Chicken GLUT4 function via enhancing mitochondrial oxidative phosphorylation and inhibiting ribosome pathway in skeletal muscle satellite cells by Lin Zhang, Pengna Luo, Huihong Li, Yuxian Pan, Huaiyong Zhang, Xuemeng Si, Wen Chen, Yanqun Huang

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Bacillus anthracis lethal toxin disrupts TCR signaling in CD1d-restricted NKT cells leading to functional anergy. by Sunil K Joshi, Gillian A Lang, Jason L Larabee, T Scott Devera, Lindsay M Aye, Hemangi B Shah, Jimmy D Ballard, Mark L Lang

“…We propose that Bacillus anthracis-derived LT causes a novel form of functional anergy in NKT cells and therefore has potential for contributing to immune evasion by the pathogen.…”
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Brown adipocyte-derived exosomes in type 2 diabetes mellitus impair endothelial function via regulating intracellular calcium cycle by Xiaojie Ruan, Wei Zhao, Wei Zhao

“…Functional studies revealed that ITPR3 positively regulates the Ca2+/CAMKII/eNOS signaling pathway to inhibit nitric oxide (NO) release, impairing endothelial relaxation.ConclusionBAT-derived exosomes in T2DM reduce ITPR3 expression in endothelial cells, lowering intracellular Ca2+ and NO production, thereby contributing to vascular endothelium-dependent relaxation dysfunction. …”
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Habitat Heterogeneity of Nitrogen and Phosphorus Cycling Functional Genes in Rhizosphere Microorganisms of <i>Pinus tabuliformis</i> in Qinling Mountains, China by Hang Yang, Yue Pang, Ying Yang, Dexiang Wang, Yuchao Wang

“…Microbial functional genes serve as the core genetic foundation driving microbial ecological functions; however, its microbial functional gene composition across varied habitats and its ecological adaptation interplay with plants remain understudied. …”
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Epigenetic regulation of organ-specific functions in Mikania micrantha and Mikania cordata: insights from DNA methylation and siRNA integration by Yatong Sang, Yitong Ma, Ruonan Wang, Zhen Wang, Ting Wang, Yingjuan Su

“…Abstract Background DNA methylation is a crucial epigenetic mechanism that regulates gene expression during plant growth and development. However, the role of DNA methylation in regulating the organ-specific functions of the invasive weed Mikania micrantha remains unknown. …”
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Endogenous Recovery of Hippocampal Function Following Global Cerebral Ischemia in Juvenile Female Mice Is Influenced by Neuroinflammation and Circulating Sex Hormones by Jose J. Vigil, Erika Tiemeier, James E. Orfila, Nicholas E. Chalmers, Victoria N. Chang, Danae Mitchell, Isobella Veitch, Macy Falk, Robert M. Dietz, Paco S. Herson, Nidia Quillinan

“…We performed CA/CPR in juvenile (P21-25) female mice and used slice electrophysiology and hippocampal-dependent behavior to assess hippocampal function. LTP and contextual fear were impaired 7 days after GCI and endogenously recovered by 30 days. …”
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E2F2 Reprograms Macrophage Function By Modulating Material and Energy Metabolism in the Progression of Metabolic Dysfunction‐Associated Steatohepatitis by Zheng Liu, Hao Wang, Yuan Liang, Mu Liu, Qiyuan Huang, Mingming Wang, Jinren Zhou, Qingfa Bu, Haoming Zhou, Ling Lu

“…E2F2 deficiency upregulates the expression of SLC7A5 to mediate amino acids flux, resulting in enhanced glycolysis, impaired mitochondrial function, and increased macrophages proinflammatory response in a Leu‐mTORC1‐dependent manner. …”
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Targeting TM4SF1 promotes tumor senescence enhancing CD8+ T cell cytotoxic function in hepatocellular carcinoma by Weifeng Zeng, Furong Liu, Yachong Liu, Ze Zhang, Haofan Hu, Shangwu Ning, Hongwei Zhang, Xiaoping Chen, Zhibin Liao, Zhanguo Zhang

“…Meanwhile, TM4SF1-mediated AKT phosphorylation enhanced PD-L1 expression while reducing major histocompatibility complex class I level on tumor cells, leading to impaired cytotoxic function of CD8+ T cells and an increased proportion of exhausted CD8+ T cells. …”
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11-amino acid peptide imitating the structure of erythropoietin α-helix b improves endothelial function, but stimulates thrombosis in rats. by M. V. Korokin, V. O. Soldatov, A. A. Tietze, M. V. Golubev, A. E. Belykh, M. V. Kubekina, O. A. Puchenkova, T. A. Denisyuk, V. V. Gureyev, T. G. Pokrovskaya, O. S. Gudyrev, M. A. Zhuchenko, M. A. Zatolokina, M. V. Pokrovskiy

“…Theresults of the functional tests for endothelium-dependent and endothelium-independent vasodilatation, as well as the histological picture of the aorta have evidenced that P-αB and EPO do not affect L-NAME-induced hypertension but improve the endothelium function. …”
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The interaction networks of small rubber particle proteins in the latex of Taraxacum koksaghyz reveal diverse functions in stress responses and secondary metabolism by Silva Melissa Wolters, Natalie Laibach, Jenny Riekötter, Kai-Uwe Roelfs, Boje Müller, Jürgen Eirich, Richard M. Twyman, Iris Finkemeier, Dirk Prüfer, Dirk Prüfer, Christian Schulze Gronover

