Identification of novel antiviral host factors by functional gene expression analysis using in vitro HBV infection assay systems. by Takuto Nosaka, Tatsushi Naito, Yu Akazawa, Kazuto Takahashi, Hidetaka Matsuda, Masahiro Ohtani, Tsutomu Nishizawa, Hiroaki Okamoto, Yasunari Nakamoto

Get full text

Jurkat T-cell lines exhibit marked genomic instability affecting karyotype, mutational profile, gene expression, immunophenotype and function by Andrew Wilson, Nathaniel Dasyam, Felix O’Hagan, Dianna Farrell, Claire Turner, Anne Jay, Alfonso Schmidt, Rachel Beddow, Tina Lillis, Tom Chin, Rachel Perret, Michelle McCulley, Robert Weinkove

“…These genomic changes were associated with differences in protein expression and cytokine production that may affect functional assays. …”
Get full text

Trabectedin promotes oncolytic virus antitumor efficacy, viral gene expression, and immune effector function in models of bone sarcoma by Emily M. Ringwalt, Mark A. Currier, Andrea M. Glaspell, Chun-Yu Chen, Matthew V. Cannon, Maren Cam, Amy C. Gross, Matthew Gust, Pin-Yi Wang, Louis Boon, Laura E. Biederman, Emily Schwarz, Prajwal Rajappa, Dean A. Lee, Elaine R. Mardis, William E. Carson, 3rd, Ryan D. Roberts, Timothy P. Cripe

Get full text

Hepatitis C virus induced endothelial inflammatory response depends on the functional expression of TNFα receptor subtype 2. by Joachim Pircher, Thomas Czermak, Monika Merkle, Hanna Mannell, Florian Krötz, Andrea Ribeiro, Volker Vielhauer, Jonathan Nadjiri, Erik Gaitzsch, Markus Niemeyer, Stefan Porubsky, Hermann-Josef Gröne, Markus Wörnle

“…HCV-RNA induces the endothelial expression of TNFα and TNFα receptor subtype 2 and we provide evidence that leucocyte adhesion and transmigration in response to activation of viral RNA receptors seem to depend on expression of functional TNFR2. …”
Get full text

Expression of recombination antimicrobial protein PIL22-PBD-2 in Pichia pastoris and verification of its biological function in vitro by Xian Li, Pengfei Qiu, Menglong Yue, Ying Zhang, Congshang Lei, Jingyu Wang, Xiwen Chen, Xuefeng Qi

“…Additionally, given its strong ability to repair intestinal epithelial damage and maintain intestinal mucosal barrier function, porcine interleukin-22 (PIL-22) is a potential feed additive to combat intestinal damage caused by intestinal pathogens in piglets. …”
Get full text

Correction to Expression of Concern on: Functional Improvement of Regulatory T Cells from Rheumatoid Arthritis Subjects Induced by Capsular Polysaccharide Glucuronoxylomannogalactan. by PLOS ONE Staff

Get full text

Early life ozone exposure results in dysregulated innate immune function and altered microRNA expression in airway epithelium. by Candice C Clay, Kinjal Maniar-Hew, Joan E Gerriets, Theodore T Wang, Edward M Postlethwait, Michael J Evans, Justin H Fontaine, Lisa A Miller

“…To test this hypothesis, we evaluated primary airway epithelial cell cultures derived from juvenile rhesus macaque monkeys with a prior history of episodic postnatal ozone exposure. Innate immune function was measured by expression of the proinflammatory cytokines IL-6 and IL-8 in primary cultures established following in vivo LPS challenge or, in response to in vitro LPS treatment. …”
Get full text

The Functional Role and Prognostic Significance of TIM-3 Expression on NK Cells in the Diagnostic Bone Marrows in Acute Myeloid Leukemia by Kai Sun, Zong-Yan Shi, Dai-Hong Xie, Ya-Zhe Wang, Hao Jiang, Qian Jiang, Xiao-Jun Huang, Ya-Zhen Qin

“…<b>Background:</b> Compared to other immune checkpoint molecules, T cell immunoglobulin domain and mucin domain-3 (TIM-3) is highly expressed on natural killer (NK) cells, but its functional role and prognostic significance in acute myeloid leukemia (AML) remains unclear. …”
Get full text

P5 Impact of miR-155 on histone methylation-modifying gene expression and cellular functions in prostate cancer by R. Maleckaite, M. Tamosiunaite, A. Stucinskas, A. Sipaviciute, K. Daniunaite

Get full text

From Metagenomes to Functional Expression of Resistance: <i>floR</i> Gene Diversity in Bacteria from Salmon Farms by Javiera Ortiz-Severín, Iñaki Hojas, Felipe Redin, Ervin Serón, Jorge Santana, Alejandro Maass, Verónica Cambiazo

“…Total DNA from bacterial communities was used as a template to recover <i>floR</i> gene variants, which were tested by heterologous expression and functional characterization of phenicol resistance. …”
Get full text

