Dietary Puerariae Lobatae Radix polysaccharides improve ovarian function and reproductive efficiency in laying hens with fatty liver hemorrhagic syndrome by Anqi Wang, Hui Ren, Yanyan Zhang, Hongfan Ge, Zhenlei Zhou

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Selective Modulation of Osteoclast Function by <i>Bothrops moojeni</i> Venom and Its Fractions: Implications for Therapeutic Targeting in Bone Diseases by Fernanda D’Amélio, Hugo Vigerelli, Isabel de Fátima Correia Batista, Rodrigo Pinheiro Araldi, Álvaro R. B. Prieto-da-Silva, Daniel Carvalho Pimenta, Irina Kerkis

“…Our study explores the differential effects of <i>Bothrops moojeni</i> venom and its fractions on osteoclast (OC) morphology, function, and osteoclastogenesis. The crude venom and its high-molecular-weight (HMW) fraction disrupt critical OC processes, including F-actin ring formation and mitochondrial distribution, thereby impairing bone resorption. …”
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<i>Andrographis paniculata</i> Extract Supports Skin Homeostasis by Enhancing Epidermal Stem Cell Function and Reinforcing Their Extracellular Niche by Roberta Lotti, Laetitia Cattuzzato, Xuefeng Huang, David Garandeau, Elisabetta Palazzo, Marika Quadri, Cécile Delluc, Eddy Magdeleine, Xiaojing Li, Mathilde Frechet, Alessandra Marconi

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Identification of the Oleosin Genes and Functional Analysis of <i>CeOle4</i> Gene in <i>Cyperus esculentus</i> L. by Yuanyuan Dong, Yuling Cui, Yijin Wang, Shiyu Luan, Xinyi Liu, Qi Yang, Weican Liu, Xiaowei Li, Nan Wang, Fawei Wang, Lei Gu, Ping Xue

“…The subcellular localization of CeOle4 indicated that this protein was localized exclusively to membrane, indicating that it functioned in the plasma membrane. The highly expressed gene <i>CeOle4</i> within the CeOleosin gene family was further transformed into yeast cells and plant materials. …”
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Functional analysis of two SfHsp90 genes in response to high temperature and insecticide stress in Spodoptera frugiperda (Lepidoptera: Noctuidae) by Hong-Yun RUAN, Lv ZHOU, Lei YANG, Jian-Yu MENG, Chang-Yu ZHANG

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Unlocking the Functional Food Potential of <i>Capparis spinosa</i>: Optimizing Ultrasound Extraction, Phytochemical Analysis, and Assessing Antioxidative Activities by Abdulhakim Naffati, Aleksandra Mišan, Saša Kenig, Katja Kramberger, Zala Jenko Pražnikar, Ana Petelin, Aleksandra Cvetanović Kljakić, Abdelmoumen Benmerzoug, Nasrien Elfarrah, Alena Stupar

“…By fine-tuning important extraction parameters such as ultrasound power, temperature, and ethanol concentration, this research achieved maximum yields of total phenolic content and rutin, establishing these leaves as a sustainable and valuable source of phytochemicals for applications in functional foods, nutraceuticals, and pharmaceuticals. …”
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Unraveling the structural and functional consequences of non-synonymous single-nucleotide polymorphisms (nsSNPs) in human SOCS2: an in silico approach by Tanvir Hossain, Md. Nur Islam, Md. Anwar Hossain, Md. Mofizur Rahman, Mohammed Mafizul Islam, Shipan Das Gupta

“…Multiple non-synonymous SNPs (nsSNPs) have been found in the SOCS2 gene, which could affect protein function. However, there is limited understanding of disease susceptibility and abnormal functioning associated with these mutated SOCS2 gene. …”
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Subchronic effects of HgCl2 on cognitive function and central inflammation in type 2 diabetic rats: involvement of BDNF and acetylcholinesterase by Douae Benloughmari, Samir Bikri, Samir Bikri, Meriam El Aboubi, Fatima-Zahra Yassif, Youssef Aboussaleh

“…Moreover, HgCl2 administration in diabetic rats led to a more pronounced impairment in cognitive functions compared to untreated diabetic rats (P &lt; 0.05). …”
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Formulated citrus peel extract gold lotion improves cognitive and functional recovery from traumatic brain injury (TBI) in rats by Cheng Guang, Yue Zhiwei, Wang Liwen, Miyauchi Yutaka, Suzawa Michiko, Li Shiming, Ho Chi‐Tang, Zhao Hui, Chen Naiyao

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Functional characterization of novel compound heterozygous missense SLC5A5 gene variants causing congenital dyshormonogenic hypothyroidism by Gerardo Hernán Carro, Gerardo Hernán Carro, Mariano Martín, Mariano Martín, Sofía Savy, Sofía Savy, Victoria Peyret, Victoria Peyret, Romina Celeste Geysels, Romina Celeste Geysels, Francisco Andrés Montes, Francisco Andrés Montes, Carlos Eduardo Bernal Barquero, Carlos Eduardo Bernal Barquero, Valentina Ricci, Valentina Ricci, María Eugenia Masnata, María Eugenia Masnata, Ana María Masini-Repiso, Ana María Masini-Repiso, Patricia Papendieck, Patricia Papendieck, Mariana Lorena Tellechea, Mariana Lorena Tellechea, Ana Elena Chiesa, Ana Elena Chiesa, Juan Pablo Nicola, Juan Pablo Nicola