“…Their sequence diversity and different expression profiles indicated distinct functions and the latex interactomes obtained for TkSRPP3/4/5 suggested that TkSRPP4 is a promiscuous hub protein that binds many partners from different compartments, whereas TkSRPP3 and 5 have more focused interactomes. …”
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C19orf12 inhibits mitochondrial function and enhances the antitumor effects of metformin in non-small cell lung cancer by Ran Liu, Meng Zhao, Xinrui Zhang, Hao Wu, Li Ren, Junqiang Lv, Zhe Liu, Quan Wang, Zhi Yao

“…Mechanistically, C19orf12 interacts with and suppresses the biological function of leucine-rich pentatricopeptide repeat motif-containing protein (LRPPRC) and downregulates the expression of mitochondrial electron transport chain (ETC) genes. …”
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The Effect of Dexamethasone-Mediated Atrophy on Mitochondrial Function and BCAA Metabolism During Insulin Resistance in C2C12 Myotubes by Kayla J. Ragland, Kipton B. Travis, Emmalie R. Spry, Toheed Zaman, Pamela M. Lundin, Roger A. Vaughan

“…<b>Results</b>: Both dexamethasone-induced atrophy and insulin resistance independently reduced insulin-stimulated pAkt levels, as well as mitochondrial function and content. However, neither treatment affected gene or protein expression associated with mitochondrial biogenesis or content. …”
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Towards delineating functions within the fasciola secreted cathepsin l protease family by integrating in vivo based sub-proteomics and phylogenetics. by Russell M Morphew, Hazel A Wright, E James Lacourse, Joanne Porter, John Barrett, Debra J Woods, Peter M Brophy

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Functional differences between PD-1+ and PD-1- CD4+ effector T cells in healthy donors and patients with glioblastoma multiforme. by Brittany A Goods, Amanda L Hernandez, Daniel E Lowther, Liliana E Lucca, Benjamin A Lerner, Murat Gunel, Khadir Raddassi, Vlad Coric, David A Hafler, J Christopher Love

“…Enrichment of these gene sets in tumor suggests a more metabolically active cell state with signaling through other co-receptors. PD-1 expression on CD4 cells identifies a dysfunctional subset refractory to rescue with PD-1 blocking antibodies, suggesting that the influence of immune checkpoint inhibitors may involve recovery of function in the PD-1-CD4+ T cell compartment. …”
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Functional Studies on the <i>LiAG1</i> Gene of <i>Lilium</i> ‘Ice Pink Queen’ in Flower Development by Lili Xue, Jingqi Dai, Ruyu Fu, Nana Wu, Jiaxuan Yu, Jie Dong, Tao Yang, Jinping Fan

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The flame retardant DE-71 (a mixture of polybrominated diphenyl ethers) inhibits human differentiated thyroid cell function in vitro. by Thit Mynster Kronborg, Juliana Frohnert Hansen, Åse Krogh Rasmussen, Katrin Vorkamp, Claus Henrik Nielsen, Marie Frederiksen, Jacob Hofman-Bang, Christoffer Holst Hahn, Louise Ramhøj, Ulla Feldt-Rasmussen

“…<h4>Conclusions</h4>DE-71 inhibited differentiated thyroid cell functions in a two phase response manner and a concentration-dependent inhibition of Tg and cAMP production, respectively, as well as expression of mRNA encoding Tg, TPO and TSHr. …”
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Phagocytosis is the main CR3-mediated function affected by the lupus-associated variant of CD11b in human myeloid cells. by Liliane Fossati-Jimack, Guang Sheng Ling, Andrea Cortini, Marta Szajna, Talat H Malik, Jacqueline U McDonald, Matthew C Pickering, H Terence Cook, Philip R Taylor, Marina Botto

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Low Oxygen Tension Enhances Osteogenic Potential of Bone Marrow-Derived Mesenchymal Stem Cells with Osteonecrosis-Related Functional Impairment by Lihong Fan, Ruiyu Liu, Jia Li, Zhibin Shi, Xiaoqian Dang, Kunzheng Wang

“…Glucocorticoids can affect the function of bone marrow-derived mesenchymal stem cells (BMMSCs) adversely and merit the requirement for a strategy to correct this anomaly; we assessed the effect of low oxygen (2%) on BMMSCs from rabbits with osteonecrosis. …”
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Timp2 loss-of-function mutation and TIMP2 treatment in a murine model of NSCLC: Modulation of immunosuppression and oncogenic signaling by David Peeney, Sarvesh Kumar, Tej Pratap Singh, Yueqin Liu, Sandra M. Jensen, Ananda Chowdhury, Sasha Coates-Park, Joshua Rich, Sadeechya Gurung, Yu Fan, Daoud Meerzaman, William G. Stetler-Stevenson

“…The effects of a Timp2 functional mutation and administration of recombinant TIMP2 were examined in both orthotopic and heterotopic murine models of lung cancer using C57Bl/6 syngeneic Lewis Lung 2-luciferase 2 cells (LL2-Luc2) cells. …”
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Memory-promoting function of miR-379-5p attenuates CD8+ T cell exhaustion by targeting immune checkpoints by Chia-Hsin Liu, Hong-Wei Li, Liang-Chih Liu, You-Zhe Lin, Wan-Rong Wu, Ting-Yi Liao, Chuan-Chun Lee, Feng-Chi Chung, Yi-Chun Shen, Guan-Yu Zhuo, Wei-Chung Cheng, Shao-Chun Wang

“…However, the mechanisms by which miRNAs influence T cell function in tumor environments remain unclear. This study focuses on miR-379-5p, which counteracts T cell exhaustion and enhances antitumor responses.Methods Native CD8+ T cells were isolated from the blood of healthy donors and subjected to chronic stimulation to induce exhaustion. …”
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