Phenotype and functions of human dendritic cells derived from CD14+ monocyte subsets opposed to CD16 expression by E. R. Chernykh, T. V. Tyrinova, O. Yu. Leplina, M. A. Tikhonova, Yu. D. Kurochkina, E. A. Oleynik, L. V. Sakhno, A. A. Ostanin

“…The aim of the study was to analyze the relationship between monocyte subpopulations and phenotype/ functions of monocyte-derived dendritic cells (DCs), as well as DC sensitivity to the tolerogenic effect of dexamethasone.Materials and methods. …”
Get full text

When Genetic Diversity Is Low: The Effects of Ploidy Level on Plant Functional Trait Expression in Spartina Under Global Change by Dirk Granse, Paul Wendt, Sigrid Suchrow, Dieter Hanelt, Jörg Fromm, Morgane Milin, Oscar Lima, Armel Salmon, Malika Aïnouche, Kai Jensen

Get full text

Cloning, phylogenetic analysis, tissue expression profiling, and functional roles of NPC1L1 in chickens, quails, and ducks by Xin Shu, Ziwei Chen, Hui Wang, Bingjie Xu, Li Liu, Jilong Zhang, Xiaotong Zheng, Jianfei Chen

“…Further experiments are required to elucidate the biological function of poultry NPC1L1. In summary, this study successfully cloned the full-length sequence of NPC1L1 from chickens, quails, and ducks, and conducted a comprehensive analysis of their evolutionary history and expression patterns. …”
Get full text

Human gut microbiome gene co-expression network reveals a loss in taxonomic and functional diversity in Parkinson’s disease by Rémy Villette, Polina V. Novikova, Cédric C. Laczny, Brit Mollenhauer, Patrick May, Paul Wilmes

“…Blautia, Roseburia, Faecalibacterium and Anaerobutyricum genera are the main contributors to these functions, showing significantly lower expression in PD. …”
Get full text

Transgenic Expression of a Functional Fragment of Harpin Protein Hpa1 in Wheat Represses English Grain Aphid Infestation by Man-yu XU, Ting ZHOU, Yan-ying ZHAO, Jia-bao LI, Heng XU, Han-song DONG, Chun-ling ZHANG

Get full text

Molecular cloning, expression and functional analysis of foxl2 from Chinese sturgeon (Acipenser sinensis) in relation to sex differentiation by Yacheng Hu, Yacheng Hu, Ruihua Tan, Yang Li, Yang Li, Tingting Shu, Tingting Shu, Gang Yang, Zhong Chu, Haoran Wang, Xueqing Liu, Xueqing Liu, Xin Zhu, Xin Zhu, Binzhong Wang, Binzhong Wang, Baifu Guo, Baifu Guo, Runqiu Wang, Runqiu Wang, Huantao Qu, Huantao Qu, Haoyong Song, Haoyong Song, Dezhi Zhang, Dezhi Zhang, Hejun Du, Hejun Du, Zhiyuan Li, Zhiyuan Li, Jianbo Chang, Jianbo Chang, Dianchang Wang, Dan Xu, Wei Jiang, Wei Jiang, Qingfei Li, Yuanjin Yang, Yuanjin Yang

Get full text

Carbonic anhydrase 2-derived drug-responsive domain regulates membrane-bound cytokine expression and function in engineered T cells by Mara C. Inniss, Sean G. Smith, Dan Jun Li, Benjamin Primack, Dexue Sun, Grace Y. Olinger, Kerri-Lynn Sheahan, Theresa Ross, Meghan Langley, Violet Young, Andres Alvarado, Shabnam Davoodi, Jiefei Geng, Michael Schebesta, Michelle L. Ols, Jeremy Tchaicha, Jan ter Meulen, Dhruv K. Sethi

Get full text

Effects of Dendrobium Polysaccharides on the Functions of Human Skin Fibroblasts and Expression of Matrix Metalloproteinase-2 under High-Glucose Conditions by Yajia Li, Ziqin Cao, Qiangxiang Li, Chenxu Wang, Zhuo Zhou

“…The effects of Dendrobium polysaccharides (PDC) on the functions of human skin fibroblasts (HSFs) and expression of matrix metalloproteinase-2 under high-glucose conditions and exploration of the underlying mechanism remain unclear. …”
Get full text

Closed Form Analytic Expressions for the Evanescent and Traveling Components of the Electromagnetic Green Function and for Defocused Hemispherical Focusing of Electromagnetic Waves by Colin J. R. Sheppard

“…Explicit analytic forms, in terms of Lommel functions of two variables, for the evanescent and traveling components of the electromagnetic Green tensor are presented. …”
Get full text

Functions of thyroid hormone signaling in regulating melanophore, iridophore, erythrophore, and pigment pattern formation in spotted scat (Scatophagus argus) by Yongguan Liao, Tong Han, Dongneng Jiang, Chunhua Zhu, Gang Shi, GuangLi Li, Hongjuan Shi

“…Thyroid hormones (TH) function as an important endocrine factor in regulating metamorphosis. …”
Get full text