Gallic acid alleviates ferroptosis by negatively regulating APOC3 and improves nerve function deficit caused by traumatic brain injury by Yu Liu, Xiaojia Fu, Jing Li, Jianqiang Guo, Zongren Zhao, Jinyu Zheng

“…The effect of Gallic acid on the improvement of neurological function was studied by Nissl staining and FJB staining. …”
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Analysis of p53-Independent Functions of the Mdm2-MdmX Complex Using Data-Independent Acquisition-Based Profiling by Anu Jain, Rafaela Muniz de Queiroz, Jayanta K. Chakrabarty, Karl A. T. Makepeace, Carol Prives, Lewis M. Brown

“…Mdm2 and MdmX form an E3-ligase complex that has as its most well-studied function the negative regulation of the tumor suppressor p53; however, it is also known to interact with many other proteins in a p53-independent manner. …”
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PEG-functionalized UiO-66 MOFs for targeted vincristine delivery: enhanced cytotoxicity in breast and ovarian cancer cell lines by Zahra Sadeghi Jam, Farzaneh Tafvizi, Parvin Khodarahmi, Parvaneh Jafari, Fahimeh Baghbani-Arani

“…This study aimed to develop a polyethylene glycol (PEG)-functionalized UiO-66 metal–organic framework (MOF) as a targeted drug delivery system for VIN in MDA-MB-231 (breast cancer) and A2780 (ovarian cancer) cell lines. …”
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IGFBP2 Modulates Trophoblast Function and Epithelial–Mesenchymal Transition in Preeclampsia via the PI3K/AKT Signaling Pathway by Shengping Meng, Yanping Qin, Chunyan Lyu, Sumei Wang

“…Moreover, the gain- and loss-of-function assays were conducted in human trophoblast cell line HTR-8/SVneo, and cellular models exhibiting overexpression and the knockdown of IGFBP2 were established. …”
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LuCSD3 enhances salt stress tolerance in flax: genome-wide profiling and functional validation of the SOD gene family by Yuan Zhang, Ruinan Wang, Hengping Wang, Huiyan Wang

“…Functional characterization of LuCSD3 in transgenic Arabidopsis confirmed its role in enhancing salt tolerance through ROS homeostasis modulation. …”
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Sequence and copy number analyses of HEXB gene in patients affected by Sandhoff disease: functional characterization of 9 novel sequence variants. by Stefania Zampieri, Silvia Cattarossi, Ana Maria Oller Ramirez, Camillo Rosano, Charles Marques Lourenco, Nadia Passon, Isabella Moroni, Graziella Uziel, Antonella Pettinari, Franco Stanzial, Raquel Dodelson de Kremer, Nydia Beatriz Azar, Filiz Hazan, Mirella Filocamo, Bruno Bembi, Andrea Dardis

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ARNT-dependent HIF-2α signaling protects cardiac microvascular barrier integrity and heart function post-myocardial infarction by Karim Ullah, Lizhuo Ai, Yan Li, Lifeng Liu, Qin Zhang, Kaichao Pan, Zainab Humayun, Lin Piao, Albert Sitikov, Qiong Zhao, Qiaozhu Su, Willard Sharp, Yun Fang, David Wu, James K. Liao, Rongxue Wu

“…HIF2α, predominantly expressed in cardiac endothelial cells during ischemia, has an unclear role in barrier function during MI. …”
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The WD40 gene family in recretohalophyte Limonium bicolor: genomic identification and functional analysis in salt gland development and salinity tolerance by Lu Sun, Huiying Mu, Yuqing Tan, Baoshan Wang, Xi Wang, Xi Wang, Fang Yuan, Fang Yuan

“…Although WD40 proteins are known regulators of plant stress responses, their roles in L. bicolor remain unexplored.MethodsWe performed a genome-wide analysis of WD40 genes in L. bicolor, including phylogenetic classification, subcellular localization prediction, cis-element analysis, and expression profiling during salt stress. Functional validation was conducted using virus-induced gene silencing (VIGS).ResultsAmong 367 identified WD40 genes (distributed across all chromosomes), Subfamily 6 was the largest. …”
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Physiological Function of AtrN in Regulating Intracellular NADPH Levels and the Anti-Reductive Stress Response in <i>Corynebacterium glutamicum</i> by Guotao Xu, Shuping Tian, Zhihan Gong, Jianzhong Xu

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Natural SEL1L variants rescue a model of NGLY1 deficiency and modify ERAD function and proteasome sensitivity. by Travis K Tu'ifua, Clement Y Chow

“…N-glycanase 1 (NGLY1) deficiency is an ultra-rare disease caused by autosomal recessive loss-of-function mutations in the NGLY1 gene. NGLY1 removes N-linked glycans from glycoproteins in the cytoplasm and is thought to help clear misfolded proteins from the endoplasmic reticulum (ER) through the ER associated degradation (ERAD) pathway. …”
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The Toll-like receptor 4 polymorphism Asp299Gly but not Thr399Ile influences TLR4 signaling and function. by Huaicong Long, Brian P O'Connor, Rachel L Zemans, Xiaofang Zhou, Ivana V Yang, David A Schwartz

