functional studies are required for underlying molecular mechanisms.…”
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