“…In silico analysis of the pathogenic impact of the p.L562M variant yielded inconclusive results. Functional in vitro studies showed that the p.L562M variant reduces iodide accumulation due to defective expression of the mutant NIS protein at the plasma membrane. …”
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Comparative Metabolomic Analysis of Three Medicinal <i>Paphiopedilum</i> Species Reveals Divergence in Antioxidant Capacity and Functional Compound Profiles by Jinhan Sang, Yishan Yang, Kanghua Xian, Jiang Su, Jianmin Tang, Chuanming Fu, Fengluan Tang, Xiao Wei

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AMF30a promotes survival and function of human corneal endothelial cells by regulating TGF-β/ROCK/HIPPO pathway by Yunkyoung Ryu, Hye-Jin Son, Jin Sun Hwang, Kyung Bo Noh, Sun-Hee Oh, Eun-Kyoung Choi, Young Joo Shin

“…Western blot and immunofluorescence identified protein expression and localization. RNA sequencing revealed differentially expressed genes, with functional enrichment via GO analysis. …”
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Insights into the role of GhCYP and GhTPS in the gossypol biosynthesis pathway via a multiomics and functional-based approach in cotton by Teame Gereziher Mehari, Marijana Skorić, Hui Fang, Kai Wang, Fang Liu, Tesfay Araya, Branislav Šiler, Dengbing Yao, Baohua Wang

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The Functions and Mechanism of a New Oligopeptide BP9 from Avian Bursa on Antibody Responses, Immature B Cell, and Autophagy by Xiu Li Feng, Man Man Zong, Guang Fang Zhou, Yang Zheng, Yuan Nan Yu, Rui Bing Cao, Pu Yan Chen, Mei Yang

“…The bursa of Fabricius is an acknowledged central humoral immune organ unique to birds, which is vital to B cell differentiation and antibody production. However, the function and mechanism of the biological active peptide isolated from bursa on B cell development and autophagy were less reported. …”
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A non-hypothesis-driven practical laboratory activity on functional metagenomics: “fishing” protein-coding DNA sequences from microbiomes by Melissa Morra, Denise Marradi, Luca Gandini, Vittorio Ivagnes, Giulia Ottolini, Alessandro Bovio, Grace Jabali, Lorenzo Maraschi, Ifeoluwa Ayomide Dada, Tonderai Vitalis Chawanda, Martina Gorla, Olga Tarasiuk, Chiara Mocchetti, Maria Felicia Soluri, Maria Felicia Soluri, Francesca Boccafoschi, Daniele Sblattero, Diego Cotella

“…Therefore, these libraries provide a valuable platform for training students in various validation tools, including computational methods - for example, metagenome assembly, functional annotation - and proteomics techniques, including protein expression and analysis. …”
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Decoding the striatum of drug-naive patients with obsessive-compulsive disorder: a transcriptome and longitudinal functional magnetic resonance imaging study by Yiding Han, Haohao Yan, Xiaoxiao Shan, Huabing Li, Feng Liu, Ping Li, Dongsheng Lv, Jingping Zhao, Wenbin Guo

“…Furthermore, these metrics, along with functional connectivity (FC), and effective connectivity (EC) of SSs, were analyzed. …”
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Detection of structural-functional coupling abnormalities using multimodal brain networks in Alzheimer’s disease: A comparison of three computational models by Yinping Lu, Luyao Wang, Toshiya Murai, Jinglong Wu, Dong Liang, Zhilin Zhang

“…This study aimed to explore the interaction between the structural and functional brain network in AD using advanced structural–functional coupling (S-F coupling) models to assess whether these changes correlate with cognitive function, Aβ deposition levels, and gene expression. …”
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Transcriptome analysis of hsp18.3 functions and regulatory systems using RNA-sequencing in the red flour beetle, Tribolium castaneum by Wen-feng XIONG, Jia XIE, Lu-ting WEI, Si-si ZHANG, Xiao-wen SONG, Shan-shan GAO, Bin LI

“…Additionally, 569 differentially expressed genes (DEGs) were identified from the ds-Tchsp18.3 and control groups, of which 246 DEGs were annotated in the 47 Gene Ontology (GO) functional groups and 282 DEGs were assigned to 147 Kyoto Encyclopedia of Genes and Genomes (KEGG) biological signaling pathways. …”
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Atrial electrical alterations with intact cardiac structure and contractile function in a mouse model of an HCM-linked ACTN2 variant by Maya Noureddine, Sophie Broadway-Stringer, Christopher O'Shea, Bethany A.I. Jones, Abbie Hayes, Chris Denning, Siobhan Loughna, Fiyaz Mohammed, Davor Pavlovic, Katja Gehmlich

“…Embryonic lethality was previously shown in mice expressing this variant homozygously, whereas heterozygous (Het) expression did not manifest an overt HCM phenotype. …”
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Mirodenafil improves cognitive function by reducing microglial activation and blood–brain barrier permeability in ApoE4 KI mice by Yejin Park, Subin Moon, Harry Jung, Songyi Park, Ju Won Kim, Dan-Gyeong Song, Yong-Ho In, Sang Won Han, Sang Won Han, Jong-Hee Sohn, Jong-Hee Sohn, Chan Hee Lee, Chan Hee Lee

“…AD can compromise brain function and lead to severe neurological abnormalities associated with dementia. …”
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