“…The purpose of this study was to identify the relative contributions of the Asp299Gly and the Thr399Ile variants in inhibiting the function of TLR4. 293/hMD2-CD14 cell line was transfected with lentiviral constructs containing human wild type (WT) TLR4-EGFP or TLR4-EGFP with Asp299Gly, Thr399Ile or Asp299Gly/Thr399Ile complementary DNA (cDNA). …”
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The Effects of Recombinant pBD2 on the Growth Performance, Antioxidant Capacity, Immune Function, Intestinal Barrier, and Microbiota of Weaned Piglets by Zhanwei Teng, Qing Meng, Mengting Ren, Bingke Lv, Liping Yuan, Ningning Zhang, Qinghua Wang, Kun Zhang, Chunli Li

“…Alterations in the gut microbiota were closely associated with the levels of T-AOC, SOD, IgM, and IL-10 in serum. pBD2 primarily enhanced the health of weaned piglets by influencing antioxidant capacity, intestinal barrier function, and the intestinal microbiota. Our research provides a novel perspective for addressing the issue of antibiotic residues in feed.…”
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The interrelationships between the microRNA miR-34a and the plant flavonoids apigenin and quercetin in the regulation of ovarian cell functions by Alexander V. Sirotkin, Zuzana Fabová, Barbora Loncová, Zuzana Kislíková, Abdel Halim Harrath

“…Abstract Our study aimed to examine the possible interrelationships between RNA interference and plant flavonoids in the regulation of ovarian functions. For this purpose, we compared porcine ovarian cells that were transfected or not with oligonucleotides to drive miR-34a overexpression (miR-34a mimics) and cultured in the presence of absence of apigenin or quercetin (at doses of 1, 10–100 µg/ml). …”
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Connexin43 functions as a non-canonical phenotypic stability factor in promoting hybrid Epithelial/Mesenchymal phenotype in glioblastoma cells by Anushka Mondal, Sanchari Saha, Adrish Ghosh, Justin D Lathia, Jayasri Das Sarma

“…Here, we identify a critical tumor-promoting role of Cx43 in GBM by functioning as a non-canonical phenotypic stability factor and driving partial EMT, which enhances the acquisition of stemness properties in the cells. …”
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The Important Role of Dendritic Cell (DC) in iNKT-Mediated Modulation of NK Cell Function in Chlamydia pneumoniae Lung Infection by Lei Zhao, Xiaoling Gao, Hong Bai, Antony George Joyee, Shuhe Wang, Jie Yang, Weiming Zhao, Xi Yang

“…Using in vitro DC-NK coculture and in vivo adoptive transfer approaches, we further examined the role of DCs in iNKT-mediated modulation of NK cell function. We found that NK cells expressed lower levels of activation markers and produced less IFN-γ when they were cocultured with DCs from KO mice than WT mice. …”
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Electroacupuncture Regulates Hippocampal Synaptic Plasticity via miR-134-Mediated LIMK1 Function in Rats with Ischemic Stroke by Weilin Liu, Jie Wu, Jia Huang, Peiyuan Zhuo, Yunjiao Lin, Lulu Wang, Ruhui Lin, Lidian Chen, Jing Tao

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IgG3 enhances neutralization potency and Fc effector function of an HIV V2-specific broadly neutralizing antibody. by Simone I Richardson, Bronwen E Lambson, Andrew R Crowley, Arman Bashirova, Cathrine Scheepers, Nigel Garrett, Salim Abdool Karim, Nonhlanhla N Mkhize, Mary Carrington, Margaret E Ackerman, Penny L Moore, Lynn Morris

“…BNAb functions are typically assessed independently of the constant region with which they are naturally expressed. …”
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Loss-of-function variants of CYP706A3 in two natural accessions of Arabidopsis thaliana increase floral sesquiterpene emission by Moonyoung Kang, Yuri Choi, Hyeonjin Kim, Min-Soo Choi, Seula Lee, Youbong Hyun, Sang-Gyu Kim

“…Since some natural accessions harboring a functional allele of CYP706A3 still emit the large amount of floral sesquiterpene, it is possible that rare variants located on other loci increase scent emission.…”
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Functional analysis of the PcCDPK5 gene in response to allelopathic substances on p-hydroxybenzoic acid (p-HBA) stress in patchouli by Xiaofeng Liu, Jingru Zhou, Muhammad Zeeshan Ul Haq, Zhineng Fu, Guangtao Gu, Jing Yu, Ya Liu, Dongmei Yang, Huageng Yang, Yougen Wu

“…Through this research, the function of PcCDPK5 in response to p-HBA stress has been preliminarily analyzed, laying a theoretical foundation for alleviating CC obstacles in patchouli.…”
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Dual-transcriptomics on microdissected cells reveals functional specialisation of symbiont-bearing-cells and contrasted responses to nutritional stress in the cereal weevil by Nikoletta Galambos, Nicolas Parisot, Agnès Vallier, Claudia Bevilacqua, Séverine Balmand, Carole Vincent-Monégat, Rita Rebollo, Benjamin Gillet, Sandrine Hughes, Abdelaziz Heddi, Anna Zaidman-Rémy

“…We found that central bacteriocytes overexpress transport and G-protein signalling-related genes when compared to peripheral bacteriocytes, indicating a signalling and/or transport function of these cells. Diet composition strongly impacts host and endosymbiont gene expression and reveals a molecular trade-off among metabolic pathways. …”
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