Relationships among cortical activation, cognition, and blood biomarkers in two types of dementia determined using functional near-infrared spectroscopy by Nairong Ruan, Nairong Ruan, Ming Liang, Ming Liang, Yuehong Liu, Xi Mei, Chengying Zheng

“…Brain function was assessed using a verbal fluency task (VFT). …”
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Supplementation of curcumin promotes the intestinal structure, immune barrier function and cecal microbiota composition of laying hens in early laying period by Zhengyu Xu, Wei Zhu, Dan Xu, Felix Kwame Amevor, Youhao Wu, Dongji Ma, Xueqing Cao, Shuo Wei, Gang Shu, Xiaoling Zhao

“…Curcumin also improved the intestinal immune barrier function by increasing ZO-1 and Occludin expression. …”
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Roles for the long non-coding RNA Pax6os1/PAX6-AS1 in pancreatic beta cell function by Livia Lopez-Noriega, Rebecca Callingham, Aida Martinez-Sánchez, Sameena Nawaz, Grazia Pizza, Nejc Haberman, Nevena Cvetesic, Marie-Sophie Nguyen-Tu, Boris Lenhard, Piero Marchetti, Lorenzo Piemonti, Eelco de Koning, A.M. James Shapiro, Paul R. Johnson, Isabelle Leclerc, Benoit Hastoy, Benoit R. Gauthier, Timothy J. Pullen, Guy A. Rutter

“…Summary: Long non-coding RNAs (lncRNAs) are emerging as crucial regulators of beta cell function. Here, we show that an lncRNA-transcribed antisense to Pax6, annotated as Pax6os1/PAX6-AS1, was upregulated by high glucose concentrations in human as well as murine beta cell lines and islets. …”
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Bushen-Tiansui Formula Improves Cognitive Functions in an Aβ1–42 Fibril-Infused Rat Model of Alzheimer’s Disease by Chenxia Sheng, Panpan Xu, Xinyi Liu, Weijun Peng, Daxiong Xiang, Shilin Luo

“…However, the medicinal ingredients and the mechanisms by which BTF improves cognition and memory functions have not been characterized. In this study, we used UPLC-MS to generate a chromatographic fingerprinting of BTF and identified five possible active ingredients, including stilbene glycoside; epimedin A1, B, and C; and icariin. …”
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Functions of developmental pluripotency-associated 2 and 4 (DPPA2/DPPA4) in bovine preimplantation embryo development and their potential mechanisms by QIU Jinlong, LUO Lei, HU Bingjie, DANG Yanna, LI Shuang, SHI Yan, WANG Shaohua, ZHANG Kun

“…Developmental pluripotency-associated 2 and 4 (DPPA2/DPPA4) are important regulators of genome activation in 2-cell-like embryonic stem cells (2CL ESCs), meanwhile, they can regulate the proliferation of ESCs. However, the functions of DPPA2/DPPA4 during early bovine embryo development and their potential mechanisms remain unclear. …”
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Uncoupling protein 2 haplotype does not affect human brain structure and function in a sample of community-dwelling older adults. by Verena Heise, Enikő Zsoldos, Sana Suri, Claire Sexton, Anya Topiwala, Nicola Filippini, Abda Mahmood, Charlotte L Allan, Archana Singh-Manoux, Mika Kivimäki, Clare E Mackay, Klaus P Ebmeier

“…Polymorphisms of the UCP2 gene in humans affect protein expression and function and have been linked to survival into old age. …”
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Association between Functional Polymorphisms of Foxp3 Gene and the Occurrence of Unexplained Recurrent Spontaneous Abortion in a Chinese Han Population by Zaigui Wu, Zeshan You, Cai Zhang, Zhuyu Li, Xiumei Su, Xiuming Zhang, Yinguang Li

“…Additionally, we found that the allelic distribution of rs5902434 del/ATT in URSA group was slightly different from that in the control group. We conclude that functional polymorphisms of the Foxp3 gene may confer an important susceptibility to URSA in the Chinese Han population, probably by altering Foxp3 function and/or its expression.…”
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Study on the Relationship Between MRI Functional Imaging and Multiple Immunohistochemical Features of Glioma: A Noninvasive and More Precise Glioma Management by Jing Li MD, Jingtao Sun BS, Ning Wang MS, Yan Zhang MS

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Functional characterization of the Xanthophyllomyces dendrorhous farnesyl pyrophosphate synthase and geranylgeranyl pyrophosphate synthase encoding genes that are involved in the s... by Jennifer Alcaíno, Ignacio Romero, Mauricio Niklitschek, Dionisia Sepúlveda, María Cecilia Rojas, Marcelo Baeza, Víctor Cifuentes

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Combined Effects of Exercise and Vitamin D on Neuroinflammation, Blood-Brain Barrier Integrity, Oxidative Stress, and Cognitive Function in Nonpathological Mice by Taewan Kim, Donghyun Kim, Yoonhwan Kim, Jeonghyeon Kim, Seamon Kang, Jinkyung Cho

