Functional Analysis of the <i>ZmPR5</i> Gene Related to Resistance Against <i>Fusarium verticillioides</i> in Maize by Wei Yang, Hongyu Cai, Yuanqi Zhang, Junheng Hao, Yaqi Ma, Qinxuan He, Kun Zhao, Honggang Li, Ayue Fang, Dalong Hou, Xuejiao Ren

“…The gene was subsequently cloned and its function was investigated. The <i>ZmPR5</i> gene comprises an open reading frame of 525 base pairs, encoding a protein of 175 amino acids. …”
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IFN-α and vitamin B6-induced galectin-9 promotes the immunomodulatory function of human clonal mesenchymal stem cells by Jee-Hoon Nam, Jeong Hyun Moon, Byeol Choi, Geun-Hyung Kang, Yunok Park, Se-Yeon Park, Tae-Hyun Ko, Donghee Shin, YoungSu Jung, Si-Na Kim, Yun-Kyoung Cho, Myung-Shin Jeon

“…Abstract Background Mesenchymal stem cells (MSCs) possess a variety of immunomodulatory functions that can vary depending on the MSC line. …”
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Two functional indel polymorphisms in the promoter region of the Brahma gene (BRM) and disease risk and progression-free survival in colorectal cancer. by Yajun Yu, Dangxiao Cheng, Patrick Parfrey, Geoffrey Liu, Sevtap Savas

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High-Mobility Group Box-1 Protein Serum Levels Do Not Reflect Monocytic Function in Patients with Sepsis-Induced Immunosuppression by Nadine Unterwalder, Christian Meisel, Konstantinos Savvatis, Ben Hammoud, Christina Fotopoulou, Hans-Dieter Volk, Petra Reinke, Joerg C. Schefold

“…We investigated whether systemic HMGB-1 levels are associated with indices of monocytic activation/function in patients with sepsis-induced immunosuppression. …”
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Nitazoxanide Modulates Mitochondrial Function and Inflammatory Metabolism in Chondrocytes from Patients with Osteoarthritis via AMPK/mTORC1 Signaling by Ha Eun Kim, Jong Yeong Lee, Ga-Yeon Son, Jun-Young Park, Ki Bum Kim, Chul-Min Choi, Young Jae Moon, Jin Kyeong Choi

“…Osteoarthritis (OA) is a long-term degenerative condition of the joints, characterized by persistent inflammation, progressive cartilage breakdown, and impaired mitochondrial function. Recent studies have shown that hyperactivation of the mTORC1 pathway and metabolic reprogramming of chondrocytes contribute to disease progression. …”
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Ergocalciferol and microcirculatory function in chronic kidney disease and concomitant vitamin d deficiency: an exploratory, double blind, randomised controlled trial. by Gavin Dreyer, Arthur T Tucker, Steven M Harwood, Rupert M Pearse, Martin J Raftery, Muhammad M Yaqoob

“…There were no significant changes in bone mineral parameters, blood pressure or left ventricular mass index suggesting that ergocalciferol improved endothelial function independently of these parameters. In parallel experiments, expression of endothelial nitric oxide synthase and activity were increased in human endothelial cells in a dose dependent manner.…”
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Huaju Xiaoji Formula Regulates ERS-lncMGC/miRNA to Enhance the Renal Function of Hypertensive Diabetic Mice with Nephropathy by Zeng Zhang, Xiaodong Fu, Fengzhu Zhou, Duanchun Zhang, Yanqiu Xu, Zhaohua Fan, Shimei Wen, Yanting Shao, Zheng Yao, Yanming He

“…Administering HJXJ promoted the renal function of HDN mice. HJXJ reduced the expression of ER stress makers (CHOP and GRP78) and lncMGC, miR379, miR494, miR495, miR377, CUGBP2, CPEB4, EDEM3, and ATF3 in HDN mice and model HGMCs. …”
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Common Ɣ-chain cytokine receptors as functional phenotype markers of PD-1and TIM-3-positive T cells in multiple myeloma by E. V. Batorov, V. A. Aristova, G. Yu. Ushakova, S. A. Sizikova, V. V. Denisova, E. Ya. Shevela, A. A. Ostanin, E. R. Chernykh

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Surface-functionalized UIO-66-NH2 for dual-drug delivery of vancomycin and amikacin against vancomycin-resistant Staphylococcus aureus by Nazanin Rahmanian, Pooria Moulavi, Fatemeh Ashrafi, Aram Sharifi, Sepideh Asadi

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<i>Artemisia annua</i> Residue Regulates Immunity, Antioxidant Ability, Intestinal Barrier Function, and Microbial Structure in Weaned Piglets by Jinjie Hu, Miaomiao Bai, Yueyao Xing, Junhong Liu, Kang Xu, Xia Xiong, Hongnan Liu, Yulong Yin

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Functional Characterization of Deubiquitinase UBP Family and Proteomic Analysis of Aaubp14-Mediated Pathogenicity Mechanism in <i>Alternaria alternata</i> by Jiejing Tang, Hang Zhou, Chen Jiao, Hongye Li