“…Purpose This study investigated whether the combined application of treadmill exercise and vitamin D injections exerts neuroprotective effects in nonpathological mice by enhancing cognitive function, regulating immune responses, preserving blood-brain barrier (BBB) integrity, and improving mitochondrial efficiency. …”
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Role of receptor activity modifying protein 1 in function of the calcium sensing receptor in the human TT thyroid carcinoma cell line. by Aditya J Desai, David J Roberts, Gareth O Richards, Timothy M Skerry

“…Furthermore, we show that normal RAMP1 function is required for intracellular responses to ligands. …”
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Response of Microbial Community Structure and Changes in Carbon and Nitrogen Cycling Functional Genes during Ecological Restoration in Rocky Slopes Areas by Guo Mingfan, Tang Chuiyun, Zhang Jinxin, Lv Ying, Wei Li, Liu Xingyu

“…From a molecular ecology perspective, this study elucidates the mechanism by which microbial remediation facilitates rapid ecological restoration of slopes through reshaping functional microbial networks and activating key metabolic gene expression. …”
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Identification and functional modelling of plausibly causative cis-regulatory variants in a highly-selected cohort with X-linked intellectual disability. by Hemant Bengani, Detelina Grozeva, Lambert Moyon, Shipra Bhatia, Susana R Louros, Jilly Hope, Adam Jackson, James G Prendergast, Liusaidh J Owen, Magali Naville, Jacqueline Rainger, Graeme Grimes, Mihail Halachev, Laura C Murphy, Olivera Spasic-Boskovic, Veronica van Heyningen, Peter Kind, Catherine M Abbott, Emily Osterweil, F Lucy Raymond, Hugues Roest Crollius, David R FitzPatrick

“…In male mice Fmr1CRE induced alterations in neurodevelopmental Fmr1 expression, olfactory behavior and neurophysiological indicators of FMRP function. …”
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The catalytic subunit of protein phosphatase 1 gamma regulates thrombin-induced murine platelet alpha(IIb)beta(3) function. by Francisca C Gushiken, Han Hyojeong, Subhashree Pradhan, Kimberly W Langlois, Nawaf Alrehani, Miguel A Cruz, Rolando E Rumbaut, K Vinod Vijayan

“…Thrombin-stimulated PP1cgamma(-/-) platelets showed decreased alpha(IIb)beta(3) activation despite comparable levels of alpha(IIb)beta(3), PAR3, PAR4 expression and normal granule secretion. Functions regulated by outside-in integrin alpha(IIb)beta(3) signaling like adhesion to immobilized fibrinogen and clot retraction were not altered in PP1cgamma(-/-) platelets. …”
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Integrated proteomics highlights functional activation induced by advanced-platelet rich fibrin plus (A-PRF +) in primary equine fibroblasts by Maria Rosaria Miranda, Chiara Montano, Valentina Golino, Mariaelena de Chiara, Chiara Del Prete, Giacomo Pepe, Davide De Biase, Tania Ciaglia, Alessia Bertamino, Pietro Campiglia, Eduardo Sommella, Vincenzo Vestuto, Maria Pia Pasolini

“…These findings provide insights into the molecular profile and functional responses of equine fibroblasts exposed to A-PRF + , contributing to our understanding of its cellular effects, supporting further exploration of this product in regenerative medicine applications.…”
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An Advanced Combinatorial System from <i>Vitis vinifera</i> Leaves and Propolis Enhances Antioxidants’ Skin Delivery and Fibroblasts Functionality by Sophia Athanasopoulou, Eleni Spanidi, Eleni Panagiotidou, Andrea Cavagnino, Anaïs Bobier, Konstantinos Gardikis

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Molecular Targets of Oxidative Stress: Focus on Nuclear Factor Erythroid 2–Related Factor 2 Function in Leukemia and Other Cancers by Syed K. Hasan, Sundarraj Jayakumar, Eliezer Espina Barroso, Anup Jha, Gianfranco Catalano, Santosh K. Sandur, Nelida I. Noguera

“…This review provides a comprehensive overview of Nrf2 regulation and function, highlighting its unique features in cancer biology, particularly its role in metabolic adaptation and drug resistance. …”
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Characterization of a pathogenic gain-of-function mutation in the N-terminal domain of STAT1 which is reported to be associated with eosinophilic esophagitis by Kristin Annawald, Anke Gregus, Oliver Wirths, Thomas Meyer

“…Recently, a case report described a gain-of-function (GOF) mutation in the STAT1 (signal transducer and activator of transcription 1) protein (D65A) to be associated with this disease. …”
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Effects of dietary sorghum inclusion on growth performance, liver function, antioxidant capacity and flesh quality in grass carp (Ctenopharyngodon idella) by Xuehan Wang, Xiangqin Lin, Huajing Huang, Wen Jiang, Haifeng Mi, Lu Zhang, Junming Deng

“…This study aimed to investigate the effects of dietary sorghum inclusion on the growth performance, liver function, antioxidant capacity and fillet quality of grass carp (Ctenopharyngodon idella). …”
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A dual‐AAV approach restores fast exocytosis and partially rescues auditory function in deaf otoferlin knock‐out mice by Hanan Al‐Moyed, Andreia P Cepeda, SangYong Jung, Tobias Moser, Sebastian Kügler, Ellen Reisinger

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