“…Our findings elucidate <i>Aaubp</i> gene function in development and pathogenicity, particularly the Aaubp14-mediated regulation mechanism, providing insights into ubiquitination-mediated pathogenicity in phytopathogenic fungi.…”
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Yttrium Oxide Nanoparticles Affect Both Cognitive and Memory Function by Disrupting Copper Output in Neuronal Cells in a Rat Model by Zheng M, Chen Z, Xie J, Yang Q, Mo M, Chen L

“…However, the influence of Y2O3 NPs on cognitive memory function in the brain is currently unclear.Methods: The effects of Y2O3 NPs on cognitive and memory function were evaluated by rat behavioural experiments after intraperitoneal injection in a rat model. …”
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Fatty Acid Metabolism via CPT1A Supports Poll Gland Function and Rutting Activities in Male Bactrian Camels by Qi Ma, Bohao Zhang, Bin Zhou, Quanwei Zhang, Yuan Gao

“…The results suggested that CPT1A-mediated fatty acid oxidation sustains poll gland function and reproductive behaviors in male Bactrian camels. …”
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Comparative analysis of HKT genes in Ipomoea pes-caprae unveils conserved Na+/K+ symporter functions within the gene family by Zhonghua Guo, Zhonghua Guo, Jin Sun, Jin Sun, Xingguang Chen, Hui Li, Sisi Liang, Fengying Liu, Tong Qu, Huaer Wang, Xueli Li, Zitong Ou, Zitong Ou, Haoran Feng, Jinbiao Ma, Sheng Wang, Lulu Wang, Lulu Wang, Boping Tang, Gang Wang, Yuan Qin, Yuan Qin, Yan Cheng, Yan Cheng, Yan Cheng

“…Comparative analysis of conserved motifs and intron-exon structures indicated that, despite their close evolutionary relationship, the HKT genes in IPC may exhibit functional divergence. Promoter analysis showed that their regulatory regions are enriched with cis-elements associated with responses to biotic and abiotic stresses, hormonal signaling, and growth, highlighting functional diversity within the HKT family. …”
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Sorafenib enhanced the function of myeloid-derived suppressor cells in hepatocellular carcinoma by facilitating PPARα-mediated fatty acid oxidation by Chunxiao Li, Liting Xiong, Yuhan Yang, Ping Jiang, Junjie Wang, Mengyuan Li, Shuhua Wei, Suqing Tian, Yuexuan Wang, Mi Zhang, Jie Tang

“…MDSCs were analyzed for chemotaxis, immunosuppressive functions, fatty acid oxidation (FAO), and PPARα expression. …”
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Conserved function of bat TBK1 in activating innate immunity against RNA viruses: insights into the innate immune response in bats by Qiuju Liu, Qi Shao, Caixia Xu, Chao Liu, Shuhan Li, Jie Wang, Xia Liu, Kehui Zhang, Yaxian Yan, Jianhe Sun, Yuqiang Cheng

“…Structurally, protein kinase domain (PKD), ubiquitin-like domain (ULD), and coiled-coil domain 1 (CCD1) are essential domains for bat TBK1 to function normally. In summary, this study elucidated bat TBK1 has a conserved ability to activate bat antiviral innate immunity.…”
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Microbial and molecular signatures for enhanced gut health in pigs fed a diet with spray-dried plasma as functional protein source by Soumya K. Kar, Dirkjan Schokker, Carine van Vuure, Herman van Iersel, Amy C. Harms, Amy C. Harms, Leo Kruijt, Mari A. Smits, Mari A. Smits, Alfons J. M. Jansman

“…Overall, our results highlight the nutritional and functional value of SDP as functional dietary protein source.…”
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Multi-functional PGPR Serratia liquefaciens confers enhanced resistance to lead stress and bacterial blight in soybean (Glycine max L.) by Mohamed A. El-Esawi, Hayssam M. Ali, Ashraf Atef Hatamleh, Munirah Abdullah Al-Dosary, Enas M. El-Ballat

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IL-15 transpresentation by ovarian cancer cells improves CD34+ progenitor-derived NK cell's anti-tumor functionality by M. Vidal-Manrique, T. Nieuwenstein, L. Hooijmaijers, P.K.J.D. de Jonge, M. Djojoatmo, J. Jansen, A.B. van der Waart, R. Brock, H. Dolstra

“…An approach to further improve NK cell expansion and anti-tumor functionality post-infusion includes IL-15 transpresentation (transIL-15), which involves surface expression of the IL-15 cytokine bound to IL-15Rα. …”
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Autophagy modulation by hADSCs and green light therapy alleviates inflammation and promotes functional recovery after spinal cord injury by Junjie Chen, Quanxin He, Huan Xie, Bin Gu, Liyi Zhou, Daoyuan Jiang, Hongxin Xie, Li Liang, Zhilai Zhou, Hui Zhang

“…Results The combined treatment group (hADSCs + GL) showed significant motor function recovery, pain relief, and histological improvement, outperforming either treatment alone. …”
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